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    • 1. 发明专利
    • Domestic adjustable fender
    • GB141482A
    • 1920-04-22
    • GB708019
    • 1919-03-21
    • RICHARD CROSBY COLLINS
    • A47G5/04
    • 141,482. Collins, R. C. March 21, 1919. Fenders and curbs; ashguards.-A fender, curb, or ash. guard consists of a front or main section 2 with side wings 3 pivoted to it. Preferably, each section consists of a sheet-metal frame with an open front filled with tiles 7 fitted in the turned-over edges 4, 5 of the frame. The frames are connected by pivot rods, with screw caps 12, which pass through eyepieces 10 at the ends of metal strips 9 in the edges 4, 5. The eye-pieces 10 may be formed integrally with the parts 4, 5. The pivot rods are enclosed in tubular distance-pieces 13. and the upper hinge joints are covered by ornaments 14. The tiles 7 are preferably backed by sheetmetal packing-pieces resembling trays, and the tiles and the trays are secured by turning in the vertical edges 8 of frames. Reference has been directed by the Comptroller to Specification 16850/86.
    • 6. 发明申请
    • Broadcast Television Distribution Services Architecture
    • 广播电视分配服务架构
    • US20090183216A1
    • 2009-07-16
    • US12262845
    • 2008-10-31
    • Richard Crosby
    • Richard Crosby
    • H04N7/173
    • H04N7/165H04H60/04H04N7/10H04N21/2187H04N21/2343H04N21/2402H04N21/64322H04N21/812H04N21/84
    • A system for the distribution of live broadcast television content includes an encoding apparatus receiving a live broadcast television feed. The encoding apparatus includes a circuit matching network, a digital signal processor, a metadata generator, an MPEG multiplexer, an IP encapsulator, and an IP router. A centralized management facility or network operations center (NOC) is connected to the encoding apparatus. The management facility includes a diagnostics management system (DMS), automatic signal correction circuitry and software, an advertising database, a client database, and an authentication server. A decoding apparatus at a service client side receives the signal and decodes the same for feed supply to the client. The decoding apparatus includes one or more Ethernet ports, a metadata generator, MPEG demultiplexer, audio/video circuits, and a circuit matching network.
    • 用于分发现场广播电视内容的系统包括接收直播电视馈送的编码装置。 编码装置包括电路匹配网络,数字信号处理器,元数据生成器,MPEG多路复用器,IP封装器和IP路由器。 集中管理设施或网络操作中心(NOC)连接到编码装置。 管理设施包括诊断管理系统(DMS),自动信号校正电路和软件,广告数据库,客户端数据库和认证服务器。 服务客户侧的解码装置接收信号并对其进行解码以供给客户机。 解码装置包括一个或多个以太网端口,元数据生成器,MPEG解复用器,音频/视频电路和电路匹配网络。
    • 7. 发明申请
    • BENZAZEPINE DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS
    • US20110124626A1
    • 2011-05-26
    • US13054688
    • 2009-07-17
    • Parminder Kaur PooniKevin John MerchantCatrina Morvern KerrStuart Richard CrosbyTomohiro OkawaMitsuru SasakiMika GotouGraham Andrew ShowellMartin Richard Teall
    • Parminder Kaur PooniKevin John MerchantCatrina Morvern KerrStuart Richard CrosbyTomohiro OkawaMitsuru SasakiMika GotouGraham Andrew ShowellMartin Richard Teall
    • A61K31/397C07D403/12A61K31/55C07D401/12C07D223/16C07D413/10C07D403/14A61P25/28
    • C07D403/12C07D223/16C07D401/06C07D401/12C07D401/14C07D405/12C07D405/14C07D409/12C07D409/14C07D413/12C07D417/12
    • A compound having the formula (1) wherein: R1 is a group selected from C3-8 cycloalkyl, C1-6 alkyl, C1-6 alkylene-C3-8 cycloalkyl, each of which groups may optionally be substituted with C1-6 alkyl, halogen, haloC1-6 alkyl or OR15, or R1 is heterocyclyl, optionally substituted with C1-6 alkyl, haloC1-6 alkyl or OR15; n is 0, 1, 2, 3 or 4, the alkylene group —(CH2)m— formed thereby being optionally substituted with a group selected from C1-4 alkyl, C3-8 cycloalkyl and arylsulfonyl; A is a group selected from —N(R2)CO—, —CON(R2)-, —OC(O)—, —C(O)O—, —CO—, —C(R2)(OR3)-, —C(═N—O—R3)-, —C(═CR2R3)-, —C3-8 cycloalkylene-, —C(R2)(haloC1-6alkyl)-, C1-4 alkylene and —C(OR3)(haloC1-6alkyl)-; R2 and R3 are each independently selected from H, C1-6 alkyl, and C3-8 cycloalkyl, or, when A is —N(R2)CO— and X is absent, R2 may form, together with the adjacent nitrogen atom and Z, an N-containing heterocyclyl group, which may optionally be substituted; X is absent or is C14 alkylene or C24 alkenylene, each of which may optionally be substituted with one or more C1-4 alkyl groups, OR16, halogen or haloC1-6 alkyl; Z is selected from aryl, heteroaryl, C3-8 cycloalkyl, and heterocyclyl, each of which may optionally be substituted by a group selected from —Y-aryl, heteroaryl, —Y—C3-8 cycloalkyl and —Y-heterocyclyl, or, when X is present, Z may be H, or, when X is absent and A is —C(R2)(OR3)- or —N(R2)CO—, Z may be H, or, when A is —N(R2)CO— and X is absent, Z may form, together with the adjacent nitrogen atom and R2, an N-containing heterocyclyl group which may optionally be substituted, wherein, when A is —CO—, Z is linked to X or A via a carbon atom and wherein, when A is —N(R2)CO— and Z is H, R1 is C3-8 cycloalkyl; and Y represents a bond, C1-6 alkylene, CO, NR14, COC2-6 alkenylene, O, SO2 or NHCOC1-6 alkylene; wherein said cycloalkyl, aryl, heteroaryl and heterocyclyl groups Z may be optionally substituted by one or more substituents which may be the same or different, and which are selected from halogen, haloC1-6 alkyl, hydroxy, cyano, nitro, ═O, —R4, —CO2R4, —COR4, —NR5R6, —C1-6 alkyl-NR5R6, —C3-8 cycloalkyl-NR5R6, —CONR12R13, —NR12COR13, —NR5SO2R6, —OCONR5R6, —NR5CO2R6, —NR4CONR5R6 or —SO2NR5R6-SHR8, -alkyl-OR8, —SOR8, —OR9, —SO2R9, —OSO2R9, -alkyl-SO2R9, -alkyl-CONHR9, -alkyl-SONHR9, -alkyl-COR10, —CO-alkyl-R10, —O-alkyl-R11 (wherein R4, R5 and R6 independently represent hydrogen, C1-6 alkyl, —C3-8 cycloalkyl, —C1-6 alkylene-C3-8 cycloalkyl, aryl, heterocyclyl or heteroaryl, wherein R8 represents C1-6 alkyl, wherein R9 represents C1-6 alkyl or aryl, wherein R10 represents aryl, wherein R11 represents C3-8 cycloalkyl or aryl, R12, R13, R14, R15 and R16 each independently represent H or C1-6 alkyl, and wherein —NR5R6 and —NR12R13 may represent a nitrogen containing heterocyclyl group); wherein said R4, R5, R6 R8, R9, R11 and R11 groups may be optionally substituted by one or more substituents which may be the same or different, and which are selected from the group consisting of halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, cyano, amino, ═O or trifluoromethyl; and wherein substituents of Z selected from —Y-aryl, —Y-heteroaryl, —Y—C3-8cycloalkyl and —Y-heterocyclyl may be optionally substituted by one or more substituents selected from ═O, hydroxy, cyano, nitro, halogen, haloC1-6 alkyl and C1-6alkyl; and wherein, when A is C1-4 alkylene, said cycloalkyl, aryl, heteroaryl or heterocyclyl group Z (such as a heterocyclyl group Z) is substituted at least with hydroxy, CF3, or ═O; and wherein, when A is CON(R2) n is 1; or a pharmaceutically acceptable salt or ester thereof, provided that: when A is —CO—, R1 is CH3, C3-8 cycloalkyl-substituted C1-6 alkylene or n-butyl, n is 0 and X is —CH2CH2—, Z is not N-benzyl substituted 4-piperidinyl, N-(3-fluorobenzyl)-substituted 4-piperidinyl or N-acetyl substituted 4-piperidinyl; when A is —OC(O)—, R1 is cyclobutyl, n is 0 and X is —CH2CH2—, Z is not H; when A is —OC(O)—, R1 is n-propyl, n is 0 and X is —CH2—, Z is not H; and when A is —CO—, R1 is CH3, n is 0 and X is CH2, Z is not H.