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1. 发明申请

WO2008150493A1 PHARMACEUTICAL COMPOSITION COMPRISING A SUBSTRATE AND A COATING CONTAINING AN ACTIVE INGREDIENT AND POLYVINYLALCOHOL 审中-公开
标题翻译：包含基材和含有活性成分和聚乙烯醇的涂料的药物组合物
公开(公告)号：WO2008150493A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/006914
申请日：2008-05-30
申请人： SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC. , FRITZ, Glenn, E. , REO, Joseph, P. , KABIR, Mohammed, A.
发明人： FRITZ, Glenn, E. , REO, Joseph, P. , KABIR, Mohammed, A.
IPC分类号： A61K9/32 , A61K31/137
CPC分类号： A61K31/137
摘要： Compositions of matter containing an active agent, and methods of manufacturing thereof, wherein the method comprises the step of coating a substrate with a coating composition comprising the active agent formulated for immediate release, wherein the coating composition does not contain an appreciable amount of cellulosic materials and preferably comprises polyvinyl alcohol or a polyvinyl alcohol derived copolymer..
摘要翻译：含有活性剂的物质组合物及其制造方法，其中该方法包括用包含配制成立即释放的活性剂的涂料组合物涂覆基材的步骤，其中涂料组合物不含有明显量的纤维素材料优选包含聚乙烯醇或聚乙烯醇衍生的共聚物。

2. 发明申请

WO2004010997A8 SUSTAINED-RELEASE TABLET COMPOSITION OF PRAMIPEXOLE 审中-公开
标题翻译：持续释放的片剂组合物
公开(公告)号：WO2004010997A8
公开(公告)日：2005-02-24
申请号：PCT/US0323205
申请日：2003-07-25
申请人： PHARMACIA CORP , AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： C07D277/82 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/36 , A61K31/428 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00
CPC分类号： A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/428 , A61K31/4745
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm at a solid fraction representative of a tablet.
摘要翻译：口服递送片剂形式的缓释药物组合物包含普拉克索的水溶性盐，其分散在包含亲水性聚合物的基质和抗拉强度为至少约0.15kN cm -2的淀粉中代表片剂的固体分数。

3. 发明申请

WO2004087108A1 TASTE-MASKING VEHICLE FOR COATED OXAZOLIDINONE PARTICLES 审中-公开
标题翻译：用于涂覆的氧杂环丁酮粒子的汽车掩蔽车辆
公开(公告)号：WO2004087108A1
公开(公告)日：2004-10-14
申请号：PCT/IB2004/000921
申请日：2004-03-19
申请人： PHARMACIA CORPORATION , FREDRICKSON, Jennifer, K. , KISTKA, Julia, A. , REO, Joseph, P.
发明人： FREDRICKSON, Jennifer, K. , KISTKA, Julia, A. , REO, Joseph, P.
IPC分类号： A61K9/16
CPC分类号： A61K9/0095 , A61K9/5026 , A61K9/5047 , A61K31/421 , A61K31/4439 , A61K31/5377 , A61K47/26
摘要： The present invention is directed to dry formulations of coated oxazolidinone particles, such as coated linezolid particles, which, when suspended in an aqueous solution, mask the taste of the oxazolidinone in the resulting suspension vehicle. Specifically, a mixture of sugars in the formulation, comprising sorbitol and sucrose, inhibit mass transport of the oxazolidinone from the particles into the suspension vehicle. Dry formulations of the coated oxazolidinone particles, suspensions of the same, and methods of using the same to treat or prevent infections from gram positive bacteria are all disclosed.
摘要翻译：本发明涉及涂覆的恶唑烷酮颗粒的干燥制剂，例如涂覆的利奈唑胺，其在悬浮在水溶液中时掩盖所得悬浮载体中恶唑烷酮的味道。具体地说，制剂中含有山梨糖醇和蔗糖的糖的混合物抑制恶唑烷酮从颗粒中的大量运输到悬浮载体中。所有披露的恶唑烷酮颗粒的干燥制剂，其悬浮液及其使用方法可用于治疗或预防革兰氏阳性菌感染。

4. 发明申请

WO2012058157A1 THERAPEUTIC SOLUTION CONCENTRATE 审中-公开
标题翻译：治疗方案浓度
公开(公告)号：WO2012058157A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057494
申请日：2011-10-24
申请人： MSD CONSUMER CARE, INC. , REO, Joseph, P. , FOWLER, Kevin, C. , KABIR, Mohamed, A. , TUNE, Michael, P. , NELSON, Dennis , TAI, Anna, W. , KIM, Nanhye
发明人： REO, Joseph, P. , FOWLER, Kevin, C. , KABIR, Mohamed, A. , TUNE, Michael, P. , NELSON, Dennis , TAI, Anna, W. , KIM, Nanhye
IPC分类号： B01F3/00
CPC分类号： A61K47/24 , A61K9/0095 , A61K9/08 , A61K31/765 , A61K31/77 , A61K47/02 , A61K47/12 , A61K47/18
摘要： A concentrated poly(ethylene glycol) solution that has good stability for extended storage is provided for use as a laxative. The concentrated solution comprises water, sodium benzoate, poly(ethylene glycol), and enough acid to yield a solution having a pH at 25 C in the range 3.0-5.0. It is prepared and packaged to minimize the accumulation of degradation products.
摘要翻译：提供具有良好的延长储存稳定性的浓缩聚（乙二醇）溶液用作泻药。浓缩溶液包括水，苯甲酸钠，聚（乙二醇）和足够的酸，得到pH为25℃，3.0-5.0范围内的溶液。它被制备和包装以最小化降解产物的积累。

5. 发明申请

WO2007143155A3 SUSTAINED RELEASE PHARMACEUTICAL DOSAGE FORM CONTAINING PHENYLEPHRINE 审中-公开
标题翻译：持续释放含有PHYYLEPHRINE的药物剂型
公开(公告)号：WO2007143155A3
公开(公告)日：2008-11-06
申请号：PCT/US2007013047
申请日：2007-06-01
申请人： SCHERING PLOUGH HEALTHCARE , PATTON JOHN W , KABIR MOHAMMED , REO JOSEPH P
发明人： PATTON JOHN W , KABIR MOHAMMED , REO JOSEPH P
IPC分类号： A61K9/22 , A61K9/36 , A61K31/137
CPC分类号： A61K9/2054 , A61K9/209
摘要： Pharmaceutical compositions comprising phenylephrine in a sustained release oral dosage formulation. Compositions can comprise phenylephrine alone or phenylephrine in combination additional pharmaceutically active substances such as an antihistamine and/or an analgesic.
摘要翻译：包含持续释放口服剂量制剂中的去氧肾上腺素的药物组合物。组合物可以组合另外的药物活性物质如抗组胺剂和/或止痛剂组合使用单独的苯肾上腺素或去氧肾上腺素。

6. 发明申请

WO2007143155A2 SUSTAINED RELEASE PHARMACEUTICAL DOSAGE FORM CONTAINING PHENYLEPHRINE 审中-公开
标题翻译：持续释放含有PHYYLEPHRINE的药物剂型
公开(公告)号：WO2007143155A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/013047
申请日：2007-06-01
申请人： SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC. , PATTON, John, W. , KABIR, Mohammed , REO, Joseph, P.
发明人： PATTON, John, W. , KABIR, Mohammed , REO, Joseph, P.
CPC分类号： A61K9/2054 , A61K9/209
摘要： Pharmaceutical compositions comprising phenylephrine in a sustained release oral dosage formulation. Compositions can comprise phenylephrine alone or phenylephrine in combination additional pharmaceutically active substances such as an antihistamine and/or an analgesic.
摘要翻译：包含持续释放口服剂量制剂中的去氧肾上腺素的药物组合物。组合物可以组合另外的药物活性物质如抗组胺剂和/或止痛剂组合使用单独的苯肾上腺素或去氧肾上腺素。

7. 发明申请

WO2004010998A8 SUSTAINED-RELEASE TABLET COMPRISING REBOXETINE 审中-公开
标题翻译：包含REBOXETINE的持续释放片
公开(公告)号：WO2004010998A8
公开(公告)日：2005-01-27
申请号：PCT/US0323418
申请日：2003-07-25
申请人： PHARMACIA CORP , AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , MARTINO ALICE C , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , MARTINO ALICE C , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： A61K31/513 , A61K9/20 , A61K9/22 , A61K9/28 , A61K31/428 , A61K31/4745 , A61K31/5375 , A61K47/36 , A61K47/38 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/26 , A61P25/28 , A61P25/30
CPC分类号： A61K31/428 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/4745 , A61K31/5375
摘要： A sustained-release pharmaceutical composition in s form of an orally deliverable tablet comprises an active pharmaceutical agent having solubility not less than about 10 mg/ml, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm at a solid fraction representative of the tablet.
摘要翻译：口服递送片剂形式的持续释放药物组合物包含分散在包含亲水性聚合物的基质和抗拉强度为至少约0.15的淀粉中的溶解度不小于约10mg / ml的活性药剂在表示片剂的固体分数下的kN cm -2。

8. 发明申请

WO2004066911A2 SUSPENSION VEHICLE FOR COATED DRUG PARTICLES 审中-公开
标题翻译：涂布药物悬浮液悬浮液
公开(公告)号：WO2004066911A2
公开(公告)日：2004-08-12
申请号：PCT/IB2004/000614
申请日：2004-01-23
申请人： PHARMACIA CORPORATION , FREDRICKSON, Jennifer, K. , REO, Joseph, P.
发明人： FREDRICKSON, Jennifer, K. , REO, Joseph, P.
IPC分类号： A61K
CPC分类号： A61K9/0095 , A61K9/5073
摘要： The present invention is directed to a suspension vehicle for coated drug particles. The coated drug particles are suitable for use in taste masking. The suspension vehicle disclosed enables the maintenance of coated drug particles with an average particle size of about 50 µm to about 600 µm in suspension for an extended period of time, without sedimentation or floating, even after shaking in the presence of air. The suspension vehicle of the present invention makes it possible to produce multidose oral suspensions of coated drugs, from which consistent dosages can be dispensed over time. The dry formulations, methods, and suspension vehicles of the present invention are particularly well suited for the delivery of objectionable tasting drugs, such as linezolid.
摘要翻译：本发明涉及用于涂覆的药物颗粒的悬浮媒介物。包衣药物颗粒适用于掩味。所公开的悬浮媒介能够维持平均粒径为约50微米至约600微米的涂覆药物颗粒悬浮一段延长的时间，而没有沉降或漂浮，即使在存在空气的情况下摇动后。本发明的混悬载体可以制备涂敷药物的多剂量口服混悬剂，从中可以随时间分配一致的剂量。本发明的干燥制剂，方法和混悬剂特别适用于递送令人讨厌的口味药物，如利奈唑胺。

9. 发明申请

WO2009076165A1 PHENYLEPHRINE PHARMACEUTICAL FORMULATIONS AND COMPOSITIONS FOR TRANSMUCOSAL ABSORPTION 审中-公开
标题翻译：用于转移吸收的苯乙胺药物制剂和组合物
公开(公告)号：WO2009076165A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/085523
申请日：2008-12-04
申请人： SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC. , MONTEITH, David , O'MULLANE, John , REO, Joseph P. , NELSON, Dennis , WAN, Jiansheng , CHEN, Xiaoming , KABIR, Mohammed A.
发明人： MONTEITH, David , O'MULLANE, John , REO, Joseph P. , NELSON, Dennis , WAN, Jiansheng , CHEN, Xiaoming , KABIR, Mohammed A.
IPC分类号： A61K9/00 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0053 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/4866
摘要： Pharmaceutical compositions comprising phenylephrine or a pharmaceutically acceptable salt thereof and methods for administering the pharmaceutical compositions wherein the composition is formulated for systemic absorption of phenylephrine that avoids first pass metabolism. The compositions of the invention are formulated to be applied to oral mucosa of an animal to allow for enhanced systemic delivery of therapeutically active form of phenylephrine.
摘要翻译：包含去氧肾上腺素或其药学上可接受的盐的药物组合物和用于施用药物组合物的方法，其中所述组合物被配制用于全身吸收去氧肾上腺素，其避免第一次通过代谢。将本发明的组合物配制成施用于动物的口腔粘膜，以允许治疗活性形式的去氧肾上腺素的全身递送。

10. 发明申请

WO2004010997A1 SUSTAINED-RELEASE TABLE COMPOSITION OF PRAMIPEXOLE 审中-公开
标题翻译： PRAMIPEXOLE的持续释放表组成
公开(公告)号：WO2004010997A1
公开(公告)日：2004-02-05
申请号：PCT/US2003/023205
申请日：2003-07-25
申请人： PHARMACIA CORPORATION , AMIDON, Gregory, E. , GANORKAR, Loksidh, D. , HEIMLICH, John, M. , LEE, Ernest, J. , NOACK, Robert, M. , REO, Joseph, P. , SKOUG, Connie, J.
发明人： AMIDON, Gregory, E. , GANORKAR, Loksidh, D. , HEIMLICH, John, M. , LEE, Ernest, J. , NOACK, Robert, M. , REO, Joseph, P. , SKOUG, Connie, J.
IPC分类号： A61K31/428
CPC分类号： A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/428 , A61K31/4745
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm -2 at a solid fraction representative of a tablet.
摘要翻译：口服递送片剂形式的缓释药物组合物包含普拉克索的水溶性盐，其分散在包含亲水性聚合物的基质和抗拉强度为至少约0.15kN cm -2的淀粉中代表片剂的固体分数。

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