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1. 发明公开

EP3373920A1 METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS 审中-公开
公开(公告)号：EP3373920A1
公开(公告)日：2018-09-19
申请号：EP16865180.0
申请日：2016-11-12
申请人： Sanna, Pietro Paolo
发明人： Sanna, Pietro Paolo
IPC分类号： A61K31/194 , C07J63/00 , A61P25/32
CPC分类号： A61K31/585 , A61K31/22 , A61K31/4965 , A61K31/56 , A61K31/573 , A61K31/58 , A61K38/39 , A61K45/06 , C07J63/008 , A61K2300/00
摘要： Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD inhibitor carbenoxolone (18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively employed in the clinic for the treatment of gastritis and peptic ulcer. Carbenoxolone is active on both 11β-HSD1 and 2 isoforms. Here, carbenoxolone is surprisingly shown to reduce both baseline and excessive drinking in rats and mice. The carbenoxolone diastereomer 18α-glycyrrhetinic acid 3β-O-hemisuccinate (αCBX), which the applicants discovered to be selective for 11β-HSD2, was also effective in reducing alcohol drinking in mice. Thus, 11β-HSD inhibitors are a new class of candidate alcohol abuse medications and existing 11β-HSD inhibitor drugs may be re-purposed for alcohol abuse treatment.

2. 发明公开

EP1957112A2 ROLE OF PROTEOGLYCANS IN DRUG DEPENDENCE 审中-公开
标题翻译：角色毒瘾蛋白聚糖
公开(公告)号：EP1957112A2
公开(公告)日：2008-08-20
申请号：EP06838193.8
申请日：2006-11-21
申请人： Sanna, Pietro Paolo
发明人： Sanna, Pietro Paolo
IPC分类号： A61K48/00
CPC分类号： C07K14/705 , A61K31/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.

3. 发明申请

WO2008043052A3 HUMAN ANTIBODIES NEUTRALIZING HUMAN METAPNEUMOVIRUS 审中-公开
标题翻译：人类抗体中和人类METAPNEUMOVIRUS
公开(公告)号：WO2008043052A3
公开(公告)日：2008-12-04
申请号：PCT/US2007080498
申请日：2007-10-04
申请人： SCRIPPS RESEARCH INST , UNIV VANDERBILT , WILLIAMSON ANTHONY R , CHEN ZHIFENG , SANNA PIETRO PAOLO , BURTON DENNIS R , CROWE JAMES , WILLIAMS JOHN V
发明人： WILLIAMSON ANTHONY R , CHEN ZHIFENG , SANNA PIETRO PAOLO , BURTON DENNIS R , CROWE JAMES , WILLIAMS JOHN V
IPC分类号： C07K16/00
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses methods for generating antibodies to human metapneumovirus (HMPV) polypeptides, including antibodies that immunospecifically bind to a HMPV F-protein. The invention also discloses methods for preventing, treating, or ameliorating symptoms associated with HMPV infection.
摘要翻译：本发明公开了产生针对人类偏肺病毒（HMPV）多肽的抗体的方法，包括免疫特异性结合HMPV F蛋白的抗体。本发明还公开了用于预防，治疗或改善与HMPV感染相关的症状的方法。

4. 发明申请

WO2017083795A1 METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS 审中-公开
标题翻译：治疗酒精使用障碍的方法和组合物
公开(公告)号：WO2017083795A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061729
申请日：2016-11-12
申请人： SANNA, Pietro, Paolo
发明人： SANNA, Pietro, Paolo
IPC分类号： A61K31/194 , C07J63/00 , A61P25/32
CPC分类号： A61K31/585 , A61K31/22 , A61K31/4965 , A61K31/56 , A61K31/573 , A61K31/58 , A61K38/39 , A61K45/06 , C07J63/008 , A61K2300/00
摘要： Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD inhibitor carbenoxolone (18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively employed in the clinic for the treatment of gastritis and peptic ulcer. Carbenoxolone is active on both 11β-HSD1 and 2 isoforms. Here, carbenoxolone is surprisingly shown to reduce both baseline and excessive drinking in rats and mice. The carbenoxolone diastereomer 18α-glycyrrhetinic acid 3β-O-hemisuccinate (αCBX), which the applicants discovered to be selective for 11β-HSD2, was also effective in reducing alcohol drinking in mice. Thus, 11β-HSD inhibitors are a new class of candidate alcohol abuse medications and existing 11β-HSD inhibitor drugs may be re-purposed for alcohol abuse treatment.
摘要翻译：公开了通过向患者施用11β-羟基类固醇脱氢酶（11β-HSD）抑制剂以调节糖皮质激素效应来治疗酒精依赖性的方法和组合物。一种这样的化合物是11β-HSD抑制剂生胃酮（18β-甘草次酸3β-O-半琥珀酸盐），其在临床上广泛用于治疗胃炎和消化性溃疡。 Carbenoxolone对11β-HSD1和2同种型均有活性。在这里，令人惊讶地证明甘珀酸减少大鼠和小鼠的基线和过量饮酒。本申请人发现对于11β-HSD2具有选择性的生菌酮非对映异构体18α-甘草次酸3β-O-半琥珀酸盐（αCBX）在减少小鼠饮酒中也是有效的。因此，11β-HSD抑制剂是一类新的候选酒精滥用药物，并且现有的11β-HSD抑制剂药物可能被重新用于酗酒治疗。

5. 发明申请

WO2007062048A3 ROLE OF PROTEOGLYCANS IN DRUG DEPENDENCE 审中-公开
公开(公告)号：WO2007062048A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/045078
申请日：2006-11-21
申请人： SANNA, Pietro, Paolo
发明人： SANNA, Pietro, Paolo
IPC分类号： A61K48/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.

6. 发明申请

WO2008043052A2 HUMAN ANTIBODIES NEUTRALIZING HUMAN METAPNEUMOVIRUS 审中-公开
标题翻译：人类抗体中和人类线粒体病毒
公开(公告)号：WO2008043052A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/080498
申请日：2007-10-04
申请人： THE SCRIPPS RESEARCH INSTITUTE , VANDERBILT UNIVERSITY , WILLIAMSON, Anthony, R. , CHEN, Zhifeng , SANNA, Pietro, Paolo , BURTON, Dennis, R. , CROWE, James , WILLIAMS, John, V.
发明人： WILLIAMSON, Anthony, R. , CHEN, Zhifeng , SANNA, Pietro, Paolo , BURTON, Dennis, R. , CROWE, James , WILLIAMS, John, V.
IPC分类号： C12Q1/70
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses methods for generating antibodies to human metapneumovirus (HMPV) polypeptides, including antibodies that immunospecifically bind to a HMPV F-protein. The invention also discloses methods for preventing, treating, or ameliorating symptoms associated with HMPV infection.
摘要翻译：本发明公开了产生针对人偏肺病毒（HMPV）多肽的抗体的方法，所述抗体包括免疫特异性结合HMPV F蛋白的抗体。本发明还公开了用于预防，治疗或改善与HMPV感染相关的症状的方法。

7. 发明申请

WO2007062048A2 ROLE OF PROTEOGLYCANS IN DRUG DEPENDENCE 审中-公开
标题翻译：抗生素在药物依赖中的作用
公开(公告)号：WO2007062048A2
公开(公告)日：2007-05-31
申请号：PCT/US2006045078
申请日：2006-11-21
申请人： SCRIPPS RESEARCH INST , SANNA PIETRO PAOLO
发明人： SANNA PIETRO PAOLO
IPC分类号： A61K48/00
CPC分类号： C07K14/705 , A61K31/00
摘要： The invention provides methods of preventing or treating drug addiction, or ameliorating the craving for an addictive drug, as well as compounds, peptides, and pharmaceutical compositions that may be used to prevent or treat drug addiction or ameliorate the craving for an addictive drug. The invention also provides methods for identifying agents that may be used to prevent or treat drug addiction, or ameliorate the craving for an addictive drug.
摘要翻译：本发明提供了预防或治疗药物成瘾或改善上瘾药物渴求的方法，以及可用于预防或治疗药物成瘾或改善成瘾药物渴求的化合物，肽和药物组合物的方法。本发明还提供了用于鉴定可用于预防或治疗药物成瘾或改善对上瘾药物的欲望的药剂的方法。

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