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1. 发明申请

US20150225365A1 INDOLINE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS 有权
标题翻译：吲哚酚化合物作为醛固酮合成酶抑制剂
公开(公告)号：US20150225365A1
公开(公告)日：2015-08-13
申请号：US14433441
申请日：2013-10-02
申请人： Amjad ALI , Man-Chu Michael , Edward METZGER , Lina YIN , Rolf HARTMANN , Qingzhong HU , Ralf HEIM , Christina ZIMMER , MERCK SHARP & DOHME CORP. , ELEXOPHARM GMBH
发明人： Amjad Ali , Michael Man-Chu Lo , Edward Metzger , Lina Yin , Rolf Hartmann , Qingzhong Hu , Ralf Heim , Christina Zimmer
IPC分类号： C07D401/04 , C07D409/14
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D409/14 , A61K2300/00
摘要： This invention relates to indo line compounds of the structural formula I, or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译：本发明涉及结构式I的吲哚类化合物或其药学上可接受的盐，其中变量在本文中定义。本发明化合物选择性地抑制醛固酮合酶。本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

2. 发明授权

US08541404B2 Inhibitors of the human aldosterone synthase CYP11B2 有权
标题翻译：人醛固酮合酶抑制剂CYP11B2
公开(公告)号：US08541404B2
公开(公告)日：2013-09-24
申请号：US12938581
申请日：2010-11-03
申请人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
发明人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
IPC分类号： C07D401/10 , C07D413/10 , A61K31/4745 , A61K31/4709
CPC分类号： C07D401/10 , C07D413/10 , C07D417/10 , C07D471/06
摘要： The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.
摘要翻译：本发明提供了作为人醛固酮合酶抑制剂的通式（I）化合物，以及含有这些化合物的药物组合物，以及治疗由11β-羟化酶（CYP11B1）介导的醛固酮增多症和/或病症或疾病的方法）与这些化合物。

3. 发明申请

US20120222941A1 DEVICE FOR TRANSPORTING UPRIGHT CONTAINERS IN A STRAIGHT LINE 有权
标题翻译：用于在直线上运输直升机的装置
公开(公告)号：US20120222941A1
公开(公告)日：2012-09-06
申请号：US13369744
申请日：2012-02-09
申请人： Juergen Liebhardt , Michael Kronawitter , Ralf Heim
发明人： Juergen Liebhardt , Michael Kronawitter , Ralf Heim
IPC分类号： B65G25/02
CPC分类号： B65G47/82 , B65G25/02
摘要： The device for transporting upright containers in a straight line includes a rake conveyor comprising multiple receiving sections for the containers and an opposing support element for the containers carried in the receiving sections. The rake conveyor is connected to two drives by at least two pivot systems, each with two arms, in such a way that the rake conveyor can be pushed back and forth both in the transport direction of the containers and also in the direction perpendicular to the transport direction of the containers.
摘要翻译：用于以直线运输直立容器的装置包括一个耙式输送机，该耙式输送机包括用于容器的多个接收部分和用于容纳在接收部分中的容器的相对的支撑元件。耙式输送机通过至少两个枢转系统连接到两个驱动器，每个枢轴系统具有两个臂，这两个臂以这样的方式使得耙式输送机可以沿着容器的输送方向以及在垂直于容器运输方向的集装箱。

4. 发明授权

US08403009B2 Method and device for filling containers 有权
标题翻译：填充容器的方法和装置
公开(公告)号：US08403009B2
公开(公告)日：2013-03-26
申请号：US12538523
申请日：2009-08-10
申请人： Joachim Noe , Thomas Ruelker , Ralf Heim
发明人： Joachim Noe , Thomas Ruelker , Ralf Heim
IPC分类号： B65B3/04
CPC分类号： B65B5/103 , B65B43/52 , B65B43/56 , B65G47/082 , B65G47/5127
摘要： A method for filling a plurality of containers in cycles at a predetermined number of stationary filling units arranged in a row with a first spacing from each other. The method includes providing a plurality of positively guided containers in a row, one-by-one, wherein the containers have a uniform second spacing from each other, wherein the first spacing of the individual filling units is a whole-number multiple of the second spacing of the containers, and filling a predetermined number of the containers simultaneously at the filling units. The containers are shifted in cycles along the filling units in a transport direction by a step length, which is a whole-number multiple of the second spacing of the containers and which is shorter than a third spacing between a first filling unit and a last filling unit steps of filling and shifting are repeated over a predetermined number of iterations.
摘要翻译：一种用于以预定数量的固定填充单元周期地填充多个容器的方法，所述预定数量的固定填充单元彼此排列成一行。所述方法包括一排一列地提供一排一排的带正导向的容器，其中容器彼此具有均匀的第二间隔，其中各个填充单元的第一间隔是第二间隔的整数倍容器的间隔，以及在填充单元处同时填充预定数量的容器。容器沿着输送方向沿着填充单元沿循环移动步长，其是容器的第二间距的整数倍，并且比第一填充单元和最后填充物之间的第三间隔短在预定次数的迭代中重复填充和移位的单元步骤。

5. 发明申请

US20110112067A1 Inhibitors of the Human Aldosterone Sythase CYP11B2 有权
标题翻译：人醛固酮相关CYP11B2抑制剂
公开(公告)号：US20110112067A1
公开(公告)日：2011-05-12
申请号：US12938581
申请日：2010-11-03
申请人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
发明人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
IPC分类号： A61K31/4709 , C07D401/10 , C07D417/10 , C07D413/10 , C07D471/06 , A61K31/4439 , A61K31/4725 , A61K31/55 , A61K31/4745 , A61K31/553 , A61K31/554 , A61P9/12 , A61P9/04 , A61P9/10 , A61P9/00 , A61P29/00 , A61P3/04 , A61P7/00
CPC分类号： C07D401/10 , C07D413/10 , C07D417/10 , C07D471/06
摘要： The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.
摘要翻译：本发明提供了作为人醛固酮合酶抑制剂的通式（I）化合物，以及含有这些化合物的药物组合物，以及治疗醛固酮增多症和/或由11β-羟化酶介导的疾病或疾病的方法（ CYP11B1）与这些化合物。

6. 发明申请

US20080307757A1 Device for Conveying Tablets 审中-公开
标题翻译：输送片剂装置
公开(公告)号：US20080307757A1
公开(公告)日：2008-12-18
申请号：US12134599
申请日：2008-06-06
申请人： Ralf Heim , Wolfgang Krahl , Michael Kronawitter , Rolf Armbruster , Bernd Geiselhardt , Joachim Noe
发明人： Ralf Heim , Wolfgang Krahl , Michael Kronawitter , Rolf Armbruster , Bernd Geiselhardt , Joachim Noe
IPC分类号： B65B1/08 , B65B1/30
CPC分类号： B65G27/16 , B65G27/04 , B65G27/34 , B65G2201/027
摘要： A device for conveying tablets has a lower part, an upper part with at least one guide channel for holding and conveying the tablets, and several elastic elements, arranged a certain distance apart, on each of which at least one piezoelectric vibratory element is mounted, wherein the elastic elements are arranged between the upper part and the lower part and connect the two parts together. In addition, the device has at least one control unit for exciting the piezoelectric vibratory elements and thus the elastic elements and a sorting device installed in the area of the guide channel to separate the good tablets from the bad.
摘要翻译：用于输送片剂的装置具有下部，具有用于保持和输送片剂的至少一个引导通道的上部和布置成一定距离的几个弹性元件，每个弹性元件安装有至少一个压电振动元件，其中所述弹性元件布置在所述上部和下部之间并将所述两个部分连接在一起。此外，该装置具有至少一个用于激发压电振动元件和因此弹性元件的控制单元，以及安装在引导通道的区域中的分类装置，以将好的片剂与坏的分离。

7. 发明授权

US08685960B2 6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and related compounds as inhibitors of the human aldosterone synthase CYP11B2 有权
标题翻译： 6-吡啶-3-基-3,4-二氢-1h - 喹啉-2-酮衍生物和相关化合物作为人醛固酮合酶CYP11B2的抑制剂
公开(公告)号：US08685960B2
公开(公告)日：2014-04-01
申请号：US12990909
申请日：2009-05-05
申请人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
发明人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
IPC分类号： C07D401/04 , A61K31/4745
CPC分类号： C07D401/04 , C07D215/227 , C07D221/06 , C07D401/14 , C07D471/04
摘要： The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 β-hydroxylase (CYP11 B1).
摘要翻译：本发明提供了作为人醛固酮合酶抑制剂的通式（I）化合物，以及含有这些化合物的药物组合物，以及这些化合物和其它杂芳基取代的喹啉酮衍生物用于治疗醛固酮增多症和/或病症或由11β-羟化酶（CYP11B1）介导的疾病。

8. 发明授权

US08678175B2 Device for channeling out containers 有权
标题翻译：用于引导容器的设备
公开(公告)号：US08678175B2
公开(公告)日：2014-03-25
申请号：US13369769
申请日：2012-02-09
申请人： Ralf Heim , Joachim Noe
发明人： Ralf Heim , Joachim Noe
IPC分类号： B65G21/12 , B65G47/82 , B65G61/00
CPC分类号： B65G47/82 , B65B61/28 , B65G47/918 , B65G61/00
摘要： The device for channeling out upright containers from a first transport device, which moves the container in a transport direction, includes a lateral guide section, which extends in the transport direction, and a gripper unit, which has a plurality of grippers for gripping the containers. The lateral guide section and the gripper unit are moved from a pickup position for the containers jointly in a direction transverse to the transport direction. After this joint movement the gripper unit is moved towards a discharge position for the containers. The lateral guide section and the gripper unit are then moved back to the pickup position.
摘要翻译：用于从沿着输送方向移动容器的第一输送装置引出直立容器的装置包括沿输送方向延伸的侧向引导部分和夹持单元，该夹持器单元具有用于夹持容器的多个夹持器。横向引导部分和夹持器单元在与输送方向横向的方向上共同移动用于容器的拾取位置。在该关节运动之后，夹持器单元移动到用于容器的排出位置。横向引导部分和夹持器单元然后移回到拾取位置。

9. 发明授权

US06644460B2 Apparatus for sorting pills 失效
公开(公告)号：US06644460B2
公开(公告)日：2003-11-11
申请号：US10209600
申请日：2002-07-31
申请人： Detlev Gertitschke , Ralf Heim , Hans-Martin Pöhler , Jürgen Matzenmüller , Bernd Zoller , Erich Jans , Harald Litke
发明人： Detlev Gertitschke , Ralf Heim , Hans-Martin Pöhler , Jürgen Matzenmüller , Bernd Zoller , Erich Jans , Harald Litke
IPC分类号： B65G4724
CPC分类号： B65B5/103 , B65B9/045 , B65B35/06 , B65B37/04 , B65G47/1471 , B65G2201/027
摘要： An apparatus for sorting and feeding identically shaped small objects has a funnel adapted to hold the objects and having a downwardly open outlet and a housing and a wheel together forming an arcuate passage generally centered on an axis and having an upper inlet end at the outlet and a lower outlet end so that the objects can enter the upper inlet end of the passage and move downward through the passage. The wheel has an outer periphery exposed in the passage and formed with a row of outwardly open pockets of a shape corresponding generally to a shape of the objects. The wheel is rotated such that its periphery moves upward in the passage so that the objects are separated from one another and aligned behind one another in the passage.

10. 发明申请

US20110118241A1 6-Pyridin-3-YL-3,4-Dihydro-1H-Quinolin-2-One Derivatives and Related Compounds as Inhibitors of the Human Aldosterone Synthase CYP11B2 有权
标题翻译： 6-吡啶-3-基-L-3,4-二氢-1H-喹啉-2-酮衍生物和相关化合物作为人醛固酮合酶CYP11B2的抑制剂
公开(公告)号：US20110118241A1
公开(公告)日：2011-05-19
申请号：US12990909
申请日：2009-05-05
申请人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
发明人： Rolf W. Hartmann , Ralf Heim , Simon Lucas
IPC分类号： A61K31/5415 , C07D401/10 , C07D471/06 , C07D417/10 , C07D413/10 , A61K31/4709 , A61K31/4439 , A61K31/4725 , A61K31/4745 , A61K31/506 , A61K31/538 , A61K31/498 , A61K31/536 , A61P9/12 , A61P5/40 , A61P9/04 , A61P13/12 , A61P9/10 , A61P9/00 , A61P3/04 , A61P29/00
CPC分类号： C07D401/04 , C07D215/227 , C07D221/06 , C07D401/14 , C07D471/04
摘要： The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 β-hydroxylase (CYP11 B1).
摘要翻译：本发明提供了作为人醛固酮合酶抑制剂的通式（I）化合物，以及含有这些化合物的药物组合物，以及这些化合物和其它杂芳基取代的喹啉酮衍生物用于治疗醛固酮增多症和/或病症或由11β-羟化酶（CYP11B1）介导的疾病。

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