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    • 9. 发明授权
    • Method of skin care using a skin care preparation containing a betaine
ester and an .alpha.-hydroxy acid
    • 使用含有甜菜碱酯和α-羟基酸的护肤品的护肤方法
    • US5961999A
    • 1999-10-05
    • US123264
    • 1998-07-28
    • Rudolf BimczokGuenther Lang
    • Rudolf BimczokGuenther Lang
    • A61K7/00
    • Y10S514/828Y10S514/844Y10S514/846Y10S514/847
    • The method of skin care includes applying a skin care preparation to the skin of an individual in an amount sufficient to moisturize the skin or to cause a reduction of skin wrinkling and a smoothing of the skin. The skin care preparation has a pH value of 1 to 7 and contains from 0.1 to 20 percent by weight of at least one betaine ester of formula (I)R.sub.1 --O--CO--CH.sub.2 --N.sup.+ (CH.sub.3).sub.3 A.sup.-(I),wherein R.sub.1 is a branched or straight chain alkyl group having from 10 to 30 carbon atoms and A- is a cosmetically acceptable anion; andfrom 0.05 to 20 percent by weight of at least one .alpha.-hydroxy acid present as a free acid, or in a lactone form thereof, or as a skin-compatible salt thereof with an organic base or an inorganic alkali, and/or as stereoisomers thereof, as D, L, and/or DL form. The at least one .alpha.-hydroxy acid is selected from the group consisting of alkyl .alpha.-hydroxy acids, aralkyl .alpha.-hydroxy acids, aryl .alpha.-hydroxy acids, polyhydroxy .alpha.-hydroxy acids and polycarboxylic .alpha.-hydroxy acids represented by the following chemical structure: ##STR1## wherein Ra and Rb represent, independently of each other, H, F, Cl, Br, an aryl group, an aralkyl group made from an aryl group and an alkyl radical having 1 to 25 carbon atoms, a saturated or unsaturated, straight or branched chain alkyl group having 1 to 25 carbon atoms, a cyclic group having 5 or 6 members including carbon atoms, with the proviso that Ra and Rb are not the same, and the aryl, arylalkyl and alkyl groups may have at least one substituent selected from the group consisting of OH, CHO, COOH and alkoxy groups having from 1 to 9 carbon atoms.
    • 皮肤护理方法包括将皮肤护理制剂以足以滋润皮肤或减少皮肤皱纹和使皮肤光滑的方式对个体皮肤施用。 皮肤护理制剂的pH值为1〜7,含有0.1〜20重量%的式(I)R1-O-CO-CH2-N +(CH3)3A-(Ⅰ)的至少一种甜菜碱酯, 其中R1是具有10-30个碳原子的支链或直链烷基,A-是化妆品可接受的阴离子; 和0.05至20重量%的至少一种作为游离酸存在的α-羟基酸,或以其内酯形式存在,或作为其与有机碱或无机碱的皮肤相容的盐,和/或 其立体异构体,如D,L和/或DL形式。 所述至少一种α-羟基酸选自由以下化学结构表示的α-烷基α-羟基酸,芳烷基α-羟基酸,芳基α-羟基酸,多羟基α-羟基酸和多元羧酸α-羟基酸 其中R a和R b彼此独立地表示H,F,Cl,Br,芳基,由芳基和具有1至25个碳原子的烷基构成的芳烷基,饱和或不饱和的直链或 具有1至25个碳原子的支链烷基,具有5或6个碳原子的环状基团,条件是Ra和Rb不相同,芳基,芳基烷基和烷基可以具有至少一个取代基 由OH,CHO,COOH和具有1至9个碳原子的烷氧基组成的组。