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1. 发明专利

AU2721897A Anti-cryptosporidium parvum preparations 未知
公开(公告)号：AU2721897A
公开(公告)日：1997-10-22
申请号：AU2721897
申请日：1997-03-28
申请人： PERRYMAN LANCE E , RIGGS MICHAEL W
发明人： RIGGS MICHAEL W , PERRYMAN LANCE E
IPC分类号： A61K35/20 , A61K38/00 , A61K39/00 , A61K39/012 , A61K39/395 , C07K14/44 , C07K16/20 , C12N5/20 , A61K39/002
摘要： Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for triggering the neutralizing CSP-like reaction in the parasite. Antibodies targeted against the critical epitope were shown to possess neutralizing activity, and could be combined with other anti-C. parvum monoclonal antibodies and administered to an animal to confer passive immunity. Immunogenic compositions including the purified antigen are disclosed for use in stimulating an active immune response against C. parvum.

2. 发明申请

WO2007047189A2 TARGETED BIOCIDES 审中-公开
标题翻译：目标生物
公开(公告)号：WO2007047189A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/039361
申请日：2006-10-10
申请人： IOGENETICS, LLC , IMBODEN, Michael , RIGGS, Michael, W. , SCHAEFER, Deborah
发明人： IMBODEN, Michael , RIGGS, Michael, W. , SCHAEFER, Deborah
IPC分类号： A61K39/40 , C07K16/12
CPC分类号： C07K16/14 , A61K2039/505 , C07K16/20 , C07K2317/12 , C07K2317/622 , C07K2317/76 , C07K2319/30 , C07K2319/55
摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule ( e.g., immunoglobulin or innate immune system receptor molecule) and a biocide ( e.g ., bactericidal enzyme) in transgenic animals ( e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care ( e.g ., human and veterinary), agriculture ( e.g., animal and plant production), and food processing ( e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.
摘要翻译：本发明涉及编码新单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体及其使用和生产方法。特别地，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如，免疫球蛋白或先天性免疫系统受体分子）和杀生物剂（例如，杀菌酶）的融合蛋白的方法文化。本发明还涉及在医疗保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法，牛肉屠体处理）。本发明还涉及在农业，医药，国防等不同领域的多种诊断应用中使用包含微生物靶向分子和杀生物剂的融合蛋白的方法。

3. 发明申请

WO1998007320A1 NEUTRALIZATION-SENSITIVE EPITOPES OF CRYPTOSPORIDIUM PARVUM 审中-公开
标题翻译：中华UM。。。。。。。。。。。。。。。。。
公开(公告)号：WO1998007320A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014834
申请日：1997-08-22
申请人： NORTH CAROLINA STATE UNIVERSITY , PERRYMAN, Lance, E. , JASMER, Douglas, P. , RIGGS, Michael, W. , McGUIRE, Travis, C.
发明人： NORTH CAROLINA STATE UNIVERSITY
IPC分类号： A01N43/04
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K16/20 , Y02A50/488 , Y02A50/489
摘要： DNA sequences encoding epitopes to which sporozoite-neutralizing antibodies are directed are provided. Recombinant proteins and synthetic peptides containing Cryptosporidium parvum epitopes for inducing an antigenic response are described.
摘要翻译：提供了编码针对子孢子中和抗体的表位的DNA序列。描述了含有诱导抗原应答的隐孢子虫表皮的重组蛋白和合成肽。

4. 发明申请

WO2007047189A3 TARGETED BIOCIDES 审中-公开
标题翻译：目标生物
公开(公告)号：WO2007047189A3
公开(公告)日：2007-11-15
申请号：PCT/US2006039361
申请日：2006-10-10
申请人： IOGENETICS LLC , UNIV ARIZONA , IMBODEN MICHAEL , RIGGS MICHAEL W , SCHAEFER DEBORAH
发明人： IMBODEN MICHAEL , RIGGS MICHAEL W , SCHAEFER DEBORAH
IPC分类号： A61K39/40 , C07K16/12
CPC分类号： C07K16/14 , A61K2039/505 , C07K16/20 , C07K2317/12 , C07K2317/622 , C07K2317/76 , C07K2319/30 , C07K2319/55
摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzyme) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.
摘要翻译：本发明涉及编码新型单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体以及使用和生产它的方法。具体而言，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如免疫球蛋白或先天免疫系统受体分子）和杀生物剂（例如杀菌酶）的融合蛋白的方法文化。本发明还涉及使用包含微生物靶向分子和杀生物剂的保健（例如人和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）的融合蛋白的治疗性和预防性方法，牛肉胴体加工）。本发明还涉及使用包含微生物靶向分子和杀生物剂的融合蛋白在多种不同领域如农业，医学和国防中的各种诊断应用中的方法。

5. 发明申请

WO2006132665A3 BIOCIDES 审中-公开
标题翻译：杀生物剂
公开(公告)号：WO2006132665A3
公开(公告)日：2007-04-26
申请号：PCT/US2005037709
申请日：2005-10-19
申请人： IOGENETICS LLC , HOMAN JANE , IMBODEN MICHAEL , RIGGS MICHAEL W , CARRYN STEPHANE
发明人： HOMAN JANE , IMBODEN MICHAEL , RIGGS MICHAEL W , CARRYN STEPHANE
IPC分类号： C12N1/00 , A01N25/00 , A21D2/00 , A23B7/10 , A23C9/12 , A23L13/00 , A61K8/00 , A61K38/43 , C11D3/36
CPC分类号： A61K38/465 , A01N63/02 , A23B4/20 , A23L3/3463 , A61K38/1729 , A61K38/40 , A61L2/18 , A61L2/23 , C02F1/50 , C02F2103/02
摘要： The present invention relates to the use of biocide (e.g., bactericidal enzyme) to target pathogens. In particular, the present invention provides biocides for use in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., water purification).
摘要翻译：本发明涉及杀生物剂（例如杀菌酶）用于靶向病原体的用途。特别地，本发明提供用于保健（例如人和兽医），农业（例如动物和植物生产）和食品加工（例如水净化）中的杀生物剂。

6. 发明申请

WO2006132665A2 BIOCIDES 审中-公开
标题翻译：杀生物剂
公开(公告)号：WO2006132665A2
公开(公告)日：2006-12-14
申请号：PCT/US2005/037709
申请日：2005-10-19
申请人： IOGENETICS, LLC , HOMAN, Jane , IMBODEN, Michael , RIGGS, Michael, W. , CARRYN, Stephane
发明人： HOMAN, Jane , IMBODEN, Michael , RIGGS, Michael, W. , CARRYN, Stephane
IPC分类号： A61K38/47
CPC分类号： A61K38/465 , A01N63/02 , A23B4/20 , A23L3/3463 , A61K38/1729 , A61K38/40 , A61L2/18 , A61L2/23 , C02F1/50 , C02F2103/02
摘要： The present invention relates to the use of biocide (e.g., bactericidal enzyme) to target pathogens. In particular, the present invention provides biocides for use in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., water purification).
摘要翻译：本发明涉及杀生物剂（例如杀菌酶）用于靶向病原体的用途。特别地，本发明提供用于保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如水净化）中的杀生物剂。

7. 发明申请

WO1997036612A1 ANTI-CRYPTOSPORIDIUM PARVUM PREPARATIONS 审中-公开
标题翻译：抗高血压药物制剂
公开(公告)号：WO1997036612A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005195
申请日：1997-03-28
申请人： RIGGS, Michael, W. , PERRYMAN, Lance, E.
IPC分类号： A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , C07K16/20 , Y02A50/488 , Y02A50/489 , Y10S424/807 , Y10S435/947 , Y10S530/822 , Y10S530/832
摘要： Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for triggering the neutralizing CSP-like reaction in the parasite. Antibodies targeted against the critical epitope were shown to possess neutralizing activity, and could be combined with other anti-C. parvum monoclonal antibodies and administered to an animal to confer passive immunity. Immunogenic compositions including the purified antigen are disclosed for use in stimulating an active immune response against C. parvum.
摘要翻译：用于赋予寄生虫C.小檗的被动或主动免疫的组合物和方法。分离自小曲霉的能够结合mAb 3E2的高分子量糖蛋白抗原被证明具有对于在寄生虫中触发中和的CSP样反应关键的表位。针对关键表位的抗体显示具有中和活性，并可与其他抗C结合。小鼠单克隆抗体并施用于动物以赋予被动免疫。公开了包含纯化抗原的免疫原性组合物用于刺激针对小曲霉的活性免疫应答。

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