专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006064197A3 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 审中-公开
标题翻译：用于评估药物代谢和毒性的转基因动物
公开(公告)号：WO2006064197A3
公开(公告)日：2006-09-28
申请号：PCT/GB2005004772
申请日：2005-12-13
申请人： ITI SCOTLAND LTD , WOLF CHARLES ROLAND , SCHEER NICO , FAUST NICOLE
发明人： WOLF CHARLES ROLAND , SCHEER NICO , FAUST NICOLE
IPC分类号： A01K67/027 , C12N15/09 , G01N33/50
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0393 , C07K14/721 , C07K14/80 , C12N15/8509
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.
摘要翻译：本发明涉及转基因非人动物，由其衍生的组织或细胞及其制备方法。转基因非人动物或组织或由其衍生的细胞提供了能够表达负责药物代谢的人蛋白质代替同源内源性非人动物蛋白质和用于引入动物的人基因的受控表达的系统，人类基因的表达以与人体内所见相似的方式进行调节。

2. 发明申请

WO2009109769A2 SCREENING FOR NON-GENOTOXIC CARCINOGENS 审中-公开
标题翻译：筛选非致病性致癌因子
公开(公告)号：WO2009109769A2
公开(公告)日：2009-09-11
申请号：PCT/GB2009000642
申请日：2009-03-09
申请人： ITI SCOTLAND LTD , WOLF CHARLES ROLAND , ELCOMBE CLIFFORD ROY
发明人： WOLF CHARLES ROLAND , ELCOMBE CLIFFORD ROY
IPC分类号： A01K67/027
CPC分类号： G01N33/5014 , A01K67/0278 , A01K2207/15 , A01K2217/07 , A01K2227/105 , A01K2267/03 , C07K14/47 , C07K14/70567 , C12N15/8509
摘要： The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARa, and in which the endogenous equivalent genes have been rendered inoperable.
摘要翻译：本发明涉及在动物模型中筛选非遗传毒性致癌物的作用的方法。本发明还涉及适用于这种方法的动物模型，以及衍生自这些动物的细胞系用于体外筛选目的。更具体地说，本发明涉及已被人源化为核转录因子CAR，PXR和PPARa的转基因啮齿类动物，其中内源等效基因已被使得不可操作。

3. 发明申请

WO2004091150A3 CYP2S1 AS TARGET DOR DIAGNOSIS AND THERAPY OF SKIN DISEASES 审中-公开
标题翻译： CYP2S1作为目标诊断和治疗皮肤疾病
公开(公告)号：WO2004091150A3
公开(公告)日：2005-01-20
申请号：PCT/GB2004001453
申请日：2004-04-05
申请人： UNIV DUNDEE , SMITH GILLIAN , IBBOTSON SALLY HELEN , WOLF CHARLES ROLAND
发明人： SMITH GILLIAN , IBBOTSON SALLY HELEN , WOLF CHARLES ROLAND
IPC分类号： C12N9/02 , C12Q1/26 , C12Q1/68 , A61K38/00 , A61K48/00 , C07K16/00 , C12N5/10 , C12N15/00 , G01N33/50
CPC分类号： C12N9/0077 , C12Q1/26 , C12Q1/6883
摘要： This invention relates to a retinoic acid metabolizing cytochrome P450 2S1 (CYP2S1) and to uses of sequence specific nucleic acid, primers and antibodies, in, for example, assays for the analysis of CYP2S1 messenger RNA and/or protein expression in skin. The invention also relates to assays for detecting agents which modulate CYP2S 1 expression and/or activity and methods of testing drug efficacy.
摘要翻译：本发明涉及视黄酸代谢细胞色素P450 2S1（CYP2S1）以及序列特异性核酸，引物和抗体的用途，例如用于分析CYP2S1信使RNA和/或皮肤蛋白质表达的测定法。本发明还涉及用于检测调节CYP2S1表达和/或活性的试剂和测试药物功效的方法的测定。

4. 发明专利

AU2005315438B2 Transgenic animals for assessing drug metabolism and toxicity 未知
公开(公告)号：AU2005315438B2
公开(公告)日：2012-02-23
申请号：AU2005315438
申请日：2005-12-13
申请人： ITI SCOTLAND LTD
发明人： FAUST NICOLE , WOLF CHARLES ROLAND , SCHEER NICO
IPC分类号： A01K67/027 , C12N15/09 , G01N33/50
摘要： The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in humans.

5. 发明专利

CA2701163A1 KNOCKOUT MICE FOR A P450 GENE CLUSTER 未知
公开(公告)号：CA2701163A1
公开(公告)日：2009-04-23
申请号：CA2701163
申请日：2008-10-17
申请人： ITI SCOTLAND LTD
发明人： SCHEER NICO , WOLF CHARLES ROLAND
IPC分类号： C12N15/85 , A01K67/027 , G01N33/50
摘要： The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation. One example of this complexity is reflected in the mammalian cytochrome P450 system, where the sizes of multigene families of proteins which carry out particular metabolic functions vary enormously between species.

6. 发明专利

CA2590010A1 TRANSGENIC ANIMALS FOR ASSESSING DRUG METABOLISM AND TOXICITY 未知
公开(公告)号：CA2590010A1
公开(公告)日：2006-06-22
申请号：CA2590010
申请日：2005-12-13
申请人： ITI SCOTLAND LTD
发明人： FAUST NICOLE , WOLF CHARLES ROLAND , SCHEER NICO
IPC分类号： A01K67/027 , C12N15/09 , G01N33/50

7. 发明申请

WO2004011676A3 MULTI-REPORTER GENE MODEL FOR TOXICOLOGICAL SCREENING 审中-公开
标题翻译：多媒体基因组毒理学筛选模型
公开(公告)号：WO2004011676A3
公开(公告)日：2004-05-06
申请号：PCT/GB0303192
申请日：2003-07-25
申请人： ROSLIN INST EDINBURGH , CXR BIOSCIENCES LTD , WHITELAW CHRISTOPHER BRUCE ALE , CLARK ANTHONY JOHN , WOLF CHARLES ROLAND
发明人： WHITELAW CHRISTOPHER BRUCE ALE , CLARK ANTHONY JOHN , WOLF CHARLES ROLAND
IPC分类号： A01K67/027 , C07K14/47 , C12N15/62 , C12N15/85 , G01N33/50 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2267/0393 , C07K14/4717 , C07K2319/00 , C07K2319/23 , C07K2319/41 , C07K2319/61 , C12N15/62 , C12N2800/30 , G01N33/5014 , G01N2500/10
摘要： A system for the detection of gene activation events is provided which comprises a nucleic acid construct encoding a protein of the lipocalin protein family and a peptide tag in which the expression of the construct in a cell or in the cells of a transgenic animal demonstrates the activation of a gene or genes of interest, in which the protein expressed is secreted from the cell and in which detection of the peptide tag indicates expression of the construct.
摘要翻译：提供了用于检测基因激活事件的系统，其包含编码脂质运载蛋白家族蛋白质的核酸构建体和肽标签，其中构建体在细胞中或转基因动物细胞中的表达表现出激活其中表达的蛋白质从细胞分泌并且其中肽标签的检测指示构建体的表达。

8. 发明申请

WO9802554A3 Cytochrome P450 expression in enterobacteria 审中-公开
标题翻译：细菌色素P450在肠细菌中的表达
公开(公告)号：WO9802554A3
公开(公告)日：1998-03-19
申请号：PCT/GB9701917
申请日：1997-07-17
申请人： UNIV DUNDEE , WOLF CHARLES ROLAND , FRIEDBERG THOMAS HERBERT , PRITCHARD MICHAEL PATRICK
发明人： WOLF CHARLES ROLAND , FRIEDBERG THOMAS HERBERT , PRITCHARD MICHAEL PATRICK
IPC分类号： C12N15/09 , A61K38/00 , C12N1/21 , C12N9/02 , C12N15/53 , C12N15/70 , A61K38/43 , C12N1/20 , C12N15/52 , C12N15/62 , C12Q1/26
CPC分类号： C12N9/0042 , A61K38/00 , C07K2319/02 , C12N9/0077
摘要： A bacterial cell containing a functional cytochrome P450 monooxygenase system, said cell comprising a genetic construct capable of expressing a cytochrome P450 and a genetic construct capable of expressing, separately from said cytochrome P450, a cytochrome P450 reductase wherein the N-terminus of the cytochrome P450 and the N-terminus of the cytochrome P450 reductase are each adapted to allow functional coupling of said cytochrome P450 and said cytochrome P450 reductase within said cell. A bacterial cell containing a cytochrome P450 comprising a genetic construct encoding, and capable of expressing, said cytochrome P450 wherein the cytochrome P450 comprises an N-terminal portion which directs the cytochrome P450 to a cellular compartment or membrane of the bacterial cell. The bacterial cells are useful as, for example, bioreactors, in drug testing and mutagenicity testing and as a source of cytochrome P450.

9. 发明申请

WO2006067487A2 INSECTICIDE TARGET 审中-公开
标题翻译：杀虫剂目标
公开(公告)号：WO2006067487A2
公开(公告)日：2006-06-29
申请号：PCT/GB2005005040
申请日：2005-12-23
申请人： UNIV DUNDEE , PAINE MARK JOHN INGRAHAM , WOLF CHARLES ROLAND , MCLAUGHIN LESLEY ANNE
发明人： PAINE MARK JOHN INGRAHAM , WOLF CHARLES ROLAND , MCLAUGHIN LESLEY ANNE
IPC分类号： A01N57/10 , C12N15/11 , C12N15/113 , C12N15/866 , C12Q1/26 , C12Q1/68 , G06F19/16
CPC分类号： C12N15/1137 , C12N15/111 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2320/31 , C12Y106/02004 , G06F19/16
摘要： The invention provides a method of enhancing the effectiveness of pesticides, as well as pesticidal formulations. Furthermore, it also provides the means for the de novo rational design of pesticides. The present invention also relates to a method of screening agents for potential use in insecticides, particularly against mosquitoes.
摘要翻译：本发明提供了一种提高农药有效性以及杀虫剂的方法。此外，它还为农药的从头合理设计提供了手段。本发明还涉及用于杀虫剂，特别是针对蚊子的潜在用途的筛选剂的方法。

10. 发明申请

WO0107066A3 PPAR DELTA INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：用于治疗心血管疾病的PPAR DELTA抑制剂
公开(公告)号：WO0107066A3
公开(公告)日：2001-08-09
申请号：PCT/EP0006986
申请日：2000-07-19
申请人： UNIV DUNDEE , PALMER COLIN NEIL ALEXANDER , VOSPER HELEN , WOLF CHARLES ROLAND
发明人： PALMER COLIN NEIL ALEXANDER , VOSPER HELEN , WOLF CHARLES ROLAND
IPC分类号： G01N33/50 , A61K31/00 , A61K31/4439 , A61K31/711 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C12N15/09 , C12N15/113 , C12Q1/02 , C12R1/91 , G01N33/15
CPC分类号： C12N15/1138 , A61K31/00 , A61K31/4439 , A61K48/00 , C12N2310/111 , G01N33/502 , G01N33/5055
摘要： A method of preventing or reducing foam cell development from macrophages, or removing foam cells, in a patient, the method comprising administering to the patient an effective amount of an inhibitor of PPAR delta activity. A method of preventing or treating a vascular disease associated with plaque formation and/or thrombotic blockage of the blood vessels in a patient, the method comprising administering to the patient an effective amount of an inhibitor of PPAR delta activity.
摘要翻译：一种在患者中预防或减少巨噬细胞发泡细胞或除去泡沫细胞的方法，所述方法包括向患者施用有效量的PPARδ活性抑制剂。一种预防或治疗与患者血管斑块形成和/或血栓阻塞相关的血管疾病的方法，所述方法包括向患者施用有效量的PPARδ活性抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式