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1. 发明申请

WO2011076141A1 DIAGNOSTIC KITS COMPRISING MICRORNA BIOMARKERS AND METHODS FOR DIAGNOSIS OF HEPATOCELLULAR CANCER 审中-公开
标题翻译：包含微生物标记物的诊断试剂盒和诊断肝细胞癌的方法
公开(公告)号：WO2011076141A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080230
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , WU, Ying , ZHU, Hongguang , GAO, Xue , LU, Shaohua , LI, Zhaoyong , REN, Yiping , LI, Jian
发明人： WU, Ying , ZHU, Hongguang , GAO, Xue , LU, Shaohua , LI, Zhaoyong , REN, Yiping , LI, Jian
IPC分类号： C12Q1/68 , A61K31/7088 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q2600/178
摘要： The present invention provides microRNA biomarkers and diagnostic kits comprising a plurality of nucleic acid molecules encoding said microRNA biomarkers for identifying one or more target plasma exhibiting hepatocellular cancer. The invention also provides methods for diagnosis and treatment of hepatocellular cancer, and pharmaceutical compositions for prevention and treatment of hepatocellular cancer.
摘要翻译：本发明提供了包含编码所述微小RNA生物标志物的多个核酸分子的微小RNA生物标志物和诊断试剂盒，用于鉴定一种或多种呈现肝细胞癌的靶血浆。本发明还提供了肝细胞癌的诊断和治疗方法以及预防和治疗肝细胞癌的药物组合物。

2. 发明申请

WO2010055487A3 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPESSION PROFILING OF COLORECTAL CANCER 审中-公开
标题翻译：大肠癌微RNA表达谱的组成和方法
公开(公告)号：WO2010055487A3
公开(公告)日：2010-09-30
申请号：PCT/IB2009055057
申请日：2009-11-13
申请人： KONINKL PHILIPS ELECTRONICS NV , WU YING , ZHU HONGGUANG , LI JIAN , XU LIANG , VERHAEGH WILHELMUS F J , REN YIPING , JANEVSKI ANGEL , VARADAN VINAY , LI ZHAOYONG , DIMITROVA NEVENKA
发明人： WU YING , ZHU HONGGUANG , LI JIAN , XU LIANG , VERHAEGH WILHELMUS F J , REN YIPING , JANEVSKI ANGEL , VARADAN VINAY , LI ZHAOYONG , DIMITROVA NEVENKA
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结直肠癌的微RNA（miRNA）表达谱分析的组合物和方法。具体而言，本发明涉及分子标记的诊断试剂盒，用于鉴定展现或具有发展结肠直肠癌倾向的一种或多种哺乳动物靶细胞，所述试剂盒包含多个核酸分子，每个核酸分子编码miRNA序列，其中所述多种核酸分子中的一种或多种在所述靶细胞和一种或多种对照细胞中差异表达，并且其中所述一种或多种差异表达的核酸分子一起表示核酸表达签名，或发展大肠癌的倾向。本发明进一步涉及使用此类核酸表达签名鉴定一种或多种哺乳动物靶细胞的相应方法，所述一种或多种哺乳动物靶细胞展现或具有发展结肠直肠癌的倾向以及用于预防或治疗这样的状况。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

3. 发明申请

WO2011076144A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPESSION PROFILING IN PLASMA OF LUNG CANCER 审中-公开
标题翻译：用于肺癌等离子体快速扩增分析的组合物和方法
公开(公告)号：WO2011076144A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080240
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , REN, Yiping , WU, Ying , LU, Shaohua , ZHU, Hongguang , LI, Zhaoyong , LI, Jian , HUANG, Wei
发明人： REN, Yiping , WU, Ying , LU, Shaohua , ZHU, Hongguang , LI, Zhaoyong , LI, Jian , HUANG, Wei
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/7105 , A61P35/00
CPC分类号： C12Q1/6886 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12Q2600/112 , C12Q2600/178
摘要： The invention provides diagnostic kits comprising a plurality of nucleic acid molecules encoding microRNA sequences for identifying one or more target plasma exhibiting lung cancer, wherein the nucleic acid molecules are differentially expressed in target plasma and in control plasma. The invention further provides methods for identifying one or more target plasma exhibiting lung cancer by using said nucleic acid molecules, and methods and pharmaceutical compositions for preventing or treating lung cancer.
摘要翻译：本发明提供了诊断试剂盒，其包含编码用于鉴定表现出肺癌的一种或多种靶血浆的微小RNA序列的多个核酸分子，其中所述核酸分子在靶血浆和对照血浆中差异表达。本发明还提供了通过使用所述核酸分子鉴定表现出肺癌的一种或多种目标血浆的方法，以及用于预防或治疗肺癌的方法和药物组合物。

4. 发明申请

WO2010055487A2 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPESSION PROFILING OF COLORECTAL CANCER 审中-公开
标题翻译：组合物和方法用于微小RNA显色分析
公开(公告)号：WO2010055487A2
公开(公告)日：2010-05-20
申请号：PCT/IB2009/055057
申请日：2009-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
发明人： WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结肠直肠癌的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于鉴定表现出或具有发生结肠直肠癌倾向的一种或多种哺乳动物靶细胞的分子标记用诊断试剂盒，所述试剂盒包含多个核酸分子，编码miRNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在靶细胞和一个或多个对照细胞中差异表达，并且其中所述一个或多个差异表达的核酸分子一起表示指示存在的核酸表达特征或发生结肠直肠癌的倾向。本发明还涉及使用这种核酸表达特征鉴定一种或多种表现出或具有发生结肠直肠癌倾向的哺乳动物靶细胞以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

5. 发明申请

WO2011076143A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPRESSION PROFILING OF LUNG CANCER 审中-公开
标题翻译：肺癌微阵列分型的组成及方法
公开(公告)号：WO2011076143A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080237
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Jian , WU, Ying , LU, Shaohua , ZHU, Hongguang , HUANG, Wei , REN, Yiping , LI, Zhaoyong
发明人： LI, Jian , WU, Ying , LU, Shaohua , ZHU, Hongguang , HUANG, Wei , REN, Yiping , LI, Zhaoyong
IPC分类号： C12Q1/68 , A61K31/7105 , A61P35/00
CPC分类号： A61K31/7105 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178
摘要： The invention provides diagnostic kits comprising a plurality of nucleic acid molecules encoding microRNA sequences for identifying one or more mammalian target cells exhibiting or having a predisposition to develop lung cancer. The nucleic acid molecules encoding microRNA sequences are differentially expressed in target cells and in control cells. The invention further provides methods for identifying mammalian target cells exhibiting or having a predisposition to develop lung cancer using said microRNAs, and methods and pharmaceutical compositions for preventing or treating lung cancer.
摘要翻译：本发明提供了诊断试剂盒，其包含编码微小RNA序列的多个核酸分子，用于鉴定表现出或具有发生肺癌倾向的一种或多种哺乳动物靶细胞。编码微小RNA序列的核酸分子在靶细胞和对照细胞中差异表达。本发明进一步提供用于鉴定使用所述微小RNA显示或具有发展肺癌倾向的哺乳动物靶细胞的方法，以及用于预防或治疗肺癌的方法和药物组合物。

6. 发明申请

WO2011076142A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPESSION PROFILING IN PLASMA OF COLORECTAL CANCER 审中-公开
标题翻译：彩色血浆等离子体快速成像分析的组合物和方法
公开(公告)号：WO2011076142A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080233
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Zhaoyong , WU, Ying , ZHU, Hongguang , LI, Jian , REN, Yiping
发明人： LI, Zhaoyong , WU, Ying , ZHU, Hongguang , LI, Jian , REN, Yiping
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/7105 , B82Y5/00 , B82Y15/00 , C12Q2600/178
摘要： The present invention relates to compositions and methods for microRNA (miRNA) expression profiling in plasma of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, monitoring the cancer therapy and/or treating colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a microRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of colorectal cancer and healthy control plasma, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结直肠癌血浆中的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于诊断结肠直肠癌，监测癌症治疗和/或治疗结直肠癌的血液中的分子标记物的诊断试剂盒，所述试剂盒包含多个核酸分子，编码微小RNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在结肠直肠癌和健康对照血浆的血浆中差异表达，并且其中所述一个或多个差异表达的核酸分子一起代表指示存在结肠直肠的核酸表达特征癌症。本发明还涉及使用这种核酸表达特征鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

7. 发明申请

WO2002077152A1 DEVICE AND METHOD FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的装置和方法
公开(公告)号：WO2002077152A1
公开(公告)日：2002-10-03
申请号：PCT/CN2002/000209
申请日：2002-03-28
申请人： GENETECH BIOTECHNOLOGY (SHANGHAI) COMPANY LIMITED , CHEUNG, To , LI, Bin , PENG, Yongji , REN, Yiping , GE, Haipeng , DENG, Fuqiao , DING, Li , LI, Hongmei , CAI, Qifeng , CHEN, Ying
发明人： CHEUNG, To , LI, Bin , PENG, Yongji , REN, Yiping , GE, Haipeng , DENG, Fuqiao , DING, Li , LI, Hongmei , CAI, Qifeng , CHEN, Ying
IPC分类号： C12M1/20
CPC分类号： G01N33/54366 , G01N33/54313
摘要： A device is provided for the detection of multiple analytes in at least one sample. The device contains a solid substrate with a test surface. On the test surface is defined at least one reaction area containing at least one array of discrete test sites. Each of these test sites have a test molecule immobilized on to it, and different test sites may have different test molecules immobilized thereon. A divider is provided for attachment onto the solid substrate. The divider contains a plurality of holes provided on an attachment surface. The attachment surface is complementary to the test surface of the solid device and is adapted for reversible attachment thereto such that when the two parts are attached, each of the holes is adjoined with a portion of the test surface to create a plurality of leak-proof chambers. The test surface within the chamber contains a plurality of test sites exposed within the chambers. Each of the chamber is preferably provided with an opening that is accessible from the exterior such that fluid introduced into the chambers may be contacted with the exposed test sites for testing. In another aspect of the present invention, a method is provided for analysing multiple analytes in the same samples.
摘要翻译：提供了用于在至少一个样品中检测多个分析物的装置。该装置包含具有测试表面的固体基底。在测试表面上限定至少一个包含至少一个离散测试位点阵列的反应区域。这些测试位点中的每一个具有固定在其上的测试分子，并且不同的测试位点可以具有固定在其上的不同测试分子。提供分隔件用于附着到固体基底上。分隔器包括设置在附接表面上的多个孔。附接表面与固体装置的测试表面互补，并且适于可逆地附接到其上，使得当附接两个部分时，每个孔与测试表面的一部分相邻以产生多个防漏室。室内的测试表面包含在室内暴露的多个测试部位。每个室优选地设置有可从外部接近的开口，使得引入室的流体可以与暴露的测试位置接触以进行测试。在本发明的另一方面，提供了一种用于分析相同样品中的多种分析物的方法。

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