专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005074811A1 METHOD FOR DETECTING ARTIFACTS IN DATA 审中-公开
标题翻译：检测数据中的艺术家的方法
公开(公告)号：WO2005074811A1
公开(公告)日：2005-08-18
申请号：PCT/US2004/041029
申请日：2004-12-08
申请人： ABBOTT LABORATORIES , LOWERY, Michael, G. , SHAIN, Eric, B. , KHALIL, Omar, S.
发明人： LOWERY, Michael, G. , SHAIN, Eric, B. , KHALIL, Omar, S.
IPC分类号： A61B05/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14535 , A61B5/7207 , G01N21/49
摘要： A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection oA method for identifying artifacts occuring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelenghts, at different distances between the lht introduction site (s) and the light collection site (s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts. The algorithm identifies sudden changes in the magnitude and direction in a sequence of collected signals.
摘要翻译：用于识别通过采用光学探针的装置测量生物样品中的分析物的浓度期间发生的伪影的方法，将电磁辐射引入到组织中，并且收集和检测距离该点引入电磁辐射。收集辐射强度的值，并在该方法中使用这些值，以产生这些值与组织中分析物的浓度或患者疾病状态之间的关系。该方法涉及使用识别由患者运动产生的数据中的伪像的算法，并且允许用于在生物样品中的分析物的浓度测量期间发现伪像的排斥oA方法，该方法采用温度控制的光学探针将电磁辐射引入到组织中，并收集和检测距离电磁辐射点的距离处发射的辐射。收集并在该方法中使用在不同波长处发射的辐射强度，在引入位置和光采集位点之间的不同距离处以及在不同温度下的辐射强度值，以产生这些值与组织中分析物的浓度或患者的疾病状态。该方法涉及使用识别由患者运动产生的数据中的伪影的算法，并允许拒绝包含这些伪像的数据集。该算法识别收集信号序列中的幅度和方向的突变。

2. 发明申请

WO2005062040A2 METHOD AND SYSTEM FOR ANALYZING REACTIONS USING AN INFORMATION SYSTEM 审中-公开
标题翻译：使用信息系统分析反应的方法和系统
公开(公告)号：WO2005062040A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/038298
申请日：2004-11-17
申请人： ABBOTT LABORATORIES , CLEMENS, John, M. , SHAIN, Eric, B. , JENG, Tzyy-Wen , SCHNEIDER, George, J.
发明人： CLEMENS, John, M. , SHAIN, Eric, B. , JENG, Tzyy-Wen , SCHNEIDER, George, J.
IPC分类号： G01N33/00
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译：用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的分析部分自动化。

3. 发明申请

WO2004113874A3 APPARATUS AND METHOD FOR HANDLING FLUIDS FOR ANALYSIS 审中-公开
公开(公告)号：WO2004113874A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/019049
申请日：2004-06-15
申请人： ABBOTT LABORATORIES , LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： B01L3/14
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.

4. 发明申请

WO2004113874A2 APPARATUS AND METHOD FOR HANDLING FLUIDS FOR ANALYSIS 审中-公开
标题翻译：用于处理流体分析的装置和方法
公开(公告)号：WO2004113874A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/019049
申请日：2004-06-15
申请人： ABBOTT LABORATORIES , LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： G01N1/00
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
摘要翻译：具有底部排放开口的反应容器，其通过流体的表面张力支撑选定的未压缩流体的头部。装置处理区域包括支撑隔离排列的反应容器，与其支撑的容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。分配头具有可选择性地定位在X选择的反应容器上的X个排出口。计量泵机构选择性地将X选定量的流体计量为批量供应（其中X为至少四个），并且选择性地将计量的所选量通过排放开口泵送到选定的反应容器。还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。

5. 发明申请

WO2009086415A1 ALLELIC DISCRIMINATION ANALYSIS USING AN EFFICIENCY RELATED VALUE (EFR) 审中-公开
标题翻译：使用效率相关价值（EFR）的ALLELIC DISCRIMINATION ANALYSIS
公开(公告)号：WO2009086415A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/088220
申请日：2008-12-23
申请人： ABBOTT LABORATORIES , SHAIN, Eric, B.
发明人： SHAIN, Eric, B.
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： G06F19/22 , C12Q1/6858 , G06F19/24 , C12Q2537/165
摘要： Methods for discriminating between two or more different target nucleic acids in amplification reactions comprise signals comprising an amplitude measurement representing the degree of amplification of each target nucleic acid in the amplification reaction and the time point in the amplification reaction at which the amplitude is measured; determining an efficiency related transform of the data, determining an efficiency related value for each target nucleic acid that is the maximum magnitude of the efficiency related transform; and outputting the efficiency related values in the amplification reaction for each target nucleic acid, where the relative amplitudes of the efficiency related values for each target nucleic acid is an indicator of the presence of each of said nucleic acids in said sample.
摘要翻译：用于在扩增反应中区分两种或更多种不同靶核酸的方法包括包括表示扩增反应中每个靶核酸的扩增程度的振幅测量和测量幅度的扩增反应中的时间点的信号; 确定所述数据的效率相关变换，确定作为所述效率相关变换的最大幅度的每个靶核酸的效率相关值; 并输出针对每个靶核酸的扩增反应中的效率相关值，其中每个靶核酸的效率相关值的相对幅度是所述样品中每种所述核酸的存在的指标。

6. 发明申请

WO1997030749A1 TRANSDERMAL TRANSPORT USING ULTRASONIC STANDING WAVES 审中-公开
标题翻译：超声波运输使用超声波标准波
公开(公告)号：WO1997030749A1
公开(公告)日：1997-08-28
申请号：PCT/US1997002264
申请日：1997-02-14
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ELSTROM, Tuan, A. , SHAIN, Eric, B. , HENNING, Timothy, P.
IPC分类号： A61M37/00
CPC分类号： A61B5/14514 , A61M37/0092 , A61M2037/0007
摘要： A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.
摘要翻译：跨越动物皮肤取样细胞外液的过程包括在皮肤上建立超声驻波并收集流体渗出物。可以通过将超声波与部分真空的应用组合到皮肤表面来增强采样。一种装置包括超声换能器，反射器和用于收集渗出物的吸收材料。该装置还可以包括用于降低皮肤表面上的静水压力的压力分量。

7. 发明申请

WO2002082989A1 METHOD FOR OPTICAL MEASUREMENTS OF TISSUE TO DETERMINE DISEASE STATE OR CONCENTRATION OF AN ANALYTE 审中-公开
标题翻译：用于确定疾病状态的组织的光学测量方法或分析仪的浓度
公开(公告)号：WO2002082989A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/006831
申请日：2002-03-07
申请人： ABBOTT LABORATORIES
发明人： KHALIL, Omar, S. , YEH, Shu-Jen , KANTOR, Stanislaw , HANNA, Charles, F. , SHAIN, Eric, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/7264
摘要： A method for collecting optical data at two morphologically similar, substantially non-overlapping, and preferably adjacent, areas on the surface of a tissue, while the temperature in each area is being maintained or modulated according to a temperature program. The optical data obtained are inserted into a mathematical relationship, e.g., an algorithm, that can be used to predict a disease state (such as the diabetes mellitus disease state) or the concentration of an analyte for indicating a physical condition (such as blood glucose level). This invention can be used to differentiate between disease status, such as, for example, diabetic and non-diabetic. The method involves the generation of a calibration (or training) set that utilizes the relationship between optical signals emanating from the skin under different thermal stimuli and disease status, e.g., diabetic status, established clinically. This calibration set can be used to predict the disease state of other subjects. Structural changes, as well as circulatory changes, due to a disease state are determined at two morphologically similar, but substantially non-overlapping areas on the surface of human tissue, e.g., the skin of a forearm, with each area being subjected to different temperature modulation programs. In addition to determination of a disease state, this invention can also be used to determine the concentration of an analyte in the tissues. This invention also provides an apparatus for the determination of a disease state, such as diabetes, or concentration of an analyte, such as blood glucose level, by the method of this invention.
摘要翻译：一种用于在组织表面上的两个形态上类似的，基本上不重叠的，优选相邻的区域收集光学数据的方法，同时根据温度程序维持或调节每个区域中的温度。所获得的光学数据被插入到数学关系中，例如算法，其可用于预测疾病状态（例如糖尿病状态）或用于指示身体状况的分析物的浓度（例如血糖水平）。本发明可用于区分疾病状况，例如糖尿病和非糖尿病。该方法包括产生校准（或训练）组，其利用在不同热刺激下发生的光学信号与疾病状态（例如临床确立的糖尿病状态）之间的关系。该校准集可用于预测其他受试者的疾病状态。由于疾病状态引起的结构变化以及循环变化在人组织表面上的两个形态相似但基本上非重叠的区域确定，例如前臂的皮肤，每个区域经受不同的温度调制程序。除了确定疾病状态之外，本发明还可以用于确定组织中分析物的浓度。本发明还提供了一种用于通过本发明的方法测定疾病状态的装置，例如糖尿病或分析物的浓度，例如血糖水平。

8. 发明申请

WO1997022292A1 EXTRACTION AND MONITORING OF BODILY FLUIDS 审中-公开
标题翻译：提取和监测体液
公开(公告)号：WO1997022292A1
公开(公告)日：1997-06-26
申请号：PCT/US1996019902
申请日：1996-12-12
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , HENNING, Timothy, P. , SHAIN, Eric, B. , ELSTROM, Tuan, A. , WARNKE, Kevin, C.
IPC分类号： A61B05/00
CPC分类号： A61B5/441 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/15134 , A61B5/157
摘要： This disclosure relates to a device and method for the non-invasive or minimally invasive withdrawal of fluids from a patient by the use of a self-actuated pump (12) connected to an analyte sensing unit (16). The self-actuated pump (12) is preferably mounted in the patient's shoe (38).
摘要翻译：本公开涉及一种用于通过使用连接到分析物感测单元（16）的自动泵（12）从患者非侵入性或最小程度地取出流体的装置和方法。自动泵（12）优选安装在患者鞋（38）中。

9. 发明申请

WO1997022291A1 DEVICE FOR THE DETECTION OF ANALYTE AND ADMINISTRATION OF A THERAPEUTIC SUBSTANCE 审中-公开
标题翻译：检测分析物和治疗药物的管理手段
公开(公告)号：WO1997022291A1
公开(公告)日：1997-06-26
申请号：PCT/US1996018870
申请日：1996-11-26
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , HENNING, Timothy, P. , SHAIN, Eric, B. , KHALIL, Gamal , ELSTROM, Tuan, A.
IPC分类号： A61B05/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848
摘要： The present invention relates to a device (10) for the sampling of blood or other body fluids which includes means (16) for the direct measurement of the analyte of interest within the fluid. Also disclosed is a "closed-loop" device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.
摘要翻译：本发明涉及一种用于对血液或其他体液进行取样的装置（10），其包括用于直接测量流体内感兴趣分析物的装置（16）。还公开了一种“闭环”装置和方法，其中测量分析物，并且确定和注射所需量的药物，而不从装置从患者身体移除。

10. 发明申请

WO1996010747A1 DEVICES AND METHODS UTILIZING ARRAYS OF STRUCTURES FOR ANALYTE CAPTURE 审中-公开
标题翻译：利用分析仪结构阵列的装置和方法
公开(公告)号：WO1996010747A1
公开(公告)日：1996-04-11
申请号：PCT/US1995012462
申请日：1995-09-29
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , HANSMANN, Douglas, D. , GRACE, John, P. , LOWERY, Michael, G. , OOSTA, Gary, M. , LOOMIS, Neil, W. , SHAIN, Eric, B. , SCHAPIRA, Thomas, G.
IPC分类号： G01N33/543
CPC分类号： G01N33/5304 , B01L3/502746 , B01L3/502753 , B01L2200/10 , B01L2300/0636 , B01L2300/0825 , B01L2400/0406 , B01L2400/086 , C08G18/0866 , C08G18/10 , G01N33/54366 , G01N33/54393 , Y10S435/81 , Y10S436/804 , Y10S436/805 , Y10S436/809 , Y10S436/81
摘要： The present invention relates to analytical devices for determining the presence or amount of an analyte in a test sample. The analytical devices comprise an inlet port, a vent, a channel, and an array of structures. The structures have immobilized reagent covalently or non-covalently attached to the surface of the structures. The immobilized reagent captures analyte in the test sample where it is detected by a detection system. The present invention also provides methods and reagents for performing assays utilizing the analytical devices of the present invention. The present invention also provides methods of manufacturing the analytical devices of the present invention.
摘要翻译：本发明涉及用于确定测试样品中分析物的存在或量的分析装置。分析装置包括入口，通气口，通道和结构阵列。这些结构具有共价或非共价连接到结构表面的固定化试剂。固定化的试剂捕获测试样品中的分析物，由检测系统检测。本发明还提供用于使用本发明的分析装置进行测定的方法和试剂。本发明还提供了制造本发明的分析装置的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式