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1. 发明申请

WO2005028358A3 LIQUID DELIVERY AND FLOW MEASUREMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2005028358A3
公开(公告)日：2005-03-31
申请号：PCT/US2004/030100
申请日：2004-09-15
申请人： THERAFUSE, INC. , SAGE, Burton, H., Jr. , GILLETT, David , CATANZARO, Brian
发明人： SAGE, Burton, H., Jr. , GILLETT, David , CATANZARO, Brian
IPC分类号： A61M31/00
摘要： A device and method for accurate delivery of a liquid is described. The device comprises a flow channel through which the liquid flows. During manufacture or at some other point prior to the delivery of the liquid, the flow channel is characterized in terms of one or more properties of flow of a liquid through the channel. This characterization is stored in such a way that the flow channel charaterization is available to the liquid delivery device at time of use. At time of use, the liquid delivery system reads the stored flow channel characterization and uses the stored flow channel characterization for safe and accurate delivery of the liquid. Moreover, systems and methods for measuring the flow of a fluid along a passageway are disclosed. A heat source applies thermal energy to a portion of the fluid thereby elevating its temperature and decreasing its density. An optical sensing means

2. 发明申请

WO2003097120A3 LIQUID METERING SYSTEM 审中-公开
公开(公告)号：WO2003097120A3
公开(公告)日：2003-11-27
申请号：PCT/US2002/038822
申请日：2002-12-04
申请人： THERAFUSE, INC. , SAGE, Burton, H., JR. , CATANZARO, Brian, E.
发明人： SAGE, Burton, H., JR. , CATANZARO, Brian, E.
IPC分类号： A61M5/00
摘要： A compensating drug delivery system is described. A drug-containing reservoir (10) is connected to a needle array (45) through a flow tube (11). Delivery through this flow tube is regulated by a metering means, a valving means (14) and a microprocessor (17), and inaccuracies in delivery rate are compensated. Additionally, systems and methods for measuring the flow of a liquid along a conduit a heat source (13) and an optical sensing means (16). An optical sensing means comprising a light source (36) illuminating the liquid in the conduit downstream from the heat source and an optical detector (38) sensing the change in an optical property in the portion of liquid that is heated by the heat source. The liquid velocity is calculated by the time required for the heated portion to move from the thermal application point to the optical sensing point and the distance between the two points.

3. 发明申请

WO1997011744A1 LOW-COST ELECTRODES FOR AN IONTOPHORETIC DEVICE 审中-公开
标题翻译：用于静电装置的低成本电极
公开(公告)号：WO1997011744A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015862
申请日：1996-09-27
申请人： BECTON DICKINSON AND COMPANY , REDDY, Vilambi, Nrk , SAGE, Burton, H. , DENUZZIO, John, D. , BOCK, Carl, R. , HAYNES, John, L.
发明人： BECTON DICKINSON AND COMPANY
IPC分类号： A61N01/30
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448
摘要： The present invention claims an apparatus for transdermal delivery of medicaments, with novel electrode systems, which avoids burns caused by changes in pH or excessive current applied at the sight of delivery, which is low in cost and easy to manufacture. In the present invention, preferably, the anode of the electrode system is predominantly formed from a low-cost bulk base metal which includes a coating of a precious metal thereon. The cathode of the electrode system is preferably formed from a chemically inert material which is a poor electron conductor and is coated on a good electron conductive material which has poor chemical stability. The electrode system of the present invention is highly efficient, easy to manufacture and cost-effective.
摘要翻译：本发明要求一种用于药物透皮递送的装置，具有新颖的电极系统，其避免了在成本和成本容易制造的情况下施加的pH或pH过大引起的灼伤。在本发明中，优选地，电极系统的阳极主要由低成本的贱金属形成，其中包括贵金属的涂层。电极系统的阴极优选由化学惰性材料形成，该材料是不良的电子导体，并且涂覆在具有差的化学稳定性的良好的电子传导材料上。本发明的电极系统是高效率，易于制造和成本有效的。

4. 发明申请

WO03097120B1 LIQUID METERING SYSTEM 审中-公开
标题翻译：液体计量系统
公开(公告)号：WO03097120B1
公开(公告)日：2004-06-10
申请号：PCT/US0238822
申请日：2002-12-04
申请人： THERAFUSE INC , SAGE BURTON H JR , CATANZARO BRIAN E
发明人： SAGE BURTON H JR , CATANZARO BRIAN E
IPC分类号： G01F1/704 , G01F1/708 , A61M5/00
CPC分类号： G01F1/7086 , A61M5/1452 , A61M5/16886 , A61M2005/16863 , A61M2205/3306 , A61M2205/3368 , G01F1/7044 , G01F1/7084
摘要： A compensating drug delivery system is described. A drug-containing reservoir (10) is connected to a needle array (45) through a flow tube (11). Delivery through this flow tube is regulated by a metering means, a valving means (14) and a microprocessor (17), and inaccuracies in delivery rate are compensated. Additionally, systems and methods for measuring the flow of a liquid along a conduit a heat source (13) and an optical sensing means (16). An optical sensing means comprising a light source (36) illuminating the liquid in the conduit downstream from the heat source and an optical detector (38) sensing the change in an optical property in the portion of liquid that is heated by the heat source. The liquid velocity is calculated by the time required for the heated portion to move from the thermal application point to the optical sensing point and the distance between the two points.
摘要翻译：描述补偿药物输送系统。药物储存器（10）通过流管（11）连接到针阵列（45）。通过该流量管的输送通过计量装置，阀门装置（14）和微处理器（17）来调节，并且补偿了输送速率的不准确性。另外，用于测量沿着热源（13）和光学传感装置（16）的导管的液体流量的系统和方法。一种光学传感装置，包括照射位于热源下游的导管中的液体的光源（36）和检测被热源加热的液体部分中的光学性质变化的光学检测器（38）。液体速度通过加热部分从热施加点移动到光学感测点所需的时间和两点之间的距离来计算。

5. 发明申请

WO2003097120A2 LIQUID METERING SYSTEM 审中-公开
标题翻译：液体计量系统
公开(公告)号：WO2003097120A2
公开(公告)日：2003-11-27
申请号：PCT/US2002/038822
申请日：2002-12-04
申请人： SAGE, Burton, H., JR. , CATANZARO, Brian, E.
发明人： SAGE, Burton, H., JR. , CATANZARO, Brian, E.
IPC分类号： A61M
CPC分类号： G01F1/7086 , A61M5/1452 , A61M5/16886 , A61M2005/16863 , A61M2205/3306 , A61M2205/3368 , G01F1/7044 , G01F1/7084
摘要： A compensating drug delivery system for delivery of medicaments to animals is described. A drug-containing reservoir is connected to a needle array through a flow tube. Medicament delivery to the animal through this flow tube is regulated by the combined action of a metering means and a valving means, and inaccuracies in delivery rate are compensated. The metering means and the valving means are microprocessor controlled to insure that the medication administered is according to a pre-established protocol. Additionally, systems and methods for measuring the flow of a liquid along a conduit are disclosed. A heat source applies thermal energy to a portion of a liquid flowing along a conduit thereby elevating its temperature. An optical sensing means comprising a light source illuminating the liquid in the conduit downstream from the position of application of the thermal energy and an optical detector receiving a portion of this illumination senses the heated portion of liquid by measures a change in an optical property of the illumination caused by a change in the index of refraction of the heated portion of liquid. The time required for the heated portion of the liquid to move from the point of application of thermal energy to the point of optical sensing is measured. This measured time, along with the distance of separation of the heat source and the optical sensing means permits calculation of the velocity of the liquid in the conduit.
摘要翻译：描述了用于将药物递送给动物的补偿药物递送系统。药物储存器通过流管连接到针阵列。通过该流管向药物输送到动物通过计量装置和阀装置的组合作用来调节，并补偿输送速率的不准确性。计量装置和阀装置被微处理器控制，以确保所施用的药物是根据预先建立的方案。另外，公开了用于测量沿管道的液体流动的系统和方法。热源将热能施加到沿着导管流动的液体的一部分，从而升高其温度。一种光学感测装置，包括一个光源，该光源照亮来自施加热能的位置的导管中的液体，并且接收该部分照明的光学检测器通过测量液体的光学特性的变化来感测加热的液体部分由加热部分的液体的折射率的变化引起的照明。测量加热部分的液体从热能施加点移动到光学感测点所需的时间。该测量时间以及热源和光学感测装置的分离距离允许计算导管中液体的速度。

6. 发明申请

WO03097120A9 LIQUID METERING SYSTEM 审中-公开
标题翻译：液体计量系统
公开(公告)号：WO03097120A9
公开(公告)日：2004-02-19
申请号：PCT/US0238822
申请日：2002-12-04
申请人： THERAFUSE INC , SAGE BURTON H JR , CATANZARO BRIAN E
发明人： SAGE BURTON H JR , CATANZARO BRIAN E
IPC分类号： G01F1/704 , G01F1/708 , A61M
CPC分类号： G01F1/7086 , A61M5/1452 , A61M5/16886 , A61M2005/16863 , A61M2205/3306 , A61M2205/3368 , G01F1/7044 , G01F1/7084
摘要： A compensating drug delivery system for delivery of medicaments to animals is described. A drug-containing reservoir is connected to a needle array through a flow tube. Medicament delivery to the animal through this flow tube is regulated by the combined action of a metering means and a valving means, and inaccuracies in delivery rate are compensated. The metering means and the valving means are microprocessor controlled to insure that the medication administered is according to a pre-established protocol. Additionally, systems and methods for measuring the flow of a liquid along a conduit are disclosed. A heat source applies thermal energy to a portion of a liquid flowing along a conduit thereby elevating its temperature. An optical sensing means comprising a light source illuminating the liquid in the conduit downstream from the position of application of the thermal energy and an optical detector receiving a portion of this illumination senses the heated portion of liquid by measures a change in an optical property of the illumination caused by a change in the index of refraction of the heated portion of liquid. The time required for the heated portion of the liquid to move from the point of application of thermal energy to the point of optical sensing is measured. This measured time, along with the distance of separation of the heat source and the optical sensing means permits calculation of the velocity of the liquid in the conduit.
摘要翻译：描述了用于将药物递送给动物的补偿药物递送系统。药物储存器通过流管连接到针阵列。通过该流管向药物输送到动物通过计量装置和阀装置的组合作用来调节，并补偿输送速率的不准确性。计量装置和阀装置被微处理器控制，以确保所施用的药物是根据预先建立的方案。另外，公开了用于测量沿管道的液体流动的系统和方法。热源将热能施加到沿着导管流动的液体的一部分，从而升高其温度。一种光学感测装置，包括一个光源，该光源照亮来自施加热能的位置的导管中的液体，并且接收该部分照明的光学检测器通过测量液体的光学特性的变化来感测加热的液体部分由加热部分的液体的折射率的变化引起的照明。测量加热部分的液体从热能施加点移动到光学感测点所需的时间。该测量时间以及热源和光学感测装置的分离距离允许计算导管中液体的速度。

7. 发明申请

WO1997048443A1 IONTOPHORETIC DELIVERY OF CELL ADHESION INHIBITORS 审中-公开
标题翻译：静电递送细胞粘附抑制剂
公开(公告)号：WO1997048443A1
公开(公告)日：1997-12-24
申请号：PCT/US1997010650
申请日：1997-06-18
申请人： BECTON DICKINSON AND COMPANY , SAGE, Burton, H., Jr. , BOCK, Carl, Randolph , GREEN, Philip, G.
发明人： BECTON DICKINSON AND COMPANY
IPC分类号： A61N01/30
CPC分类号： A61K31/4545 , A61K9/0009 , A61K31/42 , A61K31/4439
摘要： This invention relates to novel methods and devices for iontophoretically administering therapeutic doses of cell adhesion receptor antagonists in a controlled manner through the skin. Such antagonist compounds include but are not limited to antagonists of the IIb/IIIa integrins and related cell surface adhesive protein receptors. The present invention includes iontophoretic delivery devices (50) comprising cell adhesion receptor antagonists. Such methods and devices are useful, alone or in combination with other therapeutic agents, for the treatment of thromboembolic disorders, angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, restenosis, macular degeneration and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
摘要翻译：本发明涉及以受控方式通过皮肤离子电渗治疗施用治疗剂量的细胞粘附受体拮抗剂的新方法和装置。这种拮抗剂化合物包括但不限于IIb / IIIa整联蛋白和相关细胞表面粘附蛋白受体的拮抗剂。本发明包括包含细胞粘附受体拮抗剂的离子电渗疗法输送装置（50）。这样的方法和装置可单独使用或与其它治疗剂组合用于治疗血栓栓塞障碍，血管生成障碍，炎症，骨退化，癌转移，糖尿病性视网膜病变，再狭窄，黄斑变性以及由细胞粘附和/ 或细胞迁移和/或血管发生。

8. 发明申请

WO2017196504A1 SPRING-DRIVEN DRUG DELIVERY DEVICE 审中-公开
标题翻译：弹簧驱动的药物递送装置
公开(公告)号：WO2017196504A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/028208
申请日：2017-04-18
申请人： SAGE, Burton, H., Jr. , STETSKO, Gina, G.
发明人： SAGE, Burton, H., Jr. , STETSKO, Gina, G.
IPC分类号： A61M5/152
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14593 , A61M5/158 , A61M5/16804 , A61M5/5086 , A61M2005/14252 , A61M2005/14506 , A61M2005/1583 , A61M2005/1585 , A61M2205/3334 , A61M2205/583 , A61M2205/584
摘要： A drug delivery device or patch-like delivery device which employs a spring force and an inclined surface to apply pressure on a fluid reservoir, thereby delivering medicament to a user's body. The slope of the inclined surface may be engineered to control the drug delivery rate. The device may be low profile and wearable, for example in the form of a patch. A visual indicator of the amount of medicament delivered or remaining may be incorporated, for example via a transparent window that shows the progression of an inclined surface as it presses on the reservoir. The device may incorporate mechanisms for automatic extension and retraction of a cannula at the beginning and end of drug delivery. Drug delivery rate may be limited with flow restrictors, and by using a two-reservoir system with a viscous liquid displacing a reservoir containing the medicament.
摘要翻译：药物输送装置或贴片状输送装置，其采用弹簧力和倾斜表面对流体储存器施加压力，由此将药物输送至使用者的身体。可以设计倾斜表面的斜率以控制药物输送速率。该装置可以是薄型和可穿戴的，例如以贴片的形式。可以例如通过透明窗口结合输送或保留的药物量的可视指示器，该透明窗口显示倾斜表面在按压在储存器上时的进展。该装置可以包含用于在药物输送的开始和结束时自动延伸和缩回套管的机构。药物输送速率可能受限流器限制，并且通过使用具有粘性液体的双储液器系统替代含有药物的储液器。

9. 发明申请

WO2011008581A3 DEVICES, METHODS, AND KITS FOR DETERMINING ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定分析物浓度的装置，方法和试剂盒
公开(公告)号：WO2011008581A3
公开(公告)日：2011-04-21
申请号：PCT/US2010040845
申请日：2010-07-01
申请人： FREELANCE CORP , FINKELSHTEIN IRINA V , MOYER JAMES W , POTTS RUSSEL O , SAGE BURTON H , SHARTLE ROBERT J , WILSON DONALD R , WONG BRUCE D
发明人： FINKELSHTEIN IRINA V , MOYER JAMES W , POTTS RUSSEL O , SAGE BURTON H , SHARTLE ROBERT J , WILSON DONALD R , WONG BRUCE D
IPC分类号： G01N33/48 , G01N21/25 , G01N21/78 , G01N33/487 , G01N33/52
CPC分类号： C12Q1/006 , A61B5/14517 , A61B5/14532 , A61B5/1455 , A61B10/0064 , G01N21/78 , G01N21/8483 , G01N33/52 , G01N2021/7786
摘要： Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat.
摘要翻译：描述了用于测量或以其他方式评估体液中一种或多种分析物的浓度的装置，方法和试剂盒。装置，方法和/或试剂盒可以是非侵入性的。在一些变型中，用于测量受试者的汗液中的分析物浓度的方法可以包括使比色膜与受试者的皮肤表面接触，使得膜从皮肤表面收集一定体积的汗液，并且分析比色膜以确定收集的汗液体积中分析物的浓度。

10. 发明申请

WO2011008581A2 DEVICES, METHODS, AND KITS FOR DETERMINING ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定分析浓度的装置，方法和试剂盒
公开(公告)号：WO2011008581A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/040845
申请日：2010-07-01
申请人： FREELANCE CORPORATION , FINKELSHTEIN, Irina, V. , MOYER, James, W. , POTTS, Russel, O. , SAGE, Burton, H. , SHARTLE, Robert, J. , WILSON, Donald, R. , WONG, Bruce, D.
发明人： FINKELSHTEIN, Irina, V. , MOYER, James, W. , POTTS, Russel, O. , SAGE, Burton, H. , SHARTLE, Robert, J. , WILSON, Donald, R. , WONG, Bruce, D.
IPC分类号： G01N33/48 , G01N33/487 , G01N21/25 , G01N21/78 , G01N33/52
CPC分类号： C12Q1/006 , A61B5/14517 , A61B5/14532 , A61B5/1455 , A61B10/0064 , G01N21/78 , G01N21/8483 , G01N33/52 , G01N2021/7786
摘要： Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat.
摘要翻译：描述了用于测量或以其它方式评价体液中的一种或多种分析物的浓度的装置，方法和试剂盒。装置，方法和/或试剂盒可以是非侵入性的。在一些变型中，用于测量受试者汗液中分析物浓度的方法可以包括使比色膜与受试者的皮肤表面接触，使得膜从皮肤表面收集体积的汗液，并分析比色膜以确定所收集体积的汗液中分析物的浓度。

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