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1. 发明申请

WO2011008517A3 IMMUNOGLOBULIN FC POLYPEPTIDES 审中-公开
标题翻译：多柔比星FC多糖
公开(公告)号：WO2011008517A3
公开(公告)日：2011-07-21
申请号：PCT/US2010040304
申请日：2010-06-29
申请人： RES DEV FOUNDATION , GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , G01N33/53
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Fc?RI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
摘要翻译：涉及具有糖基化抗体Fc结构域的多肽的方法和组合物。在某些实施方案中，多肽具有与天然Fc结构域相比含有一个或多个取代的糖基化Fc结构域。另外，一些实施方案涉及结合一些Fc受体而不是其它Fc受体的Fc结构域。例如，提供多肽具有糖基化Fc结构域，其选择性地结合FcαRI在糖基化Fc结构域的2倍以内的水平，但是与其它Fc受体结合显着降低。此外，提供了使用具有修饰的糖苷基化Fc结构域和第二非Fc结合结构域的多肽来促进抗体依赖性细胞介导的毒性（ADCC）的方法和组合物，其可以是抗体或非抗体的抗原结合区域 - 抗原结合区。一些实施方案涉及具有这样的多肽的抗体，其可以具有相同或不同的非Fc结合结构域。

2. 发明申请

WO2008137475A3 IMMUNOGLOBULIN FC LIBRARIES 审中-公开
标题翻译：免疫球蛋白图书馆
公开(公告)号：WO2008137475A3
公开(公告)日：2009-01-08
申请号：PCT/US2008062090
申请日：2008-04-30
申请人： RES DEV FOUNDATION , GEORGIOU GEORGE , JUNG SANG TAEK
发明人： GEORGIOU GEORGE , JUNG SANG TAEK
IPC分类号： C07K16/28
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/32 , C07K2317/52 , C07K2317/72 , C07K2319/035 , C07K2319/30
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.
摘要翻译：用于筛选和分离糖基化抗体Fc结构域多肽的方法和组合物。例如，在某些方面，描述了用于鉴定结合Fc受体或优先结合特定Fc受体的糖基化Fc结构域的方法。此外，本发明提供以高亲和力结合Fc受体的糖基化Fc结构域。还提供了用于基于原核的相互作用筛选的增强的方法和介质。

3. 发明公开

EP2448972A4 IMMUNOGLOBULIN FC POLYPEPTIDES 审中-公开
标题翻译：免疫球蛋白Fc的多肽
公开(公告)号：EP2448972A4
公开(公告)日：2012-11-28
申请号：EP10800284
申请日：2010-06-29
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , G01N33/53
CPC分类号： G01N33/56911 , C07K16/00 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/6857 , G01N2500/10

4. 发明专利

CA2826467A1 ENGINEERED IMMUNOGLOBULIN FC POLYPEPTIDES 未知
公开(公告)号：CA2826467A1
公开(公告)日：2012-08-16
申请号：CA2826467
申请日：2012-02-06
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , KELTON WILLIAM , KANG TAE HYUN
IPC分类号： C07K16/28
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcyRIIa, but that is significantly reduced for binding to the highly homologous FcyRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

5. 发明专利

AU2010273763A1 Immunoglobulin Fc polypeptides 未知
公开(公告)号：AU2010273763A1
公开(公告)日：2012-01-19
申请号：AU2010273763
申请日：2010-06-29
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , G01N33/53
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

6. 发明专利

CA2766065A1 IMMUNOGLOBULIN FC POLYPEPTIDES 未知
公开(公告)号：CA2766065A1
公开(公告)日：2011-01-20
申请号：CA2766065
申请日：2010-06-29
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , REDDY SAI
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , G01N33/53
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Fc?RI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

7. 发明专利

CA2685675A1 IMMUNOGLOBULIN FC LIBRARIES 未知
公开(公告)号：CA2685675A1
公开(公告)日：2008-11-13
申请号：CA2685675
申请日：2008-04-30
申请人： RES DEV FOUNDATION
发明人： JUNG SANG TAEK , GEORGIOU GEORGE
IPC分类号： C07K16/28
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferent ially bind to particular Fc receptors are described. Furthermore, the invent ion provides aglycosylated Fc domains that bind to Fc receptors with high af finity. Enhanced methods and media for prokaryotic based interaction screeni ng are also provided.

8. 发明专利

CA2685675C IMMUNOGLOBULIN FC LIBRARIES 未知
公开(公告)号：CA2685675C
公开(公告)日：2016-02-16
申请号：CA2685675
申请日：2008-04-30
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK
IPC分类号： C07K16/28
摘要： Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.

9. 发明专利

DK2155789T3 Immunoglobulin-Fc-biblioteker 未知
公开(公告)号：DK2155789T3
公开(公告)日：2013-10-21
申请号：DK08747239
申请日：2008-04-30
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK
IPC分类号： C07K16/28

10. 发明专利

AU2012214643A1 Engineered immunoglobulin Fc polypeptides 未知
公开(公告)号：AU2012214643A1
公开(公告)日：2013-08-15
申请号：AU2012214643
申请日：2012-02-06
申请人： RES DEV FOUNDATION
发明人： GEORGIOU GEORGE , JUNG SANG TAEK , KELTON WILLIAM , KANG TAE HYUN
IPC分类号： C07K16/28
摘要： Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcyRIIa, but that is significantly reduced for binding to the highly homologous FcyRIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

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