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1. 发明授权

US5476095A Intracavity probe and interface device for MRI imaging and spectroscopy 失效
标题翻译：用于MRI成像和光谱学的腔内探针和界面装置
公开(公告)号：US5476095A
公开(公告)日：1995-12-19
申请号：US203245
申请日：1994-03-01
申请人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack
发明人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack
IPC分类号： A61B5/055 , A61F2/958 , A61M25/095 , G01R33/34 , G01R33/36
CPC分类号： G01R33/341 , A61B5/055 , A61B5/4381 , A61M25/1011 , G01R33/34084 , A61M2025/1013 , A61M25/1002 , G01R33/34007 , G01R33/3657
摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatable inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft. The interface network receives the interconnecting cable of the pickup probe and includes impedance matching means, tuning means, and decoupling means for interfacing the probe with a magnetic resonance imaging scanner. In addition, the interface includes an electronic circuit for automatically adjusting the control voltage of a varactor diode in a Pi network which comprises the tuning means.
摘要翻译：可插入的探头和用于磁共振成像和光谱学的接口网络。优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。界面气囊包括由柔性外气囊包围的可充气内球囊。接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。接口网络接收拾取探头的互连电缆，并且包括阻抗匹配装置，调谐装置和用于将探针与磁共振成像扫描器对接的去耦装置。此外，该接口包括用于在包括调谐装置的Pi网络中自动调节变容二极管的控制电压的电子电路。

2. 发明申请

US20110040173A1 Imaging Agents For Use In Magnetic Resonance Blood Flow/Perfusion Imaging 有权
标题翻译：成像剂用于磁共振血流/灌注成像
公开(公告)号：US20110040173A1
公开(公告)日：2011-02-17
申请号：US12308439
申请日：2007-06-19
申请人： David Alsop , Elena Vinogradov , Aaron K. Grant , Robert E. Lenkinski
发明人： David Alsop , Elena Vinogradov , Aaron K. Grant , Robert E. Lenkinski
IPC分类号： A61B5/055
CPC分类号： A61K49/10
摘要： In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a compound having at least one hyperpolarized nucleus having a T1 greater than 15 seconds and a water-octanol partition coefficient between −1 and 1, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal. In another aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a carbon-13 enriched alcohol, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal.
摘要翻译：一方面，提供了使用磁共振成像（MRI）对受试者的感兴趣区域中的血液流动进行成像的方法。该方法包括将成像剂引入受试者，成像剂包括具有至少一个具有T1超过15秒的T1的超极化核和-1和1之间的水 - 辛醇分配系数的化合物，提供至少一个激发信号所述感兴趣区域，所述至少一个激励信号被配置为至少在所引入的成像剂中调用核磁共振（NMR）效应，以及响应于所述至少一个激励信号检测由所述感兴趣区域发射的NMR信号。在另一方面，提供了一种使用磁共振成像（MRI）对受试者感兴趣区域中的血液流动进行成像的方法。该方法包括将成像剂引入受试者，成像剂包括富含碳-13的醇，向感兴趣区域提供至少一个激发信号，所述至少一个激发信号被配置为调用核磁共振（NMR）至少在引入的成像剂中起作用，并且响应于至少一个激发信号，检测由感兴趣区域发射的NMR信号。

3. 发明授权

US5435302A Flexible surface coils for use in nuclear magnetic resonance imaging 失效
标题翻译：用于核磁共振成像的柔性表面线圈
公开(公告)号：US5435302A
公开(公告)日：1995-07-25
申请号：US124847
申请日：1993-09-22
申请人： Robert E. Lenkinski , Herbert Y. Kressel
发明人： Robert E. Lenkinski , Herbert Y. Kressel
IPC分类号： A61B10/00 , A61B5/055 , G01R33/34 , G01R33/341 , G01R33/36 , H01F7/20
CPC分类号： G01R33/34 , G01R33/34084 , G01R33/341 , G01R33/3628
摘要： Flexible, conforming surface coils for use in nuclear magnetic resonance (NMR) imaging are disclosed. The coils comprise a flexible outer body with antennas disposed within the body. The coils closely adopt the contours and shapes of the particular part of the patient's body under observation and provide considerable comfort. Since the coils closely conform to the patient, detection of artifacts and aliasing is minimized thus providing highly resolved images of the area of the patient that is being examined. The coils are readily utilized with preexisting NMR magnets and support equipment thereby allowing efficient and cost effective NMR imaging.
摘要翻译：公开了用于核磁共振（NMR）成像的柔性的，符合标准的表面线圈。线圈包括柔性外体，其具有布置在体内的天线。线圈密切采用观察者身体的特定部位的轮廓和形状，并提供相当的舒适度。由于线圈紧密地符合患者，所以检测伪像和混叠被最小化，从而提供正在检查的患者区域的高度分辨的图像。线圈易于与先前存在的NMR磁体和支撑设备一起使用，从而允许有效且成本有效的NMR成像。

4. 发明授权

US08742755B2 Positive magnetic resonance imaging contrast methods and apparatus using chemical exchange saturation transfer 有权
标题翻译：正磁共振成像对比方法和使用化学交换饱和转移的装置
公开(公告)号：US08742755B2
公开(公告)日：2014-06-03
申请号：US12936711
申请日：2009-04-09
申请人： Elena Vinogradov , Robert E. Lenkinski
发明人： Elena Vinogradov , Robert E. Lenkinski
IPC分类号： G01V3/00
CPC分类号： G01R33/485 , G01N24/087 , G01R33/5601
摘要： In one aspect, an apparatus for performing chemical exchange saturation transfer (CEST) magnetic resonance imaging on a region of an object being imaged is provided. The method comprises at least one coil capable of being operated to emit radio frequency (RF) signals, at least one detector capable of detecting nuclear magnetic resonance signals, and at least one controller to operate the at least one coil to provide at least one inversion sequence to the region to flip at least some spins in the region by a desired flip-angle, operate the at least one coil to provide at least one first pulse sequence at a first frequency offset from a peak resonant frequency of water by a first amount in a first direction to magnetize at least one exchange group in the region, operate the at least one coil to provide at least one second pulse sequence at a second frequency offset from the peak resonant frequency of water by the first amount in a second direction opposite the first direction, operate the at least one detector to measure a first signal emitted from the region as a result of providing the at least one first pulse sequence after a predetermined time interval after applying the first inversion sequence, and operate the at least one detector to measure a second signal emitted from the region as a result of providing the at least one second sequence at the predetermined time interval after applying the at least one inversion sequence, wherein the predetermined time interval is selected such that positive contrast is achieved with respect to the first signal relative to the second signal.
摘要翻译：在一个方面，提供了一种用于在被成像物体的区域上进行化学交换饱和转移（CEST）磁共振成像的装置。该方法包括能够被操作以发射射频（RF）信号的至少一个线圈，能够检测核磁共振信号的至少一个检测器，以及至少一个控制器，用于操作至少一个线圈以提供至少一个反转序列到所述区域以使所述区域中的至少一些自旋翻转所需的翻转角度，操作所述至少一个线圈以提供至少一个第一脉冲序列，所述第一脉冲序列以水的峰值共振频率偏移第一量在第一方向上磁化该区域中的至少一个交换组，操作该至少一个线圈以提供至少一个第二脉冲序列，该第二脉冲序列以与水的峰值共振频率偏移的第二频率相反的第二方向第一方向，操作至少一个检测器，以测量从该区域发射的第一信号，作为在预定时间之后提供至少一个第一脉冲序列的结果并且在应用第一反转序列之后操作至少一个检测器以测量从该区域发射的第二信号，作为在施加至少一个反转序列之后以预定时间间隔提供至少一个第二序列的结果，其中选择预定时间间隔使得相对于第二信号相对于第一信号获得正对比度。

5. 发明授权

US08623327B2 Imaging agents for use in magnetic resonance blood flow/perfusion imaging 有权
标题翻译：用于磁共振血流/灌注成像的成像剂
公开(公告)号：US08623327B2
公开(公告)日：2014-01-07
申请号：US12308439
申请日：2007-06-19
申请人： David Alsop , Elena Vinogradov , Aaron K. Grant , Robert E. Lenkinski
发明人： David Alsop , Elena Vinogradov , Aaron K. Grant , Robert E. Lenkinski
IPC分类号： A61B5/055
CPC分类号： A61K49/10
摘要： In one aspect, a method of imaging blood flow in a region of interest of a subject using magnetic resonance imaging (MRI) is provided. The method includes introducing an imaging agent into the subject, the imaging agent including a compound having at least one hyperpolarized nucleus having a T.sub.1 greater than 15 seconds and a water-octanol partition coefficient between −1 and 1, providing at least one excitation signal to the region of interest, the at least one excitation signal configured to invoke a nuclear magnetic resonance (NMR) effect at least in the introduced imaging agent, and detecting an NMR signal emitted by the region of interest in response to the at least one excitation signal. In another aspect, the imaging agent includes a carbon-13 enriched alcohol.
摘要翻译：一方面，提供了使用磁共振成像（MRI）对受试者的感兴趣区域中的血液流动进行成像的方法。该方法包括将成像剂引入受试者，成像剂包括具有至少一个具有大于15秒的T.sub.1的超极化核的化合物和-1至1之间的水 - 辛醇分配系数，至少提供所述至少一个激励信号被配置为至少在所引入的成像剂中调用核磁共振（NMR）效应，并且响应于所述至少一个激发信号检测由感兴趣区域发射的NMR信号至少一个激励信号。另一方面，成像剂包括富含碳-13的醇。

6. 发明申请

US20110221440A1 POSITIVE MAGNETIC RESONANCE IMAGING CONTRAST METHODS AND APPARATUS USING CHEMICAL EXCHANGE SATURATION TRANSFER 有权
标题翻译：积极磁共振成像对比方法和使用化学交换饱和转移的装置
公开(公告)号：US20110221440A1
公开(公告)日：2011-09-15
申请号：US12936711
申请日：2009-04-09
申请人： Elena Vinogradov , Robert E. Lenkinski
发明人： Elena Vinogradov , Robert E. Lenkinski
IPC分类号： G01R33/44
CPC分类号： G01R33/485 , G01N24/087 , G01R33/5601
摘要： In one aspect, an apparatus for performing chemical exchange saturation transfer (CEST) magnetic resonance imaging on a region of an object being imaged is provided. The method comprises at least one coil capable of being operated to emit radio frequency (RF) signals, at least one detector capable of detecting nuclear magnetic resonance signals, and at least one controller to operate the at least one coil to provide at least one inversion sequence to the region to flip at least some spins in the region by a desired flip-angle, operate the at least one coil to provide at least one first pulse sequence at a first frequency offset from a peak resonant frequency of water by a first amount in a first direction to magnetize at least one exchange group in the region, operate the at least one coil to provide at least one second pulse sequence at a second frequency offset from the peak resonant frequency of water by the first amount in a second direction opposite the first direction, operate the at least one detector to measure a first signal emitted from the region as a result of providing the at least one first pulse sequence after a predetermined time interval after applying the first inversion sequence, and operate the at least one detector to measure a second signal emitted from the region as a result of providing the at least one second sequence at the predetermined time interval after applying the at least one inversion sequence, wherein the predetermined time interval is selected such that positive contrast is achieved with respect to the first signal relative to the second signal.
摘要翻译：在一个方面，提供了一种用于在被成像物体的区域上进行化学交换饱和转移（CEST）磁共振成像的装置。该方法包括能够被操作以发射射频（RF）信号的至少一个线圈，能够检测核磁共振信号的至少一个检测器，以及至少一个控制器，用于操作至少一个线圈以提供至少一个反转序列到所述区域以使所述区域中的至少一些自旋翻转所需的翻转角度，操作所述至少一个线圈以提供至少一个第一脉冲序列，所述第一脉冲序列以水的峰值共振频率偏移第一量在第一方向上磁化该区域中的至少一个交换组，操作该至少一个线圈以提供至少一个第二脉冲序列，该第二脉冲序列以与水的峰值共振频率偏移的第二频率相反的第二方向第一方向，操作至少一个检测器，以测量从该区域发射的第一信号，作为在预定时间之后提供至少一个第一脉冲序列的结果并且在应用第一反转序列之后操作至少一个检测器以测量从该区域发射的第二信号，作为在施加至少一个反转序列之后以预定时间间隔提供至少一个第二序列的结果，其中选择预定时间间隔使得相对于第二信号相对于第一信号获得正对比度。

7. 发明授权

US5348010A Intracavity probe and interface device for MRI imaging and spectroscopy 失效
标题翻译：用于MRI成像和光谱学的腔内探针和界面装置
公开(公告)号：US5348010A
公开(公告)日：1994-09-20
申请号：US949918
申请日：1992-09-24
申请人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack , Theodore C. Claiborne , George J. Misic , Thomas R. Welch , Edward J. Rhinehart
发明人： Mitchell D. Schnall , Robert E. Lenkinski , Herbert Y. Kressel , Howard M. Pollack , Theodore C. Claiborne , George J. Misic , Thomas R. Welch , Edward J. Rhinehart
IPC分类号： A61B5/055 , A61F2/958 , A61M25/095 , G01R33/34 , G01R33/36 , A61B5/55
CPC分类号： G01R33/341 , A61B5/055 , A61B5/4381 , A61M25/1011 , G01R33/34084 , A61M2025/1013 , A61M25/1002 , G01R33/34007 , G01R33/3657
摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatabe inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft. An interface network is also provided which receives the interconnecting cable of the pickup probe and includes impedance matching means, tuning means, and decoupling means for interfacing the probe with a magnetic resonance imaging scanner. In addition, the interface includes an electronic circuit for automatically adjusting the control voltage of a varactor diode in a Pi network which comprises the tuning means.
摘要翻译：可插入的探头和用于磁共振成像和光谱学的接口网络。优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。界面气囊包括由柔性外气囊包围的发泡内气囊。接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。还提供接口网络，其接收拾取探针的互连电缆，并且包括阻抗匹配装置，调谐装置和用于将探针与磁共振成像扫描器对接的去耦装置。此外，该接口包括用于在包括调谐装置的Pi网络中自动调节变容二极管的控制电压的电子电路。

8. 发明申请

US20090027280A1 MICRO-SCALE RESONANT DEVICES AND METHODS OF USE 审中-公开
标题翻译：微尺度谐振器件及其使用方法
公开(公告)号：US20090027280A1
公开(公告)日：2009-01-29
申请号：US11913661
申请日：2006-05-05
申请人： John V. Frangioni , Jonathan Bernstein , Jonathan J. Rosen , Robert E. Lenkinski
发明人： John V. Frangioni , Jonathan Bernstein , Jonathan J. Rosen , Robert E. Lenkinski
IPC分类号： G01R29/08 , H01Q1/40 , H01Q1/00
CPC分类号： A61K49/0032 , A61K49/18 , A61N1/08
摘要： The invention relates to micro-resonant devices (MRDs) that generate resonance at radio frequencies not present in an animal or human body, or present at low, background levels in the body. These individual, often monolithic devices, can be located in three-dimensional space and tracked anywhere in a target area, e.g., in a human or animal body, or within a cell within a body, using a conventional magnetic resonance imaging (MRI) scanner or other transducers, e.g., radiofrequency transducers. The MRDs generate high sensitivity contrast in conventional clinical MRI scanners, have a diameter of anywhere from a few nanometers to 1000 microns, and can in some embodiments be manufactured using Micro-Electro-Mechanical Systems (MEMS) technology. The devices are optionally coated to isolate them from the environment, and this coating can be a biocompatible coating for medical and biotechnology uses.
摘要翻译：本发明涉及在体内不存在于动物或人体内或存在于体内低背景水平的射频产生共振的微振荡装置（MRD）。这些单独的，通常是整体的装置可以位于三维空间中，并使用传统的磁共振成像（MRI）扫描仪在目标区域的任何地方（例如在人体或动物体内）或身体内的细胞内进行跟踪或其他换能器，例如射频换能器。 MRD在常规临床MRI扫描仪中产生高灵敏度对比度，其直径可以从几纳米到1000微米，并且在一些实施例中可以使用微机电系统（MEMS）技术制造。该装置可选地涂覆以将其与环境隔离，并且该涂层可以是用于医疗和生物技术用途的生物相容性涂层。

9. 发明授权

US5451232A Probe for MRI imaging and spectroscopy particularly in the cervical region 失效
标题翻译：探测MRI成像和光谱特别是在宫颈区域
公开(公告)号：US5451232A
公开(公告)日：1995-09-19
申请号：US132152
申请日：1993-10-05
申请人： Edward J. Rhinehart , Herbert Y. Kresel , Mitchell Schnall , Robert E. Lenkinski , Barton Milestone
发明人： Edward J. Rhinehart , Herbert Y. Kresel , Mitchell Schnall , Robert E. Lenkinski , Barton Milestone
IPC分类号： A61B5/055 , A61F2/958 , A61M25/095 , G01R33/28 , G01R33/34 , A61M25/10
CPC分类号： B82Y15/00 , A61B5/055 , G01R33/285 , A61M25/1002 , G01R33/34084
摘要： An insertable intracavity probe for use in magnetic resonance imaging of an area of interest in a relatively inaccessible region of the body particularly the cervix is disclosed. The probe has an inflatable balloon structure with an internal pickup coil carried at the distal end of a shaft for rectal insertion of the coil and an inflatable anti-migration cuff to hold the probe in position and prevent outward migration thereof during a procedure. The balloon structure has an outer balloon shaped to facilitate insertion and accommodation of the coil to areas of the anatomy adjacent the cervix. Internally, the balloon structure has an inflatable balloon which can be used to adjust the shape of the coil to accommodate uniquely shaped anatomical areas.
摘要翻译：公开了一种可插入的腔内探针，用于在身体的相对不可接近的区域，特别是子宫颈中的感兴趣区域的磁共振成像。探头具有可膨胀的球囊结构，其内部拾取线圈承载在轴的远端，用于直线插入线圈，以及可膨胀的防移动箍，以将探针保持在适当位置并防止在手术过程中向外移动探针。球囊结构具有形状为便于将线圈插入和容纳到与子宫颈相邻的解剖结构的区域的外部球囊。在内部，球囊结构具有可膨胀气球，其可用于调节线圈的形状以适应独特形状的解剖区域。

10. 发明授权

US5307814A Externally moveable intracavity probe for MRI imaging and spectroscopy 失效
标题翻译：外部可动的腔内探针，用于MRI成像和光谱学
公开(公告)号：US5307814A
公开(公告)日：1994-05-03
申请号：US760463
申请日：1991-09-17
申请人： Herbert Y. Kressel , Edward J. Rhinehart , Mitchell Schnall , Robert E. Lenkinski , Yutaka Imai
发明人： Herbert Y. Kressel , Edward J. Rhinehart , Mitchell Schnall , Robert E. Lenkinski , Yutaka Imai
IPC分类号： G01R33/48 , A61B5/055 , A61F2/958 , A61M25/00 , G01R33/28 , G01R33/34 , A61M25/10
CPC分类号： G01R33/341 , A61B5/055 , A61B5/4255 , G01R33/285 , A61M25/1011 , G01R33/34084
摘要： An insertable intracavity probe for use in magnetic resonance imaging of an area of interest in a body cavity particularly the colon, has an elongate shaft with a handle at its proximal end and an inflatable balloon structure at its distal end. The balloon structure has an outer balloon containing a loop-type pickup coil for connection to an interfacing network. The coil is sandwiched between two internal separately inflatable balloons, and when the probe is inserted, the coil can be optimally positioned relative to the area of interest by controlled differential inflation of the balloons. The probe also has an insertable rod-like mandrel for providing twisting orbital-type movement of the balloon structure on the shaft, by rotation of the mandrel, useful to steer the probe along curves or bends in the body cavity when it is being inserted. In a modified form of the probe, the mandrel can be used to rotate the coil and the internal balloons as a unit within the outer balloon for optimal in situ angular positioning of the coil.
摘要翻译：用于在体腔特别是结肠中的感兴趣区域的磁共振成像的可插入腔内探针具有在其近端具有手柄的细长轴和在其远端处的可充气球囊结构。球囊结构具有外球囊，其包含用于连接到接口网络的环形拾取线圈。线圈被夹在两个内部单独可充气的气球之间，并且当插入探头时，线圈可以通过气囊的可控差动充气相对于感兴趣区域进行最佳定位。探针还具有可插入的杆状心轴，用于通过心轴的旋转来提供气球结构在轴上的扭转轨道式运动，其用于在探测器被插入时沿曲线或弯曲部弯曲弯曲。在探针的改进形式中，心轴可以用于将线圈和内部气球作为单元旋转到外部球囊内，用于线圈的最佳原位角定位。

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