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1. 发明申请

WO2012092259A1 QUANTITATING HIGH TITER SAMPLES BY DIGITAL PCR 审中-公开
标题翻译：通过数字PCR定量高TITER样品
公开(公告)号：WO2012092259A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/067366
申请日：2011-12-27
申请人： IBIS BIOSCIENCES, INC. , CLEMENS, John M. , SHAIN, Eric B.
发明人： CLEMENS, John M. , SHAIN, Eric B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6851 , G01N21/6428 , G01N2021/6441 , C12Q2545/107 , C12Q2563/159
摘要： The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital PCR analysis).
摘要翻译：本发明提供使用数字PCR进行核酸分析的系统，装置，方法，试剂盒和组合物。特别地，提供了分析高滴度样品的方法，其不能被分成足够数量的每个分区含有零个核酸分子的分区以允许泊松分析（数字PCR分析）。

2. 发明申请

WO2005062040A3 METHOD AND SYSTEM FOR ANALYZING REACTIONS USING AN INFORMATION SYSTEM 审中-公开
标题翻译：使用信息系统分析反应的方法和系统
公开(公告)号：WO2005062040A3
公开(公告)日：2006-03-30
申请号：PCT/US2004038298
申请日：2004-11-17
申请人： ABBOTT LAB , CLEMENS JOHN M , SHAIN ERIC B , JENG TZYY-WEN , SCHNEIDER GEORGE J
发明人： CLEMENS JOHN M , SHAIN ERIC B , JENG TZYY-WEN , SCHNEIDER GEORGE J
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译：用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。

3. 发明申请

WO2005062040A2 METHOD AND SYSTEM FOR ANALYZING REACTIONS USING AN INFORMATION SYSTEM 审中-公开
标题翻译：使用信息系统分析反应的方法和系统
公开(公告)号：WO2005062040A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/038298
申请日：2004-11-17
申请人： ABBOTT LABORATORIES , CLEMENS, John, M. , SHAIN, Eric, B. , JENG, Tzyy-Wen , SCHNEIDER, George, J.
发明人： CLEMENS, John, M. , SHAIN, Eric, B. , JENG, Tzyy-Wen , SCHNEIDER, George, J.
IPC分类号： G01N33/00
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译：用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的分析部分自动化。

4. 发明申请

WO2004113874A3 APPARATUS AND METHOD FOR HANDLING FLUIDS FOR ANALYSIS 审中-公开
公开(公告)号：WO2004113874A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/019049
申请日：2004-06-15
申请人： ABBOTT LABORATORIES , LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： B01L3/14
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.

5. 发明申请

WO2005074811A1 METHOD FOR DETECTING ARTIFACTS IN DATA 审中-公开
标题翻译：检测数据中的艺术家的方法
公开(公告)号：WO2005074811A1
公开(公告)日：2005-08-18
申请号：PCT/US2004/041029
申请日：2004-12-08
申请人： ABBOTT LABORATORIES , LOWERY, Michael, G. , SHAIN, Eric, B. , KHALIL, Omar, S.
发明人： LOWERY, Michael, G. , SHAIN, Eric, B. , KHALIL, Omar, S.
IPC分类号： A61B05/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14535 , A61B5/7207 , G01N21/49
摘要： A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection oA method for identifying artifacts occuring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelenghts, at different distances between the lht introduction site (s) and the light collection site (s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts. The algorithm identifies sudden changes in the magnitude and direction in a sequence of collected signals.
摘要翻译：用于识别通过采用光学探针的装置测量生物样品中的分析物的浓度期间发生的伪影的方法，将电磁辐射引入到组织中，并且收集和检测距离该点引入电磁辐射。收集辐射强度的值，并在该方法中使用这些值，以产生这些值与组织中分析物的浓度或患者疾病状态之间的关系。该方法涉及使用识别由患者运动产生的数据中的伪像的算法，并且允许用于在生物样品中的分析物的浓度测量期间发现伪像的排斥oA方法，该方法采用温度控制的光学探针将电磁辐射引入到组织中，并收集和检测距离电磁辐射点的距离处发射的辐射。收集并在该方法中使用在不同波长处发射的辐射强度，在引入位置和光采集位点之间的不同距离处以及在不同温度下的辐射强度值，以产生这些值与组织中分析物的浓度或患者的疾病状态。该方法涉及使用识别由患者运动产生的数据中的伪影的算法，并允许拒绝包含这些伪像的数据集。该算法识别收集信号序列中的幅度和方向的突变。

6. 发明申请

WO2009086415A1 ALLELIC DISCRIMINATION ANALYSIS USING AN EFFICIENCY RELATED VALUE (EFR) 审中-公开
标题翻译：使用效率相关价值（EFR）的ALLELIC DISCRIMINATION ANALYSIS
公开(公告)号：WO2009086415A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/088220
申请日：2008-12-23
申请人： ABBOTT LABORATORIES , SHAIN, Eric, B.
发明人： SHAIN, Eric, B.
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： G06F19/22 , C12Q1/6858 , G06F19/24 , C12Q2537/165
摘要： Methods for discriminating between two or more different target nucleic acids in amplification reactions comprise signals comprising an amplitude measurement representing the degree of amplification of each target nucleic acid in the amplification reaction and the time point in the amplification reaction at which the amplitude is measured; determining an efficiency related transform of the data, determining an efficiency related value for each target nucleic acid that is the maximum magnitude of the efficiency related transform; and outputting the efficiency related values in the amplification reaction for each target nucleic acid, where the relative amplitudes of the efficiency related values for each target nucleic acid is an indicator of the presence of each of said nucleic acids in said sample.
摘要翻译：用于在扩增反应中区分两种或更多种不同靶核酸的方法包括包括表示扩增反应中每个靶核酸的扩增程度的振幅测量和测量幅度的扩增反应中的时间点的信号; 确定所述数据的效率相关变换，确定作为所述效率相关变换的最大幅度的每个靶核酸的效率相关值; 并输出针对每个靶核酸的扩增反应中的效率相关值，其中每个靶核酸的效率相关值的相对幅度是所述样品中每种所述核酸的存在的指标。

7. 发明申请

WO9824366A3 METHOD AND APPARATUS FOR OBTAINING BLOOD FOR DIAGNOSTIC TESTS 审中-公开
标题翻译：用于获取血液进行诊断测试的方法和装置
公开(公告)号：WO9824366A3
公开(公告)日：1998-10-29
申请号：PCT/US9722618
申请日：1997-12-04
申请人： ABBOTT LAB , CUNNINGHAM DAVID D , HENNING TIMOTHY P , SHAIN ERIC B , YOUNG DOUGLAS F , LOWERY MICHAEL G , SCHAPIRA THOMAS G , GRAHAM HUGH W , MUETTERTIES ANDREW J , CHAMBERS GEOFFREY R , HUGHES GRAHAM J , WATKIN JARED L , PROKOP GARY F , GOLDFARB JOSHUA P
发明人： CUNNINGHAM DAVID D , HENNING TIMOTHY P , SHAIN ERIC B , YOUNG DOUGLAS F , LOWERY MICHAEL G , SCHAPIRA THOMAS G , GRAHAM HUGH W , MUETTERTIES ANDREW J , CHAMBERS GEOFFREY R , HUGHES GRAHAM J , WATKIN JARED L , PROKOP GARY F , GOLDFARB JOSHUA P
IPC分类号： A61B5/151 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1473 , A61B5/15 , A61B5/154 , A61B5/157 , G01N33/48 , G01N33/66 , A61B5/14
CPC分类号： A61B5/15186 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150099 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150664 , A61B5/15113 , A61B5/15125 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B5/411 , A61B2562/0295
摘要： Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing. In a further aspect of the invention, a pneumatic lancing assembly is provided. The pneumatic lancing assembly uses differential gas pressure to thrust a lancet into skin tissue. In another aspect of this invention, an article is provided for an article capable of both collecting blood and detecting an analyte in that blood. The article, which contains an appropriate detection element for determining the amount of analyte in the blood, can be used in conjunction with a meter that measures the signal generated by the detection element of the article.

8. 发明申请

WO1998024366A2 METHOD AND APPARATUS FOR OBTAINING BLOOD FOR DIAGNOSTIC TESTS 审中-公开
标题翻译：用于获取血液进行诊断测试的方法和装置
公开(公告)号：WO1998024366A2
公开(公告)日：1998-06-11
申请号：PCT/US1997022618
申请日：1997-12-04
申请人： ABBOTT LABORATORIES , CUNNINGHAM, David, D. , HENNING, Timothy, P. , SHAIN, Eric, B. , YOUNG, Douglas, F. , LOWERY, Michael, G. , SCHAPIRA, Thomas, G. , GRAHAM, Hugh, W. , MUETTERTIES, Andrew, J. , CHAMBERS, Geoffrey, R. , HUGHES, Graham, J. , WATKIN, Jared, L. , PROKOP, Gary, F. , GOLDFARB, Joshua, P.
发明人： ABBOTT LABORATORIES
IPC分类号： A61B05/14
CPC分类号： A61B5/15186 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150099 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150664 , A61B5/15113 , A61B5/15125 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B5/411 , A61B2562/0295
摘要： Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) forming an unobstructed opening in the area of the skin from which the sample of blood is to be extracted; and (b) extracting the sample of blood from the unobstructed opening in the skin, with the aid of a vacuum and a stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which said sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing. In a further aspect of the invention, a pneumatic lancing assembly is provided. The pneumatic lancing assembly uses differential gas pressure to thrust a lancet into skin tissue. In another aspect of this invention, an article is provided for an article capable of both collecting blood and detecting an analyte in that blood. The article, which contains an appropriate detection element for determining the amount of analyte in the blood, can be used in conjunction with a meter that measures the signal generated by the detection element of the article.
摘要翻译：用于从患者获得血样的方法和装置用于随后的诊断测试，例如葡萄糖监测。在本发明的一个方面，所述方法包括以下步骤：（a）在要从其中提取血液样本的皮肤区域中形成无障碍的开口; 和（b）借助于真空和皮肤拉伸从皮肤中的无障碍开口提取血液样品。在本发明的另一方面，提供一种用于执行前述方法的装置。该装置包括：（a）用于在皮肤区域形成无障碍的开口的装置，所述皮肤区域将从所述皮肤区域中提取所述样品，优选为采血组件; 和（b）真空泵。优选地，该装置还包括壳体。在本发明的另一方面，提供一种气动采血组件。气动采血组件使用差压气体将刺血针推入皮肤组织。在本发明的另一方面，提供了一种能够收集血液并检测该血液中的分析物的物品。包含用于确定血液中分析物的量的适当检测元件的物品可以与测量由物品的检测元件产生的信号的仪表一起使用。

9. 发明申请

WO2004113874A2 APPARATUS AND METHOD FOR HANDLING FLUIDS FOR ANALYSIS 审中-公开
标题翻译：用于处理流体分析的装置和方法
公开(公告)号：WO2004113874A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/019049
申请日：2004-06-15
申请人： ABBOTT LABORATORIES , LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： G01N1/00
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
摘要翻译：具有底部排放开口的反应容器，其通过流体的表面张力支撑选定的未压缩流体的头部。装置处理区域包括支撑隔离排列的反应容器，与其支撑的容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。分配头具有可选择性地定位在X选择的反应容器上的X个排出口。计量泵机构选择性地将X选定量的流体计量为批量供应（其中X为至少四个），并且选择性地将计量的所选量通过排放开口泵送到选定的反应容器。还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。

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