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1. 发明申请

WO2012106478A2 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于免疫组化应用的方法和装置
公开(公告)号：WO2012106478A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023553
申请日：2012-02-01
申请人： KNUTSON, Chistopher, R. , GRANT, Christopher, F. , KLINE, Timothy, R. , DOORNEWEERD, Derek, D. , KURELLA, Sridevi , MUETH, Daniel, M. , RUNYON, Matthew, K. , FU, Haojun , GUEVARA, Sergio, O.
发明人： KNUTSON, Chistopher, R. , GRANT, Christopher, F. , KLINE, Timothy, R. , DOORNEWEERD, Derek, D. , KURELLA, Sridevi , MUETH, Daniel, M. , RUNYON, Matthew, K. , FU, Haojun , GUEVARA, Sergio, O.
IPC分类号： B04B7/02 , B01D43/00
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject, for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), thus allowing for more efficient detection and reduced test time. In one embodiment, the optimized antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. In another embodiment, an optimized antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.
摘要翻译：公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。在一个实施方案中，优化的抗体筛选方法和装置显着降低了与表面的非特异性结合（例如，与红细胞（rbcm）制剂结合的测试表面）的水平，从而允许更有效的检测和减少的测试时间。在一个实施方案中，优化的抗体筛选方法包括免疫球蛋白G（IgG）结合部分，所述免疫球蛋白G（IgG）结合部分选择性且特异性地结合相对于裂解的rbcm制剂的结合而存在的血浆IgG。在另一个实施方案中，公开了一种优化的抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。在其他实施例中，本发明提供了用于目标捕获的方法和装置，其包括用于捕获的可选地具有优化角度的基本平坦的表面。公开了用于捕获的替代固相几何形状。还公开了细胞沉积的优化方法。因此，公开了用于评估样品的优化方法，装置，试剂盒测定。

2. 发明申请

WO2012106478A3 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于免疫组化应用的方法和装置
公开(公告)号：WO2012106478A3
公开(公告)日：2012-10-18
申请号：PCT/US2012023553
申请日：2012-02-01
申请人： KNUTSON CHISTOPHER R , GRANT CHRISTOPHER F , KLINE TIMOTHY R , DOORNEWEERD DEREK D , KURELLA SRIDEVI , MUETH DANIEL M , RUNYON MATTHEW K , FU HAOJUN , GUEVARA SERGIO O
发明人： KNUTSON CHISTOPHER R , GRANT CHRISTOPHER F , KLINE TIMOTHY R , DOORNEWEERD DEREK D , KURELLA SRIDEVI , MUETH DANIEL M , RUNYON MATTHEW K , FU HAOJUN , GUEVARA SERGIO O
IPC分类号： C12N5/07 , C07K16/18 , G01N33/555
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject for detecting a target red blood cell protein or antibody are disclosed. Antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), allowing for more efficient detection and reduced test time. The antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. An antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. Additional methods and devices for target capturing include a substantially planar surface having an optimized angle for capture, or alternative solid phase geometries for capture.
摘要翻译：公开了用于评估来自受试者的用于检测靶红细胞蛋白或抗体的样品例如血浆样品的方法和装置。抗体筛选方法和装置显着降低了与表面（例如，与红细胞（rbcm）制剂结合的测试表面）的非特异性结合的水平，允许更有效的检测和减少的测试时间。抗体筛选方法包括免疫球蛋白G（IgG）结合部分，其与选择性且特异性结合相对于与裂解的rbcm制剂的结合存在的血浆IgG。公开了一种抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过在铰链区中特异性切割人IgG的试剂降低。用于靶捕获的附加方法和装置包括具有用于捕获的优化角度或用于捕获的替代固相几何形状的基本平坦的表面。

3. 发明申请

WO2012106442A1 CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
标题翻译：用于分离和加工复合流体的离心转子
公开(公告)号：WO2012106442A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023503
申请日：2012-02-01
申请人： ARRYX, INC. , RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
发明人： RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
IPC分类号： B04B5/02
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.
摘要翻译：提供转子用于离心机系统，该离心机系统构造成旋转转子以分离复杂流体。转子包括构造成由离心机系统固定的壳体和形成在壳体中的若干室。每个室包括具有形成在其中的端口的第一室部分和与第一室部分的端口流体连通的第二室部分。第二室部分可以大致设置在第一室部分的端口下方。进一步公开了用于分离复杂流体的其它转子设计和方法。

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