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1. 发明申请

WO2005063804A1 COMPOUNDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF MALARIA 审中-公开
标题翻译：化合物在疟疾的诊断和治疗中有用
公开(公告)号：WO2005063804A1
公开(公告)日：2005-07-14
申请号：PCT/DK2004/000922
申请日：2004-12-28
申请人： KØBENHAVNS UNIVERSITET PANUM , JENSEN, Anja, T., R. , HVIID, Lars , JØRGENSEN, Louise , LAVSTEN, Thomas , MAGISTRADO, Pamela , NIELSEN, Morten, A. , SALANTI, Ali , STAALSØ, Trine , THEANDER, Thor, G.
发明人： JENSEN, Anja, T., R. , HVIID, Lars , JØRGENSEN, Louise , LAVSTEN, Thomas , MAGISTRADO, Pamela , NIELSEN, Morten, A. , SALANTI, Ali , STAALSØ, Trine , THEANDER, Thor, G.
IPC分类号： C07K14/445
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： The present invention relates to nucleic acid molecules related to the PFD1235w/MAL7P1.1, PF11_0008 , and PF13_0003 gene familles as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to endotheilial cells, which is characteristic for the pathogenesis of severe malaria (SM). Accordingly, the invention provides pharmaceutical compositions and vaccines hereunder nucleotide-based vaccines comprising compounds that are related to VAR4, VAR5, and/or VAR6 polypeptides and PFD1235w/MAL7P1.1 PF11_0008 , and/or PF13_0003 nucleic acid molecules. The invention further relates to the use of these compounds as medicaments and for the manufacture of compositions, such as immunogenic compositions. In addition, the invention relates to methods of treatment and prevention of sever malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR4, VAR5, and/or VAR6 dependent adhesion to endothelial cells and agent capable of interacting with VAR4, VAR5, and/or VAR6. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.
摘要翻译：本发明涉及与PFD1235w / MAL7P1.1，PF11_0008和PF13_0003基因家族相关的核酸分子，以及由这些核酸分子编码的氨基酸序列相对于介导感染的红细胞粘附到内皮细胞中的作用细胞，这是严重疟疾（SM）发病机制的特征。因此，本发明提供了基于核苷酸的疫苗的药物组合物和疫苗，其包含与VAR4，VAR5和/或VAR6多肽和PFD1235w / MAL7P1.1 PF11_0008和/或PF13_0003核酸分子相关的化合物。本发明还涉及这些化合物作为药物和制备组合物如免疫原性组合物的用途。此外，本发明涉及治疗和预防严重疟疾的方法，其中这些方法基于本发明的核酸分子和多肽。由于这些化合物也可用作生物技术工具，本发明提供了体外诊断方法和试剂盒，其中包括用于此类方法的试剂和IgG /抗体。本发明还涉及鉴定能够调节VAR4，VAR5和/或VAR6对内皮细胞和能够与VAR4，VAR5和/或VAR6相互作用的试剂依赖性粘附的试剂的方法。最后，本发明提供了鉴定多肽的方法，所述多肽在给予受试者时将诱导特异性IgG /抗体应答。

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