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1. 发明专利

IL176376A METHOD FOR ANALYZING A GLYCOMOLECULE 未知
公开(公告)号：IL176376A
公开(公告)日：2011-11-30
申请号：IL17637606
申请日：2006-06-18
申请人： PROCOGNIA ISRAEL LTD , MARKMAN OFER , ROSENFELD RAKEFET , AMOR YEHUDIT , KOLOG-GULKO MIRIT , SAMOKOVLISTKY ALBENA , KLEINMAN FREDI , ALERGAND TAL , MAYA RUTH , KASUTO-KELSON IDIL , REBE SABINA , BANGIO HAIM
发明人： MARKMAN OFER , ROSENFELD RAKEFET , AMOR YEHUDIT , KOLOG-GULKO MIRIT , SAMOKOVLISTKY ALBENA , KLEINMAN FREDI , ALERGAND TAL , MAYA RUTH , KASUTO-KELSON IDIL , REBE SABINA , BANGIO HAIM
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.

2. 发明申请

WO0065467A9 METHODS FOR IDENTIFYING PHARMACOPHORE CONTAINING MOLECULES FROM A VIRTUAL LIBRARY 审中-公开
标题翻译：从虚拟图书馆鉴定含有分子的药物的方法
公开(公告)号：WO0065467A9
公开(公告)日：2001-12-20
申请号：PCT/IL0000218
申请日：2000-04-12
申请人： PEPTOR LTD , OLENDER ROBERTO , ROSENFELD RAKEFET
发明人： OLENDER ROBERTO , ROSENFELD RAKEFET
IPC分类号： C07K1/04 , G06F17/00 , G06F17/50 , G06F19/00
CPC分类号： C07K1/047
摘要： A method for constructing a potentially pharmaceutically useful molecule that displays a predefined pharmacophore associated with a desired biological activity is disclosed. The pharmacophore is first used to screen a virtual library of scaffolds, described by three-dimensional coordinates, in order to identify one or more scaffold(s) which could potentially display substituents that alone or together with scaffold atoms comprise a pharmacophore. The screening process involves first placing rotamers from a virtual library of substituents onto each attachment point of each scaffold, and then examining the resultant Virtual Combinatorial Library (VCL) according to one or more parameters required by the pharmacophore. Preferably, the VCLs are filtered with a series of filters of increasing complexity, in order to eliminate those scaffolds incompatible with the pharmacophore of choice and to identify scaffolds which could display substituents compatible with the pharmacophore, as well as the corresponding substituent rotamers themselves. The compatible scaffolds and corresponding substituents are combined to represent one or more molecule or molecules containing the desired pharmacophore. Thus, the method of the present invention is able to efficiently screen very large numbers of molecular entities for the presence of a desired pharmacophore.
摘要翻译：公开了一种用于构建显示与所需生物活性相关联的预定药效团的潜在的药学上有用的分子的方法。药效团首先用于筛选由三维坐标描述的支架的虚拟文库，以便鉴定可能单独或与支架原子一起包含药效团的取代基的一个或多个支架。筛选过程包括首先将来自取代基的虚拟文库的旋转异构体放置到每个支架的每个附着点上，然后根据药效团所需的一个或多个参数检查所得的虚拟组合库（VCL）。优选地，用一系列增加复杂性的过滤器过滤VCL，以便消除与所选择的药效团不相容的那些支架，并鉴定可显示与药效团相容的取代基的支架以及相应的取代基旋转异构体本身。将相容的支架和相应的取代基组合以代表含有所需药效团的一个或多个分子或分子。因此，本发明的方法能够有效地筛选非常大量的分子实体来存在所需的药效团。

3. 发明申请

WO2011027351A3 DIAGNOSIS OF GASTROINTESTINAL CANCERS THROUGH GLYCOME ANALYSIS 审中-公开
标题翻译：通过糖分析分析胃肠癌的诊断
公开(公告)号：WO2011027351A3
公开(公告)日：2011-06-30
申请号：PCT/IL2010000739
申请日：2010-09-07
申请人： PROCOGNIA ISRAEL LTD , LANDSTEIN DORIT , SAMOKOVLISKY ALBENA , GORELIK BORIS , ROSENFELD RAKEFET , BITON OSHRY , ROZENBERG MOR , BELZER ILANA , YAKIR YESHAYAHU
发明人： LANDSTEIN DORIT , SAMOKOVLISKY ALBENA , GORELIK BORIS , ROSENFELD RAKEFET , BITON OSHRY , ROZENBERG MOR , BELZER ILANA , YAKIR YESHAYAHU
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N33/57446 , G01N2333/42 , G01N2400/02
摘要： Markers and methods of diagnosis and monitoring of cancer through global glycome analysis.
摘要翻译：通过全球糖蛋白分析诊断和监测癌症的标志物和方法。

4. 发明申请

WO2008007373A1 METHOD AND ASSAY FOR GLYCOSYLATION PATTERN DETECTION RELATED TO CELL STATE 审中-公开
标题翻译：用于与细胞状态相关的糖蛋白模式检测的方法和测定
公开(公告)号：WO2008007373A1
公开(公告)日：2008-01-17
申请号：PCT/IL2007/000871
申请日：2007-07-11
申请人： PROCOGNIA (ISRAEL) LTD , ROSENFELD, Rakefet , SAMOKOVLISKY, Albena , MAYA, Ruth , YAKIR, Yeshayahu , LANDSTEIN, Dorit , ZALLE, Noa , ALONI, Ronny
发明人： ROSENFELD, Rakefet , SAMOKOVLISKY, Albena , MAYA, Ruth , YAKIR, Yeshayahu , LANDSTEIN, Dorit , ZALLE, Noa , ALONI, Ronny
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , G01N2333/42 , G01N2333/4724 , G01N2800/52
摘要： A method and assay for characterizing populations of cells according to their glycosylation pattern, particularly for distinguishing between cell populations. In preferred embodiments the present invention is able to determine the state of a stem cell (ie differentiated or undifferentiated) and/or the state of a cancer cell, for example with regard to malignancy. Preferably the present invention is also able to determine whether a patient is likely to respond to a drug according to the glycosylation pattern of a sample of cancer cells taken from the patient (or alternatively examined while in the patient, as described in greater detail below). Also optionally, it may be used to analyze a cell population before and after treatment with a drug for example.
摘要翻译：根据其糖基化模式来表征细胞群体的方法和测定法，特别是用于区分细胞群体。在优选的实施方案中，本发明能够确定例如关于恶性肿瘤的干细胞（即分化或未分化）和/或癌细胞的状态的状态。优选地，本发明还能够确定患者是否可能根据从患者取得的癌细胞的样品的糖基化模式（或在患者中进行检查，如下文更详细描述）中对药物作出反应）。也可选地，其可以用于分析用例如药物治疗之前和之后的细胞群体。

5. 发明申请

WO2005059563A2 METHOD FOR ANALYZING A GLYCOMOLECULE 审中-公开
标题翻译：分析糖蛋白的方法
公开(公告)号：WO2005059563A2
公开(公告)日：2005-06-30
申请号：PCT/IB2004/004432
申请日：2004-12-20
申请人： PROCOGNIA LTD. , AMOR, Yehudit , MARKMAN, Ofer , GULKO, Mirit, Kolog , SAMOKOVLISTKY, Albena , KLEINMAN, Fredi , ALERGAND, Tal , ROSENFELD, Rakefet , MAYA, Ruth , REBE, Sabina , KASUTO, Idil, Kelson , BANGIO, Haim
发明人： AMOR, Yehudit , MARKMAN, Ofer , GULKO, Mirit, Kolog , SAMOKOVLISTKY, Albena , KLEINMAN, Fredi , ALERGAND, Tal , ROSENFELD, Rakefet , MAYA, Ruth , REBE, Sabina , KASUTO, Idil, Kelson , BANGIO, Haim
IPC分类号： G01N33/68
CPC分类号： G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
摘要翻译：本发明一般涉及含有糖分子的大分子的结构分析，例如与蛋白质（蛋白聚糖，糖蛋白），脂质或游离糖相连的那些大分子。

6. 发明申请

WO2011027351A2 DIAGNOSIS OF CANCERS THROUGH GLYCOME ANALYSIS 审中-公开
标题翻译：通过糖果分析诊断癌症
公开(公告)号：WO2011027351A2
公开(公告)日：2011-03-10
申请号：PCT/IL2010/000739
申请日：2010-09-07
申请人： Procognia (Israel) Ltd , LANDSTEIN, Dorit , SAMOKOVLISKY, Albena , GORELIK, Boris , ROSENFELD, Rakefet , BITON, Oshry , ROZENBERG, Mor , BELZER, Ilana , YAKIR, Yeshayahu
发明人： LANDSTEIN, Dorit , SAMOKOVLISKY, Albena , GORELIK, Boris , ROSENFELD, Rakefet , BITON, Oshry , ROZENBERG, Mor , BELZER, Ilana , YAKIR, Yeshayahu
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N33/57446 , G01N2333/42 , G01N2400/02
摘要： Markers and methods of diagnosis and monitoring of cancer through global glycome analysis.
摘要翻译：通过全球糖蛋白分析诊断和监测癌症的标志物和方法。

7. 发明申请

WO2009078015A3 METHOD AND ASSAY FOR GLYCOSYLATION PATTERN DETECTION RELATED TO CELL STATE OF STEM CELLS 审中-公开
标题翻译：用于干细胞细胞状态的糖蛋白模式检测的方法和测定
公开(公告)号：WO2009078015A3
公开(公告)日：2010-03-11
申请号：PCT/IL2008001628
申请日：2008-12-17
申请人： PROCOGNIA ISRAEL LTD , YEDA RES & DEV , ZIPORI DOV , MORAD VERED , ROSENFELD RAKEFET , SAMOKOVLISTKY ALBENA , YAKIR YESHAYAHU , LANDSTEIN DORIT , ZALLE NOA , ALONI RONNY
发明人： ZIPORI DOV , MORAD VERED , ROSENFELD RAKEFET , SAMOKOVLISTKY ALBENA , YAKIR YESHAYAHU , LANDSTEIN DORIT , ZALLE NOA , ALONI RONNY
IPC分类号： C12Q1/00
CPC分类号： G01N33/54306 , C12N5/0663 , C12N2501/70 , C12N2501/90 , G01N33/56966 , G01N2400/00
摘要： A method and assay for characterizing populations of stem cells according to their glycosylation pattern, particularly for distinguishing between stem cell populations, for example with regard to state of differentiation.
摘要翻译：根据其糖基化模式来表征干细胞群体的方法和测定法，特别是用于区分干细胞群体，例如关于分化状态。

8. 发明申请

WO2009078015A2 METHOD AND ASSAY FOR GLYCOSYLATION PATTERN DETECTION RELATED TO CELL STATE OF STEM CELLS 审中-公开
标题翻译：用于干细胞细胞状态的糖蛋白模式检测的方法和测定
公开(公告)号：WO2009078015A2
公开(公告)日：2009-06-25
申请号：PCT/IL2008/001628
申请日：2008-12-17
申请人： PROCOGNIA (ISRAEL) LTD , YEDA RESEARCH AND DEVELOPMENT CO. LTD. , ZIPORI, Dov , MORAD, Vered , ROSENFELD, Rakefet , SAMOKOVLISTKY, Albena , YAKIR, Yeshayahu , LANDSTEIN, Dorit , ZALLE, Noa , ALONI, Ronny
发明人： ZIPORI, Dov , MORAD, Vered , ROSENFELD, Rakefet , SAMOKOVLISTKY, Albena , YAKIR, Yeshayahu , LANDSTEIN, Dorit , ZALLE, Noa , ALONI, Ronny
IPC分类号： G01N33/554
CPC分类号： G01N33/54306 , C12N5/0663 , C12N2501/70 , C12N2501/90 , G01N33/56966 , G01N2400/00
摘要： A method and assay for characterizing populations of stem cells according to their glycosylation pattern, particularly for distinguishing between stem cell populations, for example with regard to state of differentiation.
摘要翻译：根据其糖基化模式来表征干细胞群体的方法和测定法，特别是用于区分干细胞群体，例如关于分化状态。

9. 发明申请

WO2008007373B1 METHOD AND ASSAY FOR GLYCOSYLATION PATTERN DETECTION RELATED TO CELL STATE 审中-公开
标题翻译：糖基化模式检测与细胞状态相关的方法和检测方法
公开(公告)号：WO2008007373B1
公开(公告)日：2008-03-13
申请号：PCT/IL2007000871
申请日：2007-07-11
申请人： PROCOGNIA ISRAEL LTD , ROSENFELD RAKEFET , SAMOKOVLISKY ALBENA , MAYA RUTH , YAKIR YESHAYAHU , LANDSTEIN DORIT , ZALLE NOA , ALONI RONNY
发明人： ROSENFELD RAKEFET , SAMOKOVLISKY ALBENA , MAYA RUTH , YAKIR YESHAYAHU , LANDSTEIN DORIT , ZALLE NOA , ALONI RONNY
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , G01N2333/42 , G01N2333/4724 , G01N2800/52
摘要： A method and assay for characterizing populations of cells according to their glycosylation pattern, particularly for distinguishing between cell populations. In preferred embodiments the present invention is able to determine the state of a stem cell (ie differentiated or undifferentiated) and/or the state of a cancer cell, for example with regard to malignancy. Preferably the present invention is also able to determine whether a patient is likely to respond to a drug according to the glycosylation pattern of a sample of cancer cells taken from the patient (or alternatively examined while in the patient, as described in greater detail below). Also optionally, it may be used to analyze a cell population before and after treatment with a drug for example.
摘要翻译：用于根据其糖基化模式表征细胞群体的方法和测定，特别是用于区分细胞群体。在优选的实施方案中，本发明能够确定干细胞的状态（即分化的或未分化的）和/或癌细胞的状态，例如关于恶性肿瘤。优选地，本发明还能够根据取自患者的癌细胞样品的糖基化模式确定患者是否可能对药物作出反应（或者在患者体内进行检查时，如下文更详细描述的那样）。还任选地，它可以用于例如在用药物治疗之前和之后分析细胞群体。

10. 发明申请

WO2005059563A3 METHOD FOR ANALYZING A GLYCOMOLECULE 审中-公开
标题翻译：分析GLYCOMOLECULLE的方法
公开(公告)号：WO2005059563A3
公开(公告)日：2005-10-27
申请号：PCT/IB2004004432
申请日：2004-12-20
申请人： PROCOGNIA LTD , AMOR YEHUDIT , MARKMAN OFER , GULKO MIRIT KOLOG , SAMOKOVLISTKY ALBENA , KLEINMAN FREDI , ALERGAND TAL , ROSENFELD RAKEFET , MAYA RUTH , REBE SABINA , KASUTO IDIL KELSON , BANGIO HAIM
发明人： AMOR YEHUDIT , MARKMAN OFER , GULKO MIRIT KOLOG , SAMOKOVLISTKY ALBENA , KLEINMAN FREDI , ALERGAND TAL , ROSENFELD RAKEFET , MAYA RUTH , REBE SABINA , KASUTO IDIL KELSON , BANGIO HAIM
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
摘要翻译：本发明一般涉及含糖分子的大分子的结构分析，例如与蛋白质（蛋白聚糖，糖蛋白），脂质或游离糖连接的那些。

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