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1. 发明授权

US10494626B2 Dynamic mixing and electroporation chamber and system 有权
公开(公告)号：US10494626B2
公开(公告)日：2019-12-03
申请号：US13261509
申请日：2011-05-11
申请人： Alan D King , Stephen B Deitz , Donald J Rodis, Jr. , Derin C Walters , Robert J Walters
发明人： Alan D King , Richard E Walters , Stephen B Deitz , Donald J Rodis, Jr. , Derin C Walters
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12N13/00 , C12M35/02
摘要： An electroporation apparatus and its novel chamber with inlet ports for mixing cells and exogenous material. The inlet ports are oriented in nonparallel to each other immediately adjacent at the same top corner of the first wall of the chamber. The mixing chamber comprises successive wall sections, two curved walls at its bottom; the first curved corner is on the same side of the chamber where the liquids enter the chamber, and directs the liquids to the second curved corner at the opposing side of the chamber which in turn further redirects the mixing to the first curved corner. The direction of the liquid flow mixture change direction at least twice into the mixing chamber.

2. 发明授权

US09285248B2 Microelectronic displacement damage dose detector 有权
标题翻译：微电子位移损伤剂量检测器
公开(公告)号：US09285248B2
公开(公告)日：2016-03-15
申请号：US14205187
申请日：2014-03-11
申请人： Scott R. Messenger , Cory D. Cress , Michael K. Yakes , Jeffrey H. Warner , Robert J. Walters
发明人： Scott R. Messenger , Cory D. Cress , Michael K. Yakes , Jeffrey H. Warner , Robert J. Walters
IPC分类号： G01T1/02 , G01D9/00
CPC分类号： G01D9/005 , G01T1/026
摘要： A device is described that includes sensors that are sensitive to displacement damage, and can be configured to display a characteristic damage curve. The sensors, or diodes, can be made of one or more semiconductor materials that are sensitive to displacement damage, and can be operated in dark illumination conditions. The sensors can have multiple shields of a specific or varied thickness. The shields can be formed in different configurations, though the shielding thickness can be designed to change the level of displacement damage absorbed by the sensors. The characteristic damage curve can provide a sensor response variable that displays a functional dependence on displacement damage. For example, the characteristic damage curve can provide a sensor response variable that is one or more currents measured at one or more fixed voltages, or one or more voltages measured at one or more fixed currents.
摘要翻译：描述了包括对位移损伤敏感的传感器的装置，并且可以被配置为显示特征损伤曲线。传感器或二极管可以由对位移损伤敏感的一种或多种半导体材料制成，并且可以在暗照明条件下操作。传感器可以具有特定或变化厚度的多个屏蔽。屏蔽可以以不同的结构形成，尽管屏蔽厚度可被设计成改变由传感器吸收的位移损伤的水平。特征损伤曲线可以提供传感器响应变量，显示对位移损伤的功能依赖。例如，特征损伤曲线可以提供传感器响应变量，其是在一个或多个固定电压或在一个或多个固定电流下测量的一个或多个电压测量的一个或多个电流。

3. 发明授权

US08979818B2 Method and apparatus for the delivery of polynucleotide vaccines to mammalian skin 有权
标题翻译：用于将哺乳动物皮肤递送多核苷酸疫苗的方法和装置
公开(公告)号：US08979818B2
公开(公告)日：2015-03-17
申请号：US13065135
申请日：2011-03-15
申请人： Derin C. Walters , Alan D. King , Anna-Karin Roos , Robert J. Walters
发明人： Richard E. Walters , Derin C. Walters , Alan D. King , Anna-Karin Roos
IPC分类号： A61N1/30 , A61M31/00 , A61M35/00 , A61N1/32 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61N1/327 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/70 , A61N1/306 , C07K14/005 , C12N2770/24122 , C12N2770/24134
摘要： An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation. The sequence of at least three waveforms has one, two, or three of the following characteristics (1) at least two of the at least three waveforms differ from each other in waveform amplitude, (2) at least two of the at least three waveforms differ from each other in waveform width, and (3) a first waveform interval for a first set of two of the at least three waveforms is different from a second waveform interval for a second set of two of the at least three waveforms.
摘要翻译：本发明的目的是提供一种用于将多核苷酸疫苗递送到哺乳动物皮肤细胞中以增加T细胞应答并减少由于长电波形应用引起的疼痛和不适以及由于肌肉收缩引起的疼痛和不适的方法和装置。用于将多核苷酸疫苗递送到哺乳动物皮肤细胞中的方法包括以下步骤：（a）在给药部位将多核苷酸疫苗施用于皮肤，（b）将针电极施用于给药的附近的皮肤站点，以及（c）应用脉冲间隔小于100毫秒的至少三个单个，操作者控制的，独立编程的窄间隔电波形序列，以通过电穿孔将多核苷酸疫苗递送到皮肤细胞中。至少三个波形的序列具有以下特征（1）中的一个，两个或三个，所述至少三个波形中的至少两个波形在波形幅度上彼此不同，（2）至少三个波形中的至少两个波形在波形宽度上彼此不同，以及（3）至少三个波形中的两个的第一组的第一波形间隔与用于至少三个波形中的两个的第二组的第二波形间隔不同。

4. 发明授权

US08878161B2 Tunnel diodes incorporating strain-balanced, quantum-confined heterostructures 有权
标题翻译：掺杂应变平衡的量子限制异质结构的隧道二极管
公开(公告)号：US08878161B2
公开(公告)日：2014-11-04
申请号：US14198735
申请日：2014-03-06
申请人： Matthew Lumb , Michael K. Yakes , María González , Christopher Bailey , Robert J. Walters
发明人： Matthew Lumb , Michael K. Yakes , María González , Christopher Bailey , Robert J. Walters
IPC分类号： H01L29/06 , H01L29/15
CPC分类号： H01L29/122 , H01L29/155 , H01L29/205 , H01L29/882 , H01L29/885
摘要： A strain-balanced quantum well tunnel junction (SB-QWTJ) device. QW structures are formed from alternating quantum well and barrier layers situated between n++ and p++ layers in a tunnel junction formed on a substrate. The quantum well layers exhibit a compressive strain with respect to the substrate, while the barrier layers exhibit a tensile strain. The composition and layer thicknesses of the quantum well and barrier layers are configured so that the compressive and tensile strains in the structure are balanced.
摘要翻译：应变平衡量子阱隧道结（SB-QWTJ）装置。 QW结构由位于衬底上形成的隧道结中的n ++和p ++层之间的交替量子阱和阻挡层形成。量子阱层相对于衬底表现出压缩应变，而阻挡层表现出拉伸应变。量子阱和阻挡层的组成和层厚度被构造成使得结构中的压缩和拉伸应变平衡。

5. 发明申请

US20140252312A1 Tunnel Diodes Incorporating Strain-Balanced, Quantum-Confined Heterostructures 有权
标题翻译：隧道二极管并入应变平衡，量子密闭异质结构
公开(公告)号：US20140252312A1
公开(公告)日：2014-09-11
申请号：US14198735
申请日：2014-03-06
申请人： Matthew Lumb , Michael K. Yakes , Marla González , Christopher Bailey , Robert J. Walters
发明人： Matthew Lumb , Michael K. Yakes , Marla González , Christopher Bailey , Robert J. Walters
IPC分类号： H01L29/15
CPC分类号： H01L29/122 , H01L29/155 , H01L29/205 , H01L29/882 , H01L29/885
摘要： A strain-balanced quantum well tunnel junction (SB-QWTJ) device. QW structures are formed from alternating quantum well and barrier layers situated between n++ and p++ layers in a tunnel junction formed on a substrate. The quantum well layers exhibit a compressive strain with respect to the substrate, while the barrier layers exhibit a tensile strain. The composition and layer thicknesses of the quantum well and barrier layers are configured so that the compressive and tensile strains in the structure are balanced.
摘要翻译：应变平衡量子阱隧道结（SB-QWTJ）装置。 QW结构由位于衬底上形成的隧道结中的n ++和p ++层之间的交替量子阱和阻挡层形成。量子阱层相对于衬底表现出压缩应变，而阻挡层表现出拉伸应变。量子阱和阻挡层的组成和层厚度被构造成使得结构中的压缩和拉伸应变平衡。

6. 发明授权

US07301172B2 Sequentially charged nanocrystal light emitting device 有权
标题翻译：顺序充电的纳米晶体发光器件
公开(公告)号：US07301172B2
公开(公告)日：2007-11-27
申请号：US11100807
申请日：2005-04-06
申请人： Harry A. Atwater , Robert J. Walters
发明人： Harry A. Atwater , Robert J. Walters
IPC分类号： H01L27/15
CPC分类号： H01L33/16 , B82Y20/00 , H01L33/0004 , H01L33/0041 , H01L33/08 , Y10S977/95
摘要： A light emitting device including a transistor structure formed on a semiconductor substrate. The transistor structure having a source region, a drain region, a channel region between the source and drain regions, and a gate oxide on the channel region. The light emitting device including a plurality of nanocrystals embedded in the gate oxide, and a gate contact made of semitransparent or transparent material formed on the gate oxide. The nanocrystals are adapted to be first charged with first type charge carriers, and then provided second type charge carriers, such that the first and second type charge carriers form excitons used to emit light.
摘要翻译：一种发光器件，包括形成在半导体衬底上的晶体管结构。晶体管结构具有源极区，漏极区，源区和漏区之间的沟道区以及沟道区上的栅极氧化物。该发光器件包括嵌入栅极氧化物中的多个纳米晶体，以及由栅极氧化物上形成的半透明或透明材料制成的栅极接触。纳米晶体适于首先带有第一类型的电荷载体，然后提供第二类型的载流子，使得第一和第二类型的载流子形成用于发光的激子。

7. 发明申请

US20150325720A1 Multijunction Solar Cells Lattice Matched to InP Using Sb-Containing Alloys 审中-公开
标题翻译：使用含Sb的合金匹配InP的多结太阳能电池晶格
公开(公告)号：US20150325720A1
公开(公告)日：2015-11-12
申请号：US14740348
申请日：2015-06-16
申请人： Robert J. Walters , Phillip Jenkins , Maria Gonzalez , Igor Vurgaftman , Jerry R. Meyer , Joshua Abell , Nicholas Ekins-Daukes , Jessica Adams , Paul Stavrinou , Michael K. Yakes , Joseph G. Tischler , Cory D. Cress , Matthew P. Lumb , Ngai Chan
发明人： Robert J. Walters , Phillip Jenkins , Maria Gonzalez , Igor Vurgaftman , Jerry R. Meyer , Joshua Abell , Nicholas Ekins-Daukes , Jessica Adams , Paul Stavrinou , Michael K. Yakes , Joseph G. Tischler , Cory D. Cress , Matthew P. Lumb , Ngai Chan
IPC分类号： H01L31/0304 , H01L31/036
CPC分类号： H01L31/0304 , B82Y20/00 , H01L31/035236 , H01L31/036 , H01L31/06875 , Y02E10/544
摘要： A multijunction (MJ) solar cell grown on an InP substrate using materials that are lattice-matched to InP. In an exemplary three-junction embodiment, the top cell is formed from In1-xAlxAs1-ySby (with x and y adjusted so as to achieve lattice-matching with InP, hereafter referred to as InAlAsSb), the middle cell from In1-a-bGaaAlbAs (with a and b adjusted so as to achieve lattice-matching with InP, hereafter referred to as InGaAlAs), and the bottom cell also from InGaAlAs, but with a much lower Al composition, which in some embodiments can be zero so that the material is InGaAs. Tunnel junctions (TJs) connect the junctions and allow photo-generated current to flow. In an exemplary embodiment, an InAlAsSb TJ connects the first and second junctions, while an InGaAlAs TJ connects the second and third junctions.
摘要翻译：使用与InP晶格匹配的材料在InP衬底上生长的多结（MJ）太阳能电池。在示例性的三结实施例中，顶部单元由In1-xAlxAs1-ySby（其中x和y被调整以便实现与InP的晶格匹配，以下称为InAlAsSb），In1-a- bGaaAlbAs（其中a和b被调整以便实现与InP的晶格匹配，以下称为InGaAlAs），并且底部单元也是来自InGaAlAs，但具有低得多的Al组成，其在一些实施例中可以为零，材料是InGaAs。隧道结（TJ）连接接头并允许光电流流动。在示例性实施例中，InAlAsSb TJ连接第一和第二结，而InGaAlAs TJ连接第二和第三结。

8. 发明申请

US20150083890A1 ULTRA LOW POWER SOLID STATE SPECTRAL RADIOMETER 有权
标题翻译：超低功率固态光谱仪
公开(公告)号：US20150083890A1
公开(公告)日：2015-03-26
申请号：US14322234
申请日：2014-07-02
申请人： Raymond Hoheisel , David A. Scheiman , Justin R. Lorentzen , Phillip P. Jenkins , Robert J. Walters
发明人： Raymond Hoheisel , David A. Scheiman , Justin R. Lorentzen , Phillip P. Jenkins , Robert J. Walters
IPC分类号： G01J3/32 , G01J5/46 , G01J5/30
CPC分类号： G01J3/32 , G01J3/0264 , G01J3/0291 , G01J3/2803 , G01J3/36 , G01J5/30 , G01J5/46
摘要： A spectral radiometer system, measures incoming light intensity and spectral distribution in different wavelength-bands. An additional data storage device allows recording of the measured data. The inclusive sensor system yields very high sensitivity to incoming light. Furthermore, outstanding linearity of the detector response over several orders of magnitude of incoming light is achieved. Additional benefits are ultra low power consumption and minimum size. The sensor system can be used in remote solar radiation monitoring applications like mobile solar power units as well as in long-term environmental monitoring systems where high precision and low power consumption is a necessity.
摘要翻译：光谱辐射计系统测量不同波段的入射光强度和光谱分布。附加数据存储设备允许记录测量数据。包含的传感器系统对入射光产生非常高的灵敏度。此外，实现了在几个数量级的入射光下的检测器响应的出色的线性度。额外的优点是超低功耗和最小尺寸。传感器系统可用于远程太阳辐射监测应用，如移动太阳能发电机组以及需要高精度和低功耗的长期环境监测系统。

9. 发明申请

US20140312239A1 Microelectronic Displacement Damage Dose Detector 有权
标题翻译：微电子位移损伤剂量检测器
公开(公告)号：US20140312239A1
公开(公告)日：2014-10-23
申请号：US14205187
申请日：2014-03-11
申请人： Scott R. Messenger , Cory D. Cress , Michael K. Yakes , Jeffrey H. Warner , Robert J. Walters
发明人： Scott R. Messenger , Cory D. Cress , Michael K. Yakes , Jeffrey H. Warner , Robert J. Walters
IPC分类号： G01T1/02 , G01D9/00
CPC分类号： G01D9/005 , G01T1/026
摘要： A device is described that includes sensors that are sensitive to displacement damage, and can be configured to display a characteristic damage curve. The sensors, or diodes, can be made of one or more semiconductor materials that are sensitive to displacement damage, and can be operated in dark illumination conditions. The sensors can have multiple shields of a specific or varied thickness. The shields can be formed in different configurations, though the shielding thickness can be designed to change the level of displacement damage absorbed by the sensors. The characteristic damage curve can provide a sensor response variable that displays a functional dependence on displacement damage. For example, the characteristic damage curve can provide a sensor response variable that is one or more currents measured at one or more fixed voltages, or one or more voltages measured at one or more fixed currents.
摘要翻译：描述了包括对位移损伤敏感的传感器的装置，并且可以被配置为显示特征损伤曲线。传感器或二极管可以由对位移损伤敏感的一种或多种半导体材料制成，并且可以在暗照明条件下操作。传感器可以具有特定或变化厚度的多个屏蔽。屏蔽可以以不同的结构形成，尽管屏蔽厚度可被设计成改变由传感器吸收的位移损伤的水平。特征损伤曲线可以提供传感器响应变量，显示对位移损伤的功能依赖。例如，特征损伤曲线可以提供传感器响应变量，其是在一个或多个固定电压或在一个或多个固定电流下测量的一个或多个电压测量的一个或多个电流。

10. 发明申请

US20140220665A1 DYNAMIC MIXING AND ELECTROPORATION CHAMBER AND SYSTEM 审中-公开
标题翻译：动力混合动力室和系统
公开(公告)号：US20140220665A1
公开(公告)日：2014-08-07
申请号：US13261509
申请日：2011-05-11
申请人： Robert J Walters
发明人： Alan D. King , Richard E Walters , Stephen B Deitz , Donald J Rodis, JR. , Derin C Walters
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , C12M35/02
摘要： The present invention relates to an apparatus for mixing cells and exogenous material for delivery of the exogenous material into cells using electroporation in a manner that preserves cell viability and integrity of the exogenous material. The exogenous material can be polynucleotides, peptides, proteins or other pharmaceutical molecules. It further provides a chamber that can be used to electroporate the contents of the chamber after mixing. In accordance with the invention, cell suspensions that may be contaminated with degrading enzymes are stored separately from water-based liquids that contain the exogenous material. Contact of the two water-based liquids (cell suspension and exogenous material) first occurs within the chamber. The chamber of the present invention has two or more inlet ports to allow separate entrance of water-based liquids. Two other ports are vent and exit ports. The inside of the chamber allows flow of all water-based liquids down the same side of the chamber and curved corners for redirecting flow direction and gently mixing water-based liquids. The chamber also includes electrodes as chamber walls for electroporation of chamber contents.
摘要翻译：本发明涉及一种用于混合细胞和外源材料的装置，用于以保持细胞存活力和外源性材料的完整性的方式使用电穿孔将外源材料递送到细胞中。外源物质可以是多核苷酸，肽，蛋白质或其它药物分子。它进一步提供一个室，可以用于混合后电化室的内容物。根据本发明，可能被降解酶污染的细胞悬浮液与含有外源性物质的水基液体分离储存。首先在室内发生两种水性液体（细胞悬浮液和外源性物质）的接触。本发明的腔室具有两个或更多个入口端口，以允许单独进入水基液体。另外两个端口是排气口和出口。腔室内部允许所有水基液体在腔室的同一侧流动，并且弯曲的角部用于重新定向流动方向并轻轻混合水基液体。该室还包括电极作为用于室内容物电穿孔的室壁。

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