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1. 发明专利

IL242020A Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways 未知
公开(公告)号：IL242020A
公开(公告)日：2019-08-29
申请号：IL24202015
申请日：2015-10-11
申请人： SAUMITRA SENGUPTA , ASANA BIOSCIENCES LLC , SCOTT K THOMPSON , ROGER A SMITH , SANJEEVA REDDY , TYLER M JOHN , VIJAY KUMAR NYAVANANDI , HOSAHALLI SUBRAMANYA , VIJAY POTLURI , SUNIL KUMAR PANIGRAHI , PRABHAKARA RAO NADIPALLI
发明人： SAUMITRA SENGUPTA , SCOTT K THOMPSON , ROGER A SMITH , SANJEEVA REDDY , TYLER M JOHN , VIJAY KUMAR NYAVANANDI , HOSAHALLI SUBRAMANYA , VIJAY POTLURI , SUNIL KUMAR PANIGRAHI , PRABHAKARA RAO NADIPALLI
IPC分类号： A61K31/5377 , A61P35/00
摘要： The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in for co-regulating RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways by administering a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, T and R4, and R6 to R8′ are defined herein, to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment/the disease is cancer.

2. 发明专利

IL262314D0 Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways 未知
公开(公告)号：IL262314D0
公开(公告)日：2018-11-29
申请号：IL26231418
申请日：2018-10-11
申请人： SAUMITRA SENGUPTA , ASANA BIOSCIENCES LLC , SCOTT K THOMPSON , ROGER A SMITH , SANJEEVA REDDY , TYLER M JOHN , VIJAY KUMAR NYAVANANDI , HOSAHALLI SUBRAMANYA , VIJAY POTLURI , SUNIL KUMAR PANIGRAHI , PRABHAKARA RAO NADIPALLI
发明人： SAUMITRA SENGUPTA , SCOTT K THOMPSON , ROGER A SMITH , SANJEEVA REDDY , TYLER M JOHN , VIJAY KUMAR NYAVANANDI , HOSAHALLI SUBRAMANYA , VIJAY POTLURI , SUNIL KUMAR PANIGRAHI , PRABHAKARA RAO NADIPALLI
IPC分类号： A61K20060101
摘要： The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in for co-regulating RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways by administering a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, T and R4, and R6 to R8′ are defined herein, to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment/the disease is cancer.

3. 发明授权

US07074813B2 Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译：取代的N' - （芳基羰基） - 苯甲酰肼，N' - （芳基羰基） - 亚苄基酰肼和类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途
公开(公告)号：US07074813B2
公开(公告)日：2006-07-11
申请号：US10816893
申请日：2004-04-05
申请人： Sui Xiong Cai , Shailaja Kasibhatla , John Drewe , P. Sanjeeva Reddy , Han-Zhong Zhang
发明人： Sui Xiong Cai , Shailaja Kasibhatla , John Drewe , P. Sanjeeva Reddy , Han-Zhong Zhang
IPC分类号： A61K31/44 , C07D213/643 , C07D213/69 , C07D213/70
CPC分类号： A61K31/165 , A61K31/44 , C07D213/87 , C07D213/89 , C07D401/14
摘要： The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, Ar2, and R1–R2 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由式I和II表示的取代的N' - （芳基羰基） - 苯甲酰肼，N' - （芳基羰基） - 亚苄基 - 酰肼及其类似物：其中Ar 1，Ar 本文定义了R 2，R 2和R 2 -R 2。本发明还涉及具有式I和II的化合物是胱天蛋白酶的活化剂和凋亡诱导剂的发现。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

4. 发明授权

US07256219B2 Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译：多氟取代的查尔酮和类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途
公开(公告)号：US07256219B2
公开(公告)日：2007-08-14
申请号：US10471720
申请日：2002-03-14
申请人： Sui Xiong Cai , P. Sanjeeva Reddy , John A. Drewe , Bao Ngoc Nguyen , Shailaja Kasibhatla
发明人： Sui Xiong Cai , P. Sanjeeva Reddy , John A. Drewe , Bao Ngoc Nguyen , Shailaja Kasibhatla
IPC分类号： A61K31/12 , C07C49/00 , C07D333/00 , C07D307/02 , C07D221/02 , C07D209/04 , C07D207/18
CPC分类号： C07D213/50 , A61K31/12 , A61K31/34 , A61K31/40 , A61K31/47 , A61K45/06 , C07C45/74 , C07C49/84 , C07C205/45 , A61K2300/00
摘要： The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由通式I表示的多氟取代的查尔酮及其类似物：其中Ar和R 6 -R 10是本文定义的。本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

5. 发明授权

US07226927B2 Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译：取代的2-芳基-4-芳基氨基嘧啶和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
公开(公告)号：US07226927B2
公开(公告)日：2007-06-05
申请号：US10704448
申请日：2003-11-10
申请人： Sui Xiong Cai , John A Drewe , P. Sanjeeva Reddy , Bao Nguyen , Azra Pervin
发明人： Sui Xiong Cai , John A Drewe , P. Sanjeeva Reddy , Bao Nguyen , Azra Pervin
IPC分类号： A61K31/53 , A61K31/505 , A61K31/506 , C07D239/02 , C07D409/00 , C07D251/00 , C07C49/00 , C07C255/17
CPC分类号： C07D239/42 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/53 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D417/14
摘要： The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由通式I表示的取代的2-芳基-4-芳基氨基嘧啶及其类似物：其中A，Ar 1，Ar 2，本文定义了SUB 1和R 3。本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。本发明的化合物可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

6. 发明申请

US20100220558A1 Real Time Clock 有权
标题翻译：实时时钟
公开(公告)号：US20100220558A1
公开(公告)日：2010-09-02
申请号：US12395326
申请日：2009-02-27
申请人： Sanjeeva Reddy Pindi
发明人： Sanjeeva Reddy Pindi
IPC分类号： G06F1/04
CPC分类号： G06F1/14 , G06F1/3203 , G06F1/325
摘要： Various apparatuses, methods and systems for a real time clock are disclosed herein. For example, some embodiments provide a real time clock including a clock generator having a first input connected to a clock signal and a second input connected to a time set signal. The clock generator produces a time change signal at an output of the clock generator. Counters, each adapted to track a different unit of time, are connected to the time change signal. The clock generator is adapted to generate a pulse on the time change signal for each pulse of the time set signal, and to generate separate pulses on the time change signal for consecutive pulses on the clock signal and the time set signal.
摘要翻译：这里公开了用于实时时钟的各种装置，方法和系统。例如，一些实施例提供实时时钟，其包括具有连接到时钟信号的第一输入和连接到时间设定信号的第二输入的时钟发生器。时钟发生器在时钟发生器的输出端产生时变信号。每个适用于跟踪不同时间单位的计数器连接到时间变化信号。时钟发生器适于根据时间设定信号的每个脉冲对时变信号产生脉冲，并且对时钟信号和时间设定信号上的连续脉冲在时变信号上产生单独的脉冲。

7. 发明授权

US07041685B2 Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译：取代的3-芳基-5-芳基 - [1,2,4] - 恶二唑和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途
公开(公告)号：US07041685B2
公开(公告)日：2006-05-09
申请号：US10164705
申请日：2002-06-10
申请人： Sui Xiong Cai , Han-Zhong Zhang , John A. Drewe , P. Sanjeeva Reddy , Shailaja Kasibhatla , Jared Daniel Kuemmerle , Kristin P. Ollis
发明人： Sui Xiong Cai , Han-Zhong Zhang , John A. Drewe , P. Sanjeeva Reddy , Shailaja Kasibhatla , Jared Daniel Kuemmerle , Kristin P. Ollis
IPC分类号： A61K31/44 , C07D413/14
CPC分类号： C07D413/14 , A61K31/335 , A61K31/38 , A61K31/395 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14 , C07D471/04
摘要： The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由式I表示的取代的3-芳基-5-芳基 - [1,2,4] - 恶二唑及其类似物：其中Ar 1，Ar 3 A，B和D在本文中定义。本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

8. 发明授权

US06794400B2 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译： 4-取代-1-（芳基亚甲基）氨基硫脲，4-取代-1-（芳基羰基）氨基硫脲和类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途
公开(公告)号：US06794400B2
公开(公告)日：2004-09-21
申请号：US10158827
申请日：2002-06-03
申请人： Sui Xiong Cai , Bao Ngoc Nguyen , John Drewe , P. Sanjeeva Reddy , Shailaja Kasibhatla , Azra Pervin
发明人： Sui Xiong Cai , Bao Ngoc Nguyen , John Drewe , P. Sanjeeva Reddy , Shailaja Kasibhatla , Azra Pervin
IPC分类号： A61K3144
CPC分类号： C07D207/335 , A61K31/175 , A61K31/435 , A61K31/44 , A61K31/4965 , C07C281/14 , C07C337/08 , C07C2602/42 , C07D213/53 , C07D213/61 , C07D213/84 , C07D213/86 , C07D231/16 , C07D233/64 , C07D277/28 , C07D277/56 , C07D285/06 , C07D295/135 , C07D307/52 , C07D307/76 , C07D333/22 , C07D333/44 , A61K2300/00
摘要： The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae I and II: wherein A1, A2, Q and R1-R3 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由式I和II表示的任选取代的4-取代-1-（芳基亚甲基）氨基硫脲，4-取代-1-（芳基羰基）氨基硫脲及其类似物：其中A1，A2，Q和R1- R3在本文中定义。本发明还涉及具有式I和II的化合物是胱天蛋白酶的活化剂和凋亡诱导剂的发现。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于在异常细胞发生不受控制的生长和扩散的各种临床病症中诱导细胞死亡。

9. 发明申请

WO2010049947A3 PREPARATION OF GEMCITABINE AND INTERMEDIATES THEREOF 审中-公开
标题翻译：化合物的制备及其中间体
公开(公告)号：WO2010049947A3
公开(公告)日：2011-04-14
申请号：PCT/IN2009000602
申请日：2009-10-26
申请人： ACCRETE PHARMACEUTICAL PRIVATE LTD , NALINI MOHAN REDDY DODLE , SUDHIR RAVULAPALLI , SANJEEVA REDDY KUNDURU
发明人： NALINI MOHAN REDDY DODLE , SUDHIR RAVULAPALLI , SANJEEVA REDDY KUNDURU
IPC分类号： C07H5/02
CPC分类号： C07H5/02 , Y02P20/55
摘要： The present patent application relates to a process for the preparation gemcitabine or a salt thereof. More particularly it relates to preparation of 3,5- dihydroxy protected -2-deoxy-2,2-difluoro -1-oxoribose, an intermediate used in the preparation of gemcitabine and its salts by using cyclohexylidene or cyclopentylidene protecting group, with high yield and purity.
摘要翻译：本专利申请涉及制备吉西他滨或其盐的方法。更具体地说，涉及3,5-二羟基保护的-2-脱氧-2,2-二氟-1-氧代核糖的制备，其是通过使用环己基或环戊叉基保护基以高产率制备吉西他滨及其盐的中间体和纯度。

10. 发明申请

WO2010049947A2 PREPARATION OF GEMCITABINE AND INTERMEDIATES THEREOF 审中-公开
标题翻译：化合物的制备及其中间体
公开(公告)号：WO2010049947A2
公开(公告)日：2010-05-06
申请号：PCT/IN2009/000602
申请日：2009-10-26
申请人： ACCRETE PHARMACEUTICAL PRIVATE LIMITED , NALINI MOHAN REDDY, Dodle , SUDHIR, Ravulapalli , SANJEEVA REDDY, Kunduru
发明人： NALINI MOHAN REDDY, Dodle , SUDHIR, Ravulapalli , SANJEEVA REDDY, Kunduru
IPC分类号： C07H5/02
CPC分类号： C07H5/02 , Y02P20/55
摘要： The present patent application relates to a process for the preparation gemcitabine or a salt thereof. More particularly it relates to preparation of 3,5- dihydroxy protected -2-deoxy-2,2-difluoro -1-oxoribose, an intermediate used in the preparation of gemcitabine and its salts by using cyclohexylidene or cyclopentylidene protecting group, with high yield and purity.
摘要翻译：本专利申请涉及制备吉西他滨或其盐的方法。更具体地说，涉及3,5-二羟基保护的-2-脱氧-2,2-二氟-1-氧代核糖的制备，其是通过使用亚环己基或环戊叉基保护基以高产率制备吉西他滨及其盐的中间体和纯度。

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