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1. 发明授权

US5541617A Monolithic quadrifilar helix antenna 失效
标题翻译：单片四线螺旋天线
公开(公告)号：US5541617A
公开(公告)日：1996-07-30
申请号：US271858
申请日：1994-07-07
申请人： Peter J. Connolly , Steren G. Ow , Robert D. McCarthy
发明人： Peter J. Connolly , Steren G. Ow , Robert D. McCarthy
IPC分类号： H01Q11/08 , H01Q1/38
CPC分类号： H01Q11/08
摘要： A quadrifilar helix antenna containing a hybrid junction power divider feed circuit and a plurality of radiating elements. The radiating elements are connected on one end to the hybrid junction power divider feed circuit and are free to radiate on the other end. In a particular embodiment, the antenna includes a microstrip hybrid junction power divider feed circuit deposited on the lower rectangular section of a dielectric substrate. The hybrid junction power divider feed circuit provides both a 0 to 180 degree phase shift and impedance matching. The antenna also includes four radiating microstrip elements deposited on the upper section of the dielectric substrate at a predetermined angle to form a helical pattern upon turning the planar antenna into a cylinder. The radiating elements are connected to the microstrip hybrid junction power divider feed circuit in pairs. The first pair is connected to the hybrid junction power divider feed circuit at the location of the 0 degree phase shift whereas the other pair is located at the 180 degree phase shift location. The second element of each pair is shorter than the first element by a predetermined distance to provide a phase quadrature between them. Therefore through this method, the required phase relationships for a circularly polarized beam pattern are achieved.
摘要翻译：包含混合接合功率分配器馈电电路和多个辐射元件的四极螺旋天线。辐射元件一端连接到混合接合功率分配器馈电电路，另一端可自由辐射。在特定实施例中，天线包括沉积在电介质基底的下矩形部分上的微带混合连接功率分配器馈电电路。混合结功率分配器馈电电路提供0到180度的相移和阻抗匹配。天线还包括以预定角度沉积在电介质基板的上部上的四个辐射微带元件，以在将平面天线转动成圆柱体时形成螺旋图案。辐射元件成对连接到微带混合接合功率分配器馈电电路。第一对在0度相移的位置连接到混合接合功率分配器馈电电路，而另一对位于180度相移位置。每对的第二元件比第一元件短一个预定距离以在它们之间提供相位正交。因此，通过该方法，实现了圆偏振光束图案所需的相位关系。

2. 发明授权

US06825478B1 MALDI plate with removable magnetic insert 失效
标题翻译： MALDI板带可移动磁性插件
公开(公告)号：US06825478B1
公开(公告)日：2004-11-30
申请号：US10683024
申请日：2003-10-10
申请人： Robert D. McCarthy , Kevin M. Hayden , Timothy E. Hutchins , Philip J. Savickas , Peter C. Cranshaw
发明人： Robert D. McCarthy , Kevin M. Hayden , Timothy E. Hutchins , Philip J. Savickas , Peter C. Cranshaw
IPC分类号： B01D5944
CPC分类号： B01L9/523 , B01L2200/04 , B01L2300/0829 , H01J49/0418
摘要： A sample plate structure is provided including a retainer plate having a central recess with a trough along its periphery, a sample insert plate which fits into and rests on contact surface of the recess, and a magnet that is held below the contact surface. A portion of the bottom surface of the insert is formed of a magnetic material. The magnet provides sufficient force to retain the insert plate in the retainer plate during MALDI MS analysis. The sample insert plate is provided with a peripheral configuration, which assures that the sample insert plate is properly oriented within the sample plate support structure and is held flat. A hole for a protrusion allows easy insert installation and alignment against the orientation feature in the recess as well as easy removal of the insert simply by pushing up from underneath the retainer plate. While the insert sample plate can be a consumable, the remaining portion of the apparatus can be reused.
摘要翻译：提供了样品板结构，其包括保持板，该保持板具有沿着其周边具有槽的中心凹部，嵌入并搁置在凹部的接触表面上的样品插入板以及保持在接触表面下方的磁体。插入件底面的一部分由磁性材料形成。在MALDI MS分析期间，磁体提供足够的力以将插入板保持在保持板中。样品插入板设置有周边结构，其确保样品插入板适当地定位在样品板支撑结构内并保持平坦。用于突起的孔允许容易的插入件安装和对准凹部中的取向特征，并且简单地通过从保持板的下方向上推动来容易地移除插入件。当插入样品板可以是消耗品时，装置的剩余部分可以重复使用。

3. 发明授权

US5019390A Anticancer agent--IMIC 失效
标题翻译：抗癌剂--ICIC
公开(公告)号：US5019390A
公开(公告)日：1991-05-28
申请号：US56504
申请日：1987-05-29
申请人： Robert D. McCarthy, deceased , Arun Kilara , David B. Pierce
发明人： Robert D. McCarthy, deceased , Arun Kilara , David B. Pierce
IPC分类号： A61K35/20
CPC分类号： A61K35/20
摘要： The present invention relates to a novel antineoplastic agent, designated IMIC (Inhibitor of Mevalonate Incorporation Into Cholesterol) having the following characteristics:(a) is present in the retentate of dialyzed skim milk;(b) is non-dialyzable;(c) has general properties of pyrimidines;(d) is bound to a protein in the proteose-peptone fration of milk;(e) is soluble in water;(f) is insoluble in organic solvents;(g) is stable in acid;(h) is not bound or retained by a C.sub.18 or C.sub.8 reverse phase HPLC columns;(i) is not retained by a C.sub.18 or silica gel sep. pak;(j) has .lambda. maximum absorbance at 208 nm and 278 nm (UV) in neutral ad acidic solution and in a basic solution at 223 and 290 nm;(k) provides peaks with a retention time of 7.52 minutes upon fractionation by HFLC on a Biorad Aminex resin column (30 cm .times.7.9 nm) with 0.05 NH.sub.2 SO.sub.4 as the mobile phase and with a flow rate of 0.7 ml/minute;(l) provides peaks with a retention time of 9.9 minutes upon fractionation on an HPLC Biorad Ag 50 Mx-8 resin column (22 mm.times.20 cm) with 0.035N formic acid as the mobil phase and a flow rate of 4 ml/minutes.(m) inhibits cholesterolgenesis by inhibiting mevalonate incorporation into cholesterol along the cholesterol biosynthetic pathway.IMIC can be employed in compositions of pharmaceutically acceptable dosages and, specifically, in a method of treating neoplastic disorders in mammals.
摘要翻译：本发明涉及具有以下特征的称为IMIC（Mevalonate Incorporated into Cholesterol）的新型抗肿瘤剂：（a）存在于透析脱脂乳的滞留物中; （b）不可透析; （c）具有嘧啶的一般性质; （d）与牛奶的蛋白胨蛋白胨中的蛋白质结合; （e）可溶于水; （f）不溶于有机溶剂; （g）在酸中稳定; （h）不被C18或C8反相HPLC柱结合或保留; （i）不被C18或硅胶sep保留。帕克（j）在中性酸性溶液中和在223和290nm的碱性溶液中在208nm和278nm（UV）下具有λ最大吸光度; （k）通过HFLC在具有0.05NH 2 SO 4作为流动相的Biorad Aminex树脂柱（30cm×7.9nm）上分离并以0.7ml /分钟的流速提供保留时间为7.52分钟的峰。（l）提供在具有0.035N甲酸作为移动相的HPLC Biorad Ag 50 Mx-8树脂柱（22mm×20cm）上分离时的保留时间为9.9分钟的峰，流速为4ml /分钟。（m）通过抑制胆固醇生物合成途径中的甲羟戊酸引入胆固醇来抑制胆固醇生成。 IMIC可以用于药学上可接受的剂量的组合物，具体地，用于治疗哺乳动物中的肿瘤性疾病的方法。

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