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1. 发明申请

WO2011031351A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 审中-公开
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：WO2011031351A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/033794
申请日：2010-05-05
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter
发明人： RULE, Peter
IPC分类号： A61B5/00
CPC分类号： G10L21/0208 , A61M5/168 , A61M5/1723
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e g insulin, dextrose, etc ) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

2. 发明申请

WO2006088785A1 ANALYTE DETECTION SYSTEM WITH DISTRIBUTED SENSING 审中-公开
标题翻译：分布式感知分析检测系统
公开(公告)号：WO2006088785A1
公开(公告)日：2006-08-24
申请号：PCT/US2006/005005
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
发明人： BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , RULE, Peter , KEENAN, Richard
IPC分类号： A61B5/15 , A61M1/36
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

3. 发明申请

WO2004062493A1 WEARABLE DEVICE FOR MEASURING ANALYTE CONCENTRATION 审中-公开
标题翻译：用于测量分析仪浓度的可测装置
公开(公告)号：WO2004062493A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041579
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HERRERA, Roger, O. , WITTE, Kenneth, G. , MUNROW, Michael, A. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/14532 , A61B5/1455
摘要： An analyte detection system includes a first wearable module, a detector, and a processor. The first wearable module has an optical input through which electromagnetic radiation may enter said first wearable module. The first wearable module is configured to be worn on and engage a living wearer’s body such that electromagnetic radiation omitted by the body of the wearer can enter the first wearable module via the optical input. The detector is in optical communication with the optical input. The processor is in communication with the detector. The processor is configured to estimate the concentration of an analyte in the wearer’s tissue based on the emitted electromagnetic radiation.
摘要翻译：分析物检测系统包括第一耐磨模块，检测器和处理器。第一可佩戴模块具有光学输入，电磁辐射可通过该输入进入所述第一可穿戴模块。第一可穿戴模块被配置为佩戴在活体佩戴者的身体上并使其接合，使得佩戴者的身体省略的电磁辐射可经由光学输入进入第一佩戴模块。检测器与光学输入端光学通信。处理器与检测器通信。处理器被配置为基于发射的电磁辐射来估计穿着者组织中的分析物的浓度。

4. 发明申请

WO2003030731A3 METHOD AND APPARATUS FOR IMPROVING CLINICAL ACCURACY OF ANALYTE MEASUREMENTS 审中-公开
公开(公告)号：WO2003030731A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032281
申请日：2002-10-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
发明人： BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
IPC分类号： A61B5/00
摘要： Herein is described a system that includes a processing circuit for identifying possible zone D errors among estimated blood glucose concentration values. The system converts estimated blood glucose concentration values which are identified as possible zone D errors into adjusted blood glucose concentration values which are lower in blood glucose concentration magnitude than their corresponding estimated blood glucose concentration values, thereby decreasing the occurrence of zone D errors. Herein is also disclosed a method for improving the clinical accuracy of an analyte concentration measurement. One method includes a first act of computing an estimated analyte concentration having an associated first error that is clinically significant and a second act of processing the estimated analyte concentration to generate an adjusted analyte concentration having a second error that is clinically insignificant.

5. 发明申请

WO2003005894A1 STANDARD FOR NON-INVASIVE OPTICAL MEASUREMENT SYSTEMS 审中-公开
标题翻译：无入射光学测量系统的标准
公开(公告)号：WO2003005894A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/021888
申请日：2002-07-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , CORTELLA, Julian, M. , MUNROW, Mike , WITTE, Kenneth, G. , SMITH, Heidi, M. , HARTSTEIN, Philip, C. , HERRERA, Roger, O. , RULE, Peter
发明人： BRAIG, James, R. , CORTELLA, Julian, M. , MUNROW, Mike , WITTE, Kenneth, G. , SMITH, Heidi, M. , HARTSTEIN, Philip, C. , HERRERA, Roger, O. , RULE, Peter
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B2560/0233
摘要： In accordance with one embodiment there is provided a method of providing a known spectrum to a noninvasive optical detection system of the type having a window for receiving infrared energy. The method comprises affixing a standard to the window. The standard comprises a body formed from a material having known and stable spectral properties. The method further comprises placing at least a portion of the body directly against the window, and operating the optical detection system to detect an emission spectrum of the body. In accordance with another embodiment an infrared spectrometer comprises a window for receiving infrared energy. The window has an exposed surface. The infrared spectrometer further comprises a standard comprising a body formed of a material having known and stable spectral properties. At least part of the body is removably disposed directly against the exposed surface of the window.
摘要翻译：根据一个实施例，提供了一种向具有用于接收红外能量的窗口的类型的无创光学检测系统提供已知光谱的方法。该方法包括将标准附加到窗口。该标准包括由具有已知且稳定的光谱性质的材料形成的主体。该方法还包括将身体的至少一部分直接放置在窗户上，并且操作光学检测系统以检测身体的发射光谱。根据另一实施例，红外光谱仪包括用于接收红外能量的窗口。窗户有一个暴露的表面。红外光谱仪还包括标准，其包括由具有已知且稳定的光谱性质的材料形成的主体。身体的至少一部分可拆卸地直接设置在窗户的暴露表面上。

6. 发明申请

WO2007073392A1 ANALYTE DETECTION SYSTEM AND METHOD WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER 审中-公开
标题翻译：分析仪检测系统和方法与定期抽样和体液分析仪
公开(公告)号：WO2007073392A1
公开(公告)日：2007-06-28
申请号：PCT/US2006/005113
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter
发明人： BRAIG, James, R. , RULE, Peter
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/1486 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61M5/14232 , A61M2005/1726 , A61M2230/201 , G01N27/3271 , G01N33/49
摘要： Described is a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system (203) is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element (9520) is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system (334) is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.
摘要翻译：描述了一种用于分析患者的体液的系统，包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。泵系统（203）联接到流体输送网络。泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体运输网络通过患者终点。至少一个电化学测试元件位于流体输送网络的流体输送点附近。电化学测试元件（9520）定位成接收由流体输送网络输送到输送点的体液的一部分。分析物检测系统（334）被配置为接收测试元件并且测量体液部分中的至少一种分析物。

7. 发明申请

WO2006091426A2 METHODS AND APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID 审中-公开
标题翻译：提取和分析一种体液的方法和装置
公开(公告)号：WO2006091426A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/005112
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
发明人： CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system 334, 1700 and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system 334, 1700 remains in fluid communication with the patient. The analyte detection system 334, 1700 analyzes the first component to measure a concentration of an analyte.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括建立分析物检测系统334,1700与患者体液之间的流体连通。体液的一部分从患者身上抽出。被拉伸的部分被分离成体液的第一组分，而分析物检测系统334,1700与患者保持流体连通。分析物检测系统334,1700分析第一组分以测量分析物的浓度。

8. 发明申请

WO2006086019A3 METHODS OF TREATING DIABETES 审中-公开
公开(公告)号：WO2006086019A3
公开(公告)日：2006-08-17
申请号：PCT/US2005/037699
申请日：2005-10-21
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter
发明人： RULE, Peter
IPC分类号： A61B5/00
摘要： A method of treating a diabetic condition of a patient comprises providing a glucose detection system which is portable and usable by the patient, and which is configured to measure glucose levels with a standard error of less than about 30 mg/dL. The method further comprises making a plurality of measurements of the patient's glucose level with the portable, patient-usable glucose detection system. The method further comprises administering a diabetes treatment to the patient based on one or more of the measurements of the patient's glucose level.

9. 发明申请

WO2004091387A2 DUAL MEASUREMENT ANALYTE DETECTION SYSTEM 审中-公开
标题翻译：双测量分析仪检测系统
公开(公告)号：WO2004091387A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011432
申请日：2004-04-14
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , STERLING, Bernhard, B.
发明人： BRAIG, James, R. , RULE, Peter , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , STERLING, Bernhard, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system (10) is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element (120, 302, 402, 602). The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统（10）被配置为测量由样品元件（120,302,402,602）支撑的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

10. 发明申请

WO2004062500A1 CARTRIDGE LANCE 审中-公开
公开(公告)号：WO2004062500A1
公开(公告)日：2004-07-29
申请号：PCT/US2003/041610
申请日：2003-12-30
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/15
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/15087 , A61B5/15142 , A61B5/1519 , A61B5/157 , G01N21/71
摘要： An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1741) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.
摘要翻译：提供了一种用于分析体液的分析物检测系统（1709），包括分析部分和样品收集部分，其被配置为可移除地耦合到分析部分。分析部分包括被配置为检测电磁辐射和电磁辐射源（220）的检测器（250）。源相对于检测器定位，使得由源发射的电磁辐射由检测器接收。样品收集部分包括壳体，喷枪（1741）和样品室（1734）。喷枪相对于壳体安装并可移动。样品室被配置为在样品收集部分与分析部分相对于源和检测器耦合时可定位，使得由源发射的任何电磁辐射的至少一部分在被存在之前通过样品室由检测器接收。

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