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1. 发明申请

US20120271291A1 FLUID CONTROL SYSTEM FOR A MEDICAL DEVICE 审中-公开
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20120271291A1
公开(公告)日：2012-10-25
申请号：US13526620
申请日：2012-06-19
申请人： Marwan ABBOUD , Rachid MAHROUCHE , Teresa Ann MIHALIK , Chadi HARMOUCHE , Jean-Luc PAGEARD , John W. LEHMANN
发明人： Marwan ABBOUD , Rachid MAHROUCHE , Teresa Ann MIHALIK , Chadi HARMOUCHE , Jean-Luc PAGEARD , John W. LEHMANN
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. A check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. Additionally, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。包括止回阀，其与第一柔韧元件和第二柔韧元件之间的接合部流体连通，所述阀还与排气腔流体连通。此外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监测装置。

2. 发明授权

US07842031B2 Bioimpedance measurement system and method 有权
标题翻译：生物阻抗测量系统和方法
公开(公告)号：US07842031B2
公开(公告)日：2010-11-30
申请号：US11283057
申请日：2005-11-18
申请人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B18/18 , A61B5/05
CPC分类号： A61B5/0537 , A61B18/02 , A61B2017/00026 , A61B2018/0022 , A61B2018/0212
摘要： Methods and systems for detecting fluid egress, assessing lesion quality, determining tissue composition or structure, determining ice coverage of catheter tip and providing tissue contact assessment, by providing a catheter having a shaft with a proximal end portion and a distal end portion, the proximal end portion and the distal end portion define at least one fluid pathway therebetween with the shaft having a plurality of electrodes, positioning the catheter at a tissue treatment site, applying an electrical current between at least two of the plurality of electrodes, measuring impedance voltage between the at least two of the plurality of electrodes and, processing the measured impedance voltage caused by the applied electrical current to determine if fluid egress is present, to assess lesion quality, to determine tissue composition, ice cover of catheter tip, and to provide contact assessment. The system may have a control unit, a microprocessor, an impedance measuring device or the like to perform processing of impedance data.
摘要翻译：用于检测流体出口的方法和系统，评估病变质量，确定组织组成或结构，通过提供具有近端部分和远端部分的轴的导管，确定导管尖端的冰覆盖和提供组织接触评估，末端部分和远端部分限定其间的至少一个流体通路，其中轴具有多个电极，将导管定位在组织治疗部位，在多个电极中的至少两个之间施加电流，测量多个电极之间的阻抗电压所述多个电极中的至少两个，并且处理由施加的电流引起的测量的阻抗电压以确定是否存在流体出口，以评估病变质量，确定组织组成，导管尖端的冰盖，并提供接触评定。系统可以具有控制单元，微处理器，阻抗测量装置等，以执行阻抗数据的处理。

3. 发明申请

US20080200829A1 BIOIMPEDANCE MEASUREMENT SYSTEM AND METHOD 有权
公开(公告)号：US20080200829A1
公开(公告)日：2008-08-21
申请号：US12109942
申请日：2008-04-25
申请人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abboud , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B5/053 , A61B18/02
CPC分类号： A61B5/0537 , A61B18/02 , A61B2017/00026 , A61B2018/0022 , A61B2018/0212
摘要： Methods and systems for detecting fluid egress, assessing lesion quality, determining tissue composition or structure, determining ice coverage of catheter tip and providing tissue contact assessment, by providing a catheter having a shaft with a proximal end portion and a distal end portion, the proximal end portion and the distal end portion define at least one fluid pathway therebetween with the shaft having a plurality of electrodes, positioning the catheter at a tissue treatment site, applying an electrical current between at least two of the plurality of electrodes, measuring impedance voltage between the at least two of the plurality of electrodes and, processing the measured impedance voltage caused by the applied electrical current to determine if fluid egress is present, to assess lesion quality, to determine tissue composition, ice cover of catheter tip, and to provide contact assessment. The system may have a control unit, a microprocessor, an impedance measuring device or the like to perform processing of impedance data.

4. 发明申请

US20060212026A1 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20060212026A1
公开(公告)日：2006-09-21
申请号：US11074293
申请日：2005-03-07
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Jean-Luc Pageard , John Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Mihalik , Chadi Harmouche , Jean-Luc Pageard , John Lehmann
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

5. 发明授权

US08771264B2 Contact assessment of balloon catheters 有权
标题翻译：球囊导管接触评估
公开(公告)号：US08771264B2
公开(公告)日：2014-07-08
申请号：US12245176
申请日：2008-10-03
申请人： Marwan Abboud , Teresa Ann Mihalik , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abboud , Teresa Ann Mihalik , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B18/02
CPC分类号： A61B5/6885 , A61B5/053 , A61B5/0538 , A61B5/6886 , A61B18/02 , A61B2017/00026 , A61B2017/00039 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/065
摘要： A medical apparatus and system for determining contact assessment includes a catheter having an elongate body having a proximal end, a distal end opposite the proximal end, and defining an injection lumen and an exhaust lumen, an expandable membrane defining a cooling chamber disposed at a point along the elongate body, the cooling chamber in fluid communication with the injection lumen and the exhaust lumen, and a contact assessment element which may be a temperature sensor located proximate the coolant return lumen for measuring an internal temperature of the chamber. The system may include the catheter, a console having a fluid supply, an exhaust path and at least one control mechanism operationally coupled to the temperature sensor for processing a temperature signal received from the temperature sensor. The apparatus and system can also have multiple electrodes to measure and process various impedances to determine contact assessment.
摘要翻译：用于确定接触评估的医疗装置和系统包括具有细长主体的导管，所述细长主体具有近端，与近端相对的远端，并且限定注射腔和排气腔，限定设置在一点的冷却室的可扩张膜沿着细长体，与注射腔和排气腔流体连通的冷却室和接触评估元件，其可以是靠近冷却剂返回腔的温度传感器，用于测量腔室的内部温度。该系统可以包括导管，具有流体供应的控制台，排气路径和可操作地耦合到温度传感器的至少一个控制机构，用于处理从温度传感器接收的温度信号。该装置和系统还可以具有多个电极来测量和处理各种阻抗以确定接触评估。

6. 发明申请

US20090030288A1 CONTACT ASSESSMENT OF BALLOON CATHETERS 有权
标题翻译：气球导管接触评估
公开(公告)号：US20090030288A1
公开(公告)日：2009-01-29
申请号：US12245176
申请日：2008-10-03
申请人： Marwan Abboud , Teresa Ann Mihalik , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abboud , Teresa Ann Mihalik , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B18/02 , A61B5/00
CPC分类号： A61B5/6885 , A61B5/053 , A61B5/0538 , A61B5/6886 , A61B18/02 , A61B2017/00026 , A61B2017/00039 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/065
摘要： A medical apparatus and system for determining contact assessment includes a catheter having an elongate body having a proximal end, a distal end opposite the proximal end, and defining an injection lumen and an exhaust lumen, an expandable membrane defining a cooling chamber disposed at a point along the elongate body, the cooling chamber in fluid communication with the injection lumen and the exhaust lumen, and a contact assessment element which may be a temperature sensor located proximate the coolant return lumen for measuring an internal temperature of the chamber. The system may include the catheter, a console having a fluid supply, an exhaust path and at least one control mechanism operationally coupled to the temperature sensor for processing a temperature signal received from the temperature sensor. The apparatus and system can also have multiple electrodes to measure and process various impedances to determine contact assessment.
摘要翻译：用于确定接触评估的医疗装置和系统包括具有细长主体的导管，所述细长主体具有近端，与近端相对的远端，并且限定注射腔和排气腔，限定设置在一点的冷却室的可扩张膜沿着细长体，与注射腔和排气腔流体连通的冷却室和接触评估元件，其可以是靠近冷却剂返回腔的温度传感器，用于测量腔室的内部温度。该系统可以包括导管，具有流体供应的控制台，排气路径和可操作地耦合到温度传感器的至少一个控制机构，用于处理从温度传感器接收的温度信号。该装置和系统还可以具有多个电极来测量和处理各种阻抗以确定接触评估。

7. 发明申请

US20080200828A1 BIOIMPEDANCE MEASUREMENT SYSTEM AND METHOD 审中-公开
标题翻译：生物测量系统和方法
公开(公告)号：US20080200828A1
公开(公告)日：2008-08-21
申请号：US12109734
申请日：2008-04-25
申请人： Marwan ABBOUD , Johnny AL ASMAR , Chadi HARMOUCHE
发明人： Marwan ABBOUD , Johnny AL ASMAR , Chadi HARMOUCHE
IPC分类号： A61B5/05
CPC分类号： A61B5/0537 , A61B18/02 , A61B2017/00026 , A61B2018/0022 , A61B2018/0212
摘要： Methods and systems for detecting fluid egress, assessing lesion quality, determining tissue composition or structure, determining ice coverage of catheter tip and providing tissue contact assessment, by providing a catheter having a shaft with a proximal end portion and a distal end portion, the proximal end portion and the distal end portion define at least one fluid pathway therebetween with the shaft having a plurality of electrodes, positioning the catheter at a tissue treatment site, applying an electrical current between at least two of the plurality of electrodes, measuring impedance voltage between the at least two of the plurality of electrodes and, processing the measured impedance voltage caused by the applied electrical current to determine if fluid egress is present, to assess lesion quality, to determine tissue composition, ice cover of catheter tip, and to provide contact assessment. The system may have a control unit, a microprocessor, an impedance measuring device or the like to perform processing of impedance data.
摘要翻译：用于检测流体出口的方法和系统，评估病变质量，确定组织组成或结构，通过提供具有近端部分和远端部分的轴的导管，确定导管尖端的冰覆盖和提供组织接触评估，末端部分和远端部分限定其间的至少一个流体通路，其中轴具有多个电极，将导管定位在组织治疗部位，在多个电极中的至少两个之间施加电流，测量多个电极之间的阻抗电压所述多个电极中的至少两个，并且处理由施加的电流引起的测量的阻抗电压以确定是否存在流体出口，以评估病变质量，确定组织组成，导管尖端的冰盖，并提供接触评定。系统可以具有控制单元，微处理器，阻抗测量装置等，以执行阻抗数据的处理。

8. 发明授权

US09027389B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US09027389B2
公开(公告)日：2015-05-12
申请号：US13526620
申请日：2012-06-19
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61B18/02 , G01M3/28 , A61B17/00 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. A check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. Additionally, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。包括止回阀，其与第一柔韧元件和第二柔韧元件之间的接合部流体连通，所述阀还与排气腔流体连通。此外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监测装置。

9. 发明授权

US08206345B2 Fluid control system for a medical device 有权
公开(公告)号：US08206345B2
公开(公告)日：2012-06-26
申请号：US11074293
申请日：2005-03-07
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.

10. 发明授权

US07442190B2 Contact assessment of balloon catheters 有权
标题翻译：球囊导管接触评估
公开(公告)号：US07442190B2
公开(公告)日：2008-10-28
申请号：US11129205
申请日：2005-05-13
申请人： Marwan Abbound , Teresa Ann Mihalik , Johnny Al Asmar , Chadi Harmouche
发明人： Marwan Abbound , Teresa Ann Mihalik , Johnny Al Asmar , Chadi Harmouche
IPC分类号： A61B18/18 , A61B5/02
CPC分类号： A61B5/6885 , A61B5/053 , A61B5/0538 , A61B5/6886 , A61B18/02 , A61B2017/00026 , A61B2017/00039 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/065
摘要： A method and system for determining contact assessment includes the steps of positioning a catheter at a tissue treatment site, where the catheter has a proximal end portion and a distal end portion, the proximal end portion defining at least one fluid inlet port and at least one fluid outlet port, an expandable membrane defining a cooling chamber a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, a coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber, the coolant injection tube, the cooling chamber, and the primary coolant return lumen defining a fluid pathway and a temperature sensor located near the coolant return lumen; measuring an internal temperature of the chamber, and modifying the position of the catheter in response to the measured temperature. The method and system can also use a measured impedance to determine contact assessment.
摘要翻译：用于确定接触评估的方法和系统包括将导管定位在组织治疗部位的步骤，其中所述导管具有近端部分和远端部分，所述近端部分限定至少一个流体入口端口和至少一个流体出口端口，限定冷却室的可膨胀膜，与所述至少一个流体入口和所述冷却室流体连通的冷却剂注入腔，与所述至少一个流体出口和所述冷却室流体连通的冷却剂返回内腔冷却剂注入管，冷却室和第一冷却剂回流腔限定流体通路和位于冷却剂回流腔附近的温度传感器; 测量腔室的内部温度，以及响应于测量的温度改变导管的位置。该方法和系统还可以使用测量的阻抗来确定接触评估。

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