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1. 发明授权

US08608730B2 Cryoablation catheter handle 失效
标题翻译：冷冻消融导管手柄
公开(公告)号：US08608730B2
公开(公告)日：2013-12-17
申请号：US11220268
申请日：2005-09-06
申请人： Marwan Abboud , Domenic Santoianni , Philippe Marchand , Rachid Mahrouche , Patrick St-Louis
发明人： Marwan Abboud , Domenic Santoianni , Philippe Marchand , Rachid Mahrouche , Patrick St-Louis
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61M25/0136 , A61M25/0147 , A61M39/1011 , A61M39/105
摘要： A thermal treatment medical system including an umbilical having a first portion and a second portion, and a connector including a male coupling body connected to the first portion, the male coupling body having a central shank defining first and second lumens, a female coupling body connected to the second portion, the female coupling body, matable with the male coupling body and defining third and fourth lumens matable to be in fluid communication with the first and second lumens, respectively, to define first and second fluid flow pathways, respectively, through the connector when the male coupling body is mated with the female coupling body. The second fluid flow pathway is co-axially disposed about a central axis coincident with the first fluid flow pathway. The connector includes a mating mechanism for spatially locking the male and female coupling bodies with respect to each other. Additionally, the thermal treatment medical system includes a multiple lumen co-axial connector for connecting the catheter flow pathways with a fluid source and control console.
摘要翻译：一种热处理医疗系统，包括具有第一部分和第二部分的脐带，以及包括连接到第一部分的阳联接体的连接器，阳联接体具有限定第一和第二腔的中心柄，连接到阴连接体所述阴联结体分别与所述阳连接体配合并且限定可分别与所述第一和第二腔流体连通的第三和第四腔，以分别限定第一和第二流体流动通道阳联接器与阴联结体配合时的连接器。第二流体流动路径围绕与第一流体流动路径重合的中心轴线同轴设置。连接器包括用于相对于彼此空间地锁定阳联结体和阴联结体的配合机构。此外，热处理医疗系统包括用于将导管流动路径与流体源和控制台连接的多管腔同轴连接器。

2. 发明授权

US08298218B2 Compliant balloon 有权
标题翻译：符合气球
公开(公告)号：US08298218B2
公开(公告)日：2012-10-30
申请号：US12511403
申请日：2009-07-29
申请人： Rachid Mahrouche
发明人： Rachid Mahrouche
IPC分类号： A61B18/12
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/0212
摘要： A cryogenic medical device is provided, including a catheter body defining a proximal portion and a distal portion; a expandable treatment element on the distal portion of the catheter body; a plurality of granules disposed within the expandable treatment element; an encapsulation member surrounding the plurality of granules, the encapsulating member having a plurality of selectable geometric configurations; and an actuator element coupled to the encapsulation member for the selective adjustment thereof. A method for thermally treating a selected region of tissue is also provided.
摘要翻译：提供一种低温医疗装置，包括限定近端部分和远端部分的导管主体; 在导管主体的远端部分上的可扩张治疗元件; 设置在所述可膨胀处理元件内的多个颗粒; 围绕所述多个颗粒的包封构件，所述封装构件具有多个可选择的几何构型; 以及联接到所述密封构件以用于其选择性调节的致动器元件。还提供了用于热处理选定区域的组织的方法。

3. 发明授权

US08298217B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US08298217B2
公开(公告)日：2012-10-30
申请号：US12410835
申请日：2009-03-25
申请人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik
发明人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

4. 发明申请

US20090182319A1 ENDOVASCULAR CRYOTREATMENT CATHETER 有权
标题翻译：内膜切开导管
公开(公告)号：US20090182319A1
公开(公告)日：2009-07-16
申请号：US12410835
申请日：2009-03-25
申请人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Mihalik
发明人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Mihalik
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

5. 发明申请

US20070161974A1 Cooling system 有权
公开(公告)号：US20070161974A1
公开(公告)日：2007-07-12
申请号：US11709964
申请日：2007-02-23
申请人： Marwan Abboud , Rachid Mahrouche , Jean-Pierre Lalonde , Dan Wittenberger
发明人： Marwan Abboud , Rachid Mahrouche , Jean-Pierre Lalonde , Dan Wittenberger
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.

6. 发明授权

US08361059B2 Cooling system 有权
公开(公告)号：US08361059B2
公开(公告)日：2013-01-29
申请号：US11581185
申请日：2006-10-13
申请人： Marwan Abboud , Rachid Mahrouche , Jean-Pierre Lalonde , Dan Wittenberger
发明人： Marwan Abboud , Rachid Mahrouche , Jean-Pierre Lalonde , Dan Wittenberger
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.

7. 发明申请

US20120271291A1 FLUID CONTROL SYSTEM FOR A MEDICAL DEVICE 审中-公开
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20120271291A1
公开(公告)日：2012-10-25
申请号：US13526620
申请日：2012-06-19
申请人： Marwan ABBOUD , Rachid MAHROUCHE , Teresa Ann MIHALIK , Chadi HARMOUCHE , Jean-Luc PAGEARD , John W. LEHMANN
发明人： Marwan ABBOUD , Rachid MAHROUCHE , Teresa Ann MIHALIK , Chadi HARMOUCHE , Jean-Luc PAGEARD , John W. LEHMANN
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. A check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. Additionally, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。包括止回阀，其与第一柔韧元件和第二柔韧元件之间的接合部流体连通，所述阀还与排气腔流体连通。此外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监测装置。

8. 再颁专利

USRE43007E1 Cooling system 有权
标题翻译：冷却系统
公开(公告)号：USRE43007E1
公开(公告)日：2011-12-06
申请号：US12173536
申请日：2008-07-15
申请人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00119 , A61B2018/0212 , A61B2018/0262
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.
摘要翻译：低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。控制台控制医疗设备的温度。所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温

9. 发明申请

US20110029048A1 COMPLIANT BALLOON 有权
标题翻译：合适的气球
公开(公告)号：US20110029048A1
公开(公告)日：2011-02-03
申请号：US12511403
申请日：2009-07-29
申请人： Rachid MAHROUCHE
发明人： Rachid MAHROUCHE
IPC分类号： A61F7/12
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/0212
摘要： A cryogenic medical device is provided, including a catheter body defining a proximal portion and a distal portion; a expandable treatment element on the distal portion of the catheter body; a plurality of granules disposed within the expandable treatment element; an encapsulation member surrounding the plurality of granules, the encapsulating member having a plurality of selectable geometric configurations; and an actuator element coupled to the encapsulation member for the selective adjustment thereof. A method for thermally treating a selected region of tissue is also provided.
摘要翻译：提供一种低温医疗装置，包括限定近端部分和远端部分的导管主体; 在导管主体的远端部分上的可扩张治疗元件; 设置在所述可膨胀处理元件内的多个颗粒; 围绕所述多个颗粒的包封构件，所述封装构件具有多个可选择的几何构型; 以及联接到所述密封构件以用于其选择性调节的致动器元件。还提供了用于热处理选定区域的组织的方法。

10. 发明申请

US20060212026A1 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20060212026A1
公开(公告)日：2006-09-21
申请号：US11074293
申请日：2005-03-07
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Jean-Luc Pageard , John Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Jean-Luc Pageard , John Lehmann
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

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