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1. 发明申请

US20080243284A1 ANATOMICALLY COMPLIANT AAA MODEL AND THE METHOD OF MANUFACTURE FOR IN VITRO SIMULATED DEVICE TESTING 审中-公开
标题翻译：独立的AAA模型和用于体外模拟设备测试的制造方法
公开(公告)号：US20080243284A1
公开(公告)日：2008-10-02
申请号：US11692615
申请日：2007-03-28
申请人： Randy-David Burce Grishaber , Daniel Olsen
发明人： Randy-David Burce Grishaber , Daniel Olsen
IPC分类号： G06F19/00
CPC分类号： G01N3/32 , B33Y80/00 , G01N2203/0073 , G01N2203/0298 , G09B23/30
摘要： The present invention is directed to the fabrication of a test apparatus and the test apparatus itself. The test apparatus is designed to be a component used in a durability/fatigue testing unit.
摘要翻译：本发明涉及一种测试设备和测试设备本身的制造。测试装置被设计为用于耐久/疲劳测试单元中的部件。

2. 发明申请

US20070168066A1 AAA model for fatigue testing 审中-公开
标题翻译： AAA型疲劳试验
公开(公告)号：US20070168066A1
公开(公告)日：2007-07-19
申请号：US11334680
申请日：2006-01-18
申请人： Randy-David Burce Grishaber , Daniel Olsen
发明人： Randy-David Burce Grishaber , Daniel Olsen
IPC分类号： G06F19/00
CPC分类号： G09B23/10 , B33Y70/00 , B33Y80/00 , G09B23/30
摘要： The present invention is directed to the fabrication of a test apparatus and the test apparatus itself. The test apparatus is designed to be a component used in a durability/fatigue testing unit. One such test apparatus made in accordance with the present invention is a life-size model of an Abdominal Aortic Aneurysm made with any rapid prototyping process that creates solid freeform parts with flexible material. A preferred rapid prototyping process used to make the AAA model in accordance with the present invention is the process known as selective laser sintering (SLS), while the preferred material used in said process is an elastomeric polymer.
摘要翻译：本发明涉及一种测试设备和测试设备本身的制造。测试装置被设计为用于耐久/疲劳测试单元中的部件。根据本发明制造的一种这样的测试装置是通过用柔性材料产生固体自由形成部分的任何快速成型工艺制成的腹主动脉瘤的寿命模型。用于制造根据本发明的AAA模型的优选快速成型方法是称为选择性激光烧结（SLS）的方法，而在所述方法中使用的优选材料是弹性体聚合物。

3. 发明申请

US20080132994A1 Geometry and non-metallic material for high strength, high flexibility, controlled recoil stent 审中-公开
标题翻译：几何和非金属材料高强度，高柔韧性，可控反冲支架
公开(公告)号：US20080132994A1
公开(公告)日：2008-06-05
申请号：US10961127
申请日：2004-10-08
申请人： Robert Burgermeister , Vipul Dave , Randy-David Burce Grishaber
发明人： Robert Burgermeister , Vipul Dave , Randy-David Burce Grishaber
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2230/0013 , A61L31/022 , A61L31/04 , A61L31/042 , A61L31/043 , A61L31/14
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. The biocompatible material may comprise metallic and non-metallic materials. These materials may be designed with a microstructure that facilitates or enables the design of devices with a wide range of geometries adaptable to various loading conditions.
摘要翻译：生物相容性材料可以配置成任何数量的可植入医疗装置，包括腔内支架。生物相容性材料可以包括金属和非金属材料。这些材料可以被设计成具有微结构，其有助于或使得能够设计具有适用于各种加载条件的宽范围几何形状的装置。

4. 发明授权

US08834562B2 Patent foramen ovale closure device with steerable delivery system 有权
标题翻译：专利卵圆孔闭合装置，具有可转向的输送系统
公开(公告)号：US08834562B2
公开(公告)日：2014-09-16
申请号：US11483240
申请日：2006-07-07
申请人： Chao Chin-Chen , Randy David Burce Grishaber , Gene W. Kammerer , Issac John Khan , Jin Park , Daniel Olsen , Rudolph Cedro
发明人： Chao Chin-Chen , Randy David Burce Grishaber , Gene W. Kammerer , Issac John Khan , Jin Park , Daniel Olsen , Rudolph Cedro
IPC分类号： A61F2/24 , A61B17/00 , A61B17/06 , A61B17/04
CPC分类号： A61B17/0057 , A61B2017/003 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/0409 , A61B2017/0419 , A61B2017/06052
摘要： The present invention relates to a delivery system for delivering a device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The delivery system has an elongate member having a proximal and distal end. A deflectable needle assembly having luminal and abluminal surfaces is slideably engaged within the elongate member. An actuator is slideabley engaged within the elongate member and attached to the needle tip assembly such that translational movement of the actuator causes deflection of the deflectable needle assembly.
摘要翻译：本发明涉及一种用于递送用于封闭体内通道的装置的递送系统，例如心脏中的卵孔卵泡（PFO）。递送系统具有具有近端和远端的细长构件。具有管腔和外侧表面的可偏转针组件可滑动地接合在细长构件内。致动器可滑动地接合在细长构件内并附接到针尖组件，使得致动器的平移运动导致可偏转针组件的偏转。

5. 发明授权

US08579933B2 Patent foramen ovale closure device 有权
标题翻译：卵圆孔闭合装置
公开(公告)号：US08579933B2
公开(公告)日：2013-11-12
申请号：US11446477
申请日：2006-06-02
申请人： Chao Chin-Chen , Randy David Burce Grishaber , Gene W. Kammerer , Issac John Khan , Jin Park , Daniel Olsen
发明人： Chao Chin-Chen , Randy David Burce Grishaber , Gene W. Kammerer , Issac John Khan , Jin Park , Daniel Olsen
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/00867 , A61B2017/0409 , A61B2017/0419
摘要： A device for deploying a mechanical closure device for closing a passageway in a body, for example a patent foramen ovale (PFO) in a heart. The deployment device has a first tubular structure having proximal and distal ends. A second tubular structure is substantially coaxial to and slideably engaged within the first tubular structure. The second tubular structure has a first substantially linear shape when constrained within the first tubular structure, and a second curvilinear shape when telescopically extended from the distal end of the first tubular structure. A third tubular structure is substantially coaxial to and slideably engaged within the second tubular structure. The third tubular structure is configured to provide sufficient rigidity to push the mechanical closure device from the distal end of the second tubular structure, and provide sufficient flexibility to assume a curvilinear shape when deflected by the second tubular structure.
摘要翻译：用于部署用于封闭身体中的通道的机械闭合装置的装置，例如心脏中的卵孔卵泡（PFO）。展开装置具有第一管状结构，其具有近端和远端。第二管状结构与第一管状结构基本同轴并可滑动地接合。第二管状结构当被限制在第一管状结构内时具有第一基本线性形状，以及当从第一管状结构的远端可伸缩地延伸时的第二曲线形状。第三管状结构基本上与第二管状结构同轴并可滑动地接合。第三管状结构被构造成提供足够的刚度以从第二管状结构的远端推动机械闭合装置，并且当由第二管状结构偏转时提供足够的柔性以呈现曲线形状。

6. 发明申请

US20080047356A1 SYSTEMS AND METHODS FOR FATIGUE TESTING STENTS 失效
标题翻译：用于疲劳试验的系统和方法
公开(公告)号：US20080047356A1
公开(公告)日：2008-02-28
申请号：US11511096
申请日：2006-08-28
申请人： Erin Black , Robert Burgermeister , Randy-David Burce Grishaber , David W. Overaker
发明人： Erin Black , Robert Burgermeister , Randy-David Burce Grishaber , David W. Overaker
IPC分类号： G01N3/32
CPC分类号： G01N3/32 , A61F2/82 , G01N2203/0005 , G01N2203/0073 , G01N2203/0266
摘要： Systems and methods for fatigue testing one or more stents based on measured electrical resistance levels of each stent. Pairs of lead lines from an ohmmeter are connected to a respective stent. The respective stent is mounted onto an expander having an interior tapered portion into which a correspondingly tapered expansion pin is received. Cyclic loading strains are applied to the respective stent as an expansion pin is inserted into a corresponding one of the expanders. Stent fracture or failure occurs when cyclic loading exceeds the stents architectural and material capacity. Such fracture fatigue or failure is identified by increased electrical resistance levels. Resistance may be continuously monitored to more readily identify the onset of fatigue or failure. The expansion pins extend from a movable plate, and the expanders comprise a part of corresponding stations that extend from a fixed plate.
摘要翻译：基于每个支架的测量电阻水平疲劳测试一个或多个支架的系统和方法。来自欧姆表的一对引线连接到相应的支架。相应的支架安装在具有内锥形部分的膨胀机上，相应的锥形膨胀销被容纳在该内锥形部分中。当将膨胀销插入对应的一个膨胀机时，将循环负荷应变施加到相应的支架上。当循环加载超过支架的建筑和材料能力时，发生支架断裂或破裂。这种断裂疲劳或故障是通过增加的电阻水平来确定的。可以连续监测电阻以更容易地识别疲劳或失效的发作。膨胀销从可移动板延伸，并且膨胀器包括从固定板延伸的相应工位的一部分。

7. 发明授权

US07363821B2 Systems and methods for fatigue testing stents 失效
标题翻译：疲劳测试支架的系统和方法
公开(公告)号：US07363821B2
公开(公告)日：2008-04-29
申请号：US11511096
申请日：2006-08-28
申请人： Erin Black , Robert Burgermeister , Randy-David Burce Grishaber , David W. Overaker
发明人： Erin Black , Robert Burgermeister , Randy-David Burce Grishaber , David W. Overaker
IPC分类号： G01N3/32
CPC分类号： G01N3/32 , A61F2/82 , G01N2203/0005 , G01N2203/0073 , G01N2203/0266
摘要： Systems and methods for fatigue testing one or more stents based on measured electrical resistance levels of each stent. Pairs of lead lines from an ohmmeter are connected to a respective stent. The respective stent is mounted onto an expander having an interior tapered portion into which a correspondingly tapered expansion pin is received. Cyclic loading strains are applied to the respective stent as an expansion pin is inserted into a corresponding one of the expanders. Stent fracture or failure occurs when cyclic loading exceeds the stents architectural and material capacity. Such fracture fatigue or failure is identified by increased electrical resistance levels. Resistance may be continuously monitored to more readily identify the onset of fatigue or failure. The expansion pins extend from a movable plate, and the expanders comprise a part of corresponding stations that extend from a fixed plate.
摘要翻译：基于每个支架的测量电阻水平疲劳测试一个或多个支架的系统和方法。来自欧姆表的一对引线连接到相应的支架。相应的支架安装在具有内锥形部分的膨胀机上，相应的锥形膨胀销被容纳在该内锥形部分中。当将膨胀销插入对应的一个膨胀机时，将循环负荷应变施加到相应的支架上。当循环加载超过支架的建筑和材料能力时，发生支架断裂或破裂。这种断裂疲劳或故障是通过增加的电阻水平来确定的。可以连续监测电阻以更容易地识别疲劳或失效的发作。膨胀销从可移动板延伸，并且膨胀器包括从固定板延伸的相应工位的一部分。

8. 发明申请

US20060100692A1 Cobalt-chromium-molybdenum fatigue resistant alloy for intravascular medical devices 审中-公开
标题翻译：用于血管内医疗器械的钴铬钼耐疲劳合金
公开(公告)号：US20060100692A1
公开(公告)日：2006-05-11
申请号：US10984213
申请日：2004-11-09
申请人： Robert Burgermeister , Vipul Dave , Randy-David Burce Grishaber
发明人： Robert Burgermeister , Vipul Dave , Randy-David Burce Grishaber
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61L27/045 , C22C19/07
摘要： A solid-solution alloy may be formed into any number of implantable medical devices such as intraluminal scaffolds. The biocompatible, solid-solution alloy comprises a combination of elements in specific ratios that improve its fatigue resistance while retaining the characteristics required for intraluminal scaffolds. The biocompatible, solid-solution alloy is an essentially carbon free cobalt-chromium-molydenum metallic material.
摘要翻译：固溶体合金可以形成任何数量的可植入医疗装置，例如管腔内支架。生物相容的固溶体合金包括特定比例的元素的组合，其在保持管腔内支架所需的特性的同时提高其抗疲劳性。生物相容的固溶体合金是一种基本上不含碳的钴铬钼钼金属材料。

9. 发明申请

US20050273156A1 Biocompatible alloy for implantable medical devices 审中-公开
标题翻译：用于可植入医疗器械的生物相容性合金
公开(公告)号：US20050273156A1
公开(公告)日：2005-12-08
申请号：US10862246
申请日：2004-06-07
申请人： Rober Burgermeister , Randy-David Burce Grishaber
发明人： Rober Burgermeister , Randy-David Burce Grishaber
IPC分类号： A61L31/00 , A61F2/06 , A61F2/30 , A61F2/84 , A61L27/04 , A61L31/02 , A61M29/02
CPC分类号： A61L27/047 , A61L31/022
摘要： A biocompatible solid-solution alloy may be formed into any number of implantable medical devices. The solid-solution alloy comprises a combination of elements in specific ratios that make it magnetic resonance imaging compatible while retaining the characteristics required for implantable medical devices. The biocompatible solid-solution alloy is a Cobalt-Chromium alloy having substantially reduced Iron, Silicon, Phosphorous and Sulfur content.
摘要翻译：生物相容的固溶体合金可以形成任意数量的可植入医疗装置。固溶体合金包括特定比例的元件的组合，使得磁共振成像兼容，同时保持可植入医疗装置所需的特性。生物相容性固溶体合金是钴，铬，磷和硫含量大大降低的钴铬合金。

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