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1. 发明申请

WO2006069331A2 COMPOSITIONS AND METHODS FOR PRODUCING RECOMBINANT PROTEINS 审中-公开
标题翻译：用于生产重组蛋白的组合物和方法
公开(公告)号：WO2006069331A2
公开(公告)日：2006-06-29
申请号：PCT/US2005046853
申请日：2005-12-21
申请人： SALK INST FOR BIOLOGICAL STUDI , ROOSILD TARMO , GREENWALD JASON , CHOE SENYON , RIEK ROLAND , VEGA MARK
发明人： ROOSILD TARMO , GREENWALD JASON , CHOE SENYON , RIEK ROLAND , VEGA MARK
CPC分类号： C07K14/32 , C07K2319/01 , C07K2319/03
摘要： A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic polypeptides and Mistic fusion proteins are disclosed herein. Also described are methods of using Mistic polypeptides and Mistic fusion proteins to produce and/or isolate recombinant proteins (including without limitation classes of eukaryotic proteins that have previously been intractable to recombinant bacterial expression, such as, eukaryotic integral membrane proteins).
摘要翻译：本文公开了一类称为Mistic多肽，其变体，融合蛋白（包括Mistic多肽结构域）和编码Mistic多肽和Mistic融合蛋白的核酸分子的整合膜蛋白。还描述了使用Mistic多肽和Mistic融合蛋白来产生和/或分离重组蛋白（包括但不限于以前对重组细菌表达难以处理的真核蛋白的类别，例如真核整合膜蛋白）的方法。

2. 发明申请

WO2006031322A3 DETERMINATION OF THE 3D-STRUCTURE OF AN EXTRACELLULAR DOMAIN OF A B1 G-PROTEIN COUPLED RECEPTOR BY NMR ANALYSIS 审中-公开
标题翻译：通过NMR分析确定B1 G蛋白偶联受体的细胞外结构域的三维结构
公开(公告)号：WO2006031322A3
公开(公告)日：2006-05-18
申请号：PCT/US2005028231
申请日：2005-08-09
申请人： RES DEV FOUNDATION , ROYAPPA GRACE CHRISTY RANI , PERRIN MARILYN H , RIVIER JEAN E , VALE WYLIE W , RIEK ROLAND
发明人： ROYAPPA GRACE CHRISTY RANI , PERRIN MARILYN H , RIVIER JEAN E , VALE WYLIE W , RIEK ROLAND
IPC分类号： C07K14/72 , G01N33/50
CPC分类号： C07K14/723 , C07K2299/00 , G01N2333/726 , G06F19/16 , G06F19/18
摘要： The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
摘要翻译：本发明涉及用于鉴定B1G-蛋白偶联受体调节剂的方法。本发明还涉及用于鉴定促肾上腺皮质激素释放因子受体2（CRFR2）的拮抗剂或激动剂的方法。本发明还涉及一种改善CRFR2拮抗剂或激动剂的方法。本发明还涉及作为B1GPCR亚族的代表性的CRFR2的三维结构及其作为B1GPCR的拮抗剂或激动剂的合理药物设计的基础的用途。

3. 发明申请

WO2004009614A2 RECEPTOR (SSTR4)- SELECTIVE SOMATOSTATIN ANALOGS 审中-公开
标题翻译：受体（SSTR4） - 选择性SOMATOSTATIN ANALOGS
公开(公告)号：WO2004009614A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022600
申请日：2003-07-18
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , RIVIER, Jean, E., F. , REUBI, Jean Claude , ERCHEGYI, Judit , RIEK, Roland
发明人： RIVIER, Jean, E., F. , REUBI, Jean Claude , ERCHEGYI, Judit , RIEK, Roland
IPC分类号： C07K
CPC分类号： C07K14/655 , A61K38/00
摘要： Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA 1,2,4,5,12,13 [Ala 7 ] -SRIF; des-AA 1,2,4,5,12,13 [Aph 7 ] -SRIF, des-AA 1'2,4,5,12,13 [Aph 7 ] Cbm-SRIF; desAA 1,4,5,12,13 [Tyr 2 Ala 7 ] -Cbm-SRIF, and des-AA 1'2,4,5,12,13 [Tyr 7 , C B Me-L2Nal 8 ]-SRIF, and counterparts incorporating D-Cys 3 and/or DTrp 8 and/or Ala 11 , bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.
摘要翻译：与其他克隆的SRIF受体相比，选择性SSTR4的SRIF的类似物可用于确定受体SSTR4的组织和细胞表达及其在调节肿瘤生长中的生物学作用。 SRIF类似物肽，如des-AA <1,2,4,5,12,13> [Ala 7] -SRIF; des-AA <1,2,4,5,12,13> [Aph 7] -SRIF，des-AA <1,2,4,5,12,13> [Aph 7] Cbm-SRIF ; desAA <1,4,5,12,13> [Tyr 2 Ala 7] -C bm-SRIF和des-AA <1,2,4,5,12,13> [Tyr 7] 结合D-Cys 3和/或DTrp 8和/或Ala 11的对应物以高亲和力结合到克隆的人受体SSTR4并激活受体，但它们不以与人SSTR1，SSTR2，SSTR3或SSTR5的显着亲和力结合。通过在这些SSTR4选择性SRIF类似物中加入位置2的碘化酪氨酸，可以提供用于药物筛选方法的标记化合物。或者，为了用于治疗，细胞毒素或高度放射性元素可以是N-末端偶联或与其复合的。

4. 发明申请

WO2004009614A3 RECEPTOR (SSTR4)- SELECTIVE SOMATOSTATIN ANALOGS 审中-公开
标题翻译：受体（SSTR4） - 选择性SOMATOSTATIN ANALOGS
公开(公告)号：WO2004009614A3
公开(公告)日：2006-08-03
申请号：PCT/US0322600
申请日：2003-07-18
申请人： SALK INST FOR BIOLOGICAL STUDI , RIVIER JEAN E F , REUBI JEAN CLAUDE , ERCHEGYI JUDIT , RIEK ROLAND
发明人： RIVIER JEAN E F , REUBI JEAN CLAUDE , ERCHEGYI JUDIT , RIEK ROLAND
IPC分类号： A61K38/00 , A61K38/12 , C07K14/655
CPC分类号： C07K14/655 , A61K38/00
摘要： Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA 1,2,4,5,12,13 [Ala 7 ] -SRIF; des-AA 1,2,4,5,12,13 [Aph 7 ] -SRIF, des-AA 1'2,4,5,12,13 [Aph 7 ] Cbm-SRIF; desAA 1,4,5,12,13 [Tyr 2 Ala 7 ] -Cbm-SRIF, and des-AA 1'2,4,5,12,13 [Tyr 7 , C B Me-L2Nal 8 ]-SRIF, and counterparts incorporating D-Cys 3 and/or DTrp 8 and/or Ala 11 , bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.
摘要翻译：与其他克隆的SRIF受体相比，选择性SSTR4的SRIF的类似物可用于确定受体SSTR4的组织和细胞表达及其在调节肿瘤生长中的生物学作用。 SRIF类似物肽，如des-AA 1,2,4,5,12,13，[Ala 7] -SRIF; des-AA 1,2,4,5,12,13 [Aph] 7RIF，des-AA 1,2,4,5,12 ，13β-Cpm-SRIF; desAA 1,4,5,12,13 [Tyr 2] Ala 7-C bm-SRIF和des-AA 1 '2,4,5,12,13 [Tyr 7]，C B 2 Me-L2 Nal 8 -SRIF，和结合D-Cys 3和/或DTrp 8和/或Ala 11的对应物以高亲和力结合克隆的人受体SSTR4并激活受体，但它们不以与人SSTR1，SSTR2，SSTR3或SSTR5的显着亲和力结合。通过在这些SSTR4选择性SRIF类似物中加入位置2的碘化酪氨酸，可以提供用于药物筛选方法的标记化合物。或者，为了用于治疗，细胞毒素或高度放射性元素可以是N-末端偶联或与其复合的。

5. 发明申请

WO2006069331A3 COMPOSITIONS AND METHODS FOR PRODUCING RECOMBINANT PROTEINS 审中-公开
公开(公告)号：WO2006069331A3
公开(公告)日：2006-06-29
申请号：PCT/US2005/046853
申请日：2005-12-21
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , ROOSILD, Tarmo , GREENWALD, Jason , CHOE, Senyon , RIEK, Roland , VEGA, Mark
发明人： ROOSILD, Tarmo , GREENWALD, Jason , CHOE, Senyon , RIEK, Roland , VEGA, Mark
IPC分类号： C07K14/32
摘要： A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic polypeptides and Mistic fusion proteins are disclosed herein. Also described are methods of using Mistic polypeptides and Mistic fusion proteins to produce and/or isolate recombinant proteins (including without limitation classes of eukaryotic proteins that have previously been intractable to recombinant bacterial expression, such as, eukaryotic integral membrane proteins).

6. 发明申请

WO2006031322A2 STRUCTURE-BASED MODULATORS OF B1 G-PROTEIN COUPLED RECEPTORS 审中-公开
标题翻译： B1 G蛋白偶联受体的结构调节剂
公开(公告)号：WO2006031322A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/028231
申请日：2005-08-09
申请人： RESEARCH DEVELOPMENT FOUNDATION , ROYAPPA, Grace, Christy, Rani , PERRIN, Marilyn, H. , RIVIER, Jean, E. , VALE, Wylie, W. , RIEK, Roland
发明人： ROYAPPA, Grace, Christy, Rani , PERRIN, Marilyn, H. , RIVIER, Jean, E. , VALE, Wylie, W. , RIEK, Roland
IPC分类号： C07K14/72 , G01N33/50
CPC分类号： C07K14/723 , C07K2299/00 , G01N2333/726 , G06F19/16 , G06F19/18
摘要： The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.
摘要翻译：本发明涉及用于鉴定B1G-蛋白偶联受体调节剂的方法。本发明还涉及用于鉴定促肾上腺皮质激素释放因子受体2（CRFR2）的拮抗剂或激动剂的方法。本发明还涉及一种改善CRFR2拮抗剂或激动剂的方法。本发明还涉及作为B1GPCR亚家族代表的CRFR2的三维结构及其作为B1GPCR拮抗剂或激动剂合理药物设计的基础的用途。

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