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1. 发明申请

US20070027133A1 BICYCLIC PYRAZOLYL AND IMIDAZOLYL COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：双丙基吡唑并咪唑化合物及其用途
公开(公告)号：US20070027133A1
公开(公告)日：2007-02-01
申请号：US11470695
申请日：2006-09-07
申请人： Philip Carpino , Robert Dow , David Griffith
发明人： Philip Carpino , Robert Dow , David Griffith
IPC分类号： A61K31/554 , A61K31/553 , A61K31/5513 , A61K31/55 , C07D487/02 , C07D491/02 , C07D498/02
CPC分类号： C07D487/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals.
摘要翻译：式（I）化合物在本文中描述。已经显示这些化合物作为大麻素受体配体，因此可用于治疗与动物中的大麻素受体的介导相关的疾病。

2. 发明申请

US20060241100A1 Acylaminobicyclic heteroaromatic compounds and uses thereof 审中-公开
标题翻译：酰氨基双环杂芳族化合物及其用途
公开(公告)号：US20060241100A1
公开(公告)日：2006-10-26
申请号：US11409458
申请日：2006-04-20
申请人： Robert Dow , Philip Carpino
发明人： Robert Dow , Philip Carpino
IPC分类号： A61K31/55 , A61K31/4162 , C07D491/02 , C07D487/02
CPC分类号： C07D487/04 , C07D491/04
摘要： Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals.
摘要翻译：式（I）化合物在本文中描述。已经显示这些化合物作为大麻素受体配体，因此可用于治疗与动物中的大麻素受体的介导相关的疾病。

3. 发明申请

US20060205720A1 Cannabinoid receptor ligands and uses thereof 失效
公开(公告)号：US20060205720A1
公开(公告)日：2006-09-14
申请号：US11433848
申请日：2006-05-12
申请人： Philip Carpino , Robert Dow
发明人： Philip Carpino , Robert Dow
IPC分类号： C07D471/02 , A61K31/5377 , A61K31/4745
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.

4. 发明申请

US20050101592A1 Bicyclic pyrazolyl and imidazolyl compounds and uses thereof 失效
标题翻译：双环吡唑基和咪唑基化合物及其用途
公开(公告)号：US20050101592A1
公开(公告)日：2005-05-12
申请号：US10971599
申请日：2004-10-22
申请人： Philip Carpino , Robert Dow , David Griffith
发明人： Philip Carpino , Robert Dow , David Griffith
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/02 , C07D498/02 , C07D498/04 , C07D513/04
CPC分类号： C07D487/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals.
摘要翻译：式（I）化合物在本文中描述。已经显示这些化合物作为大麻素受体配体，因此可用于治疗与动物中的大麻素受体的介导相关的疾病。

5. 发明授权

US4404507A Forming contours 失效
标题翻译：形成轮廓
公开(公告)号：US4404507A
公开(公告)日：1983-09-13
申请号：US324671
申请日：1981-11-24
申请人： Stanley K. Dean , Robert Dow
发明人： Stanley K. Dean , Robert Dow
IPC分类号： G05B19/40 , G05B19/4103 , G05B19/24
CPC分类号： G05B19/40 , G05B19/4103 , G05B2219/33099 , G05B2219/33182 , G05B2219/34087 , G05B2219/34098 , G05B2219/34187 , G05B2219/34215 , G05B2219/35439 , G05B2219/36383
摘要： There is disclosed a method of controlling, and a control system for, an apparatus, such as a machine tool (100), for forming a straight configured contour, or a straight configured segment forming part of a curvilinear contour, and having co-ordinates in at least two directions (X, Y and Z), said apparatus incorporating a work piece support (102), a contour forming means, such as a milling cutter (107), incremental drives (M.sub.X, M.sub.Y and M.sub.Z) to effect relative movement between said support (102) and said milling cutter (107) in said directions, and involving determining the components of said contour or segment in said directions (X, Y and Z) as a number of increments of length equal to a predetermined distance, providing a continuous feed of input pulses in a computer (S B C), continuously counting in the S B C, in respect of each said direction, a predetermined number of input pulses in the ratio of the inverses of said number of increments, and subsequently feeding via motor control (MCB) and motor drive (MDB) boards,(i) a drive pulse to one of said incremental drives (M.sub.X, M.sub.Y or M.sub.Z) to effect movement in one of said direct directions (X, Y or Z) over said predetermined distance each time the predetermined number of input pulses relevant to that direction have been counted, and(ii) a drive pulse to at least one other of said incremental drives (M.sub.X, M.sub.Y or M.sub.Z) to effect movement in one other of said directions (X, Y or Z) over the same predetermined distance each time the predetermined number of input pulses relevant to that direction have been counted,whereby said movements combine to form a relative movement between said support (102) and said milling cutter (107) such as to produce said contour or said segment.
摘要翻译：公开了一种用于形成直线构造轮廓的装置，例如机床（100）的控制和控制系统的方法，或形成曲线轮廓的一部分的直线构造段，并且具有坐标在至少两个方向（X，Y和Z）上，所述装置包括工件支撑件（102），轮廓形成装置，例如铣刀（107），增量驱动器（MX，MY和MZ）在所述方向上在所述支撑件（102）和所述铣刀（107）之间的运动，并且涉及将所述方向（X，Y和Z）上的所述轮廓或段的分量确定为等于预定距离的长度增量在计算机（SBC）中连续馈送输入脉冲，在SBC中相对于每个所述方向连续计数预定数量的输入脉冲，其中所述增量数量的反转比例，以及随后的通过电机控制（M CB）和马达驱动器（MDB）板，（i）到所述增量驱动器（MX，MY或MZ）之一的驱动脉冲，以在所述直接方向（X，Y或Z）中的一个上移动所述预定距离已经计数与该方向相关的预定数量的输入脉冲，并且（ii）到所述增量驱动器（MX，MY或MZ）中的至少另一个的驱动脉冲，以实现所述方向（X， Y或Z），每当与该方向相关的预定数量的输入脉冲被计数时，相同的预定距离，由此所述运动组合以形成所述支撑件（102）和所述铣刀（107）之间的相对运动，产生所述轮廓或所述段。

6. 发明申请

US20070254935A1 PYRAZOLE AND IMIDAZOLE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：吡唑和咪唑化合物及其用途
公开(公告)号：US20070254935A1
公开(公告)日：2007-11-01
申请号：US11766442
申请日：2007-06-21
申请人： Robert Dow , Marlys Hammond
发明人： Robert Dow , Marlys Hammond
IPC分类号： A61K31/415 , A61K31/4164 , C07D231/00 , C07D233/54
CPC分类号： C07D231/12 , C07D233/64 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/08
摘要： Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders modulated by cannabinoid receptor antagonists in animals are described herein.
摘要翻译：本文描述了作为大麻素受体配体的式（I）化合物及其在治疗由大麻素受体拮抗剂在动物中调节的疾病，病症和/或病症中的用途。

7. 发明申请

US20060205948A1 Cannabinoid receptor ligands and uses thereof 失效
标题翻译：大麻素受体配体及其用途
公开(公告)号：US20060205948A1
公开(公告)日：2006-09-14
申请号：US11433171
申请日：2006-05-12
申请人： Philip Carpino , Robert Dow
发明人： Philip Carpino , Robert Dow
IPC分类号： A61K31/4745 , C07D471/02 , C07D403/02 , A61K31/4184
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.
摘要翻译：本文描述了作为大麻素受体配体的式（I）和（II）的化合物及其用于治疗与动物中的大麻素受体的介导相关的疾病的用途。

8. 发明授权

US2261147A Double hung door mounting and latching means 失效
标题翻译：双挂门安装和锁定装置
公开(公告)号：US2261147A
公开(公告)日：1941-11-04
申请号：US21703239
申请日：1939-05-01
申请人： ROBERT DOW
发明人： ROBERT DOW
IPC分类号： E05D15/50
CPC分类号： E05D15/507 , E05Y2900/132 , Y10T16/5285

9. 发明授权

US2220308A Generator cooler 失效
标题翻译：发电机冷却器
公开(公告)号：US2220308A
公开(公告)日：1940-11-05
申请号：US28716939
申请日：1939-07-28
申请人： FRANK ROBERT DOW
发明人： WHITMAN GERALD D
IPC分类号： F01P1/06 , F01P7/02 , F01P11/06 , F02M17/34 , F02M35/04
CPC分类号： F02M35/04 , F01P1/06 , F01P7/02 , F01P11/06 , F02M17/34

10. 发明申请

US20070117805A1 Glucocorticoid receptor modulators 有权
标题翻译：糖皮质激素受体调节剂
公开(公告)号：US20070117805A1
公开(公告)日：2007-05-24
申请号：US11580996
申请日：2006-10-13
申请人： Robert Dow , Kevin Liu , Bradley Morgan , Andrew Swick
发明人： Robert Dow , Kevin Liu , Bradley Morgan , Andrew Swick
IPC分类号： A61K31/4965 , A61K31/44 , C07D241/02
CPC分类号： C07D213/40 , C07D213/30 , C07D233/64 , C07D241/12 , C07D295/13 , C07D295/205 , C07D455/06
摘要： The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to the diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.
摘要翻译：本发明提供了类固醇受体的选择性调节剂（即激动剂和拮抗剂），特别是糖皮质激素受体的式I的非类固醇化合物。本发明还提供含有这些化合物的药物组合物和使用这些化合物治疗需要糖皮质激素受体激动剂或拮抗剂治疗的动物的方法。糖皮质激素受体调节剂可用于如下所述的疾病，例如肥胖，糖尿病，炎症等。本发明还提供了制备这些化合物的中间体和方法。

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