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1. 发明申请

WO2009106073A2 MHC MULTIMERS IN BORRELIA DIAGNOSTICS AND DISEASE 审中-公开
标题翻译：波多黎各诊断和疾病中的MHC多态性
公开(公告)号：WO2009106073A2
公开(公告)日：2009-09-03
申请号：PCT/DK2008000451
申请日：2008-12-30
申请人： DAKO DENMARK AS , BRIX LISELOTTE , PEDERSEN HENRIK , SCHOLLER JORGEN
发明人： BRIX LISELOTTE , PEDERSEN HENRIK , SCHOLLER JORGEN
CPC分类号： C07K14/70539 , A61K39/0225 , G01N2333/70539
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the sample-mounted use of MHC complexes and MHC multimers. Also comprised by the invention is the field of therapy and vaccine, including therapeutic/vaccine methods and therapeutic/vaccine compositions.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种含有一种或多种疏螺旋体衍生肽的MHC分子的新型MHC复合物。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及MHC复合物和MHC多聚体的样品安装使用。本发明还包括治疗和疫苗领域，包括治疗/疫苗方法和治疗/疫苗组合物。

2. 发明申请

WO2009039854A2 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
标题翻译： MHC多聚体结核病的诊断，疫苗和治疗药物
公开(公告)号：WO2009039854A2
公开(公告)日：2009-04-02
申请号：PCT/DK2008000339
申请日：2008-09-29
申请人： DAKO DENMARK AS , SCHOLLER JORGEN , BRIX LISELOTTE , PEDERSEN HENRIK , JAKOBSEN TINA
发明人： SCHOLLER JORGEN , BRIX LISELOTTE , PEDERSEN HENRIK , JAKOBSEN TINA
IPC分类号： C07K14/705 , G01N33/50 , G01N33/569
CPC分类号： C07K14/70539 , A61K39/0011 , A61K39/04 , A61K39/12 , A61K39/245 , A61K47/61 , A61K47/6425 , A61K2039/605 , A61K2039/6087 , A61K2039/625 , C12N2710/16134 , G01N33/56972 , G01N2333/35 , G01N2333/70539
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.
摘要翻译：本发明涉及MHC-肽复合物及其在诊断，治疗或预防个体疾病中的用途。更具体地说，本发明公开了包含结核分枝杆菌抗原肽的MHC复合物及其用途。

3. 发明申请

WO2009106073A3 MHC MULTIMERS IN BORRELIA DIAGNOSTICS AND DISEASE 审中-公开
公开(公告)号：WO2009106073A3
公开(公告)日：2009-09-03
申请号：PCT/DK2008/000451
申请日：2008-12-30
申请人： DAKO DENMARK A/S , BRIX, Liselotte , PEDERSEN, Henrik , SCHOLLER, Jorgen
发明人： BRIX, Liselotte , PEDERSEN, Henrik , SCHOLLER, Jorgen
IPC分类号： A61K39/02 , A61K47/48 , C07K14/705 , G01N33/569 , A61P31/04
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the sample-mounted use of MHC complexes and MHC multimers. Also comprised by the invention is the field of therapy and vaccine, including therapeutic/vaccine methods and therapeutic/vaccine compositions.

4. 发明申请

WO2009039854A8 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
公开(公告)号：WO2009039854A8
公开(公告)日：2009-04-02
申请号：PCT/DK2008/000339
申请日：2008-09-29
申请人： DAKO DENMARK A/S , SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
发明人： SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
IPC分类号： C07K14/705 , A61K47/48 , A61K39/00 , A61K38/17 , G01N33/50 , A61P31/00
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.

5. 发明申请

WO2009039854A3 MHC MULTIMERS IN TUBERCULOSIS DIAGNOSTICS, VACCINE AND THERAPEUTICS 审中-公开
公开(公告)号：WO2009039854A3
公开(公告)日：2009-04-02
申请号：PCT/DK2008/000339
申请日：2008-09-29
申请人： DAKO DENMARK A/S , SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
发明人： SCHOLLER, Jorgen , BRIX, Liselotte , PEDERSEN, Henrik , JAKOBSEN, Tina
IPC分类号： C07K14/705 , A61K47/48 , A61K39/00 , A61K38/17 , G01N33/50 , A61P31/00
摘要： The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.

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