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1. 发明申请

US20190163876A1 Kiosk Dispenser Interactive Original Order Entry Software Application 审中-公开
公开(公告)号：US20190163876A1
公开(公告)日：2019-05-30
申请号：US14830353
申请日：2015-08-19
申请人： Randall Nelson Remme , Kevin Cyril Anstey , Peter Matthew Tyson
发明人： Randall Nelson Remme , Kevin Cyril Anstey , Peter Matthew Tyson
IPC分类号： G06F19/00 , G06Q30/06 , G06Q50/22 , B65C9/00 , B65C9/26
摘要： A control center receives an order from a patient's smart phone to fill a new prescription prescribed by a doctor to a patient, along with a selection of one drug dispensing kiosk. A remotely located pharmacist video teleconferences with the patient via the patient's smart phone to provide counseling about the prescribed pharmaceutical. The patient goes to the drug dispensing kiosk where the patient inputs information that is communicated to the control center. In response to the patient's input, the remotely located pharmacist initiates a transmission to the control center. In response to receiving input from the remotely located pharmacist, the control center communicates an order to dispense the new prescription to the patient from the drug dispensing kiosk such that the order to dispense the new prescription to the patient from the drug dispensing kiosk is initiated by a human so as to be as a subjective dispensing decision.

2. 发明申请

US20070128734A1 METHOD AND APPARATUS FOR MASS SPECTROMETRIC IMMUNOASSAY ANALYSIS OF SPECIFIC BIOLOGICAL FLUID PROTEINS 审中-公开
标题翻译：特异性生物流体蛋白质质谱免疫分析方法与装置
公开(公告)号：US20070128734A1
公开(公告)日：2007-06-07
申请号：US11671576
申请日：2007-02-06
申请人： Urban Kiernan , Eric Niederkofler , Kemmons Tubbs , Dobrin Nedelkov , Randall Nelson
发明人： Urban Kiernan , Eric Niederkofler , Kemmons Tubbs , Dobrin Nedelkov , Randall Nelson
IPC分类号： G01N33/543
CPC分类号： G01N33/6803
摘要： Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to working curves constructed from samples containing known concentrations of the protein or variants.
摘要翻译：本文介绍的是存在于复杂生物液体或提取物中的蛋白质及其变体的质谱法免疫测定（MSIA）的方法，装置和试剂盒。蛋白质和变体水平可以使用定量方法来确定，其中蛋白质/变体信号被归一化为内部参考标准物质的信号（在MSIA分析前掺入样品或与靶蛋白共提取的其它内源性蛋白质）并且与从含有已知浓度的蛋白质或变体的样品构建的工作曲线相比较的值。

3. 发明申请

US20070042426A1 Biomarkers and assays for myocardial infarction 审中-公开
标题翻译：生物标志物和心肌梗塞测定
公开(公告)号：US20070042426A1
公开(公告)日：2007-02-22
申请号：US11343625
申请日：2006-01-30
申请人： Urban Kiernan , Dobrin Nedelkov , Randall Nelson
发明人： Urban Kiernan , Dobrin Nedelkov , Randall Nelson
IPC分类号： G01N33/53 , G01N33/50
CPC分类号： G01N33/6893 , G01N2800/324
摘要： Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of myocardial infarction (MI). A multiplexed, mass spectrometric immunoassay (MSIA) able to simultaneously assay for the new/novel biomarkers as well other MI markers is also presented. Means and methods for evaluating data generated using multiple biomarkers in order to validate findings and further the use of the multiplexed MI assay in clinical, diagnostic and therapeuatic uses is also included.
摘要翻译：本文提出的是与心血管疾病相关的新型血浆/血清生物标志物。这些新确定的生物标志物使用传统的生物测定技术为多次（单次）测定创造了基础，并且当组合使用时，在确定心肌梗死（MI）时产生特殊的临床敏感性和特异性。还提供了能够同时测定新的/新的生物标志物以及其他MI标记物的多功能质谱免疫测定（MSIA）。还包括用于评估使用多种生物标志物产生的数据的方法和方法，以验证发现和进一步使用多种MI测定在临床，诊断和治疗用途。

4. 发明申请

US20120198000A1 WEB-BASED GROUPWARE SYSTEM 有权
标题翻译：基于WEB的组织系统
公开(公告)号：US20120198000A1
公开(公告)日：2012-08-02
申请号：US13441548
申请日：2012-04-06
申请人： Gerald William Smith , Charles Edward Tatham , Randall Nelson Remme
发明人： Gerald William Smith , Charles Edward Tatham , Randall Nelson Remme
IPC分类号： G06F15/16
CPC分类号： G06Q10/10 , H04L29/06 , H04L67/02 , H04L67/2819 , H04L67/2842 , H04L67/36 , H04L67/42 , H04L69/329
摘要： The present invention relates to a system and method for providing a communication network. The system comprises a network-connected server having input and access capabilities, a site builder, a transmitter, a communicator, and memory. The site-builder receives instructions input from a first user and creates a dedicated network site based on the received instructions. The transmitter communicates the existence of the dedicated network site to a nominated second user. The communicator provides accesses to the contents of the dedicated network site by the first and second users. The memory stores information input by the first and the second user in the dedicated network site.
摘要翻译：本发明涉及一种用于提供通信网络的系统和方法。该系统包括具有输入和访问能力的网络连接服务器，站点构建器，发射器，通信器和存储器。站点构建器接收从第一用户输入的指令，并基于接收到的指令创建专用网站。发射机将专用网络的存在与指定的第二用户进行通信。通信器由第一和第二用户提供对专用网站的内容的访问。存储器存储由专用网站中的第一和第二用户输入的信息。

5. 发明授权

US08176122B2 Web-based groupware system 有权
标题翻译：基于Web的组件系统
公开(公告)号：US08176122B2
公开(公告)日：2012-05-08
申请号：US12768387
申请日：2010-04-27
申请人： Gerald William Smith , Charles Edward Tatham , Randall Nelson Remme
发明人： Gerald William Smith , Charles Edward Tatham , Randall Nelson Remme
IPC分类号： G06F15/16
CPC分类号： G06Q10/10 , H04L29/06 , H04L67/02 , H04L67/2819 , H04L67/2842 , H04L67/36 , H04L67/42 , H04L69/329
摘要： The present invention relates to a system and method for providing a communication network. The system comprises a network-connected server having input and access capabilities, a site builder, a transmitter, a communicator, and memory. The site-builder receives instructions input from a first user and creates a dedicated network site based on the received instructions. The transmitter communicates the existence of the dedicated network site to a nominated second user. The communicator provides accesses to the contents of the dedicated network site by the first and second users. The memory stores information input by the first and the second user in the dedicated network site.
摘要翻译：本发明涉及一种用于提供通信网络的系统和方法。该系统包括具有输入和访问能力的网络连接服务器，站点构建器，发射器，通信器和存储器。站点构建器接收从第一用户输入的指令，并基于接收到的指令创建专用网站。发射机将专用网络的存在与指定的第二用户进行通信。通信器由第一和第二用户提供对专用网站的内容的访问。存储器存储由专用网站中的第一和第二用户输入的信息。

6. 发明申请

US20080064044A9 Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods 审中-公开
标题翻译：通过使用基于亲和力的质谱法分析来自生物液体的胰岛素样生长因子
公开(公告)号：US20080064044A9
公开(公告)日：2008-03-13
申请号：US10756100
申请日：2004-01-12
申请人： Randall Nelson , Dobrin Nedelkov , Urban Kiernan , Kemmons Tubbs
发明人： Randall Nelson , Dobrin Nedelkov , Urban Kiernan , Kemmons Tubbs
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/54373 , G01N33/6851 , G01N2333/475
摘要： Presented herein are affinity-based mass spectrometric methods and assays for analysis of insulin like growth factors 1 and 2 (IGF-1 and IGF-2) present in complex biological mixtures and fluids. IGF-1 and IGF-2 were assayed from human plasma via BIA/MS, utilizing antibodies as ligands for affinity retrieval. Detection of both targeted and non-targeted IGFs in the mass spectra indicated possible protein complex retrieval by the individual antibodies. Plasma samples were investigated under variable denaturing conditions to confirm the detection of both free and bound IGFs. In a MSIA approach to IGF detection, pipettor tips containing porous solid supports covalently derivatized with anti-IGF antibodies were used to extract specific IGFs from plasma in preparation for mass spectrometry. Single or multiplex IGF-1 and IGF-2 assays were performed, resulting in detection of wild-type IGF-1 and 2, and a truncated IGF-2 variant, missing its N-terminal Alanine (also detected in the BIA/MS experiments). IGF-1 was quantified from several individuals via the use of internal reference standard species (rat IGF-1, doped into the samples prior to the MSIA analysis) and a working curve constructed from samples containing known concentrations of IGF-1.
摘要翻译：本文提出了基于亲和力的质谱法和用于分析复合生物混合物和流体中存在的胰岛素样生长因子1和2（IGF-1和IGF-2）的分析方法。通过BIA / MS从人血浆中检测IGF-1和IGF-2，利用抗体作为亲和力检索的配体。在质谱中检测靶向和非靶向IGFs表明可能的单个抗体的蛋白质复合物检索。在可变变性条件下研究血浆样品，以确认游离和结合的IGF的检测。在用于IGF检测的MSIA方法中，使用含有用抗IGF抗体共价衍生的多孔固体支持物的移液器尖端来提取来自血浆的特异性IGF，以进行质谱分析。进行单次或多重IGF-1和IGF-2测定，导致野生型IGF-1和2以及截短的IGF-2变体的检测，缺失其N-末端丙氨酸（也在BIA / MS实验中检测到）。通过使用内部参考标准物质（大鼠IGF-1，在MSIA分析之前掺入样品中）从几个个体定量IGF-1和从含有已知浓度的IGF-1的样品构建的工作曲线。

7. 发明申请

US20070259447A1 METHOD AND APPARATUS FOR MASS SPECTROMETRIC IMMUNOASSAY ANALYSIS OF SPECIFIC BIOLOGICAL FLUID PROTEINS 审中-公开
公开(公告)号：US20070259447A1
公开(公告)日：2007-11-08
申请号：US11694180
申请日：2007-03-30
申请人： Urban Kiernan , Eric Niederkofler , Kemmons Tubbs , Dobrin Nedelkov , Randall Nelson
发明人： Urban Kiernan , Eric Niederkofler , Kemmons Tubbs , Dobrin Nedelkov , Randall Nelson
IPC分类号： G01N33/566
CPC分类号： G01N33/6803
摘要： Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to working curves constructed from samples containing known concentrations of the protein or variants.

8. 发明申请

US20070133604A1 Virtual network adapter for automatically maximizing frame sizes and avoiding physical network IP fragmentation 审中-公开
标题翻译：用于自动最大化帧大小并避免物理网络IP碎片的虚拟网络适配器
公开(公告)号：US20070133604A1
公开(公告)日：2007-06-14
申请号：US11297306
申请日：2005-12-08
申请人： Randall Nelson , Eric Thiemann
发明人： Randall Nelson , Eric Thiemann
IPC分类号： H04J3/16
CPC分类号： H04L47/10 , H04L47/365 , H04L69/16 , H04L69/166
摘要： A method, virtual network adapter and computer program product are provided for automatically maximizing frame sizes and avoiding physical network Internet Protocol (IP) fragmentation. A maximum frame size of a selected physical adapter is identified. A frame size for the virtual adapter is calculated using the identified maximum frame size of the selected physical adapter. The calculated frame size of the virtual adapter is reported to an operating system.
摘要翻译：提供了一种方法，虚拟网络适配器和计算机程序产品，用于自动最大化帧大小并避免物理网络Internet协议（IP）碎片。识别所选物理适配器的最大帧大小。使用所选物理适配器的已识别的最大帧大小计算虚拟适配器的帧大小。将虚拟适配器的计算帧大小报告给操作系统。

9. 发明申请

US20060253106A1 Implantable reservoir and system for delivery of a therapeutic agent 审中-公开
公开(公告)号：US20060253106A1
公开(公告)日：2006-11-09
申请号：US11430530
申请日：2006-05-09
申请人： Randall Nelson , Charles Truwit
发明人： Randall Nelson , Charles Truwit
IPC分类号： A61K9/22
CPC分类号： A61M5/14276 , A61M5/14236 , A61M5/14586 , A61M5/148 , A61M5/16881 , A61M5/1723 , A61M2205/3507 , A61M2205/3523 , A61M2210/0687 , A61M2210/0693
摘要： There is disclosed method and apparatus for retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, including providing a deformable pouch or rigid cylinder for dispensing the therapeutic agent from the reservoir to a location in the body of the subject. In one embodiment, a pump is used to pump the agent from the reservoir to the location in the subject's body. In another example embodiment, there is provided method and apparatus for forming at least one cavity in the cranium of the subject, and placing at least a portion of the pump in the cavity. Power is applied to the pump in a variety of ways.

10. 发明申请

US20050032116A1 Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods 审中-公开
标题翻译：通过使用基于亲和力的质谱法分析来自生物液体的胰岛素样生长因子
公开(公告)号：US20050032116A1
公开(公告)日：2005-02-10
申请号：US10756100
申请日：2004-01-12
申请人： Randall Nelson , Dobrin Nedelkov , Urban Kiernan , Kemmons Tubbs
发明人： Randall Nelson , Dobrin Nedelkov , Urban Kiernan , Kemmons Tubbs
IPC分类号： C12M1/34 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54373 , G01N33/6851 , G01N2333/475
摘要： Presented herein are affinity-based mass spectrometric methods and assays for analysis of insulin like growth factors 1 and 2 (IGF-1 and IGF-2) present in complex biological mixtures and fluids. IGF-1 and IGF-2 were assayed from human plasma via BIA/MS, utilizing antibodies as ligands for affinity retrieval. Detection of both targeted and non-targeted IGFs in the mass spectra indicated possible protein complex retrieval by the individual antibodies. Plasma samples were investigated under variable denaturing conditions to confirm the detection of both free and bound IGFs. In a MSIA approach to IGF detection, pipettor tips containing porous solid supports covalently derivatized with anti-IGF antibodies were used to extract specific IGFs from plasma in preparation for mass spectrometry. Single or multiplex IGF-1 and IGF-2 assays were performed, resulting in detection of wild-type IGF-1 and 2, and a truncated IGF-2 variant, missing its N-terminal Alanine (also detected in the BIA/MS experiments). IGF-1 was quantified from several individuals via the use of internal reference standard species (rat IGF-1, doped into the samples prior to the MSIA analysis) and a working curve constructed from samples containing known concentrations of IGF-1.
摘要翻译：本文提出了基于亲和力的质谱法和用于分析复合生物混合物和流体中存在的胰岛素样生长因子1和2（IGF-1和IGF-2）的分析方法。通过BIA / MS从人血浆中检测IGF-1和IGF-2，利用抗体作为亲和力检索的配体。在质谱中检测靶向和非靶向IGFs表明可能的单个抗体的蛋白质复合物检索。在可变变性条件下研究血浆样品，以确认游离和结合的IGF的检测。在用于IGF检测的MSIA方法中，使用含有用抗IGF抗体共价衍生的多孔固体支持物的移液器尖端来提取来自血浆的特异性IGF，以进行质谱分析。进行单次或多重IGF-1和IGF-2测定，导致野生型IGF-1和2以及截短的IGF-2变体的检测，缺失其N-末端丙氨酸（也在BIA / MS实验中检测到）。通过使用内部参考标准物质（大鼠IGF-1，在MSIA分析之前掺入样品中）从几个个体定量IGF-1和从含有已知浓度的IGF-1的样品构建的工作曲线。

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