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1. 发明授权

US09161714B2 Specificity of analyte detection in etalons 有权
标题翻译：标准具中分析物检测的特异性
公开(公告)号：US09161714B2
公开(公告)日：2015-10-20
申请号：US12195942
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： A61B5/00 , A61B5/1459 , A61B5/145 , G01N21/33 , G01N21/359
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。第一容器包括（i）光腔检测区域，（ii）用于一个或多个光腔检测区域的一个或多个光学特性的修改器的储存器，以及（iii）一组或多个边界区域，流体中的物体可以转移到容器中。光腔检测区域和储存器限定第一容器的分开的区域。储存器和光腔检测区域之间的一个或多个改性剂的运动响应于分析物浓度的变化。第二容器包括光学腔检测区域和一组一个或多个界限区域，流体中的物体可通过该区域传送到容器中。还提供了用于将光引导到第一和第二容器的光学腔检测区域中的光学部件。

2. 发明授权

US08040526B2 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US08040526B2
公开(公告)日：2011-10-18
申请号：US12968115
申请日：2010-12-14
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01B9/02
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

3. 发明授权

US07914735B2 Use of physical barriers to minimize evaporative heat losses 有权
标题翻译：使用物理障碍来减少蒸发热损失
公开(公告)号：US07914735B2
公开(公告)日：2011-03-29
申请号：US11037666
申请日：2005-01-18
申请人： Francisco E. Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory B. Anderson , Alan G. Bell , Richard H. Bruce
发明人： Francisco E. Torres , Michael Chabinyc , Scott Elrod , Eric Peeters , Gregory B. Anderson , Alan G. Bell , Richard H. Bruce
IPC分类号： G01N33/00
CPC分类号： G01N25/482 , G01K17/006
摘要： A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.
摘要翻译：检测系统包括检测装置和防蒸发装置。检测装置包括被配置为合并至少两个小液滴并且检测由液滴的合并产生的潜在瞬态信号的区域。防蒸发被配置为包围该区域并限制该区域的蒸发。一种用于检测信号的方法包括以下步骤：在滴合并区域内的检测装置上沉积潜在的反应性化学溶液滴; 将防蒸发装置放置在熔融合并区域上以形成围绕滴合并区域的密封; 合并潜在的活性化学溶液滴; 并且测量在合并溶液中发生的信号下降。

4. 发明授权

US07707413B2 Systems and methods for protecting private information in a mobile environment 失效
标题翻译：在移动环境中保护私人信息的系统和方法
公开(公告)号：US07707413B2
公开(公告)日：2010-04-27
申请号：US11004748
申请日：2004-12-02
申请人： Teresa F Lunt , Daniel H Greene , Philippe J Golle , Richard H Bruce , Jessica N Staddon
发明人： Teresa F Lunt , Daniel H Greene , Philippe J Golle , Richard H Bruce , Jessica N Staddon
IPC分类号： H04L9/32
CPC分类号： H04L63/0421 , H04L63/102
摘要： Techniques for protecting non-public information in a mobile environment are provided. A request for non-public information about users in a mobile environment is received. Privacy policies, non-public and optional public information about the users affected by the request are determined. An optional privacy impact indicator is determined based on how satisfying the request increases the current public information about the users. Crowds of users having similar attribute name/values are optionally determined. User and optional requestor privacy policies which associate threshold release criteria such minimum crowd size, minimum consideration with the non-public information are determined. A privacy agreement is reached for the disclosure of the requested non-public information based on the compatibility of the requester and user privacy policies. Privacy protecting transformations are optionally determined and applied to create crowds or groups associated with the requested attribute.
摘要翻译：提供了在移动环境中保护非公开信息的技术。接收到关于用户在移动环境中的非公开信息的请求。确定关于受请求影响的用户的隐私政策，非公开和可选的公开信息。可选的隐私影响指标是根据请求如何满足当前有关用户的公开信息来确定的。具有相似属性名称/值的用户群可以任选地确定。用户和可选择的请求者隐私策略，其将阈值释放标准与最小人群大小，最小考虑与非公开信息相关联。根据请求者和用户隐私政策的兼容性，达成了所要求的非公开信息披露的隐私协议。可选地确定并应用隐私保护转换以创建与所请求的属性相关联的人群或组。

5. 发明授权

US07545498B2 System and method for removing auto-fluorescence through the use of multiple detection channels 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：US07545498B2
公开(公告)日：2009-06-09
申请号：US11612228
申请日：2006-12-18
申请人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
发明人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.
摘要翻译：一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

6. 发明授权

US07473030B2 Thermal sensing 有权
标题翻译：热传感
公开(公告)号：US07473030B2
公开(公告)日：2009-01-06
申请号：US11167746
申请日：2005-06-27
申请人： Richard H. Bruce , Dirk De Bruyker , Francisco E. Torres , Michal V. Wolkin
发明人： Richard H. Bruce , Dirk De Bruyker , Francisco E. Torres , Michal V. Wolkin
IPC分类号： G01K17/00
CPC分类号： G01K7/30 , G01K17/00 , G01K17/006 , G01N25/482
摘要： In thermal sensing devices, such as for calorimetry, a support layer or central layer can have a thermometer element or other thermal sensor on one side and a thermally conductive structure or component on the other. The thermally conductive structure can conduct temperature or other thermal input signals laterally across the support layer or central layer. The temperature or signals can then be provided to the thermometer element, such as by thermal contact through the support layer. An electrically conducting, thermally isolating anti-coupling layer, such as of gold or chromium, can reduce capacitive coupling between the thermally conductive structure and the thermometer element or other thermal sensor.
摘要翻译：在诸如用于量热法的热感测装置中，支撑层或中心层可以在一侧具有温度计元件或其它热传感器，而在另一侧可以具有导热结构或部件。导热结构可以横跨支撑层或中心层横向传导温度或其他热输入信号。然后可以将温度或信号提供给温度计元件，例如通过通过支撑层的热接触。导电的，热隔离的抗耦合层（例如金或铬）可以减少导热结构和温度计元件或其它热传感器之间的电容耦合。

7. 发明申请

US20080313035A1 System and method for providing print advertisements 有权
标题翻译：提供打印广告的系统和方法
公开(公告)号：US20080313035A1
公开(公告)日：2008-12-18
申请号：US11818327
申请日：2007-06-13
申请人： Eric Peeters , Richard H. Bruce , Ana Arias , James (Bo) M.A. Begole , Ross Bringans , Celia Chow , Lawrence Lee , Lisa Fahey , Linda Jacobson , Marc Mosko , Susan (Susie) Mulhern , Nitin Parekh , David Weinerth
发明人： Eric Peeters , Richard H. Bruce , Ana Arias , James (Bo) M.A. Begole , Ross Bringans , Celia Chow , Lawrence Lee , Lisa Fahey , Linda Jacobson , Marc Mosko , Susan (Susie) Mulhern , Nitin Parekh , David Weinerth
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0239 , G06Q30/0251 , G06Q30/0275 , G06Q30/0277
摘要： A system and method for providing print advertisements is presented. A target audience is assembled from characteristics about readers. Advertising content is targeted to the target audience. The characteristics of the target audience are analyzed against the advertising content to identify potential advertisers. At least one of the potential advertisers is selected. At least one print advertisement for the selected advertiser is included on the document.
摘要翻译：提出了一种用于提供打印广告的系统和方法。目标受众是从读者的特点来组织的。广告内容针对目标受众。根据广告内容分析目标受众的特征，以识别潜在的广告客户。至少有一个潜在的广告客户被选中。所选择的广告商的至少一个打印广告包括在文档中。

8. 发明申请

US20080144009A1 SYSTEM AND METHOD FOR REMOVING AUTO-FLUORESCENCE THROUGH THE USE OF MULTIPLE DETECTION CHANNELS 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：US20080144009A1
公开(公告)日：2008-06-19
申请号：US11612228
申请日：2006-12-18
申请人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
发明人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/00
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.
摘要翻译：一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

9. 发明授权

US07305112B2 Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media 有权
标题翻译：将稀有细胞扫描仪图像坐标转换成显微镜坐标的方法，使用样品介质上的标线标记
公开(公告)号：US07305112B2
公开(公告)日：2007-12-04
申请号：US10740972
申请日：2003-12-19
申请人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic , Huangpin B. Hsieh , Richard A. Lerner
发明人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic , Huangpin B. Hsieh , Richard A. Lerner
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N15/1468 , G01N2015/0065 , G06K9/00134 , G06K9/32 , G06T7/73 , G06T2207/30024
摘要： Provided is a method for obtaining a position of an object. A slide which carries at least one object and has reticle marks arranged at positions which form substantially a right angle, is positioned in a slide holder of a first imaging system. A first coordinate space of the imaging system is defined, and coordinates of the reticle marks in the first coordinate space are designated. A second coordinate space of a second imaging system is defined, and the coordinates of the reticle marks in the second coordinate space is designated. Using the designated coordinates of the reticle marks of the first coordinate space, the coordinate conversion parameters are computed. Thereafter, coordinates of at least one object in the first coordinate space are designated, and the first coordinate space coordinates of the object are converted into unique coordinates in a second coordinate space, using the coordinate conversion parameters.
摘要翻译：提供了一种用于获得对象的位置的方法。携带至少一个物体并且具有布置在形成基本上直角的位置处的标线标记的滑块位于第一成像系统的滑动架中。定义成像系统的第一坐标空间，并且指定第一坐标空间中的标线标记的坐标。定义第二成像系统的第二坐标空间，并且指定第二坐标空间中的标线标记的坐标。使用第一坐标空间的标线标记的指定坐标，计算坐标转换参数。此后，指定第一坐标空间中的至少一个对象的坐标，并且使用坐标转换参数将对象的第一坐标空间坐标转换为第二坐标空间中的唯一坐标。

10. 发明授权

US5941501A Passively addressable cantilever valves 失效
标题翻译：被动寻址的悬臂阀
公开(公告)号：US5941501A
公开(公告)日：1999-08-24
申请号：US711338
申请日：1996-09-06
申请人： David K. Biegelsen , Patrick C. P. Cheung , Andrew A. Berlin , Warren B. Jackson , Lars-Erik Swartz , Raj B. Apte , Richard H. Bruce
发明人： David K. Biegelsen , Patrick C. P. Cheung , Andrew A. Berlin , Warren B. Jackson , Lars-Erik Swartz , Raj B. Apte , Richard H. Bruce
IPC分类号： G05D7/06 , B65G51/03 , F15C5/00 , F16K31/02 , G03G15/00
CPC分类号： F16K99/0001 , B65G51/03 , F15C5/00 , F16K31/02 , F16K99/0007 , F16K99/0051 , G03G15/6529 , F16K2099/0069 , F16K2099/0084
摘要： A bistable valve useful for paper handling applications is disclosed. The valve can be batch fabricated in two dimensional valve arrays, with each valve in the array being controlled by passive matrix addressing. Typically, each valve includes a valve housing an electrically conductive movable element such as cantilever beam, diaphragm or film. Valve action is provided by use of housing embedded switching electrodes for moving the movable element between an aperture blocking position and an aperture open position. To reduce unswitched movement when the switching electrode bias is reduced or not present, electrostatic or mechanical catches can be used.
摘要翻译：公开了一种用于纸张处理应用的双稳态阀。阀门可以批量制造在二维阀门阵列中，阵列中的每个阀门都被无源矩阵寻址控制。通常，每个阀包括容纳导电可移动元件（例如悬臂梁，隔膜或膜）的阀。通过使用壳体嵌入式开关电极来提供阀动作，用于在可动元件在孔径阻挡位置和开口位置之间移动。为了减少或不存在开关电极偏压时的非开关动作，可以使用静电或机械式捕捉。

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