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1. 发明申请

WO2004010998A8 SUSTAINED-RELEASE TABLET COMPRISING REBOXETINE 审中-公开
标题翻译：包含REBOXETINE的持续释放片
公开(公告)号：WO2004010998A8
公开(公告)日：2005-01-27
申请号：PCT/US0323418
申请日：2003-07-25
申请人： PHARMACIA CORP , AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , MARTINO ALICE C , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , MARTINO ALICE C , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： A61K31/513 , A61K9/20 , A61K9/22 , A61K9/28 , A61K31/428 , A61K31/4745 , A61K31/5375 , A61K47/36 , A61K47/38 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/26 , A61P25/28 , A61P25/30
CPC分类号： A61K31/428 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/4745 , A61K31/5375
摘要： A sustained-release pharmaceutical composition in s form of an orally deliverable tablet comprises an active pharmaceutical agent having solubility not less than about 10 mg/ml, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm at a solid fraction representative of the tablet.
摘要翻译：口服递送片剂形式的持续释放药物组合物包含分散在包含亲水性聚合物的基质和抗拉强度为至少约0.15的淀粉中的溶解度不小于约10mg / ml的活性药剂在表示片剂的固体分数下的kN cm -2。

2. 发明申请

WO2004010997A8 SUSTAINED-RELEASE TABLET COMPOSITION OF PRAMIPEXOLE 审中-公开
标题翻译：持续释放的片剂组合物
公开(公告)号：WO2004010997A8
公开(公告)日：2005-02-24
申请号：PCT/US0323205
申请日：2003-07-25
申请人： PHARMACIA CORP , AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： C07D277/82 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/36 , A61K31/428 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00
CPC分类号： A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/428 , A61K31/4745
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm at a solid fraction representative of a tablet.
摘要翻译：口服递送片剂形式的缓释药物组合物包含普拉克索的水溶性盐，其分散在包含亲水性聚合物的基质和抗拉强度为至少约0.15kN cm -2的淀粉中代表片剂的固体分数。

3. 发明专利

JP2009185051A Sustained-release tablet comprising reboxetine 审中-公开
标题翻译：包含REBOXETINE的持续释放片
公开(公告)号：JP2009185051A
公开(公告)日：2009-08-20
申请号：JP2009097049
申请日：2009-04-13
申请人： Pharmacia Corp , ファルマシアコーポレーション
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , MARTINO ALICE C , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： A61K31/513 , A61K47/36 , A61K9/20 , A61K9/22 , A61K9/28 , A61K31/428 , A61K31/4745 , A61K31/5375 , A61K47/38 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/26 , A61P25/28 , A61P25/30 , C07D265/30 , C07D277/82
CPC分类号： A61K31/428 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/4745 , A61K31/5375
摘要： PROBLEM TO BE SOLVED: To provide a method for determining compatibility of a starch used for sustained-release tablet composition in an orally deliverable tablet form, and to provide a method for producing tablet.
SOLUTION: Provided is the sustained-release composition comprises an active pharmaceutical agent having solubility not less than about 10 mg/ml, dispersed in a matrix comprising a hydrophilic polymer, a starch having a tensile strength of at least about 0.15 kNcm
-2 at a solid fraction representative of the tablet, wherein the compatibility of the starch is determined in the method estimating the tensile strength.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于测定用于缓释片剂组合物的可口服递送片形式的淀粉的相容性的方法，并提供制备片剂的方法。提供了缓释组合物，其包含具有不小于约10mg / ml的溶解度的活性药剂，分散在包含亲水性聚合物的基质中，抗拉强度为至少约0.15kN / SP> -2 ，代表片剂的固体分数，其中在估计拉伸强度的方法中确定淀粉的相容性。版权所有（C）2009，JPO＆INPIT

4. 发明专利

MEP52308A SUSTAINED-RELEASE TABLET COMPOSITION OF PRAMIPEXOLE 未知
公开(公告)号：MEP52308A
公开(公告)日：2011-02-10
申请号：MEP52308
申请日：2003-07-25
申请人： PHARMACIA CORP
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： C07D277/82 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/36 , A61K31/428 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm -2 at a solid fraction representative of a tablet.

5. 发明专利

DE60331153D1 未知
公开(公告)号：DE60331153D1
公开(公告)日：2010-03-18
申请号：DE60331153
申请日：2003-07-25
申请人： PHARMACIA CORP
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , MARTINO ALICE C , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： A61K31/428 , A61K31/513 , A61K9/20 , A61K9/22 , A61K9/28 , A61K31/4745 , A61K31/5375 , A61K47/36 , A61K47/38 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/26 , A61P25/28 , A61P25/30
摘要： A sustained - release pharmaceutical composition in a form of an orally deliverable tablet comprising an active pharmaceutical agent having solubility not less than about 10mg/ml, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15kNcm -2 at a solid fraction representative of the tablet.

6. 发明专利

NZ562495A Sustained-release tablet comprising pramipexole 未知
公开(公告)号：NZ562495A
公开(公告)日：2009-03-31
申请号：NZ56249503
申请日：2003-07-25
申请人： PHARMACIA CORP
发明人： NOACK RAINER , REO JOSEPH P , AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , SKOUG CONNIE J
IPC分类号： A61K31/513 , A61K31/428 , A61K9/20 , A61K9/28 , A61K31/4745 , A61K31/5375
摘要： A method for determining suitability of a starch for use in a sustained-release orally deliverable tablet comprising an active pharmaceutical agent, having solubility not less than about 10 mg/ml is disclosed, wherein the method comprises the steps of: (a) preparing compacts of a sample of the starch on an automated tablet press at a range of compression forces applied for a dwell time of at least about 4 seconds; (b) measuring hardness of each compact, expressed as the force required to cause crushing of the compact; (c) determining solid fraction of each compact; (d) calculating tensile strength of each compact from the equation given in the specification; (e) establishing relationship of tensile strength to solid fraction of the compacts; and (f) using said relationship to estimate tensile strength at a solid fraction representative of a desired sustained-release tablet; the starch being deemed suitable for said use if its tensile strength as so estimated is at least about 0.15 kN cm-2. Also disclosed is a process for preparing a sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprising an active pharmaceutical agent which is pramipexole or a salt thereof, the process comprising selecting by a suitable test a starch having a tensile strength of at least about 0.15 kN cm-2 at a solid fraction representative of the tablet; admixing with the selected starch a hydrophilic polymer and pramipexole or a salt thereof to provide a mixture wherein the agent is dispersed in a matrix comprising the polymer and the starch; and compressing the mixture to form said tablet.

7. 发明专利

GEP20074048B SUSTAINED-RELEASE TABLET COMPOSITION OF PRAMIPEXOLE 未知
公开(公告)号：GEP20074048B
公开(公告)日：2007-02-26
申请号：GEAU2003008599
申请日：2003-07-25
申请人： PHARMACIA CORP
发明人： AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： A61K31/428 , C07D277/82 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/36 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00
摘要： A composition comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch.

8. 发明专利

AP200503205A0 Sustained-release tablet composition of pramipexole. 未知
公开(公告)号：AP200503205A0
公开(公告)日：2005-03-31
申请号：AP200503205
申请日：2003-07-25
申请人： PHARMACIA CORP
发明人： AMIDON GREGORY E , HEIMLICH JOHN M , LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J
IPC分类号： C07D277/82 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/36 , A61K31/428 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00 , A61K
CPC分类号： A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/428 , A61K31/4745

9. 发明专利

AU2003261241A1 SUSTAINED-RELEASE TABLE COMPOSITION OF PRAMIPEXOLE 未知
公开(公告)号：AU2003261241A1
公开(公告)日：2004-02-16
申请号：AU2003261241
申请日：2003-07-25
申请人： PHARMACIA CORP
发明人： LEE ERNEST J , NOACK ROBERT M , REO JOSEPH P , SKOUG CONNIE J , AMIDON GREGORY E , GANORKAR LOKSIDH D , HEIMLICH JOHN M
IPC分类号： C07D277/82 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/36 , A61K31/428 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00
摘要： A sustained-release pharmaceutical composition in a form of an orally deliverable tablet comprises a water-soluble salt of pramipexole, dispersed in a matrix comprising a hydrophilic polymer and a starch having a tensile strength of at least about 0.15 kN cm -2 at a solid fraction representative of a tablet.

10. 发明专利

CU23440B7 COMPOSICIÓN DE LIBERACIÓN SOSTENIDA DE PRAMIPEXOL 未知
公开(公告)号：CU23440B7
公开(公告)日：2009-10-16
申请号：CU20050018
申请日：2005-01-25
申请人： PHARMACIA CORP
发明人： SKOUG CONNIE J , NOACK ROBERT M , LEE ERNEST J , HEIMLICH JOHN M , GANORKAR LOKSIDH D , AMIDON GREGORY E , REO JOSEPH P
IPC分类号： C07D277/82 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/28 , A61K9/36 , A61K31/428 , A61K31/4745 , A61K47/30 , A61K47/36 , A61K47/38 , A61P25/16 , A61P43/00
摘要： Una composición farmacéutica en forma de tableta oral que comprende una sal de Pramipexol soluble en agua dispersa en una matrix que comprende un polímero hidrofílico y un almidón que tiene una resistencia a tracción de al menos aproximadamente 0,175KN cm a una tracción de sólidos representativa del comprimido.

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