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1. 发明申请

WO2008126065A3 POLYNUCLEOTIDES AND POLYPEPTIDES INVOLVED IN GESTATIONAL MALARIA, AND BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：涉及疟疾的多核苷酸和多肽以及生物应用
公开(公告)号：WO2008126065A3
公开(公告)日：2008-12-31
申请号：PCT/IB2008051482
申请日：2008-04-17
申请人： INST RECH DEVELOPPEMENT IRD , PASTEUR INSTITUT , DELORON PHILIPPE LUCIEN , TUIKUE NDAM NICAISE GEORGES , BERTIN GWLADYS IRENEE , DAVID PETER , BISCHOFF EMMANUEL , PROUX CAROLINE STEPHANIE , COPPEE JEAN-YVES , SALANTI ALI , LAVSTSEN THOMAS
发明人： DELORON PHILIPPE LUCIEN , TUIKUE NDAM NICAISE GEORGES , BERTIN GWLADYS IRENEE , DAVID PETER , BISCHOFF EMMANUEL , PROUX CAROLINE STEPHANIE , COPPEE JEAN-YVES , SALANTI ALI , LAVSTSEN THOMAS
IPC分类号： C12N15/30 , A61K39/015 , A61K39/40 , C07K14/445 , C07K16/12 , G01N33/53 , G01N33/68
CPC分类号： C07K14/445 , C07K16/205
摘要： The present invention relates to novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including said sequences for the preparation of immunogenic compositions and vaccines, antibodies, and to the use thereof for treating gestational malaria. The invention also relates to diagnostic methods and kits.
摘要翻译：本发明涉及涉及妊娠期疟疾的新抗原，更具体地涉及包含用于制备免疫原性组合物和疫苗的所述序列的多核苷酸和多肽序列，缀合物，克隆载体，抗体及其用于治疗妊娠期疟疾的用途。本发明还涉及诊断方法和试剂盒。

2. 发明申请

WO2004067559A1 COMPOUNDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF PREGNANCY-ASSOCIATED MALARIA 审中-公开
标题翻译：诊断和治疗妊娠相关疟疾的化合物
公开(公告)号：WO2004067559A1
公开(公告)日：2004-08-12
申请号：PCT/DK2003/000938
申请日：2003-12-30
申请人： KØBENHAVNS UNIVERSITET , THEANDER, Thor, Grundtvig , SALANTI, Ali , HVIID, Lars , STAALSØ, Trine , JENSEN, Anja, Tatiana, Ramstedt , LAVSTSEN, Thomas , DAHLBÄCK, Madeleine
发明人： THEANDER, Thor, Grundtvig , SALANTI, Ali , HVIID, Lars , STAALSØ, Trine , JENSEN, Anja, Tatiana, Ramstedt , LAVSTSEN, Thomas , DAHLBÄCK, Madeleine
IPC分类号： C07K14/445
CPC分类号： C07K16/205 , A61K38/00 , Y10S435/975
摘要： The present invention relates to nucleic acid molecules related to the var2csa gene family as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to chondroitin sulphate A (CSA) in the placenta which is characteristic for the pathogenesis of pregnancy associated malaria (PAM). Accordingly, The invention provides the use compounds that are related to VAR2CSA polypeptides and var2csa nucleic acid molecules as medicaments, as well as it provides pharmaceutical compositions, in particular immunological compositions and vaccines, hereunder nucleotide-based vaccines comprising these compounds. In addition, the invention provides the use of the compounds mentionedfor the manufacture of compositions, such as immunogenic compositions. Other aspects of the invention relates to methods of treatment and prevention of pregnancy associated malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR2CSA dependent adhesion to CSA and agent capable of interacting with VAR2CSA. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.
摘要翻译：本发明涉及与var2csa基因家族有关的核酸分子，以及由这些核酸分子编码的氨基酸序列，涉及其介导感染的红细胞与胎盘中硫酸软骨素A（CSA）的粘附的作用是怀孕相关疟疾（PAM）发病机制的特征。因此，本发明提供了与VAR2CSA多肽和var2csa核酸分子作为药物相关的用途化合物，以及其提供了包含这些化合物的基于核苷酸的疫苗的药物组合物，特别是免疫组合物和疫苗。此外，本发明提供了所述化合物用于制备组合物如免疫原性组合物的用途。本发明的其它方面涉及治疗和预防妊娠相关疟疾的方法，其中这些方法基于本发明的核酸分子和多肽。由于这些化合物也可以用作生物技术工具，本发明提供体外诊断方法和试剂盒，其中包括用于这些方法的试剂和IgG /抗体。本发明还涉及鉴定能够调节VAR2CSA对CSA的依赖性粘附和能够与VAR2CSA相互作用的试剂的鉴定剂的方法。最后，本发明提供了鉴定多肽的方法，该多肽在给予受试者时将诱导特异的IgG /抗体应答。

3. 发明申请

WO2008126065A2 POLYNUCLÉOTIDES ET POLYPEPTIDES IMPLIQUÉS DANS LE PALUDISME GESTATIONNEL, ET APPLICATIONS BIOLOGIQUES 审中-公开
标题翻译：参与疟疾和生物应用的多核苷酸和多肽
公开(公告)号：WO2008126065A2
公开(公告)日：2008-10-23
申请号：PCT/IB2008/051482
申请日：2008-04-17
申请人： INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.) , INSTITUT PASTEUR , DELORON, Philippe, Lucien , TUIKUE NDAM, Nicaise, Georges , BERTIN, Gwladys, Irénée , DAVID, Peter , BISCHOFF, Emmanuel , PROUX, Caroline, Stéphanie , COPPEE, Jean-Yves , SALANTI, Ali , LAVSTSEN, Thomas
发明人： DELORON, Philippe, Lucien , TUIKUE NDAM, Nicaise, Georges , BERTIN, Gwladys, Irénée , DAVID, Peter , BISCHOFF, Emmanuel , PROUX, Caroline, Stéphanie , COPPEE, Jean-Yves , SALANTI, Ali , LAVSTSEN, Thomas
IPC分类号： C12N15/30 , C07K14/445 , C07K16/12 , C12N1/21 , A61K39/015 , A61K39/40 , G01N33/53 , G01N33/68
CPC分类号： C07K14/445 , C07K16/205
摘要： La présente invention est relative à de nouveaux antigènes impliqués dans le paludisme gestationnel et plus particulièrement à des séquences polynucléotidiques et polypeptidiques, des conjugués, des vecteurs de clonages comportant lesdites séquences en vue de la réalisation de compositions immunogènes et vaccins, d'anticorps et à leurs utilisation pour le traitement du paludisme gestationnel. L' invention vise également des méthodes et des kits de diagnostic.
摘要翻译：本发明涉及涉及妊娠疟疾的新抗原，更具体地涉及多核苷酸和多肽序列，缀合物，包括用于制备免疫原性组合物和疫苗，抗体的所述序列的克隆载体及其用于治疗妊娠疟疾的用途。本发明还涉及诊断方法和试剂盒。

4. 发明申请

WO2005063804A1 COMPOUNDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF MALARIA 审中-公开
标题翻译：化合物在疟疾的诊断和治疗中有用
公开(公告)号：WO2005063804A1
公开(公告)日：2005-07-14
申请号：PCT/DK2004/000922
申请日：2004-12-28
申请人： KØBENHAVNS UNIVERSITET PANUM , JENSEN, Anja, T., R. , HVIID, Lars , JØRGENSEN, Louise , LAVSTEN, Thomas , MAGISTRADO, Pamela , NIELSEN, Morten, A. , SALANTI, Ali , STAALSØ, Trine , THEANDER, Thor, G.
发明人： JENSEN, Anja, T., R. , HVIID, Lars , JØRGENSEN, Louise , LAVSTEN, Thomas , MAGISTRADO, Pamela , NIELSEN, Morten, A. , SALANTI, Ali , STAALSØ, Trine , THEANDER, Thor, G.
IPC分类号： C07K14/445
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： The present invention relates to nucleic acid molecules related to the PFD1235w/MAL7P1.1, PF11_0008 , and PF13_0003 gene familles as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to endotheilial cells, which is characteristic for the pathogenesis of severe malaria (SM). Accordingly, the invention provides pharmaceutical compositions and vaccines hereunder nucleotide-based vaccines comprising compounds that are related to VAR4, VAR5, and/or VAR6 polypeptides and PFD1235w/MAL7P1.1 PF11_0008 , and/or PF13_0003 nucleic acid molecules. The invention further relates to the use of these compounds as medicaments and for the manufacture of compositions, such as immunogenic compositions. In addition, the invention relates to methods of treatment and prevention of sever malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR4, VAR5, and/or VAR6 dependent adhesion to endothelial cells and agent capable of interacting with VAR4, VAR5, and/or VAR6. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.
摘要翻译：本发明涉及与PFD1235w / MAL7P1.1，PF11_0008和PF13_0003基因家族相关的核酸分子，以及由这些核酸分子编码的氨基酸序列相对于介导感染的红细胞粘附到内皮细胞中的作用细胞，这是严重疟疾（SM）发病机制的特征。因此，本发明提供了基于核苷酸的疫苗的药物组合物和疫苗，其包含与VAR4，VAR5和/或VAR6多肽和PFD1235w / MAL7P1.1 PF11_0008和/或PF13_0003核酸分子相关的化合物。本发明还涉及这些化合物作为药物和制备组合物如免疫原性组合物的用途。此外，本发明涉及治疗和预防严重疟疾的方法，其中这些方法基于本发明的核酸分子和多肽。由于这些化合物也可用作生物技术工具，本发明提供了体外诊断方法和试剂盒，其中包括用于此类方法的试剂和IgG /抗体。本发明还涉及鉴定能够调节VAR4，VAR5和/或VAR6对内皮细胞和能够与VAR4，VAR5和/或VAR6相互作用的试剂依赖性粘附的试剂的方法。最后，本发明提供了鉴定多肽的方法，所述多肽在给予受试者时将诱导特异性IgG /抗体应答。

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