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1. 发明申请

WO2006029347A3 INTEGRIN CD18 IS A NOVEL STROMAL STEM CELL MARKER AND FUNCTIONS TO PROMOTE OSTEOGENESIS 审中-公开
标题翻译： INTEGRIN CD18是一种新的结构干细胞标记和功能来促进骨质疏松
公开(公告)号：WO2006029347A3
公开(公告)日：2006-12-07
申请号：PCT/US2005032220
申请日：2005-09-06
申请人： UNIV MARYLAND , ZHANG LI , MIURA YASUO , SHI SONGTAO
发明人： ZHANG LI , MIURA YASUO , SHI SONGTAO
IPC分类号： G01N33/567 , A01N1/02 , C12N5/077 , C12N5/0775
CPC分类号： C12N5/0663 , A61K35/28 , A61K48/00 , A61K2035/124 , G01N33/56966 , Y10T436/25375
摘要： The present invention is directed to a new bone marrow stromal stem cell (BMSSC) marker, CD18, for use in selecting a population of cells enriched in BMSSCs, from bone marrow cells, adipose cells, or peripheral blood. The invention is further directed to methods for selecting a population of cells enriched in BMSSCs based on the selective expression of CD18 on their surface, using techniques known in the art such as fluorescent assisted cell sorting, an immunomagnetic method, flow microfluorimetry, immunofluorescence, immunoperoxidase staining, radioimmunoassay and immunoaffinity chromatography. The invention is further directed to the BMSSCs isolated based on CD18 expression, and their use to treat various diseases. In one aspect, the BMSSCs are transformed with a vector having a normal gene for CD18, and the transformed BMSSCs are administered to treat bone degenerative diseases and diseases of bone involving abnormal expression of CD18 expression of CD18.
摘要翻译：本发明涉及用于从骨髓细胞，脂肪细胞或外周血中选择富含BMSSC的细胞群的新型骨髓基质干细胞（BMSSC）标记物CD18。本发明还涉及使用本领域已知的技术例如荧光辅助细胞分选，免疫磁性法，流量显微荧光法，免疫荧光，免疫过氧化物酶，基于CD18在其表面上的选择性表达来选择富集BMSSC的细胞群的方法染色，放射免疫测定和免疫亲和层析。本发明进一步针对基于CD18表达分离的BMSSC及其用于治疗各种疾病的用途。一方面，用具有CD18正常基因的载体转化BMSSC，并施用转化的BMSSC以治疗涉及CD18 CD18表达异常表达的骨退行性疾病和骨疾病。

2. 发明申请

WO2012149046A1 METHODS AND COMPOSITIONS FOR IMPROVED TISSUE REGENERATION BY SUPPRESSION OF INTERFERON -GAMMA AND TUMOR NECROSIS FACTOR-ALPHA 审中-公开
标题翻译：通过抑制干扰素和肿瘤坏死因子-ATPHA来改善组织再生的方法和组合物
公开(公告)号：WO2012149046A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035036
申请日：2012-04-25
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , SHI, Songtao , LIU, Yi , WANG, Lei
发明人： SHI, Songtao , LIU, Yi , WANG, Lei
IPC分类号： A01N63/00
CPC分类号： A61K35/28 , A61K31/616 , A61K35/17 , A61K45/06 , A61L27/3834 , A61L27/54 , A61L2300/41 , A61K2300/00
摘要： The present invention discloses methods, compositions and devices for improving tissue regeneration by suppressing the effects of several proinflammatory cytokines such as TNF-α and IFN-γ. Compositions and devices of this invention will generally include one or more anti-inflammatory agent(s) capable of reducing the level of TNF-α, IFN-γ, or both. Methods for improving tissue regeneration in accordance with this invention will generally have the step of applying a composition or device of the invention to a site in need of the composition or device. Also disclosed are methods for forming composition and devices of the invention and pharmaceutical compositions comprising one or more ants-inflammatory agent(s) effective of inhibiting or reducing the levels of TNF-α, IFN-γ, or both.
摘要翻译：本发明公开了通过抑制TNF-α和IFN-α等几种促炎细胞因子的作用来改善组织再生的方法，组合物和装置。本发明的组合物和装置通常包括能够降低TNF-α，IFN-α或两者的水平的一种或多种抗炎剂。根据本发明的用于改善组织再生的方法通常具有将本发明的组合物或装置应用于需要组合物或装置的部位的步骤。还公开了形成本发明的组合物和装置的方法以及包含一种或多种有效抑制或降低TNF-α，IFN-α或两者的水平的蚂蚁炎症药物的药物组合物。

3. 发明申请

WO2012012570A2 HIGH TELOMERASE ACTIVITY BONE MARROW MESENCHYMAL STEM CELLS, METHODS OF PRODUCING THE SAME AND PHARMACEUTICALS AND TREATMENT METHODS BASED THEREON 审中-公开
标题翻译：高TELOMERASE活性骨髓基质干细胞，其生产方法和药物及其治疗方法
公开(公告)号：WO2012012570A2
公开(公告)日：2012-01-26
申请号：PCT/US2011044731
申请日：2011-07-20
申请人： UNIV SOUTHERN CALIFORNIA , SHI SONGTAO , AKIYAMA KENTARO , CHEN CHIDER
发明人： SHI SONGTAO , AKIYAMA KENTARO , CHEN CHIDER
IPC分类号： C12N5/077
CPC分类号： A61K35/28 , A61K31/60 , A61K2035/122 , C12N5/0663 , C12N2501/02 , A61K2300/00
摘要： Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tBMMSCs). Also disclosed are isolated human CD34+ bone marrow mesenchymal stem cells. Also disclosed are bone marrow mesenchymal stem cells treated with a telomerase induction agent.
摘要翻译：公开了具有高端粒酶活性（tBMMSC）的分离的人骨髓间充质干细胞。还公开了分离的人CD34 +骨髓间充质干细胞。还公开了用端粒酶诱导剂处理的骨髓间充质干细胞。

4. 发明申请

WO2010068707A3 ANIMAL MODEL SUBCUTANEOUSLY TRANSPLANTED WITH MESENCHYMAL STEM CELLS 审中-公开
标题翻译：用MESENCHYMAL STEM CELLS传播的动物模型
公开(公告)号：WO2010068707A3
公开(公告)日：2010-08-26
申请号：PCT/US2009067398
申请日：2009-12-09
申请人： UNIV SOUTHERN CALIFORNIA , SHI SONGTAO , YAMAZA TAKAYOSHI , AKIYAMA KENTARO
发明人： SHI SONGTAO , YAMAZA TAKAYOSHI , AKIYAMA KENTARO
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2227/105 , A01K2267/03
摘要： This invention discloses a stem cell modified animal model useful as a research tool for investigating aging-related degeneration processes and treatments. The animal model is preferably a rodent subcutaneously transplanted with a mesenchymal stem cell capable of generating a functional bone or marrow element. Also provided are a method for extending the lifespan and improving the quality of life of a subject by subcutaneously transplanting a plurality of mesenchymal stem cells to the subject, wherein the mesenchymal stem cells are capable of generating a functional bone or marrow element. Compositions and source of stem cells suitable for use with the methods of this invention, including stem cells from human exfoliated deciduous teeth (SHED), are also disclosed. Further disclosed is a method for identifying progenitor bone marrow mesenchymal stem cells, and a method for treating SLE-like autoimmune diseases by infusion of mesenchymal stem cells.
摘要翻译：本发明公开了一种干细胞修饰动物模型，可用作研究老化相关变性过程和治疗的研究工具。动物模型优选是皮下移植能够产生功能性骨或骨髓元件的间充质干细胞的啮齿动物。还提供了一种通过将多个间充质干细胞皮下移植到受试者来延长使用寿命并提高受试者的生活质量的方法，其中间充质干细胞能够产生功能性骨或骨髓元件。还公开了适用于本发明方法的干细胞的组合物和来源，包括来自人脱落落叶牙（SHED）的干细胞。进一步公开了一种鉴定祖细胞骨髓间充质干细胞的方法，以及通过输注间充质干细胞治疗SLE样自身免疫性疾病的方法。

5. 发明申请

WO2007070709A2 SKELETAL SITE -SPECIFIC CHARACTERIZATION OF OROFACIAL AND ILIAC CREST HUMAN BONE MARROW TROMAL CELLS IN SAME INDIVIDUALS 审中-公开
标题翻译：骨骼位置 - 在同一个体中OROFACIAL和ILIAC CROSS人骨髓瘤细胞的特征表征
公开(公告)号：WO2007070709A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/048104
申请日：2006-12-14
申请人： THE TRUSTEES THE UNIVERSITY OF PENNESYLVANIA , AKINTOYE, Sunday, O. , SHI, Songtao , ROBEY, Pamela, G.
发明人： AKINTOYE, Sunday, O. , SHI, Songtao , ROBEY, Pamela, G.
IPC分类号： G01N33/53
CPC分类号： G01N33/5005 , G01N33/566 , G01N33/567 , G01N2800/245
摘要： The present invention relates to methods and compositions useful for the detection, enrichment and use of orofacial-derived bone marrow stromal cells. In one aspect, the invention relates to the use of characteristics specific to orofacial-derived bone marrow stromal cells to distinguish orofacial-derived bone marrow stromal cells from other cells.
摘要翻译：本发明涉及可用于检测，富集和使用口腔衍生的骨髓基质细胞的方法和组合物。一方面，本发明涉及用于口面衍生的骨髓基质细胞特异性的特征来区分来自其他细胞的口腔衍生的骨髓基质细胞。

6. 发明申请

WO2006029347A2 INTEGRIN CD18 IS A NOVEL STROMAL STEM CELL MARKER AND FUNCTIONS TO PROMOTE OSTEOGENESIS 审中-公开
标题翻译： INTEGRIN CD18是一种新型的STROMAL STEM细胞标记物和促进成骨细胞增殖的功能
公开(公告)号：WO2006029347A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/032220
申请日：2005-09-06
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , ZHANG, Li , MIURA, Yasuo , SHI, Songtao
发明人： ZHANG, Li , MIURA, Yasuo , SHI, Songtao
IPC分类号： A61K48/00
CPC分类号： C12N5/0663 , A61K35/28 , A61K48/00 , A61K2035/124 , G01N33/56966 , Y10T436/25375
摘要： The present invention is directed to a new bone marrow stromal stem cell (BMSSC) marker, CD18, for use in selecting a population of cells enriched in BMSSCs, from bone marrow cells, adipose cells, or peripheral blood. The invention is further directed to methods for selecting a population of cells enriched in BMSSCs based on the selective expression of CD18 on their surface, using techniques known in the art such as fluorescent assisted cell sorting, an immunomagnetic method, flow microfluorimetry, immunofluorescence, immunoperoxidase staining, radioimmunoassay and immunoaffinity chromatography. The invention is further directed to the BMSSCs isolated based on CD18 expression, and their use to treat various diseases. In one aspect, the BMSSCs are transformed with a vector having a normal gene for CD18, and the transformed BMSSCs are administered to treat bone degenerative diseases and diseases of bone involving abnormal expression of CD18 expression of CD18.
摘要翻译：本发明涉及一种新的骨髓基质干细胞（BMSSC）标记CD18，用于从骨髓细胞，脂肪细胞或外周血中选择富含BMSSC的细胞群血液。本发明还涉及使用本领域已知的技术如荧光辅助细胞分选，免疫磁性方法，流式微量荧光测定法，免疫荧光法，免疫过氧化物酶染色，放射免疫测定和免疫亲和层析。本发明进一步涉及基于CD18表达分离的BMSSCs及其用于治疗各种疾病的用途。一方面，用具有正常CD18基因的载体转化BMSSC，并且施用转化的BMSSC以治疗骨退行性疾病和涉及CD18的CD18表达异常表达的骨疾病。

7. 发明申请

WO2004085630A1 PERIVASCULAR MESENCHYMAL PRECURSOR CELLS 审中-公开
标题翻译：周围蛋白前体细胞
公开(公告)号：WO2004085630A1
公开(公告)日：2004-10-07
申请号：PCT/AU2004/000416
申请日：2004-03-29
申请人： MEDVET SCIENCE PTY LTD , ANGIOBLAST SYSTEMS INCORPORATED , GRONTHOS, Stan , ZANNETTINO, Andrew , SHI, Songtao
发明人： GRONTHOS, Stan , ZANNETTINO, Andrew , SHI, Songtao
IPC分类号： C12N5/00
CPC分类号： C12N5/0663 , A61K9/0014 , A61K35/28 , A61K35/44 , A61K38/00 , C12N5/0668 , C12N5/0691 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/165 , C12N2501/235 , C12N2501/39 , C12N2506/1392 , A61K2300/00
摘要： Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilising a perivascular marker. A new mesenchymal precursor cell phenotype is described characterised by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC 18, VCAM-l and STRO-1 bri . The perivascular mesenchymal precursor cell is multipotential and is shown to form, vascular tissue, as well as bone marrow dentin and pulp. A method of enriching using cell sorting based on these markers is also described.
摘要翻译：间充质前体细胞已经使用血管周围标志物从一系列组织的血管周围位置中分离出来。描述了新的间充质前体细胞表型，其特征在于存在血管周围标志物3G5，优选还包括α平滑肌肌动蛋白以及早期发育标志物如MUC18，VCAM-1和STRO-1。血管周围间质前体细胞是多能的，并且显示出形成血管组织，以及骨髓牙本质和纸浆。还描述了使用基于这些标记的细胞分选进行富集的方法。

8. 发明申请

WO2007070709A3 SKELETAL SITE -SPECIFIC CHARACTERIZATION OF OROFACIAL AND ILIAC CREST HUMAN BONE MARROW TROMAL CELLS IN SAME INDIVIDUALS 审中-公开
标题翻译：骨骼位置 - 在同种异体中的OROFACIAL和ILIAC CROSS人骨髓瘤细胞的特征表征
公开(公告)号：WO2007070709A3
公开(公告)日：2008-04-03
申请号：PCT/US2006048104
申请日：2006-12-14
申请人： TRUSTEES THE UNIVERSITY OF PEN , AKINTOYE SUNDAY O , SHI SONGTAO , ROBEY PAMELA G
发明人： AKINTOYE SUNDAY O , SHI SONGTAO , ROBEY PAMELA G
IPC分类号： C12M3/00 , A61K48/00 , C12Q1/70
CPC分类号： G01N33/5005 , G01N33/566 , G01N33/567 , G01N2800/245
摘要： The present invention relates to methods and compositions useful for the detection, enrichment and use of orofacial-derived bone marrow stromal cells. In one aspect, the invention relates to the use of characteristics specific to orofacial-derived bone marrow stromal cells to distinguish orofacial-derived bone marrow stromal cells from other cells.
摘要翻译：本发明涉及用于检测，富集和使用口腔衍生的骨髓基质细胞的方法和组合物。一方面，本发明涉及用于口面衍生的骨髓基质细胞特异性的特征来区分来自其他细胞的口腔衍生的骨髓基质细胞。

9. 发明申请

WO2005052140A3 MULTIPOTENT POSTNATAL STEM CELLS FROM HUMAN PERIODONTAL LIGAMENT AND USES THEREOF 审中-公开
标题翻译：人淋巴瘤多发性骨髓间充质干细胞及其用途
公开(公告)号：WO2005052140A3
公开(公告)日：2005-09-15
申请号：PCT/US2004039248
申请日：2004-11-22
申请人： US GOV HEALTH & HUMAN SERV , SHI SONGTAO , SEO BYOUNG-MOO , MIURA MASAKO
发明人： SHI SONGTAO , SEO BYOUNG-MOO , MIURA MASAKO
IPC分类号： A01N1/02 , A61C8/00 , A61K35/12 , A61K35/54 , C12N5/077 , C12N5/06 , A61K6/00
CPC分类号： A61K35/32 , A01N1/02 , A01N1/0205 , A01N1/0221 , A61C8/0006 , A61K9/0063 , A61L27/3834 , A61L27/3865 , A61L27/3895 , A61L2300/412 , A61L2300/64 , C12N5/0664
摘要： The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation.
摘要翻译：本发明一般涉及产后牙周韧带干细胞及其使用方法。更具体地，本发明在一个方面涉及产后牙周韧带多能干细胞，使用细胞产生牙周膜，细胞分化和组织冷冻保存方法。

10. 发明申请

WO2004094588A3 POSTNATAL STEM CELLS AND USES THEREOF 审中-公开
标题翻译：后期干细胞及其用途
公开(公告)号：WO2004094588A3
公开(公告)日：2004-12-16
申请号：PCT/US0312276
申请日：2003-04-19
申请人： NAT INST HEALTH , SHI SONGTAO , ROBEY PAMELA GEHRON
发明人： SHI SONGTAO , ROBEY PAMELA GEHRON
IPC分类号： A01N63/00 , A61K48/00 , C12N5/00 , C12N5/02 , C12N5/077 , A01N65/00 , C12N5/08
CPC分类号： A61K35/30 , A61K35/12 , A61K47/02 , C12N5/0602 , C12N5/0618 , C12N5/0654 , C12N5/0664 , C12N2501/11 , C12N2501/115 , C12N2506/1361 , C12N2533/54
摘要： The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
摘要翻译：本发明一般涉及产后牙干细胞及其使用方法。更具体地，本发明在一个方面涉及产后牙髓干细胞，细胞产生牙本质的用途以及细胞的分化。另一方面，本发明涉及人类产后落叶牙髓多能干细胞，细胞产生牙本质的使用以及细胞的分化。

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