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1. 发明申请

US20140066320A1 IDENTIFYING CAUSAL GENETIC MARKERS FOR A SPECIFIED PHENOTYPE 审中-公开
标题翻译：鉴定指定基因的原始基因标记
公开(公告)号：US20140066320A1
公开(公告)日：2014-03-06
申请号：US13603403
申请日：2012-09-04
申请人： David Earl Heckerman , Jennifer Listgarten , Christoph Anthony Lippert , Jing Xiang , Nicolo Fusi , Carl M. Kadie , Robert I. Davidson
发明人： David Earl Heckerman , Jennifer Listgarten , Christoph Anthony Lippert , Jing Xiang , Nicolo Fusi , Carl M. Kadie , Robert I. Davidson
IPC分类号： C40B30/02
CPC分类号： G16B20/00 , G16B40/00
摘要： Described herein are technologies pertaining to computationally-efficiently performing genome-wide association studies. Feature selection methods are used to identify genetic markers for addressing potential confounding in the data. Then, single SNPs, or groups of genetic markers are analyzed to ascertain whether such groups are causal or tagging of causal as to a specified phenotype, after taking in to account the feature-selected SNPs. Group and univariate analysis is accomplished by way of analyzing a group of genetic markers conditioned upon other genetic markers that are found to be predictive of the specified phenotype.
摘要翻译：这里描述的是涉及计算上有效执行全基因组关联研究的技术。特征选择方法用于识别用于解决数据中潜在混淆的遗传标记。然后分析单核苷酸多态性（SNPs）或遗传标记物组，以确定这些群体在考虑特征选择的单核苷酸多态性之后，是否因为特定表型的因果性或标记因素。组和单变量分析是通过分析一组基于其他遗传标记的遗传标记来实现的，这些遗传标记被发现是预测指定的表型。

2. 发明授权

US06292934B1 Method and system for improving the locality of memory references during execution of a computer program 失效
标题翻译：用于在计算机程序执行期间改善存储器引用的位置的方法和系统
公开(公告)号：US06292934B1
公开(公告)日：2001-09-18
申请号：US08846893
申请日：1997-05-01
申请人： Robert I. Davidson , Nathan Myhrvold , Keith Randel Vogel , Gideon Andreas Yuval , Richard Shupak , Norman Eugene Apperson
发明人： Robert I. Davidson , Nathan Myhrvold , Keith Randel Vogel , Gideon Andreas Yuval , Richard Shupak , Norman Eugene Apperson
IPC分类号： G06F945
CPC分类号： G06F8/4442
摘要： The present invention provides a method and system for determining an optimal placement order for basic blocks within a computer program to improve locality of reference and reduce the working set of the computer program. By reducing the working set, the computer program requires less memory than it normally would require to execute on a computer system. The optimal placement order for basic blocks within a computer program reflects the concurrency of usage for basic blocks during execution of the computer program. The method for determining an optimal placement order includes analyzing the computer program to identify all of the basic blocks, determining how many times each basic block is executed, assigning a placement order to each basic block depending upon how many times each basic block was executed, and reordering the basic blocks according to their assigned placement orders to produce an optimized computer program. The method used to identify all of the basic blocks includes disassembling known instruction addresses to identify the beginning and end of basic blocks and processing jump tables to identify more instruction addresses. Processing jump tables includes processing the first entry of every jump table before processing the second entry of any jump table. The present invention further optimizes a computer program by replacing rarely executed instructions with other instructions that require a smaller amount of storage space.
摘要翻译：本发明提供了一种用于确定计算机程序内的基本块的最佳布置顺序以改善参考的位置并减少计算机程序的工作集合的方法和系统。通过减少工作集，计算机程序需要比通常在计算机系统上执行的更少的内存。计算机程序中基本块的最佳布局顺序反映了在执行计算机程序期间基本块的使用的并发性。用于确定最佳放置顺序的方法包括分析计算机程序以识别所有基本块，确定执行每个基本块的次数，根据执行每个基本块的次数为每个基本块分配布局顺序，并根据其分配的布置顺序重新排序基本块，以生成优化的计算机程序。用于识别所有基本块的方法包括拆分已知的指令地址以识别基本块的开始和结束，并处理跳转表以识别更多的指令地址。处理跳转表包括在处理任何跳转表的第二个条目之前处理每个跳转表的第一个条目。本发明通过用少量存储空间的其他指令替换很少执行的指令来进一步优化计算机程序。

3. 发明授权

US5664191A Method and system for improving the locality of memory references during execution of a computer program 失效
标题翻译：用于在计算机程序执行期间改善存储器引用的位置的方法和系统
公开(公告)号：US5664191A
公开(公告)日：1997-09-02
申请号：US268277
申请日：1994-06-30
申请人： Robert I. Davidson , Nathan Myhrvold , Keith Randel Vogel , Gideon Andreas Yuval , Richard Shupak , Norman Eugene Apperson
发明人： Robert I. Davidson , Nathan Myhrvold , Keith Randel Vogel , Gideon Andreas Yuval , Richard Shupak , Norman Eugene Apperson
IPC分类号： G06F9/45 , G06F9/44
CPC分类号： G06F8/4442
摘要： The present invention provides a method and system for determining an optimal placement order for basic blocks within a computer program to improve locality of reference and reduce the working set of the computer program. By reducing the working set, the computer program requires less memory than it normally would require to execute on a computer system. The optimal placement order for basic blocks within a computer program reflects the concurrency of usage for basic blocks during execution of the computer program. The method for determining an optimal placement order includes analyzing the computer program to identify all of the basic blocks, determining how many times each basic block is executed, assigning a placement order to each basic block depending upon how many times each basic block was executed, and reordering the basic blocks according to their assigned placement orders to produce an optimized computer program. The method used to identify all of the basic blocks includes disassembling known instruction addresses to identify the beginning and end of basic blocks and processing jump tables to identify more instruction addresses. Processing jump tables includes processing the first entry of every jump table before processing the second entry of any jump table. The present invention further optimizes a computer program by replacing rarely executed instructions with other instructions that require a smaller amount of storage space.
摘要翻译：本发明提供了一种用于确定计算机程序内的基本块的最佳布置顺序以改善参考的位置并减少计算机程序的工作集合的方法和系统。通过减少工作集，计算机程序需要比通常在计算机系统上执行的更少的内存。计算机程序中基本块的最佳布局顺序反映了在执行计算机程序期间基本块的使用的并发性。用于确定最佳放置顺序的方法包括分析计算机程序以识别所有基本块，确定执行每个基本块的次数，根据执行每个基本块的次数为每个基本块分配布局顺序，并根据其分配的布置顺序重新排序基本块，以生成优化的计算机程序。用于识别所有基本块的方法包括拆分已知的指令地址以识别基本块的开始和结束，并处理跳转表以识别更多的指令地址。处理跳转表包括在处理任何跳转表的第二个条目之前处理每个跳转表的第一个条目。本发明通过用少量存储空间的其他指令替换很少执行的指令来进一步优化计算机程序。

4. 发明授权

US6067412A Automatic bottleneck detection by means of workload reconstruction from performance measurements 失效
标题翻译：通过性能测量的工作负载重建实现自动瓶颈检测
公开(公告)号：US6067412A
公开(公告)日：2000-05-23
申请号：US516176
申请日：1995-08-17
申请人： Russell P. Blake , David O. Hovel , Robert I. Davidson , David E. Heckerman , John S. Breese
发明人： Russell P. Blake , David O. Hovel , Robert I. Davidson , David E. Heckerman , John S. Breese
IPC分类号： G06F11/34 , G06F9/00
CPC分类号： G06F11/3409 , G06F11/3452 , G06F11/3414 , G06F11/3428 , G06F2201/815 , G06F2201/87 , G06F2201/885
摘要： A system and method for determining a workload placed on a target computer system during execution of a specified computer program. The system receives a set of performance measurements representing the performance of the target computer system during execution of the specified computer program. The system then identifies a plurality of workloads and for each identified workload, uses a model of the target computer system to predict a set of performance measurements that would results when a computer program that places the identified workload on the target computer system is executed. The system selects the identified workload whose set of predicted performance measurements most closely matches the received set of performance measurements as the determined workload that was place on the target computer system during execution of the specified computer program. The system uses the selected workload to predict the performance of the specified computer program on the target computer system with various different configurations. The system also determines the resource that is a bottleneck for each of the different configurations.
摘要翻译：一种用于在执行指定的计算机程序期间确定放置在目标计算机系统上的工作负载的系统和方法。系统在执行指定的计算机程序期间接收表示目标计算机系统的性能的一组性能测量。然后，系统识别多个工作负载，并且对于每个所识别的工作负载，使用目标计算机系统的模型来预测当将所识别的工作负载置于目标计算机系统上的计算机程序被执行时将导致的一组性能测量。该系统选择所识别的工作负载，其中一组预测的性能测量与所接收的一组性能测量值最接近地匹配，作为在执行指定的计算机程序期间放置在目标计算机系统上的确定的工作负载。系统使用所选择的工作负载来预测具有各种不同配置的目标计算机系统上指定的计算机程序的性能。该系统还确定作为每个不同配置的瓶颈的资源。

5. 发明授权

US4670579A Telomerization of olefins 失效
标题翻译：烯烃的聚集
公开(公告)号：US4670579A
公开(公告)日：1987-06-02
申请号：US880071
申请日：1986-06-30
申请人： Robert I. Davidson
发明人： Robert I. Davidson
IPC分类号： C07C17/093 , C07C67/347 , C07C17/22 , C07C107/06
CPC分类号： C07C17/093 , C07C67/347
摘要： An olefin, especially an activated olefin, is telomerized by reaction with an arylamine, such as an aniline, in the presence of an alkyl nitrite, a copper catalyst, and a catalytic amount of water and/or acid and in the absence of more than about 0.5 volume part of inert solvent per volume part of olefin.
摘要翻译：通过与芳胺如苯胺反应，在亚硝酸烷基酯，铜催化剂和催化量的水和/或酸的存在下，将烯烃，特别是活化的烯烃调聚，并且不存在多于约0.5体积份惰性溶剂/体积份烯烃。

6. 发明授权

US4544509A Aryl coupling process 失效
标题翻译：芳基偶合过程
公开(公告)号：US4544509A
公开(公告)日：1985-10-01
申请号：US523161
申请日：1983-08-15
申请人： Robert I. Davidson
发明人： Robert I. Davidson
IPC分类号： C07C69/616 , C07C255/32 , C07C121/66
CPC分类号： C07C255/00
摘要： An arylamine is coupled with an aromatic compound in the presence of water, an inorganic nitrite, and an alkanoic acid containing 5-7 carbons. In a preferred embodiment of the invention, 2-(4-amino-3-fluorobenzene)propionitrile is coupled with benzene in the presence of water, sodium nitrite, and hexanoic acid to form a flurbiprofen intermediate.
摘要翻译：在水，无机亚硝酸盐和含有5-7个碳的链烷酸的存在下，芳胺与芳族化合物偶合。在本发明的优选实施方案中，2-（4-氨基-3-氟苯）丙腈在水，亚硝酸钠和己酸的存在下与苯偶联以形成氟比洛芬中间体。

7. 发明授权

US5809564A Apparatus and method for swapping blocks of memory between a main memory area and a secondary storage area of a computer system 失效
标题翻译：用于交换计算机系统的主存储区域和辅助存储区域之间的存储块的装置和方法
公开(公告)号：US5809564A
公开(公告)日：1998-09-15
申请号：US266731
申请日：1994-06-27
申请人： Andrew C. Craze , Robert I. Davidson , Paul W. Davis
发明人： Andrew C. Craze , Robert I. Davidson , Paul W. Davis
IPC分类号： G06F9/42 , G06F12/02 , G06F12/08 , G06F12/10
CPC分类号： G06F9/4426 , G06F12/023 , G06F12/08
摘要： A method and system for swapping blocks of data between a main memory area and a secondary storage area of a computer system that uses absolute addresses as its native addressing format. A series of linked information structures is maintained in the main memory area of the computer system. Each information structure allocates storage for a near return address pointer, a previous information structure pointer, a reference number and an offset. A first and second data block are swapped into the main memory area of the computer system. When the first data block transfers control to the second data block, a memory location indicating an absolute address for this point of transfer is stored in an information structure associated with the first data block. Prior to swapping the first data block out of the main memory area, the absolute address is resolved into a reference number and an offset. This resolved address is then stored in an information structure associated with the first data block. When the first data block is swapped back into the main memory area, the resolved address is restored into a new absolute address which directs processing control to a proper return point in the first data block.
摘要翻译：在使用绝对地址作为其本地寻址格式的计算机系统的主存储区域和次存储区域之间交换数据块的方法和系统。在计算机系统的主存储区域中保持一系列链接的信息结构。每个信息结构为近返回地址指针，先前的信息结构指针，参考号和偏移量分配存储。第一和第二数据块被交换到计算机系统的主存储器区域中。当第一数据块将控制传送到第二数据块时，指示用于该传送点的绝对地址的存储器位置被存储在与第一数据块相关联的信息结构中。在将第一数据块从主存储区域交换之前，绝对地址被解析为参考号和偏移量。然后将该解析的地址存储在与第一数据块相关联的信息结构中。当第一个数据块被交换回主存储器区域时，解析的地址被还原成一个新的绝对地址，它将处理控制引导到第一个数据块中的正确返回点。

8. 发明授权

US4822904A Perfluoroalkylation process 失效
标题翻译：全氟烷基化方法
公开(公告)号：US4822904A
公开(公告)日：1989-04-18
申请号：US808204
申请日：1985-12-12
申请人： Robert I. Davidson
发明人： Robert I. Davidson
IPC分类号： C07B37/04 , B01J27/122 , B01J31/02 , C07B61/00 , C07C41/30 , C07C43/29 , C07C51/08 , C07C65/24 , C07C67/10 , C07C69/94 , C07C253/30 , C07C255/53 , C07C255/54 , C08B37/04 , C07C120/00
CPC分类号： C07C255/00 , C07C255/54
摘要： Perfluoroalkylaromatic compounds containing at least two carbons in the perfluoroalkyl group are prepared by reacting an aromatic bromide or iodide with a potassium perfluoroalkanoate corresponding to the formula KOOC(CF.sub.2).sub.n CF.sub.3 wherein n is an integer of at least one in the presence of cuprous iodide and a dipolar aprotic solvent.
摘要翻译：在全氟烷基中含有至少两个碳的全氟烷基芳族化合物是通过芳香族溴化物或碘化物与对应于式KOOC（CF 2）n CF 3的全氟链烷酸钾反应来制备的，其中n是碘化亚铜存在下的至少一个，偶极非质子溶剂。

9. 发明授权

US4541961A Nitrile purification 失效
标题翻译：腈净化
公开(公告)号：US4541961A
公开(公告)日：1985-09-17
申请号：US526964
申请日：1983-08-29
申请人： Robert I. Davidson
发明人： Robert I. Davidson
IPC分类号： C07C253/34 , C07C255/32 , C07C121/66
CPC分类号： C07C255/00 , C07C253/34
摘要： Nitriles, such as 2-(2-fluoro-4-biphenyl)propionitrile, contaminated with ketones having similar boiling points are purified by treating the nitrile/ketone mixture with an alkali metal borohydride, e.g., sodium borohydride, to complex the ketone. After complexing of the ketone, the nitrile can be separated therefrom by distillation.
摘要翻译：用具有相似沸点的酮污染的腈（如2-（2-氟-4-联苯基）丙腈）通过用碱金属硼氢化钠例如硼氢化钠处理腈/酮混合物来纯化以络合酮。酮络合后，可以通过蒸馏将腈分离出来。

10. 发明授权

US4476059A Chloroacetonitrile synthesis 失效
标题翻译：氯乙腈合成
公开(公告)号：US4476059A
公开(公告)日：1984-10-09
申请号：US509249
申请日：1983-06-30
申请人： Robert I. Davidson
发明人： Robert I. Davidson
IPC分类号： C07C120/00 , C07C121/16
CPC分类号： C07C255/00
摘要： A 2-hydroxyacetonitrile is reacted with thionyl chloride in the presence of a trialkylamine and a suitable solvent to form a 2-chloroacetonitrile. In a preferred embodiment of the invention, 2-chloropropionitrile is prepared by reacting lactonitrile with an excess of thionyl chloride in the presence of triethylamine and dichloromethane.
摘要翻译：在三烷基胺和合适的溶剂存在下，将2-羟基乙腈与亚硫酰氯反应，形成2-氯乙腈。在本发明的优选实施方案中，2-氯丙腈通过在三乙胺和二氯甲烷的存在下使乳腈与过量的亚硫酰氯反应来制备。

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