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1. 发明申请

WO2009048673A3 STOCHASTIC CONFINEMENT TO DETECT, MANIPULATE, AND UTILIZE MOLECULES AND ORGANISMS 审中-公开
公开(公告)号：WO2009048673A3
公开(公告)日：2009-04-16
申请号：PCT/US2008/071374
申请日：2008-07-28
申请人： UNIVERSITY OF CHICAGO , BOEDICKER, James, Q. , ISMAGILOV, Rustem, F. , KASTRUP, Christian , GERDTS, Cory , HUYNH, Toan , KIM, Hyun Jung , RUNYON, Matthew, K. , SHEN, Feng
发明人： BOEDICKER, James, Q. , ISMAGILOV, Rustem, F. , KASTRUP, Christian , GERDTS, Cory , HUYNH, Toan , KIM, Hyun Jung , RUNYON, Matthew, K. , SHEN, Feng
IPC分类号： C12Q1/02 , C12Q1/18 , G01N33/542 , G01N33/543 , C12Q1/68
摘要： Methods of detecting organisms e.g. bacteria using stochastic confinement effects with microfluidic technologies involving plugs are provided. Signal amplification methods for the detection of molecules are also disclosed.

2. 发明申请

WO2012148976A1 PILL DISPENSER 审中-公开
标题翻译：药丸分配器
公开(公告)号：WO2012148976A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/034932
申请日：2012-04-25
申请人： ACCESS BUSINESS GROUP INTERNATIONAL LLC , BAARMAN, David W. , EURICH, Sean T. , MOLLEMA, Scott A. , DEAN, Cody D. , KUYVENHOVEN, Neil W. , RUNYON, Matthew K. , VAN DEN BRINK, Joseph C. , SCHAMPER, Ryan D.
发明人： BAARMAN, David W. , EURICH, Sean T. , MOLLEMA, Scott A. , DEAN, Cody D. , KUYVENHOVEN, Neil W. , RUNYON, Matthew K. , VAN DEN BRINK, Joseph C. , SCHAMPER, Ryan D.
IPC分类号： A61J7/00 , A61J7/04
CPC分类号： A61J7/04 , A61J1/03 , A61J7/0076 , A61J7/0084 , A61J7/02 , A61J7/0481 , A61J2200/30 , A61J2200/74 , A61J2205/60 , G06F19/00 , G06F19/3462 , G06Q10/087 , G07F17/0092
摘要： A pill dispensing system that includes pill packages that can be used to dispense pills manually or with a dispenser system to provide enhanced functionality. The packages can be provided with information relating to the packaged pills or to the use of the packaged pills. By reading the information from the package, the dispenser system can know what is in the package, when it is to be taken and can understand and track inventory. The dispenser system provides reminders of when the pills should be taken. The dispenser system may have the ability to key a specific electronic device, such as a cell phone, to a specific user and the dispenser system may require the electronic device to be within proximity of the dispenser system before dispensing pills for that user.
摘要翻译：丸剂分配系统，其包括药丸包装，其可以用于手动或用分配器系统分配药丸以提供增强的功能。包装可以提供有关包装药丸的信息或使用包装的药丸。通过从包装中读取信息，分配器系统可以知道包装中的什么，何时被采集并且可以理解和跟踪库存。分配器系统提醒您何时服用药丸。分配器系统可以具有将特定电子设备（例如手机）键入特定用户的能力，并且在为该用户分配药片之前，分配器系统可能要求电子设备在分配器系统附近。

3. 发明申请

WO2012106478A2 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于免疫组化应用的方法和装置
公开(公告)号：WO2012106478A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023553
申请日：2012-02-01
申请人： KNUTSON, Chistopher, R. , GRANT, Christopher, F. , KLINE, Timothy, R. , DOORNEWEERD, Derek, D. , KURELLA, Sridevi , MUETH, Daniel, M. , RUNYON, Matthew, K. , FU, Haojun , GUEVARA, Sergio, O.
发明人： KNUTSON, Chistopher, R. , GRANT, Christopher, F. , KLINE, Timothy, R. , DOORNEWEERD, Derek, D. , KURELLA, Sridevi , MUETH, Daniel, M. , RUNYON, Matthew, K. , FU, Haojun , GUEVARA, Sergio, O.
IPC分类号： B04B7/02 , B01D43/00
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject, for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), thus allowing for more efficient detection and reduced test time. In one embodiment, the optimized antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. In another embodiment, an optimized antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.
摘要翻译：公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。在一个实施方案中，优化的抗体筛选方法和装置显着降低了与表面的非特异性结合（例如，与红细胞（rbcm）制剂结合的测试表面）的水平，从而允许更有效的检测和减少的测试时间。在一个实施方案中，优化的抗体筛选方法包括免疫球蛋白G（IgG）结合部分，所述免疫球蛋白G（IgG）结合部分选择性且特异性地结合相对于裂解的rbcm制剂的结合而存在的血浆IgG。在另一个实施方案中，公开了一种优化的抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。在其他实施例中，本发明提供了用于目标捕获的方法和装置，其包括用于捕获的可选地具有优化角度的基本平坦的表面。公开了用于捕获的替代固相几何形状。还公开了细胞沉积的优化方法。因此，公开了用于评估样品的优化方法，装置，试剂盒测定。

4. 发明申请

WO2009048673A2 STOCHASTIC CONFINEMENT TO DETECT, MANIPULATE, AND UTILIZE MOLECULES AND ORGANISMS 审中-公开
标题翻译：检测，管理和利用分子和有机物的机密协定
公开(公告)号：WO2009048673A2
公开(公告)日：2009-04-16
申请号：PCT/US2008071374
申请日：2008-07-28
申请人： UNIV CHICAGO , BOEDICKER JAMES Q , ISMAGILOV RUSTEM F , KASTRUP CHRISTIAN , GERDTS CORY , HUYNH TOAN , KIM HYUN JUNG , RUNYON MATTHEW K , SHEN FENG
发明人： BOEDICKER JAMES Q , ISMAGILOV RUSTEM F , KASTRUP CHRISTIAN , GERDTS CORY , HUYNH TOAN , KIM HYUN JUNG , RUNYON MATTHEW K , SHEN FENG
IPC分类号： C12N1/20 , C12M1/00 , C12M1/14 , C12N1/38 , C12N11/04 , C12Q1/02
CPC分类号： C12M35/08 , C12M1/14 , C12M23/34 , C12M25/01 , C12N1/20 , C12N1/38 , C12N11/04 , C12P39/00 , C12Q1/18 , G01N33/542 , G01N33/54313
摘要： Methods of detecting organisms using stochastic confinement effects with microfluidic technologies are provided.
摘要翻译：提供了使用微流控技术的随机限制效应检测生物体的方法。

5. 发明申请

WO2007089777A2 METHOD AND APPARATUS FOR ASSAYING BLOOD CLOTTING 审中-公开
标题翻译：用于测定血液粘贴的方法和装置
公开(公告)号：WO2007089777A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002532
申请日：2007-01-31
申请人： UNIVERSITY OF CHICAGO , ISMAGILOV, Rustem, F. , KASTRUP, Christian, J. , RUNYON, Matthew, K. , SONG, Helen , FENG, Shen
发明人： ISMAGILOV, Rustem, F. , KASTRUP, Christian, J. , RUNYON, Matthew, K. , SONG, Helen , FENG, Shen
IPC分类号： A61B5/00
CPC分类号： G01N33/86
摘要： This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot propagation, which includes a region with material capable of initiating a clotting pathway, and a region where the clot propagation is monitored. Also provided are methods for assaying clotting activity, assaying the integrity of a blood clotting pathway, assaying the effect of a substance on the integrity of a blood clotting pathway, monitoring clot propagation, and preventing clot propagation from one vessel to another.
摘要翻译：本发明提供了用于测定凝血活性的装置。该装置包括用于血液流体的入口和容器中的两个或更多个材料块。该材料能够在血液中引发凝血途径。本发明还提供了一种用于测量凝块传播的装置，其包括具有能够引发凝血途径的材料的区域以及监测凝块传播的区域。还提供了用于测定凝血活性，测定血液凝固途径的完整性，测定物质对血液凝固途径的完整性的影响，监测凝块传播以及防止血块从一个血管传播到另一个血管的方法。

6. 发明申请

WO2012106478A3 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于免疫组化应用的方法和装置
公开(公告)号：WO2012106478A3
公开(公告)日：2012-10-18
申请号：PCT/US2012023553
申请日：2012-02-01
申请人： KNUTSON CHISTOPHER R , GRANT CHRISTOPHER F , KLINE TIMOTHY R , DOORNEWEERD DEREK D , KURELLA SRIDEVI , MUETH DANIEL M , RUNYON MATTHEW K , FU HAOJUN , GUEVARA SERGIO O
发明人： KNUTSON CHISTOPHER R , GRANT CHRISTOPHER F , KLINE TIMOTHY R , DOORNEWEERD DEREK D , KURELLA SRIDEVI , MUETH DANIEL M , RUNYON MATTHEW K , FU HAOJUN , GUEVARA SERGIO O
IPC分类号： C12N5/07 , C07K16/18 , G01N33/555
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject for detecting a target red blood cell protein or antibody are disclosed. Antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), allowing for more efficient detection and reduced test time. The antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. An antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. Additional methods and devices for target capturing include a substantially planar surface having an optimized angle for capture, or alternative solid phase geometries for capture.
摘要翻译：公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。抗体筛选方法和装置显着降低了与表面（例如，与红细胞（rbcm）制剂结合的测试表面）的非特异性结合的水平，允许更有效的检测和减少的测试时间。抗体筛选方法包括免疫球蛋白G（IgG）结合部分，其与选择性且特异性结合相对于与裂解的rbcm制剂的结合存在的血浆IgG。公开了一种抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。用于靶捕获的附加方法和装置包括具有用于捕获的优化角度或用于捕获的替代固相几何形状的基本平坦的表面。

7. 发明申请

WO2012106442A1 CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
标题翻译：用于分离和加工复合流体的离心转子
公开(公告)号：WO2012106442A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023503
申请日：2012-02-01
申请人： ARRYX, INC. , RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
发明人： RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
IPC分类号： B04B5/02
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.
摘要翻译：提供转子用于离心机系统，该离心机系统构造成旋转转子以分离复杂流体。转子包括构造成由离心机系统固定的壳体和形成在壳体中的若干室。每个室包括具有形成在其中的端口的第一室部分和与第一室部分的端口流体连通的第二室部分。第二室部分可以大致设置在第一室部分的端口下方。进一步公开了用于分离复杂流体的其它转子设计和方法。

8. 发明申请

WO2007089777A3 METHOD AND APPARATUS FOR ASSAYING BLOOD CLOTTING 审中-公开
标题翻译：用于测定血液粘贴的方法和装置
公开(公告)号：WO2007089777A3
公开(公告)日：2008-02-07
申请号：PCT/US2007002532
申请日：2007-01-31
申请人： UNIV CHICAGO , ISMAGILOV RUSTEM F , KASTRUP CHRISTIAN J , RUNYON MATTHEW K , SONG HELEN , FENG SHEN
发明人： ISMAGILOV RUSTEM F , KASTRUP CHRISTIAN J , RUNYON MATTHEW K , SONG HELEN , FENG SHEN
IPC分类号： A61B5/00
CPC分类号： G01N33/86
摘要： This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot propagation, which includes a region with material capable of initiating a clotting pathway, and a region where the clot propagation is monitored. Also provided are methods for assaying clotting activity, assaying the integrity of a blood clotting pathway, assaying the effect of a substance on the integrity of a blood clotting pathway, monitoring clot propagation, and preventing clot propagation from one vessel to another.
摘要翻译：本发明提供了用于测定凝血活性的装置。该装置包括用于血液流体的入口和容器中的两个或更多个材料块。该材料能够在血液中引发凝血途径。本发明还提供了一种用于测量凝块传播的装置，其包括具有能够引发凝血途径的材料的区域以及监测凝块传播的区域。还提供了用于测定凝血活性，测定血液凝固途径的完整性，测定物质对血液凝固途径的完整性的影响，监测凝块传播以及防止血块从一个血管传播到另一个血管的方法。

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