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1. 发明申请

WO2004083234A3 INSULIN POLYPEPTIDE-OLIGOMER CONJUGATES, PROINSULIN POLYPEPTIDE-OLIGOMER CONJUGATES AND METHODS OF SYNTHESIZING SAME 审中-公开
标题翻译：胰岛素多肽 - 寡聚体，蛋白多肽 - 低聚物结合体及其合成方法
公开(公告)号：WO2004083234A3
公开(公告)日：2005-08-04
申请号：PCT/US2004007310
申请日：2004-03-11
申请人： NOBEX CORP , EKWURIBE NNOCHIRI N , RADHAKRISHNAN BALASINGAM , SOLTERO RICHARD , PUSKAS MONICA , SANGAL DITI
发明人： EKWURIBE NNOCHIRI N , RADHAKRISHNAN BALASINGAM , SOLTERO RICHARD , PUSKAS MONICA , SANGAL DITI
IPC分类号： A61K38/28 , A61K47/48 , C07K20060101 , C07K14/62
CPC分类号： C07K14/62 , A61K47/60
摘要： Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also provided as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates and other pro-polypeptide-oligomer conjugates are also provided.
摘要翻译：描述了用于合成胰岛素原多肽的方法，其包括通过能够被切割的肽键将包含与一个或多个肽偶联的胰岛素原多肽与足够使寡聚物与胰岛素原多肽的胰岛素多肽部分，并提供胰岛素原多肽 - 低聚物缀合物，并切割来自胰岛素原多肽 - 低聚物缀合物的一种或多种肽，以提供胰岛素多肽 - 低聚物缀合物。还提供了合成胰岛素原多肽 - 低聚物缀合物的方法，胰岛素原多肽 - 低聚物缀合物。还提供了合成C-肽多肽 - 低聚物缀合物和其它前 - 多肽 - 低聚物缀合物的方法。

2. 发明申请

WO2004083234A2 INSULIN POLYPEPTIDE-OLIGOMER CONJUGATES, PROINSULIN POLYPEPTIDE-OLIGOMER CONJUGATES AND METHODS OF SYNTHESIZING SAME 审中-公开
标题翻译：胰岛素多肽 - 寡聚体，蛋白多肽 - 低聚物结合体及其合成方法
公开(公告)号：WO2004083234A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/007310
申请日：2004-03-11
申请人： NOBEX CORPORATION , EKWURIBE, Nnochiri N. , RADHAKRISHNAN, Balasingam , SOLTERO, Richard , PUSKAS, Monica , SANGAL, Diti
发明人： EKWURIBE, Nnochiri N. , RADHAKRISHNAN, Balasingam , SOLTERO, Richard , PUSKAS, Monica , SANGAL, Diti
IPC分类号： C07K
CPC分类号： C07K14/62 , A61K47/60
摘要： Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also provided as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates and other pro-polypeptide-oligomer conjugates are also provided.
摘要翻译：描述了用于合成胰岛素原多肽的方法，其包括通过能够被切割的肽键将包含与一个或多个肽偶联的胰岛素原多肽与足够使寡聚物与胰岛素原多肽的胰岛素多肽部分，并提供胰岛素原多肽 - 低聚物缀合物，并切割来自胰岛素原多肽 - 低聚物缀合物的一种或多种肽，以提供胰岛素多肽 - 低聚物缀合物。还提供了合成胰岛素原多肽 - 低聚物缀合物的方法，胰岛素原多肽 - 低聚物缀合物。还提供了合成C-肽多肽 - 低聚物缀合物和其它前 - 多肽 - 低聚物缀合物的方法。

3. 发明申请

WO2003022210A2 PHARMACEUTICAL COMPOSITIONS OF DRUG-OLIGOMER CONJUGATES AND METHODS OF TREATING DISEASES THEREWITH 审中-公开
标题翻译：药物低聚物共轭物的药物组合物和治疗疾病的方法
公开(公告)号：WO2003022210A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028536
申请日：2002-09-06
申请人： NOBEX CORPORATION , SOLTERO, Richard , EKWURIBE, Nnochiri, N. , OPAWALE, Foyeke , REHLAENDER, Bruce , HICKEY, Anthony , BOVET, Li, Li
发明人： SOLTERO, Richard , EKWURIBE, Nnochiri, N. , OPAWALE, Foyeke , REHLAENDER, Bruce , HICKEY, Anthony , BOVET, Li, Li
IPC分类号： A61K
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60 , Y10S514/808
摘要： Pharmaceutical compositions that include a drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating diseases in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
摘要翻译：描述了包含药物 - 寡聚物缀合物，脂肪酸组分和胆汁盐组分的药物组合物。药物共价偶联到寡聚部分。脂肪酸组分和胆汁盐组分以1：5至5：1的重量比存在。还提供了使用这种药物组合物治疗需要这种治疗的受试者的疾病的方法，以及提供这种药物组合物的方法。

4. 发明申请

WO2003022210A3 PHARMACEUTICAL COMPOSITIONS OF DRUG-OLIGOMER CONJUGATES AND METHODS OF TREATING DISEASES THEREWITH 审中-公开
公开(公告)号：WO2003022210A3
公开(公告)日：2003-03-20
申请号：PCT/US2002/028536
申请日：2002-09-06
申请人： NOBEX CORPORATION , SOLTERO, Richard , EKWURIBE, Nnochiri, N. , OPAWALE, Foyeke , REHLAENDER, Bruce , HICKEY, Anthony , BOVET, Li, Li
发明人： SOLTERO, Richard , EKWURIBE, Nnochiri, N. , OPAWALE, Foyeke , REHLAENDER, Bruce , HICKEY, Anthony , BOVET, Li, Li
IPC分类号： C07J9/00
摘要： Pharmaceutical compositions that include a drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating diseases in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.

5. 发明申请

WO2008042771A2 SYSTEM AND METHOD FOR DEVELOPING AND MANAGING A MANUFACTURING PROCESS 审中-公开
标题翻译：用于开发和管理制造过程的系统和方法
公开(公告)号：WO2008042771A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/079887
申请日：2007-09-28
申请人： ALTE BIOSCIENCES, INC. , SOLTERO, Richard A.
发明人： SOLTERO, Richard A.
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06 , G06Q10/063112 , G06Q10/063118 , G06Q10/06316 , G06Q10/06395
摘要： A method for developing and managing a manufacturing process may include presenting a graphical user interface to define a project for developing and managing the manufacturing process for a product and storing the data entered to define the project in a database. The method may also include presenting a graphical user interface to at least one process development participant for entering data related to developing and managing the manufacturing process and storing the data related to developing and managing the manufacturing process in the database. The method may further include presenting selected data related to developing and managing the manufacturing process. In accordance with another embodiment of the present invention, a quality assurance system may be associated with the manufacturing process. The method may also include developing and managing the manufacturing process and the quality assurance system which may be integrated in the manufacturing process.
摘要翻译：用于开发和管理制造过程的方法可以包括呈现图形用户界面以定义用于开发和管理产品的制造过程的项目，并将输入的数据存储以将项目定义在数据库中。该方法还可以包括向至少一个过程开发参与者呈现图形用户界面，用于输入与开发和管理制造过程相关的数据，并将与开发和管理制造过程相关的数据存储在数据库中。该方法还可以包括呈现与开发和管理制造过程有关的所选数据。根据本发明的另一个实施例，质量保证系统可以与制造过程相关联。该方法还可以包括开发和管理可以集成在制造过程中的制造过程和质量保证体系。

6. 发明申请

WO03022208A3 PHARMACEUTICAL COMPOSITIONS OF INSULIN DRUG-OLIGOMER CONJUGATES AND METHODS OF TREATING DISEASES THEREWITH 审中-公开
标题翻译：胰岛素药物 - 低聚物共轭物的药物组合物及其治疗疾病的方法
公开(公告)号：WO03022208A3
公开(公告)日：2003-09-25
申请号：PCT/US0228429
申请日：2002-09-06
申请人： NOBEX CORP , SOLTERO RICHARD , RADHAKRISHNAN BALASINGHAM , EKWURIBE NNOCHIRI N , REHLAENDER BRUCE , HICKEY ANTHONY , BOVET LI LI
发明人： SOLTERO RICHARD , RADHAKRISHNAN BALASINGHAM , EKWURIBE NNOCHIRI N , REHLAENDER BRUCE , HICKEY ANTHONY , BOVET LI LI
IPC分类号： A61K47/48 , A61K38/28 , C07K14/62
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60 , Y10S514/808
摘要： Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
摘要翻译：描述了包含胰岛素药物 - 低聚物缀合物，脂肪酸组分和胆汁盐组分的药物组合物。胰岛素药物共价偶联至寡聚部分。脂肪酸组分和胆汁盐组分以1：5至5：1的重量比存在。还提供了使用这样的药物组合物治疗需要这种治疗的受试者的胰岛素缺陷的方法，以及提供这种药物组合物的方法。

7. 发明申请

WO2008042771A3 SYSTEM AND METHOD FOR DEVELOPING AND MANAGING A MANUFACTURING PROCESS 审中-公开
标题翻译：用于开发和管理制造过程的系统和方法
公开(公告)号：WO2008042771A3
公开(公告)日：2008-07-03
申请号：PCT/US2007079887
申请日：2007-09-28
申请人： ALTE BIOSCIENCES INC , SOLTERO RICHARD A
发明人： SOLTERO RICHARD A
IPC分类号： G06F19/00
CPC分类号： G06Q10/06 , G06Q10/063112 , G06Q10/063118 , G06Q10/06316 , G06Q10/06395
摘要： A method for developing and managing a manufacturing process may include presenting a graphical user interface to define a project for developing and managing the manufacturing process for a product and storing the data entered to define the project in a database. The method may also include presenting a graphical user interface to at least one process development participant for entering data related to developing and managing the manufacturing process and storing the data related to developing and managing the manufacturing process in the database. The method may further include presenting selected data related to developing and managing the manufacturing process. In accordance with another embodiment of the present invention, a quality assurance system may be associated with the manufacturing process. The method may also include developing and managing the manufacturing process and the quality assurance system which may be integrated in the manufacturing process.
摘要翻译：用于开发和管理制造过程的方法可以包括呈现图形用户界面以定义用于开发和管理产品的制造过程的项目并且将输入的数据存储在数据库中以定义项目。该方法还可以包括向至少一个过程开发参与者呈现图形用户界面，用于输入与开发和管理制造过程有关的数据，并将与开发和管理制造过程有关的数据存储在数据库中。该方法可以进一步包括呈现与开发和管理制造过程有关的选定数据。根据本发明的另一个实施例，质量保证系统可以与制造过程相关联。该方法还可以包括开发和管理制造过程和可以集成在制造过程中的质量保证系统。

8. 发明申请

WO2007145863A2 SUSTAINED RELEASE FORMULATION OF NALTREXONE 审中-公开
标题翻译：持续释放NALTREXONE的配方
公开(公告)号：WO2007145863A2
公开(公告)日：2007-12-21
申请号：PCT/US2007013030
申请日：2007-05-31
申请人： OREXIGEN THERAPEUTICS INC , MCKINNEY ANTHONY A , TOLLEFSON GARY D , SOLTERO RICHARD , DUNZO THEA ELISE
发明人： MCKINNEY ANTHONY A , TOLLEFSON GARY D , SOLTERO RICHARD , DUNZO THEA ELISE
CPC分类号： A61K9/2054 , A61K9/2031 , A61K9/209 , A61K31/135 , A61K31/137 , A61K31/485
摘要： A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
摘要翻译：提供了纳曲酮或其药学上可接受的盐的缓释口服剂型。口服剂型可以与另一种化合物一起施用。口服剂型的给药可以减少副作用，其可能是至少部分归因于减肥治疗的副作用。可以施用口服剂型以治疗体重减轻状况。

9. 发明申请

WO2003022208A2 PHARMACEUTICAL COMPOSITIONS OF INSULIN DRUG-OLIGOMER CONJUGATES AND METHODS OF TREATING DISEASES THEREWITH 审中-公开
标题翻译：胰高血糖素联合药物的药物组合物及其治疗方法
公开(公告)号：WO2003022208A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028429
申请日：2002-09-06
申请人： NOBEX CORPORATION , SOLTERO, Richard , RADHAKRISHNAN, Balasingham , EKWURIBE, Nnochiri, N. , REHLAENDER, Bruce , HICKEY, Anthony , BOVET, Li, Li
发明人： SOLTERO, Richard , RADHAKRISHNAN, Balasingham , EKWURIBE, Nnochiri, N. , REHLAENDER, Bruce , HICKEY, Anthony , BOVET, Li, Li
IPC分类号： A61K
CPC分类号： A61K47/554 , A61K47/542 , A61K47/60 , Y10S514/808
摘要： Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
摘要翻译：描述了包括胰岛素药物 - 低聚物缀合物，脂肪酸组分和胆汁盐组分的药物组合物。胰岛素药物与低聚部分共价偶联。脂肪酸组分和胆汁盐组分以1:5至5:1的重量比重存在。还提供了使用这种药物组合物治疗需要这种治疗的受试者的胰岛素缺乏症的方法，以及提供这种药物组合物的方法。

10. 发明申请

WO2007145863A3 SUSTAINED RELEASE FORMULATION OF NALTREXONE 审中-公开
公开(公告)号：WO2007145863A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/013030
申请日：2007-05-31
申请人： OREXIGEN THERAPEUTICS, INC. , MCKINNEY, Anthony A. , TOLLEFSON, Gary D. , SOLTERO, Richard , DUNZO, Thea Elise
发明人： MCKINNEY, Anthony A. , TOLLEFSON, Gary D. , SOLTERO, Richard , DUNZO, Thea Elise
IPC分类号： A61K31/135 , A61K31/137 , A61K31/485 , A61K9/20
摘要： A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.

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