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1. 发明专利

IL255419D0 Tricyclic sulfones as rorgamma modulators 未知
公开(公告)号：IL255419D0
公开(公告)日：2017-12-31
申请号：IL25541917
申请日：2017-11-03
申请人： SQUIBB BRISTOL MYERS CO , DUAN JINGWU , DHAR T G MURALI , MARCOUX DAVID , SHI QING , BATT DOUGLAS G , LIU QINGJIE , CHERNEY ROBERT J , CORNELIUS LYNDON A M , SRIVASTAVA ANURAG S , BEAUDOIN BERTRAND MYRA , WEIGELT CAROLYN A
发明人： DUAN JINGWU , DHAR T G MURALI , MARCOUX DAVID , SHI QING , BATT DOUGLAS G , LIU QINGJIE , CHERNEY ROBERT J , CORNELIUS LYNDON A M , SRIVASTAVA ANURAG S , BEAUDOIN BERTRAND MYRA , WEIGELT CAROLYN A
IPC分类号： C07F20060101
摘要： or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

2. 发明专利

IL280650D0 Indole and azaindole inhibitors of pad enzymes 未知
公开(公告)号：IL280650D0
公开(公告)日：2021-03-25
申请号：IL28065021
申请日：2021-02-04
申请人： SQUIBB BRISTOL MYERS CO , CHERNEY ROBERT J , SRIVASTAVA ANURAG S , NGU KHEHYONG
发明人： CHERNEY ROBERT J , SRIVASTAVA ANURAG S , NGU KHEHYONG
IPC分类号： A61K45/06 , A61P35/00
摘要： The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, wherein each of Ring A, L, Q, R1, R2, R3, R4, R7, and R8 along with other variables are as defined herein.

3. 发明申请

WO2008014361A3 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开
公开(公告)号：WO2008014361A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/074378
申请日：2007-07-26
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARTER, Percy H. , CHERNEY, Robert J. , HYNES, John , KO, Soo S. , SRIVASTAVA, Anurag , XIAO, Zili , YANG, Michael G.
发明人： CARTER, Percy H. , CHERNEY, Robert J. , HYNES, John , KO, Soo S. , SRIVASTAVA, Anurag , XIAO, Zili , YANG, Michael G.
IPC分类号： C07D401/12 , C07D403/12 , C07D487/04 , A61K31/4025
摘要： This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases, particularly diabetes, Crohn's disease, atherosclerosis, and multiple sclerosis, along with methods of preparing compounds and intermediates therefor. Metabolites of active compounds are also provided herein, pharmaceutical compositions and use thereof are also provided.

4. 发明申请

WO2007120486A1 DELIVERY OF SUBSCRIPTION SERVICES TO ROAMING USERS THROUGH HEAD END EQUIPMENT 审中-公开
标题翻译：通过头端设备向订购用户提供订购服务
公开(公告)号：WO2007120486A1
公开(公告)日：2007-10-25
申请号：PCT/US2007/008115
申请日：2007-03-30
申请人： LUCENT TECHNOLOGIES INC. , ACHARYA, Swarup , GUPTA, Bhawna , SRIVASTAVA, Anurag
发明人： ACHARYA, Swarup , GUPTA, Bhawna , SRIVASTAVA, Anurag
IPC分类号： H04N7/173
CPC分类号： H04N7/17318 , H04N21/218 , H04N21/2221 , H04N21/4383 , H04N21/47202 , H04N21/6408 , H04N21/643 , H04N21/6433
摘要： A subscriber or other user is provided with access to a subscription service of a signal distribution system at a location remote from a home location of the user. The subscription service comprises a plurality of selectable channels available to the user at the home location. The user is assigned one of a plurality of program streams utilizable for delivery of content from the head end equipment servicing the remote location to an interface device at the remote location. By way of example, the program streams may be part of existing unicast infrastructure in the head end equipment. The head end equipment obtains content for a first channel of the subscription service available to the user at the home location, and inserts the content for the first channel into the assigned program stream to thereby make that content accessible to the user at the remote location via the interface device. User selection via the remote location interface device of a different channel of the subscription service available to the user at the home location causes the content for the different channel to be obtained by the head end equipment and inserted into the assigned program stream in place of the content for the first channel.
摘要翻译：用户或其他用户被提供对远离用户的本地位置的位置的信号分发系统的订阅服务的访问。订阅服务包括在家庭位置可用于用户的多个可选择的频道。用户被分配为可用于从服务于远程位置的头端设备向远程位置的接口设备传送内容的多个节目流中的一个。作为示例，节目流可以是头端设备中的现有单播基础设施的一部分。头端设备获得用于家庭可用的订阅服务的第一频道的内容，并将用于第一频道的内容插入分配的节目流中，从而使该用户可以在远程位置通过用户访问内容接口设备。通过远程位置接口设备对用户在归属位置可用的订阅服务的不同频道进行的用户选择使得头端设备获得用于不同信道的内容，并将其插入分配的节目流中，代替第一个频道的内容。

5. 发明申请

WO2007085789A1 ENCLOSURE FOR SURGICAL PROCEDURES 审中-公开
标题翻译：外科手术包装
公开(公告)号：WO2007085789A1
公开(公告)日：2007-08-02
申请号：PCT/GB2007/000039
申请日：2007-01-08
申请人： UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED , WOODCOCK, John, Patrick , WESTERN, Brian, James , SRIVASTAVA, Anurag
发明人： WOODCOCK, John, Patrick , WESTERN, Brian, James , SRIVASTAVA, Anurag
IPC分类号： A61B19/00
CPC分类号： A61B90/40 , A61G10/005
摘要： The invention relates to a medical device for performing substantially bloodless surgery wherein the device comprises a double-skinned chamber with at least one through-bore.
摘要翻译：本发明涉及一种用于执行基本无血管手术的医疗装置，其中该装置包括具有至少一个通孔的双皮肤腔室。

6. 发明申请

WO2008156575A1 TARGETED ADVERTISEMENT INSERTION WITH INTERFACE DEVICE ASSISTED SWITCHING 审中-公开
标题翻译：具有接口设备辅助开关的目标广告插入
公开(公告)号：WO2008156575A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007191
申请日：2008-06-09
申请人： LUCENT TECHNOLOGIES INC. , ACHARYA, Swarup , GUPTA, Bhawna , SRIVASTAVA, Anurag
发明人： ACHARYA, Swarup , GUPTA, Bhawna , SRIVASTAVA, Anurag
IPC分类号： H04L29/06
CPC分类号： H04L65/605 , H04L65/4084
摘要： Advertisements or other types of targeted information are delivered to a set-top box (112) or other user interface device of signal distribution system, in one aspect of the invention,' a detection server (202) of the system detects (1) at least one cue associated with a first media stream, and generates timing information from the detected cue. The timing information is signaled (3) to the interface device. An advertisement server (204) of the system generates a second media stream containing targeted information for delivery (5) to the user interface device. The user interface device switches from the first stream to the second stream based on the timing information. The timing information may also be signaled (2) by the detection server to the advertisement server, for use in controlling generation of the second stream.
摘要翻译：在本发明的一个方面，广告或其他类型的目标信息被传递到信号分配系统的机顶盒（112）或其他用户接口设备，“系统的检测服务器（202）检测（1）与第一媒体流相关联的至少一个提示，并且从检测到的提示生成定时信息。定时信息（3）发信号给接口设备。系统的广告服务器（204）生成包含用于传送（5）的目标信息到用户界面设备的第二媒体流。用户接口设备基于定时信息从第一流切换到第二流。定时信息也可以由检测服务器向广告服务器通知（2），以用于控制第二流的产生。

7. 发明申请

WO2012012477A1 SUBSTITUTED 3-PHENYL-1,2,4-OXADIAZOLE COMPOUNDS 审中-公开
标题翻译：取代的3-苯基-1,2,4-氧杂氮杂环丁烷化合物
公开(公告)号：WO2012012477A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/044597
申请日：2011-07-20
申请人： BRISTOL-MYERS SQUIBB COMPANY , DAS, Jagabandhu , KO, Soo Sung , SRIVASTAVA, Anurag , MOQUIN, Robert V. , WATTERSON, Scott H.
发明人： DAS, Jagabandhu , KO, Soo Sung , SRIVASTAVA, Anurag , MOQUIN, Robert V. , WATTERSON, Scott H.
IPC分类号： C07D271/06 , C07D413/10 , C07D413/14 , A61K31/4245 , A61P37/00 , A61P9/00
CPC分类号： C07D413/10 , A61K31/4245 , A61K31/4439 , A61K31/454 , C07D271/06 , C07D413/06 , C07D413/08 , C07D413/14 , C07D487/10
摘要： Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C 1 -C 4 alkyl, or (ii) R 1 and R 2 together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C 1-6 alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.
摘要翻译：公开了式（I）的化合物：（I）或其立体异构体，盐或前药，其中：（i）R 1和R 2独立地为C 1 -C 4烷基，或（ii）R 1和R 2与其中它们相连，形成一个环状基团; 并且Q是H，C 1-6烷基，苯基或被0至3个取代基取代的5至6元杂芳基，并且G在本文中定义。还公开了使用这些化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法和包含这些化合物的药物组合物。其中化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫性疾病和慢性炎症性疾病）中的疾病或病症的进展。

8. 发明申请

WO2008014361A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开
标题翻译：周期性衍生物作为趋化因子受体活性的调节剂
公开(公告)号：WO2008014361A2
公开(公告)日：2008-01-31
申请号：PCT/US2007074378
申请日：2007-07-26
申请人： SQUIBB BRISTOL MYERS CO , CARTER PERCY H , CHERNEY ROBERT J , HYNES JOHN , KO SOO S , SRIVASTAVA ANURAG , XIAO ZILI , YANG MICHAEL G
发明人： CARTER PERCY H , CHERNEY ROBERT J , HYNES JOHN , KO SOO S , SRIVASTAVA ANURAG , XIAO ZILI , YANG MICHAEL G
IPC分类号： C07D401/12 , A61K31/4025 , C07D403/12 , C07D487/04
CPC分类号： C07D403/12 , C07D401/12 , C07D487/04
摘要： This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases, particularly diabetes, Crohn's disease, atherosclerosis, and multiple sclerosis, along with methods of preparing compounds and intermediates therefor. Metabolites of active compounds are also provided herein, pharmaceutical compositions and use thereof are also provided.
摘要翻译：本发明一般涉及趋化因子受体活性调节剂，其具有理想的药理学性质的意想不到的组合。包含其的药物组合物及其作为治疗和预防炎症，变应性疾病，自身免疫疾病，代谢疾病，癌症和/或心血管疾病，特别是糖尿病，克罗恩氏病，动脉粥样硬化和多发性硬化症的药剂的方法，以及为此制备化合物和中间体。本文还提供了活性化合物的代谢物，还提供了药物组合物和其用途。

9. 发明申请

WO2006135591A1 SYSTEMS AND METHODS FOR PROVIDING LOCATION ENABLED VOICE MAIL 审中-公开
标题翻译：用于提供位置使用语音邮件的系统和方法
公开(公告)号：WO2006135591A1
公开(公告)日：2006-12-21
申请号：PCT/US2006/021631
申请日：2006-06-05
申请人： LUCENT TECHNOLOGIES, INC. , ESH, Thomas, D. , NAGESH, Harsha, S. , POOSALA, Viswanath , SRIVASTAVA, Anurag
发明人： ESH, Thomas, D. , NAGESH, Harsha, S. , POOSALA, Viswanath , SRIVASTAVA, Anurag
IPC分类号： H04M3/533
CPC分类号： H04M3/533 , H04M3/42042 , H04M3/42102 , H04M3/42348 , H04M3/42357 , H04W4/02
摘要： Location enabled voice mail is described. Such capability can be provided by service providers to offer their customers a host of unique location based voice mail services of both an audio and video nature. By way of example, a first calling party may leave a voice mail message for a second called party at a first time. First location information for the calling device is obtained about the first time. Upon retrieving the voice mail message at a second time, the called party is provided with the location enabled voice mail services. For example, the called party may receive a map containing the location of the calling device at a first time plotted thereon.
摘要翻译：描述了启用位置的语音邮件。这样的能力可以由服务提供商提供给他们的客户一个基于音频和视频性质的独特的基于位置的语音邮件服务。作为示例，第一主叫方可以在第一时间离开第二被叫方的语音邮件消息。首次获得主叫设备的第一个位置信息。在第二次检索语音邮件消息时，向被叫方提供启用位置的语音邮件服务。例如，被叫方可以在其上绘制的第一时间接收包含呼叫设备的位置的地图。

10. 发明申请

WO2005021500A1 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开
标题翻译：作为化合物受体活性的调节剂的循环衍生物
公开(公告)号：WO2005021500A1
公开(公告)日：2005-03-10
申请号：PCT/US2004/027196
申请日：2004-08-20
申请人： BRISTOL-MYERS SQUIBB COMPANY , CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , DUNCIA, John, V. , GARDNER, Daniel, S. , KO, Soo, S. , SRIVASTAVA, Anurag, S. , YANG, Michael, G.
发明人： CARTER, Percy, H. , CHERNEY, Robert, J. , BATT, Douglas, G. , DUNCIA, John, V. , GARDNER, Daniel, S. , KO, Soo, S. , SRIVASTAVA, Anurag, S. , YANG, Michael, G.
IPC分类号： C07D207/26
CPC分类号： C07D207/273 , C04B35/632 , C07D207/34 , C07D211/86 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
摘要翻译：本申请描述了可用于治疗类风湿性关节炎，多发性硬化，动脉粥样硬化和哮喘的式（I）的MCP-1或其药学上可接受的盐形式的调节剂。

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