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1. 发明授权

US06423332B1 Method and composition for deforming soft tissues 有权
标题翻译：软组织变形的方法和组成
公开(公告)号：US06423332B1
公开(公告)日：2002-07-23
申请号：US09579214
申请日：2000-05-26
申请人： Shawn T. Huxel , Ram L. Kataria , Joel S. Rosenblatt
发明人： Shawn T. Huxel , Ram L. Kataria , Joel S. Rosenblatt
IPC分类号： A61F1300
CPC分类号： A61L27/52
摘要： The present invention provides a composition and method for augmenting soft tissue, which composition includes a continuous phase that is a solid at temperatures less than about 10° C. or greater than about 30° C. and is a fluid at temperatures between about 10° C. and about 30° C., and which contains an aqueous solvent having dissolved therein a hydrogel and a dehydrating agent, and a discontinuous phase containing a plurality of hydrophilic hydrogel particles that are swellable in the aqueous solvent, that are not biodegradable for periods of time in excess of one year, and that have a hydrated diameter of greater than about 25 microns upon hydration by physiologic fluid; wherein the final volume of the hydrophilic hydrogel particles upon hydration by physiologic fluid is substantially the same as the initial volume of the composition used to augment the soft tissue.
摘要翻译：本发明提供了一种用于增加软组织的组合物和方法，该组合物包括在低于约10℃或大于约30℃的温度下为固体的连续相，并且为约10℃ 并且含有其中溶解有水凝胶和脱水剂的水性溶剂，以及包含在水性溶剂中可溶胀的多个亲水性水凝胶颗粒的不连续相，其不能在时间段内生物降解的时间超过一年，并且通过生理液体水合时具有大于约25微米的水合直径; 其中亲水性水凝胶颗粒在生理液体水合时的最终体积基本上与用于增加软组织的组合物的初始体积相同。

2. 发明授权

US06325810B1 Foam buttress for stapling apparatus 有权
标题翻译：用于装订装置的泡沫支撑
公开(公告)号：US06325810B1
公开(公告)日：2001-12-04
申请号：US09345093
申请日：1999-06-30
申请人： Leslie Hamilton , Rao S. Bezwada , Mark B. Roller , Murty N. Vyakarnam , David A. Dalessandro , Joel S. Rosenblatt , Ram L. Kataria , Lowell G. Saferstein , James F. Martin
发明人： Leslie Hamilton , Rao S. Bezwada , Mark B. Roller , Murty N. Vyakarnam , David A. Dalessandro , Joel S. Rosenblatt , Ram L. Kataria , Lowell G. Saferstein , James F. Martin
IPC分类号： A61B1704
CPC分类号： A61B17/07207 , A61B17/07292 , A61B2017/00004 , A61B2017/07214
摘要： An apparatus for achieving hemostasis and pneumostasis along a staple line by utilizing a compliant bioabsorbable foam buttress which may be attached to one jaw of a surgical stapling apparatus by a biocompatible releasable adhesive.
摘要翻译：一种用于通过使用柔性生物可吸收的泡沫支撑件，通过生物相容的可释放粘合剂附着到外科缝合装置的一个钳口上，沿着缝合线实现止血和肺静止的装置。

3. 发明授权

US5910520A Melt processable biodegradable compositions and articles made therefrom 失效
标题翻译：可熔融加工的可生物降解组合物和由其制成的制品
公开(公告)号：US5910520A
公开(公告)日：1999-06-08
申请号：US6013
申请日：1993-01-15
申请人： Shmuel Dabi , Ram L. Kataria
发明人： Shmuel Dabi , Ram L. Kataria
IPC分类号： A61F13/26 , C08J5/18 , C08K5/05 , C08K5/06 , C08L1/00 , C08L3/00 , C08L3/02 , C08L23/04 , C08L23/08 , C08L29/04 , C08L31/04 , C08L33/10 , C08L67/00 , C08L67/02 , C08L67/04 , C08K5/103
CPC分类号： C08L67/04 , C08L3/00 , C08L3/02 , C08K5/01 , C08L2201/06 , C08L31/04 , C08L33/10 , C08L67/02
摘要： The invention presents classes of thermoplastic, biodegradable compositions. Tests indicate that these compositions exhibit good mechanical properties, and readily degrade in the presence of microorganisms. The compositions of this invention are useful for producing injection-molded, thin-walled articles that are capable of appreciably degrading in the sewage system within thirty (30) days.
摘要翻译：本发明提出了一类热塑性，可生物降解的组合物。测试表明这些组合物表现出良好的机械性能，并且在微生物存在下容易降解。本发明的组合物可用于生产在三十（30）天内能够在污水系统中明显降解的注射成型的薄壁制品。

4. 发明授权

US07220433B2 Compositions for parenteral administration and sustained-release of therapeutic agents 有权
标题翻译：用于肠胃外给药和治疗剂缓释的组合物
公开(公告)号：US07220433B2
公开(公告)日：2007-05-22
申请号：US10608507
申请日：2003-06-27
申请人： Han Cui , Joel Rosenblatt , Ram L. Kataria , Chuanbin Wu
发明人： Han Cui , Joel Rosenblatt , Ram L. Kataria , Chuanbin Wu
IPC分类号： A61K9/16
CPC分类号： A61K9/5073 , A61K47/34
摘要： The present invention is directed to parenterally-administrable microparticles for providing sustained-release of a therapeutic agent in the body, where the microparticles include a polymeric core containing a therapeutically effective amount of a therapeutic agent disposed therein, a first film encapsulating the core, the first film prepared from a first biodegradable polymer soluble in an appropriate solvent therefore, and a second film encapsulating the core and the first film, the second film prepared from a biodegradable polymer soluble in an appropriate solvent therefore, wherein the first film is insoluble in the solvent used to prepare the second film, and to parenterally-administrable compositions containing such microparticles dispersed in a suitable carrier therefore.
摘要翻译：本发明涉及用于在体内提供治疗剂持续释放的肠胃外给药微粒，其中微粒包括含有治疗有效量的治疗剂的聚合物芯，其中包含核心的第一膜，因此，由可溶于适当溶剂的第一可生物降解聚合物制备的第一膜以及包封芯和第一膜的第二膜，由可溶于适当溶剂的可生物降解的聚合物制备的第二膜，其中第一膜不溶于因此用于制备第二膜的溶剂，以及含有分散在合适载体中的这种微粒的肠胃外给药组合物。

5. 发明授权

US07101566B2 Polymer coated microparticles for sustained release 有权
标题翻译：聚合物涂层微粒用于持续释放
公开(公告)号：US07101566B2
公开(公告)日：2006-09-05
申请号：US10183260
申请日：2002-06-28
申请人： Joel Rosenblatt , Han Cui , Ram L. Kataria , Chuanbin Wu
发明人： Joel Rosenblatt , Han Cui , Ram L. Kataria , Chuanbin Wu
IPC分类号： A61F13/00 , A61F2/00 , A61K9/14 , A61K9/19
CPC分类号： A61K9/5031 , A61K47/34
摘要： The present invention is directed to sustained release microparticle formulation for parenteral administration of biologically active substances, especially drugs. More specifically it relates to coated drug containing microparticles, wherein the coating is a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.
摘要翻译：本发明涉及用于肠胃外给药生物活性物质，特别是药物的持续释放微粒制剂。更具体地说，它涉及含有包衣药物的微粒，其中涂层是合成的，生物可吸收的生物相容性聚合物蜡，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，聚合物蜡的熔点较低如通过差示扫描量热法测定的。

6. 发明授权

US5221726A Hydrophilic materials useful in preparing fluid-absorbent products 失效
标题翻译：用于制备流体吸收产品的亲水材料
公开(公告)号：US5221726A
公开(公告)日：1993-06-22
申请号：US830444
申请日：1992-02-03
申请人： Shmuel Dabi , Ram L. Kataria
发明人： Shmuel Dabi , Ram L. Kataria
IPC分类号： A61L15/26 , A61L15/42 , C08G59/50 , C08J9/06 , C08L63/00
CPC分类号： C08J9/06 , A61L15/26 , A61L15/425 , C08G59/5006 , C08L63/00 , C08J2363/00
摘要： Improved hydrophilic materials, such as foams and films, are provided. These material find use in a wide variety of fluid absorbent products, especially those relating to the absorption of bodily fluids. The soft, absorbent, and resilient foams of this invention exhibit greater wet and dry mechanical strength when compared with those known in the art, as well as improved fluid wicking capacity and lower density. These improved properties are believed attributable to the incorporation into the foams of at least one polyfunctional aliphatic amine.The provided hydrophilic materials comprise the polymeric reaction product of a mixture which comprises at least one epoxy resin, at least one amine-terminated poly(alkylene oxide), and at least one polyfunctional aliphatic amine. Methods for preparing foams and other hydrophilic materials are also provided. In general, hydrophilic materials are prepared by providing at least one epoxy resin, forming a reaction mixture by contacting the epoxy resin with at least one amine-terminated poly(alkylene oxide) and at least one polyfunctional aliphatic amine, and curing the reaction mixture.
摘要翻译：提供改进的亲水材料，如泡沫和薄膜。这些材料可用于各种各样的液体吸收产品，特别是与吸收体液有关的物质。与本领域已知的那些相比，本发明的柔软，吸收和弹性泡沫表现出更大的湿和干机械强度，以及改善的流体芯吸能力和较低的密度。这些改进的性质被认为归因于掺入到至少一种多官能脂族胺的泡沫中。所提供的亲水材料包括混合物的聚合反应产物，其包含至少一种环氧树脂，至少一种胺封端的聚（环氧烷）和至少一种多官能脂族胺。还提供了制备泡沫和其它亲水材料的方法。通常，通过提供至少一种环氧树脂制备亲水性材料，通过使环氧树脂与至少一种胺封端的聚（环氧烷）和至少一种多官能脂族胺接触形成反应混合物，并固化反应混合物。

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