专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2002026931A3 71 HUMAN SECRETED PROTEINS 审中-公开
公开(公告)号：WO2002026931A3
公开(公告)日：2002-04-04
申请号：PCT/US2001/029871
申请日：2001-09-24
申请人： HUMAN GENOME SCIENCES, INC. , RUBEN, Steven, M. , KOMATSOULIS, George , DUAN, D., Roxanne , ROSEN, Craig, A. , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David, W. , OLSEN, Henrik , BREWER, Laurie, A. , FLORENCE, Kimberly, A. , YOUNG, Paul, E. , SOPPET, Daniel, R. , ENDRESS, Gregory, A. , MUCENSKI, Michael , EBNER, Reinhard
发明人： RUBEN, Steven, M. , KOMATSOULIS, George , DUAN, D., Roxanne , ROSEN, Craig, A. , MOORE, Paul, A. , SHI, Yanggu , LAFLEUR, David, W. , OLSEN, Henrik , BREWER, Laurie, A. , FLORENCE, Kimberly, A. , YOUNG, Paul, E. , SOPPET, Daniel, R. , ENDRESS, Gregory, A. , MUCENSKI, Michael , EBNER, Reinhard
IPC分类号： C07H21/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

2. 发明申请

WO0112775A3 25 human secreted proteins 审中-公开
标题翻译： 25种人体分泌蛋白
公开(公告)号：WO0112775A3
公开(公告)日：2001-08-23
申请号：PCT/US0022325
申请日：2000-08-16
申请人： ROSEN CRAIG A , NI JIAN , FLORENCE KIMBERLY A , FISCELLA MICHELE , WEI PING , BAKER KEVIN P , BIRSE CHARLES E , YOUNG PAUL E , KOMATSOULIS GEORGE A , MOORE PAUL A , SOPPET DANIEL R , HUMAN GENOME SCIENCES INC
发明人： ROSEN CRAIG A , NI JIAN , FLORENCE KIMBERLY A , FISCELLA MICHELE , WEI PING , BAKER KEVIN P , BIRSE CHARLES E , YOUNG PAUL E , KOMATSOULIS GEORGE A , MOORE PAUL A , SOPPET DANIEL R
IPC分类号： G01N33/50 , A61K31/711 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/04 , A61P1/10 , A61P1/12 , A61P3/00 , A61P3/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/14 , A61P11/06 , A61P13/02 , A61P13/04 , A61P13/12 , A61P15/08 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P19/00 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/06 , A61P39/00 , A61P41/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/11 , C07K5/00 , C07K14/00 , C12N15/00 , C12N15/85 , C12N15/86 , C12P21/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

3. 发明申请

WO9840483A3 28 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 28人类分泌蛋白
公开(公告)号：WO9840483A3
公开(公告)日：1998-11-19
申请号：PCT/US9804858
申请日：1998-03-12
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , ROSEN CRAIG A , LI YI , ZENG ZHIZHEN , KYAW HLA , FISCHER CARRIE L , LI HAODONG , SOPPET DANIEL R , GENTZ REINER L , WEI YING FEI , MOORE PAUL A , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M
发明人： RUBEN STEVEN M , ROSEN CRAIG A , LI YI , ZENG ZHIZHEN , KYAW HLA , FISCHER CARRIE L , LI HAODONG , SOPPET DANIEL R , GENTZ REINER L , WEI YING FEI , MOORE PAUL A , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/02 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , A61K31/70 , A61K38/17 , C12N15/11 , C12N15/62 , C12Q1/48 , G01N33/53 , G01N33/60 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to 28 human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

4. 发明申请

WO2008144011A1 COMPOUNDS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 审中-公开
标题翻译：用于治疗或预防自身免疫性疾病的化合物和方法
公开(公告)号：WO2008144011A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006345
申请日：2008-05-16
申请人： AVALON PHARMACEUTICALS , MEDLMMUNE, INC. , HORRIGAN, Stephen, K. , ZONG, Qin , SOPPET, Daniel , CASTANEDA, Juana , CHEN, Bo , CIBOTTI, Ricardo , AUDOLY, Laurent, P. , COYLE, Anthony , KIENER, Peter
发明人： HORRIGAN, Stephen, K. , ZONG, Qin , SOPPET, Daniel , CASTANEDA, Juana , CHEN, Bo , CIBOTTI, Ricardo , AUDOLY, Laurent, P. , COYLE, Anthony , KIENER, Peter
IPC分类号： A61K31/135
CPC分类号： A61K31/135 , A61K31/00 , A61K31/12 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/381 , A61K31/4015 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/473
摘要： Methods of treating, ameliorating, preventing, or reducing the risk of developing an auto-immune disease and/or an inflammatory condition, such as systemic lupus erythematosus, in a patient, such as a human being, using a therapeutically effective amount of an agent(s) that inhibits the activity of one or more of of histone deacetylase (HDAC), I K B kinase (IKK-2), nuclear factor kB (NF-kB), ubiquitin/proteasome and Janus kinase (JAK) are disclosed. Compounds useful in such methods are also presented.
摘要翻译：使用治疗有效量的药物治疗，改善，预防或降低发生自身免疫疾病和/或炎性病症的风险的方法，例如患者（例如人）中的系统性红斑狼疮公开了抑制组蛋白脱乙酰酶（HDAC），IκB激酶（IKK-2），核因子kB（NF-kB），泛素/蛋白酶体和Janus激酶（JAK）中的一种或多种的活性的抑制剂。还提供了在这些方法中有用的化合物。

5. 发明申请

WO9827932A3 CEREBELLUM AND EMBRYO SPECIFIC PROTEIN 审中-公开
标题翻译：胚胎和胚胎特异性蛋白质
公开(公告)号：WO9827932A3
公开(公告)日：1999-01-28
申请号：PCT/US9723518
申请日：1997-12-18
申请人： HUMAN GENOME SCIENCES INC , SOPPET DANIEL R , RUBEN STEVEN M
发明人： SOPPET DANIEL R , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P9/00 , A61P43/00 , C07K14/47 , C07K14/515 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , A61K
CPC分类号： C07K14/515 , A61K38/00 , C12N2799/026
摘要： The present invention relates to a novel cerebellum and embryo specific (CESP) protein which is a member of the myocardial factor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human CESP protein. CESP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：本发明涉及作为心肌因子超家族成员的新型小脑和胚胎特异性（CESP）蛋白。特别地，提供编码人CESP蛋白的分离的核酸分子。还提供了CESP多肽，载体，宿主细胞和用于制备它们的重组方法。

6. 发明申请

WO1997035870A1 GROWTH FACTOR HTTER36 审中-公开
标题翻译：增长因素HTTER36
公开(公告)号：WO1997035870A1
公开(公告)日：1997-10-02
申请号：PCT/US1996004085
申请日：1996-03-26
申请人： HUMAN GENOME SCIENCES, INC. , SOPPET, Daniel, R. , LI, Haodong
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C07H21/00
CPC分类号： C07K14/475 , A61K38/00 , C12N2799/026
摘要： The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译：本发明公开了生长因子HTTER36多肽和编码这种多肽的多核苷酸。还提供了通过重组技术和包括刺激细胞生长和分化，骨形成和伤口愈合的多肽的治疗用途产生此类多肽的方法。还公开了抗这种多肽的拮抗剂及其作为治疗性肿瘤的治疗剂的用途，并防止在肝脏和肺中形成细胞外基质分子。还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

7. 发明申请

WO1996039439A1 HUMAN G-PROTEIN RECEPTOR HCEGH45 审中-公开
标题翻译：人类G蛋白受体HCEGH45
公开(公告)号：WO1996039439A1
公开(公告)日：1996-12-12
申请号：PCT/US1995007188
申请日：1995-06-06
申请人： HUMAN GENOME SCIENCES, INC. , SOPPET, Daniel, R. , LI, Yi , ROSEN, Craig, A. , RUBEN, Steven, M.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C07K14/705
CPC分类号： C07K14/7158 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
摘要翻译：公开了人类G蛋白受体HCEGH45多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。针对这种多肽的拮抗剂可以用于治疗PACAP过度分泌病症并产生药理学遗忘症模型，同时激动剂可用于治疗遗忘症和阿尔茨海默氏病。还公开了用于检测受体核酸序列中的突变并检测衍生自宿主的样品中可溶形式的受体的诊断方法。

8. 发明申请

WO0134767A3 22 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 22人分泌蛋白
公开(公告)号：WO0134767A3
公开(公告)日：2002-05-02
申请号：PCT/US0030036
申请日：2000-11-01
申请人： HUMAN GENOME SCIENCES INC , SOPPET DANIEL R , KOMATSOULIS GEORGE , SHI YANGGU , OLSEN HENRIK S , RUBEN STEVEN M
发明人： SOPPET DANIEL R , KOMATSOULIS GEORGE , SHI YANGGU , OLSEN HENRIK S , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61P1/16 , A61P5/14 , A61P7/06 , A61P11/00 , A61P11/08 , A61P13/12 , A61P17/02 , A61P21/06 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/68 , C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C12N15/63 , C12N15/85 , C12N15/86 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及新的人分泌蛋白和含有编码这些蛋白的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白的载体，宿主细胞，抗体和重组方法。本发明进一步涉及诊断和治疗方法，用于诊断和治疗与这些新的人类分泌蛋白相关的疾病，病症和/或病症。

9. 发明申请

WO1998024900A1 HUMAN G-PROTEIN RECEPTOR HCEGH45, A PACAP-LIKE (G-PROTEIN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-LIKE) RECEPTOR 审中-公开
标题翻译：人类G蛋白受体HCEGH45，一种PACAP-like（G-蛋白激酶阳离子腺苷酸环化酶活化多肽类似物）受体
公开(公告)号：WO1998024900A1
公开(公告)日：1998-06-11
申请号：PCT/US1997020547
申请日：1997-11-21
申请人： HUMAN GENOME SCIENCES, INC. , SOPPET, Daniel, R. , ROSEN, Craig, A. , RUBEN, Steven, M. , LI, Yi
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/72 , A61K38/00
摘要： A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
摘要翻译：公开了人类G蛋白受体HCEGH45多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽鉴定这种多肽的拮抗剂和激动剂的方法。针对这种多肽的拮抗剂可以用于治疗PACAP过度分泌病症并产生药理学遗忘症模型，同时激动剂可用于治疗遗忘症和阿尔茨海默氏病。还公开了用于检测受体核酸序列中的突变并检测衍生自宿主的样品中可溶形式的受体的诊断方法。

10. 发明申请

WO1997044359A1 NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR 审中-公开
标题翻译：新的人类G蛋白偶联受体
公开(公告)号：WO1997044359A1
公开(公告)日：1997-11-27
申请号：PCT/US1996007622
申请日：1996-05-20
申请人： HUMAN GENOME SCIENCES, INC. , TAKEDA CHEMICAL INDUSTRIES, LTD. , SOPPET, Daniel, R. , RUBEN, Steven, M. , LI, Yi , FUJII, Ryo , HINUMA, Shuji
发明人： HUMAN GENOME SCIENCES, INC. , TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07K14/705
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/70571 , C07K14/715 , C07K14/723 , G01N33/5008 , G01N33/567
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译：公开了人G蛋白偶联受体多肽，编码这些多肽的DNA（RNA）和使用重组技术生产这种多肽的方法。描述了使用这些多肽鉴定这些多肽的拮抗剂和激动剂的方法，以及使用这些激动剂和拮抗剂用于治疗目的的方法，以进一步治疗与低表达相关的病症。或过表达G蛋白偶联受体核酸序列中的突变以及修饰的可溶形式水平的诊断方法。这些接收器。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式