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1. 发明授权

US08323903B2 Antibody complexes and methods for immunolabeling 有权
标题翻译：抗体复合物和免疫标记方法
公开(公告)号：US08323903B2
公开(公告)日：2012-12-04
申请号：US10118204
申请日：2002-04-05
申请人： Robert A. Archer , Joseph M. Beechem , David C. Hagen , Richard P. Haugland , Rosaria P. Haugland
发明人： Robert A. Archer , Joseph M. Beechem , David C. Hagen , Richard P. Haugland , Rosaria P. Haugland
IPC分类号： G01N33/53
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y10/00 , G01N33/53 , G01N33/58 , G01N33/6857
摘要： The present invention provides novel immunolabeling complexes and certain components of such complexes, as well as methods of preparing and using such complexes, and kits for use in preparing labeling proteins and for immunolabeling. The pre-formed immunolabeling complexes of the invention comprise both a target-binding antibody and a labeling protein that contains covalently attached labels, where the labeling protein binds selectively and with high affinity to a selected region of the target-binding antibody. Novel labeling proteins of the invention include non-antibody peptides and proteins, such as a complex of protein G and a labeled albumin, and monovalent antibody fragments, such as labeled Fab fragments of an anti-Fc antibody. In methods of the invention, the preformed immunolabeling complexes are added to the sample alone or in combination, for purposes of labeling and optionally detecting the target of interest.
摘要翻译：本发明提供了新的免疫标记复合物和这些复合物的某些成分，以及制备和使用这些复合物的方法，以及用于制备标记蛋白和免疫标记的试剂盒。本发明的预先形成的免疫粘附复合物包含靶结合抗体和含有共价连接的标记的标记蛋白，其中所述标记蛋白选择性地结合并且与靶结合抗体的选定区域具有高亲和力。本发明的新型标记蛋白包括非抗体肽和蛋白质，例如蛋白G和标记的白蛋白的复合物，以及单价抗体片段，例如抗Fc抗体的标记的Fab片段。在本发明的方法中，为了标记和任选地检测目的靶标，将预先形成的免疫标记复合物单独或组合加入到样品中。

2. 发明授权

US4195024A Benzocycloheptapyrans, compositions, and method of treatment 失效
标题翻译：苯并环庚砜，组合物和治疗方法
公开(公告)号：US4195024A
公开(公告)日：1980-03-25
申请号：US7116
申请日：1979-01-29
申请人： Robert A. Archer , Moses W. McMillan
发明人： Robert A. Archer , Moses W. McMillan
IPC分类号： C07D311/94
CPC分类号： C07D311/94
摘要： Octahydro and hexahydrobenzo[b]cyclohepta[d]pyrans having the general formula ##STR1## wherein R.sup.1 is hydrogen or alkanoyl, R.sup.2 is alkyl or alkenyl, R.sup.3 is hydrogen or alkyl, and Z is a two carbon alkylene chain which is substituted or unsubstituted and saturated or unsaturated are provided. Pharmaceutical compositions containing such benzocycloheptapyrans, and a method of treating hypertension are disclosed.
摘要翻译：具有通式的八氢和六氢苯并[b]环庚三烯并[d]吡喃，其中R1是氢或烷酰基，R2是烷基或烯基，R3是氢或烷基，Z是被取代或未取代的二碳亚烷基链并提供饱和或不饱和的。公开了含有这样的苯并环庚酮的药物组合物和治疗高血压的方法。

3. 发明授权

US4087545A Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs 失效
标题翻译：六氢二苯并{8 b，d {9吡喃-9-酮作为止吐药
公开(公告)号：US4087545A
公开(公告)日：1978-05-02
申请号：US658437
申请日：1976-02-17
申请人： Robert A. Archer , Louis Lemberger
发明人： Robert A. Archer , Louis Lemberger
IPC分类号： C07D311/16 , C07D311/80 , C07D493/10 , A01N9/28 , A61K31/35
CPC分类号： C07D493/10 , C07D311/16 , C07D311/80
摘要： Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as antiemetic drugs.
摘要翻译：使用1-羟基-3-烷基-6,6a，7,8,10,10a-六氢-9H-二苯并[b，d]吡喃-9-酮作为止吐药。

4. 发明授权

US4075230A Preparation of optically active trans-hexahydrodibenzopyranones 失效
标题翻译：光学活性反式六氢二苯并吡喃酮的制备
公开(公告)号：US4075230A
公开(公告)日：1978-02-21
申请号：US740507
申请日：1976-11-10
申请人： Robert A. Archer , William A. Day
发明人： Robert A. Archer , William A. Day
IPC分类号： A61K31/352 , C07D311/80 , C07D311/78
CPC分类号： C07D311/80
摘要： Reaction of a 5-substituted resorcinol with optically active apoverbenone in the presence of aluminum chloride affords an optically active trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one.
摘要翻译：在氯化铝存在下，5-取代间苯二酚与光学活性阿扑巴醌的反应得到光学活性的反式-1-羟基-3-取代-6,6-二甲基-6,6a，7,8,10,10a-六氢 -9H-二苯并[b，d]吡喃-9-酮。

5. 发明授权

US4014028A Backfire bifilar helical antenna 失效
标题翻译：背鳍双鱼座天线
公开(公告)号：US4014028A
公开(公告)日：1977-03-22
申请号：US603429
申请日：1975-08-11
申请人： John A. Cone , Robert A. Archer , Edward R. Pacheco , Creath E. Peyton
发明人： John A. Cone , Robert A. Archer , Edward R. Pacheco , Creath E. Peyton
IPC分类号： H01Q11/08 , H01Q1/36
CPC分类号： H01Q11/08
摘要： A bifilar helical antenna which will radiate or receive in the backfire mode. The antenna consists of two interlaced helixes fed at the tip. Each helix is fed by a transmission line with energy of equal amplitude but 180.degree. out of phase. Optionally the helixes may be connected to a ground plane at the far end for mechanical stability. For the same reason an insulating right cylinder may be used to support the helixes. The two helixes have such a diameter and such a pitch or pitch distance that the currents flowing from their terminals to the far end are out of phase while the currents flowing in the reverse direction are in phase to provide a fast pseudo wave structure.

6. 发明授权

US3968125A Dihydroxyhexahydrodibenzo[b,d]pyrans 失效
标题翻译：二羟基六氢二苯并{8b，d {9 pyrans
公开(公告)号：US3968125A
公开(公告)日：1976-07-06
申请号：US413010
申请日：1973-11-05
申请人： Robert A. Archer
发明人： Robert A. Archer
IPC分类号： C07D311/74 , A61K31/35 , A61K31/352 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , C07D311/80 , C07D311/78 , C07D311/76
CPC分类号： C07D311/80
摘要： 1,9-Dihydroxy-3-alkyl-6a,7,8,9,10,10a-hexahydro-6H-dibenzo[b,d]pyrans, useful as hypotensive agents, as psychotropic drugs, particularly as anti-anxiety and/or antidepressant drugs, and as sedative and/or analgesic drugs.
摘要翻译：可用作低血压药物的1,9-二羟基-3-烷基-6a，7,8,9,10,10a-六氢-6H-二苯并[b，d]吡喃，作为精神药物，特别是抗焦虑和/ 或抗抑郁药物，以及镇静剂和/或镇痛药物。

7. 发明授权

US4208351A Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor 失效
标题翻译：六氢二苯并吡喃酮及其中间体的立体选择性制备
公开(公告)号：US4208351A
公开(公告)日：1980-06-17
申请号：US30783
申请日：1979-04-17
申请人： Robert A. Archer , William A. Day
发明人： Robert A. Archer , William A. Day
IPC分类号： C07D311/80 , C07C49/82
CPC分类号： C07C49/747 , C07C45/54 , C07D311/80
摘要： An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.
摘要翻译：使光学活性的4-（4-取代-2,6-二羟基苯基）-6,6-二甲基-2-降冰片酮与质子酸反应，得到顺式-1-羟基-3-取代-6 ，6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b，d]吡喃-9-酮。所述诺丁酮与路易斯酸的反应提供了反式-1-羟基-3-取代-6,6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b， d]吡喃-9-酮。通过5-取代的间苯二酚与光学活性的6,6-二甲基-2,4-二乙酰氧基-2-降冰片烯或光学活性的6,6-二甲基-2,2-二乙酰氧基 - 3-降冰片烯，这些化合物衍生自光学活性β-蒎烯。

8. 发明授权

US4176233A Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor 失效
公开(公告)号：US4176233A
公开(公告)日：1979-11-27
申请号：US898610
申请日：1978-04-21
申请人： Robert A. Archer , William A. Day
发明人： Robert A. Archer , William A. Day
IPC分类号： C07D311/80 , C07C69/16
CPC分类号： C07C69/013 , C07C45/54 , C07D311/80 , C07C2102/42
摘要： An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.

9. 发明授权

US4104282A Novel 3-(oxygenated alkyl)-1,9-dihydroxy and 1-hydroxy-9-keto dibenzo[b,d]p y 失效
标题翻译：新型3-（氧化烷基）-1,9-二羟基和1-羟基-9-酮二苯并{b，d {9
公开(公告)号：US4104282A
公开(公告)日：1978-08-01
申请号：US822467
申请日：1977-08-08
申请人： David S. Fukuda , Bernard J. Abbott , Robert A. Archer
发明人： David S. Fukuda , Bernard J. Abbott , Robert A. Archer
IPC分类号： A61K31/35 , A61K31/352 , A61P25/04 , C07D311/80 , C12P17/06 , C07D311/78
CPC分类号： C12P17/06 , C07D311/80 , Y10S435/822 , Y10S435/834 , Y10S435/886 , Y10S435/931
摘要： 1-Hydroxy-9-keto-3-alkyl-dibenzo[b,d]pyrans or 1,9-dihydroxy-3-alkyl-dibenzo[b,d]pyrans are oxygenated on the penultimate carbon of the alkyl side chain by fermentation with a strain of the micro-organism Bacillus cereus.
摘要翻译：通过发酵将1-羟基-9-酮-3-烷基 - 二苯并[b，d]吡喃或1,9-二羟基-3-烷基 - 二苯并[b，d]吡喃氧化在烷基侧链的倒数第二碳上具有微生物蜡样芽孢杆菌的菌株。

10. 发明授权

US4102902A Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor 失效
标题翻译：六氢二苯并吡喃酮及其中间体的立体选择性制备
公开(公告)号：US4102902A
公开(公告)日：1978-07-25
申请号：US740502
申请日：1976-11-10
申请人： Robert A. Archer , William A. Day
发明人： Robert A. Archer , William A. Day
IPC分类号： C07C69/12 , A61K31/352 , C07C45/00 , C07C49/747 , C07C67/00 , C07C69/14 , C07C69/16 , C07D311/80
CPC分类号： C07C49/747 , C07C45/54 , C07D311/80
摘要： An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.
摘要翻译：使光学活性的4-（4-取代-2,6-二羟基苯基）-6,6-二甲基-2-降冰片酮与质子酸反应，得到顺式-1-羟基-3-取代-6 ，6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b，d]吡喃-9-酮。所述诺丁酮与路易斯酸的反应提供了反式-1-羟基-3-取代-6,6-二甲基-6,6a，7,8,10,10a-六氢-9H-二苯并[b， d]吡喃-9-酮。通过5-取代的间苯二酚与光学活性的6,6-二甲基-2,4-二乙酰氧基-2-降冰片烯或光学活性的6,6-二甲基-2,2-二乙酰氧基 - 3-降冰片烯，这些化合物衍生自光学活性β-蒎烯。

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