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1. 发明申请

WO2008060964A3 UNIT DOSAGE PACKAGE AND METHODS FOR ADMINISTERING WEIGHT LOSS MEDICATIONS 审中-公开
公开(公告)号：WO2008060964A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/084178
申请日：2007-11-08
申请人： OREXIGEN THERAPEUTICS, INC. , MCKINNEY, Anthony, A. , TOLLEFSON, Gary , WEBER, Eckard , SOLTERO, Rick
发明人： MCKINNEY, Anthony, A. , TOLLEFSON, Gary , WEBER, Eckard , SOLTERO, Rick
IPC分类号： A61K9/00 , A61K9/20 , A61K31/135 , A61K31/137 , A61K31/35 , A61K31/42 , A61K31/485 , A61K31/551 , B65D83/04
摘要： Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.

2. 发明申请

WO2008060964A2 METHODS FOR ADMINISTERING WEIGHT LOSS MEDICATIONS 审中-公开
标题翻译：管理重量损失药物的方法
公开(公告)号：WO2008060964A2
公开(公告)日：2008-05-22
申请号：PCT/US2007084178
申请日：2007-11-08
申请人： OREXIGEN THERAPEUTICS INC , MCKINNEY ANTHONY A , TOLLEFSON GARY , WEBER ECKARD , SOLTERO RICK
发明人： MCKINNEY ANTHONY A , TOLLEFSON GARY , WEBER ECKARD , SOLTERO RICK
IPC分类号： A61K9/00 , A61K9/20 , A61K31/135 , A61K31/137 , A61K31/42
CPC分类号： A61K9/209 , A61J1/035 , A61J7/04 , A61J7/0454 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36 , A61K2300/00
摘要： Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
摘要翻译：用于使用包括具有第一药物和第二药物的第一单位剂量的单位剂量包装的药物的给药方法和系统，具有第一药物和第二药物的第二单位剂量，其中第二单位剂量包括不同的第二药物的量比第一单位剂量和单位剂量包装被配置为保持第一单位剂量和第二单位剂量。在优选的实施方案中，所述方法和系统用于施用减肥药物。

3. 发明申请

WO2007089318A3 COMPOSITIONS AND METHODS FOR REDUCING FOOD CRAVINGS 审中-公开
标题翻译：用于减少食物冲击的组合物和方法
公开(公告)号：WO2007089318A3
公开(公告)日：2008-03-27
申请号：PCT/US2006044968
申请日：2006-11-20
申请人： OREXIGEN THERAPEUTICS INC , MCKINNEY ANTHONY A , TOLLEFSON GARY , COWLEY MICHAEL A
发明人： MCKINNEY ANTHONY A , TOLLEFSON GARY , COWLEY MICHAEL A
IPC分类号： A61K31/485 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/19 , A61K31/197 , A61K31/343 , A61K31/351 , A61K31/381 , A61K31/4166 , A61K31/423 , A61K31/451 , A61K31/4525 , A61K45/06
CPC分类号： A61K31/485 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/19 , A61K31/197 , A61K31/343 , A61K31/351 , A61K31/381 , A61K31/4166 , A61K31/423 , A61K31/451 , A61K31/4525 , A61K31/55 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions for reducing food cravings, comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound is an a-MSH agonist. Also disclosed are methods of reducing food cravings, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance a-MSH activity.
摘要翻译：公开了用于减少食物渴求的组合物，其包含第一化合物和第二化合物，其中第一化合物是阿片样物质拮抗剂，第二化合物是α-MSH激动剂。还公开了减少食物欲望的方法，包括鉴定有需要的个体并治疗该个体以拮抗阿片受体活性并增强a-MSH活性。

4. 发明申请

WO2007084290A3 COMPOSITIONS OF AN ANTICONVULSANT AND PSYCHOTHERAPEUTIC AND METHODS OF USING THE SAME FOR REVERSING WEIGHT GAIN 审中-公开
标题翻译：抗生素和精神分裂症的组合物及其使用方法反转重量增加
公开(公告)号：WO2007084290A3
公开(公告)日：2007-09-07
申请号：PCT/US2007000576
申请日：2007-01-10
申请人： OREXIGEN THERAPEUTICS INC , MCKINNEY ANTHONY A , TOLLEFSON GARY , COWLEY MICHAEL A
发明人： MCKINNEY ANTHONY A , TOLLEFSON GARY , COWLEY MICHAEL A
IPC分类号： A61K31/135 , A61K31/423 , A61K31/498 , A61K31/5513 , A61K33/00 , A61K45/06 , A61P3/04 , A61P25/18
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/20 , A61K31/423 , A61K31/498 , A61K31/5513 , A61K31/554 , A61K33/00 , A61K2300/00
摘要： Disclosed are compositions for reversing weight gain comprising a first compound and a second compound, where the first compound is an anticonvulsant and the second compound is a psychotherapeutic agent.
摘要翻译：公开了用于逆转增重的组合物，其包含第一化合物和第二化合物，其中第一化合物是抗惊厥药，第二化合物是心理治疗剂。

5. 发明申请

WO2008060963A3 LAYERED PHARMACEUTICAL FORMULATIONS COMPRISING AN INTERMEDIATE RAPIDLY DISSOLVING LAYER 审中-公开
标题翻译：包含中间快速溶解层的分层药物制剂
公开(公告)号：WO2008060963A3
公开(公告)日：2008-07-10
申请号：PCT/US2007084177
申请日：2007-11-08
申请人： OREXIGEN THERAPEUTICS INC , MCKINNEY ANTHONY A , TOLLEFSON GARY , WEBER ECKARD , SOLTERO RICK
发明人： MCKINNEY ANTHONY A , TOLLEFSON GARY , WEBER ECKARD , SOLTERO RICK
IPC分类号： A61K9/24 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/423 , A61K31/485 , A61K31/5513
CPC分类号： A61K9/209 , A61K9/0002 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/357 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.
摘要翻译：在一个实施方案中，分层药物制剂包含两个或更多个药物层和设置在两个或更多个药物层中的至少两个之间的中间层，所述中间层被配置为在体内溶解，从而使两个或更多个药物层基本上保持完好。在一个实施方案中，至少一个药物层中的活性药物成分选自安非他酮，唑尼沙胺，纳曲酮，托吡酯，芬特明，二甲双胍，奥氮平和氟西汀。

6. 发明申请

WO2007145863A2 SUSTAINED RELEASE FORMULATION OF NALTREXONE 审中-公开
标题翻译：持续释放NALTREXONE的配方
公开(公告)号：WO2007145863A2
公开(公告)日：2007-12-21
申请号：PCT/US2007013030
申请日：2007-05-31
申请人： OREXIGEN THERAPEUTICS INC , MCKINNEY ANTHONY A , TOLLEFSON GARY D , SOLTERO RICHARD , DUNZO THEA ELISE
发明人： MCKINNEY ANTHONY A , TOLLEFSON GARY D , SOLTERO RICHARD , DUNZO THEA ELISE
CPC分类号： A61K9/2054 , A61K9/2031 , A61K9/209 , A61K31/135 , A61K31/137 , A61K31/485
摘要： A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with another compound. Administration of the oral dosage form may reduce a side effect, which may be a side effect at least partially attributable to a weight-loss treatment. The oral dosage form may be administered to treat a weight-loss condition.
摘要翻译：提供了纳曲酮或其药学上可接受的盐的缓释口服剂型。口服剂型可以与另一种化合物一起施用。口服剂型的给药可以减少副作用，其可能是至少部分归因于减肥治疗的副作用。可以施用口服剂型以治疗体重减轻状况。

7. 发明申请

WO2007062228A1 SUSTAINED-RELEASE FORMULATION OF ZONISAMIDE 审中-公开
标题翻译：持续释放配方的ZONISAMIDE
公开(公告)号：WO2007062228A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/045445
申请日：2006-11-27
申请人： OREXIGEN THERAPEUTICS, INC. , MCKINNEY, Anthony A. , TOLLEFSON, Gary , YAU, Simon , VLADYKA, Ron , SOLTERO, Rick
发明人： MCKINNEY, Anthony A. , TOLLEFSON, Gary , YAU, Simon , VLADYKA, Ron , SOLTERO, Rick
IPC分类号： A61K9/00 , A61K9/20 , A61K31/137 , A61K31/42
CPC分类号： A61K31/423 , A61K9/0002 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/5084 , A61K31/137 , A61K31/42 , A61K31/485
摘要： Pharmaceutical formulations comprise sustained-release zonisamide. Methods of preparing such pharmaceutical formulations involve intermixing zonisamide with a suitable excipient configured to control the dissolution profile of the zonisamide. Methods of treatment involve administering the pharmaceutical formulations to patients in need of such treatment.
摘要翻译：药物制剂包含缓释唑尼沙胺。制备这种药物制剂的方法包括将唑尼沙胺与配制成控制唑尼沙胺的溶出曲线的合适赋形剂混合。治疗方法包括向需要这种治疗的患者施用药物制剂。

8. 发明申请

WO2007016108B1 COMPOSITIONS FOR AFFECTING WEIGHT LOSS 审中-公开
标题翻译：影响重量损失的组合物
公开(公告)号：WO2007016108B1
公开(公告)日：2007-05-10
申请号：PCT/US2006028875
申请日：2006-07-24
申请人： OREXIGEN THERAPEUTICS INC , TOLLEFSON GARY , MCKINNEY ANTHONY A , HIGGIN MICHELLE S , MCCALL JOHN M
发明人： TOLLEFSON GARY , MCKINNEY ANTHONY A , HIGGIN MICHELLE S , MCCALL JOHN M
IPC分类号： A61K45/06 , A61K31/137 , A61K31/138 , A61K31/485 , A61P3/04
CPC分类号： A61K31/137 , A61K31/138 , A61K31/165 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a metabolite of naltrexone, such as 6-ß-naltrexol or a prodrug of a naltrexone metabolite, and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) and/or a melanocortin 4 receptor (MC4-R), and/or increases the concentration of a-MSH in the central nervous system. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity with a metabolite of naltrexone, such as 6-ß-naltrexol or a prodrug of a naltrexone metabolite, and treating that individual to enhance a-MSH activity, e.g., by administration of a second compound causes increased agonism of MC3-R and/or MC4-R, and/or increases the concentration of a-MSH in the central nervous system.
摘要翻译：公开了用于影响体重减轻的组合物，其包含第一化合物和第二化合物，其中第一化合物是纳曲酮的代谢物，例如6-β-纳曲酮或纳曲酮代谢物的前药，并且所述第二化合物引起增加的激动黑皮质素3受体（MC3-R）和/或黑皮质素4受体（MC4-R），和/或增加中枢神经系统中a-MSH的浓度。还公开了影响体重减轻，增加能量消耗，增加个体饱腹感或抑制个体食欲的方法，其包括确定有需要的个体，并用纳曲酮代谢物治疗该个体以拮抗阿片受体活性，作为6-β-纳曲酮或纳曲酮代谢物的前药，并且例如通过施用第二化合物治疗该个体以增强a-MSH活性导致MC3-R和/或MC4-R的激动性增加和/或增加中枢神经系统中a-MSH的浓度。

9. 发明申请

WO2007084290A2 COMPOSITIONS OF AN ANTICONVULSANT AND METHODS OF USING THE SAME FOR REVERSING WEIGHT GAIN 审中-公开
标题翻译：抗生素的组合物和使用相同方法反转重量增益
公开(公告)号：WO2007084290A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/000576
申请日：2007-01-10
申请人： OREXIGEN THERAPEUTICS, INC. , MCKINNEY, Anthony, A. , TOLLEFSON, Gary , COWLEY, Michael, A.
发明人： MCKINNEY, Anthony, A. , TOLLEFSON, Gary , COWLEY, Michael, A.
IPC分类号： A61K31/135 , A61K31/423 , A61K31/498 , A61K31/5513
CPC分类号： A61K45/06 , A61K31/135 , A61K31/137 , A61K31/20 , A61K31/423 , A61K31/498 , A61K31/5513 , A61K31/554 , A61K33/00 , A61K2300/00
摘要： Disclosed are compositions for reversing weight gain comprising a first compound and a second compound, where the first compound is an anticonvulsant and the second compound is a psychotherapeutic agent.
摘要翻译：公开了用于逆转体重增加的组合物，其包含第一化合物和第二化合物，其中第一化合物是抗惊厥药，第二化合物是心理治疗剂。

10. 发明申请

WO2007067341A2 COMPOSITIONS AND METHODS FOR INCREASING INSULIN SENSITIVITY 审中-公开
标题翻译：用于增加胰岛素敏感性的组合物和方法
公开(公告)号：WO2007067341A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/044966
申请日：2006-11-20
申请人： OREXIGEN THERAPEUTICS, INC. , COWLEY, Michael A. , MCKINNEY, Anthony A. , TOLLEFSON, Gary
发明人： COWLEY, Michael A. , MCKINNEY, Anthony A. , TOLLEFSON, Gary
IPC分类号： A61K31/00 , A61K31/135 , A61K31/138 , A61K31/423
CPC分类号： A61K38/28 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/357 , A61K31/423 , A61K31/445 , A61K31/4525 , A61K31/485 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/554 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for treating a blood glucose condition involve identifying a suitable subject and administering an effective amount of a composition that contains one or more of an opioid antagonist, an anticonvulsant, and a psychotherapeutic agent. The compositions can include insulin. In some embodiments, such methods and compositions can be used to modulate a blood glucose level. In preferred embodiments, such methods and compositions are useful for increasing a subject's sensitivity to insulin.
摘要翻译：用于治疗血糖状况的方法和组合物包括鉴定合适的受试者并施用有效量的含有阿片样物质拮抗剂，抗惊厥药和精神治疗药物中的一种或多种的组合物。组合物可以包括胰岛素。在一些实施方案中，这些方法和组合物可用于调节血糖水平。在优选的实施方案中，这些方法和组合物可用于增加受试者对胰岛素的敏感性。

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