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1. 发明专利

AU2021102414A4 A SYSTEM AND METHOD FOR MONITORING FACIAL EMOTIONS AND BEHAVIOR USING DEEP NEURAL NETWORK 未知
公开(公告)号：AU2021102414A4
公开(公告)日：2021-07-08
申请号：AU2021102414
申请日：2021-05-08
申请人： G SHRUTHI , KUMAR U M ASHWIN , LOVESUM S P JENO , NAGASAI TEJA MARAM VENKATA , PASHA AKRAM , REDDY CHINTAM BINDU BHARGAVA , REDDY RAGHAVENDRA , SIDDHARDHA REDDY LOKI REDDY SAI , SUMANTH M , THOTA SUREKHA
发明人： REDDY RAGHAVENDRA , REDDY CHINTAM BINDU BHARGAVA , NAGASAI TEJA MARAM VENKATA , SUMANTH M , SIDDHARDHA REDDY LOKI REDDY SAI , KUMAR U M ASHWIN , PASHA AKRAM , LOVESUM S P JENO , THOTA SUREKHA , G SHRUTHI
IPC分类号： G06K9/00 , G06N3/02 , G06T7/00
摘要： Abstract The present disclosure seeks to provide a system and method for monitoring facial emotions and behaviour using deep neural network. In this disclosure, the system comprises: a pre-processing unit for detecting face and thereby segmenting said detected face from input image/video; a feature extraction module for extracting features from said greyscale image/video; a classification module for detecting facial emotion and behavior of a person using machine learning technique; a decision unit for comparing and matching feature of detected facial emotion of a person from a dataset and a prediction module for predicting facial emotion and behavior from a set of facial emotions and behaviors. The method comprises: detecting face and thereby segmenting said detected face from input image/video; aligning and cropping segmented face from said input image/video; converting color image/video into greyscale and thereby generating eigen faces; extracting features from said greyscale image/video using a deep neural network; detecting facial emotion and behavior of a person using extracted features through machine learning technique; comparing and matching feature of detected facial emotion and behavior of a person form a dataset of a plurality of images/videos of facial emotions and behaviors; and predicting facial emotion and behavior of said person from a set of facial emotions and behaviors. b* o* t= 2i t"

2. 发明申请

WO2011146514A2 RAPID ISOLATION OF MONOCLONAL ANTIBODIES FROM ANIMALS 审中-公开
标题翻译：从动物快速分离单克隆抗体
公开(公告)号：WO2011146514A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/036852
申请日：2011-05-17
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , REDDY, Sai , GE, Xin , BOUTZ, Danny , ELLINGTON, Andrew, D. , MARCOTTE, Edward, M. , LAVINDER, Jason , GEORGIOU, George
发明人： REDDY, Sai , GE, Xin , BOUTZ, Danny , ELLINGTON, Andrew, D. , MARCOTTE, Edward, M. , LAVINDER, Jason , GEORGIOU, George
CPC分类号： G06F19/24 , C07K16/065 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12Q1/6881 , C12Q2600/16 , C40B30/04 , G01N33/6857
摘要： Methods and compositions for identification of candicate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining amino acid sequences of serum antibody CDR and abundancy level are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and frequency are provided. Furthermore, the invention provides methods for identification and generation of antibody or antigen-binding fragments that comprise highly-represented CDR.
摘要翻译：提供了用于鉴定可以具有希望的抗原特异性的抗原特异性可变区以及产生抗体或抗原结合片段的方法和组合物。例如，在某些方面，描述了确定血清抗体CDR的氨基酸序列和丰度水平的方法。在一些方面，提供了用于确定抗体可变区序列和频率的核酸序列的方法。此外，本发明提供用于鉴定和产生包含高度表示的CDR的抗体或抗原结合片段的方法。

3. 发明申请

WO2011008517A2 IMMUNOGLOBULIN FC POLYPEPTIDES 审中-公开
标题翻译：免疫球蛋白FC多肽
公开(公告)号：WO2011008517A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/040304
申请日：2010-06-29
申请人： RESEARCH DEVELOPMENT FOUNDATION , GEORGIOU, George , JUNG, Sang, Taek , REDDY, Sai
发明人： GEORGIOU, George , JUNG, Sang, Taek , REDDY, Sai
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , G01N33/53
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有非糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个置换的非糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体但不结合其他Fc结构域的Fc结构域。例如，提供具有非糖基化Fc结构域的多肽，其以糖基化Fc结构域2倍以内的水平选择性结合FcγRI，但与其他Fc受体的结合显着降低。此外，提供了使用具有修饰的非糖基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，所述第二非Fc结合结构域可以是抗体或非抗原结合区抗原结合区。一些实施方案涉及具有此类多肽的抗体，其可具有相同或不同的非Fc结合结构域。

4. 发明申请

WO2010025324A3 NANOPARTICLES FOR IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2010025324A3
公开(公告)日：2010-03-04
申请号：PCT/US2009/055301
申请日：2009-08-28
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , HUBBELL, Jeffrey, A. , O'NEIL, Conlin, P. , REDDY, Sai, T. , SWARTZ, Melody, A. , VELLUTO, Diana , VAN DER VLIES, Andre , SIMEONI, Eleonora
发明人： HUBBELL, Jeffrey, A. , O'NEIL, Conlin, P. , REDDY, Sai, T. , SWARTZ, Melody, A. , VELLUTO, Diana , VAN DER VLIES, Andre , SIMEONI, Eleonora
IPC分类号： A61K9/16 , A61K9/127 , A61K47/34 , A61P37/00 , A61P35/00
摘要： Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.

5. 发明申请

WO2010025324A2 NANOPARTICLES FOR IMMUNOTHERAPY 审中-公开
标题翻译：纳米颗粒用于免疫治疗
公开(公告)号：WO2010025324A2
公开(公告)日：2010-03-04
申请号：PCT/US2009055301
申请日：2009-08-28
申请人： ECOLE POLYTECH , HUBBELL JEFFREY A , O'NEIL CONLIN P , REDDY SAI T , SWARTZ MELODY A , VELLUTO DIANA , VAN DER VLIES ANDRE , SIMEONI ELEONORA
发明人： HUBBELL JEFFREY A , O'NEIL CONLIN P , REDDY SAI T , SWARTZ MELODY A , VELLUTO DIANA , VAN DER VLIES ANDRE , SIMEONI ELEONORA
IPC分类号： A61K9/16 , A61K9/127 , A61K47/34 , A61P35/00 , A61P37/00
CPC分类号： A61K9/5146 , A61K9/0034 , A61K9/006 , A61K38/19 , A61K39/0011 , A61K47/6907 , A61K47/6935 , A61K2039/6093 , B82Y5/00
摘要： Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.
摘要翻译：描述了在不存在生物分子的情况下激活补体的纳米粒子。显示纳米颗粒特异性靶向淋巴结中的抗原呈递细胞，而不使用生物分子进行靶向。这些颗粒是递送免疫治疗剂的有用载体。描述了纳米颗粒的表面化学和化学制剂。

6. 发明申请

WO2007098254A3 NANOPARTICLES FOR IMMUNOTHERAPY 审中-公开
标题翻译：免疫学的纳米比亚
公开(公告)号：WO2007098254A3
公开(公告)日：2008-09-25
申请号：PCT/US2007004671
申请日：2007-02-21
申请人： ECOLE POLYTECH , REDDY SAI T , HUBBELL JEFFREY A , SWARTZ MELODY A , VAN DER VLIES ANDRE
发明人： REDDY SAI T , HUBBELL JEFFREY A , SWARTZ MELODY A , VAN DER VLIES ANDRE
IPC分类号： A61K9/14
CPC分类号： A61K39/385 , A61K2039/55555 , A61K2039/6093
摘要： Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.
摘要翻译：描述了在不存在生物分子的情况下激活补体的纳米颗粒。显示了纳米颗粒特异性靶向抗原呈递细胞，特别是在淋巴结中，而不用生物分子进行靶向。这些颗粒是用于递送免疫治疗剂的有用载体。

7. 发明申请

WO2011146514A3 RAPID ISOLATION OF MONOCLONAL ANTIBODIES FROM ANIMALS 审中-公开
标题翻译：从动物快速分离单克隆抗体
公开(公告)号：WO2011146514A3
公开(公告)日：2012-11-22
申请号：PCT/US2011036852
申请日：2011-05-17
申请人： UNIV TEXAS , REDDY SAI , GE XIN , BOUTZ DANNY , ELLINGTON ANDREW D , MARCOTTE EDWARD M , LAVINDER JASON , GEORGIOU GEORGE
发明人： REDDY SAI , GE XIN , BOUTZ DANNY , ELLINGTON ANDREW D , MARCOTTE EDWARD M , LAVINDER JASON , GEORGIOU GEORGE
IPC分类号： G01N33/68 , C07K16/18 , C12Q1/68
CPC分类号： G06F19/24 , C07K16/065 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C12Q1/6881 , C12Q2600/16 , C40B30/04 , G01N33/6857
摘要： Methods and compositions for identification of candicate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining amino acid sequences of serum antibody CDR and abundancy level are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and frequency are provided. Furthermore, the invention provides methods for identification and generation of antibody or antigen-binding fragments that comprise highly-represented CDR.
摘要翻译：提供了用于鉴定可以具有希望的抗原特异性的抗体特异性可变区的方法和组合物以及抗体或抗原结合片段的产生。例如，在某些方面，描述了确定血清抗体CDR的氨基酸序列和丰度水平的方法。在一些方面，提供了用于确定抗体可变区序列和频率的核酸序列的方法。此外，本发明提供了用于鉴定和产生包含高度表示的CDR的抗体或抗原结合片段的方法。

8. 发明申请

WO2007098254A2 NANOPARTICLES FOR IMMUNOTHERAPY 审中-公开
标题翻译：免疫治疗的纳米比亚
公开(公告)号：WO2007098254A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/004671
申请日：2007-02-21
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE , REDDY, Sai, T. , HUBBELL, Jeffrey, A. , SWARTZ, Melody, A. , VAN DER VLIES, Andre
发明人： REDDY, Sai, T. , HUBBELL, Jeffrey, A. , SWARTZ, Melody, A. , VAN DER VLIES, Andre
IPC分类号： A61K39/00
CPC分类号： A61K39/385 , A61K2039/55555 , A61K2039/6093
摘要： Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.
摘要翻译：描述了在不存在生物分子的情况下激活补体的纳米颗粒。显示出纳米颗粒特异性靶向抗原提呈细胞，特别是在淋巴结中，而不用生物分子进行靶向。这些颗粒是用于递送免疫治疗剂的有用载体。

9. 发明申请

WO2011008517A3 IMMUNOGLOBULIN FC POLYPEPTIDES 审中-公开
标题翻译：多柔比星FC多糖
公开(公告)号：WO2011008517A3
公开(公告)日：2011-07-21
申请号：PCT/US2010040304
申请日：2010-06-29
申请人： RES DEV FOUNDATION , GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , G01N33/53
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Fc?RI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供多肽具有糖基化Fc结构域，其选择性地结合FcαRI在糖基化Fc结构域的2倍以内的水平，但是与其它Fc受体结合显着降低。此外，提供了使用具有修饰的糖苷基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

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