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1. 发明申请

WO2011076141A1 DIAGNOSTIC KITS COMPRISING MICRORNA BIOMARKERS AND METHODS FOR DIAGNOSIS OF HEPATOCELLULAR CANCER 审中-公开
标题翻译：包含微生物标记物的诊断试剂盒和诊断肝细胞癌的方法
公开(公告)号：WO2011076141A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080230
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , WU, Ying , ZHU, Hongguang , GAO, Xue , LU, Shaohua , LI, Zhaoyong , REN, Yiping , LI, Jian
发明人： WU, Ying , ZHU, Hongguang , GAO, Xue , LU, Shaohua , LI, Zhaoyong , REN, Yiping , LI, Jian
IPC分类号： C12Q1/68 , A61K31/7088 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q2600/178
摘要： The present invention provides microRNA biomarkers and diagnostic kits comprising a plurality of nucleic acid molecules encoding said microRNA biomarkers for identifying one or more target plasma exhibiting hepatocellular cancer. The invention also provides methods for diagnosis and treatment of hepatocellular cancer, and pharmaceutical compositions for prevention and treatment of hepatocellular cancer.
摘要翻译：本发明提供了包含编码所述微小RNA生物标志物的多个核酸分子的微小RNA生物标志物和诊断试剂盒，用于鉴定一种或多种呈现肝细胞癌的靶血浆。本发明还提供了肝细胞癌的诊断和治疗方法以及预防和治疗肝细胞癌的药物组合物。

2. 发明申请

WO2011076144A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPESSION PROFILING IN PLASMA OF LUNG CANCER 审中-公开
标题翻译：用于肺癌等离子体快速扩增分析的组合物和方法
公开(公告)号：WO2011076144A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080240
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , REN, Yiping , WU, Ying , LU, Shaohua , ZHU, Hongguang , LI, Zhaoyong , LI, Jian , HUANG, Wei
发明人： REN, Yiping , WU, Ying , LU, Shaohua , ZHU, Hongguang , LI, Zhaoyong , LI, Jian , HUANG, Wei
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/7105 , A61P35/00
CPC分类号： C12Q1/6886 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12Q2600/112 , C12Q2600/178
摘要： The invention provides diagnostic kits comprising a plurality of nucleic acid molecules encoding microRNA sequences for identifying one or more target plasma exhibiting lung cancer, wherein the nucleic acid molecules are differentially expressed in target plasma and in control plasma. The invention further provides methods for identifying one or more target plasma exhibiting lung cancer by using said nucleic acid molecules, and methods and pharmaceutical compositions for preventing or treating lung cancer.
摘要翻译：本发明提供了诊断试剂盒，其包含编码用于鉴定表现出肺癌的一种或多种靶血浆的微小RNA序列的多个核酸分子，其中所述核酸分子在靶血浆和对照血浆中差异表达。本发明还提供了通过使用所述核酸分子鉴定表现出肺癌的一种或多种目标血浆的方法，以及用于预防或治疗肺癌的方法和药物组合物。

3. 发明申请

WO2011076143A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPRESSION PROFILING OF LUNG CANCER 审中-公开
标题翻译：肺癌微阵列分型的组成及方法
公开(公告)号：WO2011076143A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080237
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Jian , WU, Ying , LU, Shaohua , ZHU, Hongguang , HUANG, Wei , REN, Yiping , LI, Zhaoyong
发明人： LI, Jian , WU, Ying , LU, Shaohua , ZHU, Hongguang , HUANG, Wei , REN, Yiping , LI, Zhaoyong
IPC分类号： C12Q1/68 , A61K31/7105 , A61P35/00
CPC分类号： A61K31/7105 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178
摘要： The invention provides diagnostic kits comprising a plurality of nucleic acid molecules encoding microRNA sequences for identifying one or more mammalian target cells exhibiting or having a predisposition to develop lung cancer. The nucleic acid molecules encoding microRNA sequences are differentially expressed in target cells and in control cells. The invention further provides methods for identifying mammalian target cells exhibiting or having a predisposition to develop lung cancer using said microRNAs, and methods and pharmaceutical compositions for preventing or treating lung cancer.
摘要翻译：本发明提供了诊断试剂盒，其包含编码微小RNA序列的多个核酸分子，用于鉴定表现出或具有发生肺癌倾向的一种或多种哺乳动物靶细胞。编码微小RNA序列的核酸分子在靶细胞和对照细胞中差异表达。本发明进一步提供用于鉴定使用所述微小RNA显示或具有发展肺癌倾向的哺乳动物靶细胞的方法，以及用于预防或治疗肺癌的方法和药物组合物。

4. 发明申请

WO2011076142A1 COMPOSITIONS AND METHODS FOR MICRORNA EXPESSION PROFILING IN PLASMA OF COLORECTAL CANCER 审中-公开
标题翻译：彩色血浆等离子体快速成像分析的组合物和方法
公开(公告)号：WO2011076142A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080233
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Zhaoyong , WU, Ying , ZHU, Hongguang , LI, Jian , REN, Yiping
发明人： LI, Zhaoyong , WU, Ying , ZHU, Hongguang , LI, Jian , REN, Yiping
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/7105 , B82Y5/00 , B82Y15/00 , C12Q2600/178
摘要： The present invention relates to compositions and methods for microRNA (miRNA) expression profiling in plasma of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, monitoring the cancer therapy and/or treating colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a microRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of colorectal cancer and healthy control plasma, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结直肠癌血浆中的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于诊断结肠直肠癌，监测癌症治疗和/或治疗结直肠癌的血液中的分子标记物的诊断试剂盒，所述试剂盒包含多个核酸分子，编码微小RNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在结肠直肠癌和健康对照血浆的血浆中差异表达，并且其中所述一个或多个差异表达的核酸分子一起代表指示存在结肠直肠的核酸表达特征癌症。本发明还涉及使用这种核酸表达特征鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

5. 发明申请

WO2010055487A2 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPESSION PROFILING OF COLORECTAL CANCER 审中-公开
标题翻译：组合物和方法用于微小RNA显色分析
公开(公告)号：WO2010055487A2
公开(公告)日：2010-05-20
申请号：PCT/IB2009/055057
申请日：2009-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
发明人： WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结肠直肠癌的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于鉴定表现出或具有发生结肠直肠癌倾向的一种或多种哺乳动物靶细胞的分子标记用诊断试剂盒，所述试剂盒包含多个核酸分子，编码miRNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在靶细胞和一个或多个对照细胞中差异表达，并且其中所述一个或多个差异表达的核酸分子一起表示指示存在的核酸表达特征或发生结肠直肠癌的倾向。本发明还涉及使用这种核酸表达特征鉴定一种或多种表现出或具有发生结肠直肠癌倾向的哺乳动物靶细胞以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

6. 发明申请

WO2011076147A1 PLASMA-BASED MICRO-RNA BIOMARKERS AND METHODS FOR EARLY DETECTION OF COLORECTAL CANCER 审中-公开
标题翻译：基于血浆的微RNA生物标记物和早期检测色素性癌症的方法
公开(公告)号：WO2011076147A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080247
申请日：2010-12-24
申请人： FUDAN UNIVERSITY , LI, Zhaoyong , WU, Ying , ZHU, Hongguang
发明人： LI, Zhaoyong , WU, Ying , ZHU, Hongguang
IPC分类号： C12Q1/68 , A61K31/7088 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/7088 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, and/or monitoring the therapeutic effect for treating colorectal cancer. The kit comprises a plurality of nucleic acid molecules, and each nucleic acid molecule encodes a microRNA biomarker, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of patient and healthy control, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression biomarker that is indicative for the presence of colorectal cancer. The invention further provides corresponding methods using such nucleic acid expression biomarkers for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention provides a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明提供用于诊断结肠直肠癌的血液中的分子标记物的诊断试剂盒和/或监测治疗结肠直肠癌的治疗效果。试剂盒包含多个核酸分子，每个核酸分子编码微小RNA生物标志物，其中多个核酸分子中的一个或多个在患者和健康对照的血浆中差异表达，并且其中所述一个或多个差异表达核酸分子一起代表指示存在结肠直肠癌的核酸表达生物标志物。本发明还提供了使用这种核酸表达生物标志物鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。最后，本发明提供了用于预防和/或治疗结肠直肠癌的药物组合物。

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