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1. 发明授权

US08473035B2 Medical imaging systems 有权
标题翻译：医学影像系统
公开(公告)号：US08473035B2
公开(公告)日：2013-06-25
申请号：US10572169
申请日：2003-09-15
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： A61B6/00
CPC分类号： A61B5/418 , A61B1/042 , A61B1/043 , A61B1/3132 , A61B5/0071 , A61B5/0084 , A61B5/415 , G06T19/20 , G06T2210/41 , G06T2219/028 , G06T2219/2012
摘要： A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.
摘要翻译：医学成像系统提供可见光和诊断或功能图像的同时呈现。该系统可以是便携式的，并且可以包括用于在开放式手术环境或laparoascopic或内窥镜环境中连接各种光源和照相机的适配器。用户界面提供对集成成像系统的功能的控制。在一个实施例中，该系统提供用于手术病理学的工具。

2. 发明授权

US08139831B2 System and method for unsupervised detection and gleason grading of prostate cancer whole mounts using NIR fluorscence 有权
标题翻译：使用NIR荧光法进行前列腺癌整体无障碍检测和gleason分级的系统和方法
公开(公告)号：US08139831B2
公开(公告)日：2012-03-20
申请号：US12326135
申请日：2008-12-02
申请人： Ali Khamene , Tina Ehtiati , John V. Frangioni , Vida Kianzad , Fred S. Azar
发明人： Ali Khamene , Tina Ehtiati , John V. Frangioni , Vida Kianzad , Fred S. Azar
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/6277 , G06T7/66 , G06T2207/10056 , G06T2207/10064 , G06T2207/20076 , G06T2207/20152 , G06T2207/30024 , G06T2207/30081
摘要： A method for unsupervised classification of histological images of prostatic tissue includes providing histological image data obtained from a slide simultaneously co-stained with NIR fluorescent and Hematoxylin-and-Eosin (H&E) stains, segmenting prostate gland units in the image data, forming feature vectors by computing discriminating attributes of the segmented gland units, and using the feature vectors to train a multi-class classifier, where the classifier classifies prostatic tissue into benign, prostatic intraepithelial neoplasia (PIN), and Gleason scale adenocarcinoma grades 1 to 5 categories.
摘要翻译：用于前列腺组织的组织学图像的无监督分类的方法包括提供从与NIR荧光和苏木精 - 曙红（H＆E）染色同时共染色的载玻片获得的组织学图像数据，在图像数据中分割前列腺单位，形成特征向量通过计算分段腺体单位的区别属性，并使用特征向量来训练多类分类器，其中分类器将前列腺组织分类为良性前列腺上皮内瘤变（PIN）和1〜5级的格里森量表腺癌。

3. 发明申请

US20110040169A1 INTEGRATION OF MICRO AND MACRO INFORMATION FOR BIOMEDICAL IMAGING 有权
标题翻译：微生物信息的整合与生物医学成像的宏观信息
公开(公告)号：US20110040169A1
公开(公告)日：2011-02-17
申请号：US12604504
申请日：2009-10-23
申请人： Ali Kamen , Fred S. Azar , John V. Frangioni
发明人： Ali Kamen , Fred S. Azar , John V. Frangioni
IPC分类号： A61B5/055
CPC分类号： G06T5/50 , A61B6/03 , A61B6/037 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B90/39 , G06T7/32 , G06T7/33 , G06T7/337 , G06T2207/10056 , G06T2207/10072 , G06T2207/30004
摘要： Macroscopic imaging data, such as from a CT, MR, PET, or SPECT scanner, is obtained. Microscopic imaging data of at least a portion of the same tissue is obtained. To align the microscopic imaging data with the macroscopic imaging data, intermediate data is also obtained. For example, photographic data is acquired at an intermediary stage of a process of preparing tissue for microscopic scan. The macroscopic and microscopic data are registered to the intermediary photographic data. Once registered to the intermediary data, the spatial relationship between the macroscopic and microscopic data is known and may be used for imaging or quantification.
摘要翻译：获得宏观成像数据，例如来自CT，MR，PET或SPECT扫描仪。得到至少一部分相同组织的显微成像数据。为了将显微成像数据与宏观成像数据对准，还获得中间数据。例如，在制备用于显微镜扫描的组织的过程的中间阶段获取摄影数据。宏观和微观数据被登记到中间摄影数据。一旦注册到中间数据，宏观和微观数据之间的空间关系是已知的，并且可以用于成像或定量。

4. 发明申请

US20100262017A1 MULTI-CHANNEL MEDICAL IMAGING SYSTEM 有权
标题翻译：多通道医学成像系统
公开(公告)号：US20100262017A1
公开(公告)日：2010-10-14
申请号：US12307204
申请日：2007-07-03
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： A61B6/00
CPC分类号： A61B1/043 , A61B1/0005 , A61B1/00186 , A61B1/0638 , A61B1/0684 , A61B1/3132 , A61B5/0071 , A61B5/0086 , A61B5/0261 , A61B90/361 , A61K49/006 , B82Y5/00 , B82Y10/00
摘要： A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light. The systems described herein provide two or more diagnostic imaging channels for capture of multiple, concurrent diagnostic images and may be used where a visible light image may be usefully supplemented by two or more images that are independently marked for functional interest.
摘要翻译：医学成像系统提供可见光和荧光图像的同时呈现。该系统可以使用保留在受试者的血液中的小分子形式的染料数分钟，允许对象的循环系统的实时成像叠加在受试者的常规可见光图像上。该系统可以提供激发光源来激发用于捕获图像的相同光导中的荧光物质和用于一般照明的可见光源。该系统可以被配置为在开放式外科手术中使用，通过提供一个与环境光线接近的操作区域。本文所描述的系统提供了用于多个并发的诊断图像的捕获的两个或更多诊断成像通道，并且可以使用其中的可见光图像可以由独立地标记为感兴趣的功能的两个或更多个图像被有效地补充。

5. 发明申请

US20090123383A1 Non-Isotopic Detection of Osteoblastic Activity In Vivo Using Modified Bisphosphonates 审中-公开
标题翻译：使用修饰的二膦酸盐体内成骨细胞活性的非同位素检测
公开(公告)号：US20090123383A1
公开(公告)日：2009-05-14
申请号：US12104724
申请日：2008-04-17
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/005 , C07F9/5728
摘要： The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures.
摘要翻译：本发明涉及用于羟基磷灰石阳性细胞和结构体外和体内检测的非同位素方法。

6. 发明授权

US08983230B2 Global error minimization in image mosaicking using graph laplacians and its applications in microscopy 有权
标题翻译：使用图形拉普拉斯算子的图像拼接中的全局误差最小化及其在显微镜中的应用
公开(公告)号：US08983230B2
公开(公告)日：2015-03-17
申请号：US13810940
申请日：2011-07-25
申请人： Parmeshwar Khurd , Rafiou Oketokoun , Ali Kamen , Leo Grady , Hari Sundar , John V. Frangioni , Tejas Gajera
发明人： Parmeshwar Khurd , Rafiou Oketokoun , Ali Kamen , Leo Grady , Hari Sundar , John V. Frangioni , Tejas Gajera
IPC分类号： G06K9/36 , G06K9/32 , G06T11/60 , G06T3/00 , G06T3/40 , G06T7/00
CPC分类号： G06T11/60 , G06T3/0068 , G06T3/4038 , G06T7/32 , G06T2200/32 , G06T2207/10056 , G06T2207/30024
摘要： An image mosaicking method includes performing pairwise registration of a plurality of tiles (101), determining absolute homographies for each of the plurality of tiles according to the pairwise registration (102B), and performing a blending of the plurality of tiles to obtain a stitched image according to the absolute homographies (103).
摘要翻译：图像拼接方法包括执行多个瓦片（101）的配对注册，根据成对配准（102B）确定多个瓦片中的每一个的绝对同位素，并且执行多个瓦片的混合以获得缝合图像根据绝对同位素（103）。

7. 发明授权

US08357350B2 Annulus fibrosus detection in intervertebral discs using molecular imaging agents 有权
标题翻译：使用分子成像剂在椎间盘中检测纤维环
公开(公告)号：US08357350B2
公开(公告)日：2013-01-22
申请号：US12370207
申请日：2009-02-12
申请人： Cristina Abucay Tan Hehir , Tiberiu Mircea Siclovan , Kenneth Michael Fish , Nicole Evelyn Barnhardt , John V. Frangioni , Carrie S. Vooght
发明人： Cristina Abucay Tan Hehir , Tiberiu Mircea Siclovan , Kenneth Michael Fish , Nicole Evelyn Barnhardt , John V. Frangioni , Carrie S. Vooght
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0052 , A61K49/085 , A61K49/10 , A61K51/0455 , A61K51/0497
摘要： The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N′,N″,N′″-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.
摘要翻译：本发明涉及使用包含式I化合物，13C或2H富集的式I化合物，19 F标记的式I化合物的试剂定量测量其在样品中的局部浓度的方法，式I的金属-ODTA（1,4,7,10-四氮杂环十二烷-N，N'，N“，N” - 四乙酸）络合物或式I的放射性同位素衍生物。

8. 发明申请

US20110256065A1 Non-Isotopic Detection of Osteoblastic Activity In Vivo Using Modified Bisphosphonates 审中-公开
标题翻译：使用修饰的二膦酸盐体内成骨细胞活性的非同位素检测
公开(公告)号：US20110256065A1
公开(公告)日：2011-10-20
申请号：US13169500
申请日：2011-06-27
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： A61K49/00 , A61P43/00 , C07F9/572
CPC分类号： A61K49/0032 , A61K49/005 , C07F9/5728
摘要： The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures.
摘要翻译：本发明涉及用于羟基磷灰石阳性细胞和结构体外和体内检测的非同位素方法。

9. 发明授权

US07794394B2 Device for wavelength-selective imaging 失效
标题翻译：波长选择成像装置
公开(公告)号：US07794394B2
公开(公告)日：2010-09-14
申请号：US10517280
申请日：2003-05-22
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： A61B1/06
CPC分类号： H01L31/111 , A61B5/0059 , A61B5/7425 , G01J3/36 , G01N21/6428 , G01N21/6456 , G02B5/201 , G02B23/12 , H01L27/14621 , H01L27/14625 , H01L27/14647 , H01L27/14806 , H01L27/14837 , H01L27/14843 , H01L27/14868 , H01L31/101
摘要： An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimposed to display regions of diagnostic significance within a visible light image. A number of imaging media may be used according to an intended application for the imaging device, and an imaging medium may have wavelengths above, below, or within the visible light spectrum. The devices described herein may be advantageously packaged within a single integrated device or other solid state device, and/or employed in an integrated, single-camera medical imaging system, as well as many non-medical imaging systems that would benefit from simultaneous capture of visible-light wavelength images along with images at other wavelengths.
摘要翻译：成像装置捕获可见光图像和诊断图像，诊断图像对应于来自对象内的成像介质的发射。可见光图像（其可以是彩色或灰度）和诊断图像可以叠加以在可见光图像内显示具有诊断意义的区域。可以根据成像装置的预期应用使用多个成像介质，并且成像介质可以具有在可见光光谱之上，之下或之内的波长。本文描述的装置可以有利地封装在单个集成装置或其他固态装置内，和/或用于集成的单相机医疗成像系统，以及许多非医学成像系统，其将受益于同时捕获可见光波长图像以及其他波长的图像。

10. 发明申请

US20090161928A1 SYSTEM AND METHOD FOR UNSUPERVISED DETECTION AND GLEASON GRADING OF PROSTATE CANCER WHOLE MOUNTS USING NIR FLUORSCENCE 有权
标题翻译：使用近红外荧光检查的前列腺癌全部病例的不稳定检测和GLEASON分级的系统和方法
公开(公告)号：US20090161928A1
公开(公告)日：2009-06-25
申请号：US12326135
申请日：2008-12-02
申请人： Ali Khamene , Tina Ehtiati , John V. Frangioni , Vida Kianzad , Fred S. Azar
发明人： Ali Khamene , Tina Ehtiati , John V. Frangioni , Vida Kianzad , Fred S. Azar
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/6277 , G06T7/66 , G06T2207/10056 , G06T2207/10064 , G06T2207/20076 , G06T2207/20152 , G06T2207/30024 , G06T2207/30081
摘要： A method for unsupervised classification of histological images of prostatic tissue includes providing histological image data obtained from a slide simultaneously co-stained with NIR fluorescent and Hematoxylin-and-Eosin (H&E) stains, segmenting prostate gland units in the image data, forming feature vectors by computing discriminating attributes of the segmented gland units, and using the feature vectors to train a multi-class classifier, where the classifier classifies prostatic tissue into benign, prostatic intraepithelial neoplasia (PIN), and Gleason scale adenocarcinoma grades 1 to 5 categories.
摘要翻译：用于前列腺组织的组织学图像的无监督分类的方法包括提供从与NIR荧光和苏木精 - 曙红（H＆E）染色同时共染色的载玻片获得的组织学图像数据，在图像数据中分割前列腺单位，形成特征向量通过计算分段腺体单位的区别属性，并使用特征向量来训练多类分类器，其中分类器将前列腺组织分类为良性前列腺上皮内瘤变（PIN）和1〜5级的格里森量表腺癌。

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