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1. 发明申请

US20140212426A1 Toll-Like Receptor 3 Antagonists 审中-公开
标题翻译： Toll样受体3拮抗剂
公开(公告)号：US20140212426A1
公开(公告)日：2014-07-31
申请号：US13751718
申请日：2013-01-28
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译：公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。

2. 发明授权

US08519107B2 IL-17A antibodies 有权
标题翻译： IL-17A抗体
公开(公告)号：US08519107B2
公开(公告)日：2013-08-27
申请号：US12915445
申请日：2010-10-29
申请人： Juan Carlos Almagro , Daniela Della Ducata , Merle Elloso , Jinquan Luo , Thomas Malia , Michael Naso , Galina Obmolova , Robert Rauchenberger , Mark Rutz , Raymond Sweet , Susann Taudte , Bingyuan Wu , Sheng-Jiun Wu
发明人： Juan Carlos Almagro , Daniela Della Ducata , Merle Elloso , Jinquan Luo , Thomas Malia , Michael Naso , Galina Obmolova , Robert Rauchenberger , Mark Rutz , Raymond Sweet , Susann Taudte , Bingyuan Wu , Sheng-Jiun Wu
IPC分类号： C07K16/24 , C12P21/08
CPC分类号： C07K16/244 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Interleukin-17A (IL-17A) antibody antagonists, polynucleotides encoding IL-17A antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译：公开了白介素-17A（IL-17A）抗体拮抗剂，编码IL-17A抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。

3. 发明申请

US20130090457A1 Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases 审中-公开
标题翻译： Toll样受体3治疗代谢和心血管疾病的拮抗剂
公开(公告)号：US20130090457A1
公开(公告)日：2013-04-11
申请号：US13628434
申请日：2012-09-27
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu , Eilyn Lacy
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Vedrana Stojanovic-Susulic , Raymond Sweet , Fang Teng , Alexey Teplyakov , Linda Wu , Sheng-Jiun Wu , Eilyn Lacy
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/28 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译：公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。

4. 发明申请

US20120251454A1 Human Anti-IL-23 Antibodies, Compositions, Methods and Uses 审中-公开
标题翻译：人类抗IL-23抗体，组合物，方法和用途
公开(公告)号：US20120251454A1
公开(公告)日：2012-10-04
申请号：US13524122
申请日：2012-06-15
申请人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号： C07K16/24 , A61K49/00 , A61P37/02 , A61P1/00 , A61P11/00 , A61P35/00 , A61K39/395 , A61P31/00
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：人抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞及其制备和使用方法在诊断和/或治疗组合物，方法和装置中的应用。

5. 发明授权

US08221760B2 Methods of treatment using human anti-IL-23 antibodies 有权
标题翻译：使用人抗IL-23抗体的治疗方法
公开(公告)号：US08221760B2
公开(公告)日：2012-07-17
申请号：US13173090
申请日：2011-06-30
申请人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：人抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞及其制备和使用方法在诊断和/或治疗组合物，方法和装置中的应用。

6. 发明授权

US08153583B2 Toll like receptor 3 antagonists, methods and uses 有权
标题翻译： Toll样受体3拮抗剂，方法和用途
公开(公告)号：US08153583B2
公开(公告)日：2012-04-10
申请号：US11291140
申请日：2005-11-30
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K38/00 , C07K16/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
摘要翻译：公开了Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂的多核苷酸，以及制备和使用前述物质的方法。

7. 发明申请

US20110268655A1 ANTI-ALPHA V IMMUNOLIPOSOME COMPOSITIONS, METHODS AND USES 有权
标题翻译：抗ALPHA V免疫球蛋白组合物，方法和用途
公开(公告)号：US20110268655A1
公开(公告)日：2011-11-03
申请号：US13105643
申请日：2011-05-11
申请人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
发明人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
IPC分类号： A61K39/395 , A61P35/00 , A61K51/12 , C07K16/28 , A61K9/127
CPC分类号： C07K16/2839 , A61K47/6849 , A61K47/6913 , A61K51/1027 , A61K51/1234 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
摘要： An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor comprising an alpha V subunit including αvβ1, αvβ3 αvβ5, αvβ6, or αvβ8 integrin cell receptors is described. The antibody-derived targeting ligand may be a Fab′ fragment, a scFv, or the like. Binding of the immunoliposome to αv-integrin expressing cells, preferably results in internalization of the immunoliposome for cytoplasmic delivery of a liposome-entrapped agent.
摘要翻译：靶向整合素受体的αV整联蛋白亚单位的免疫脂质体组合物，其由具有至少一种衍生自抗体的靶向配体的配体靶向脂质体组成，并且对至少一种整合素受体具有结合特异性，所述整联蛋白受体包含αv和bgr; αv＆bgr;3αv＆bgr; 5，αv＆bgr; 6或αv＆bgr; 8整合素细胞受体。抗体衍生的靶向配体可以是Fab'片段，scFv等。免疫脂质体与表达αv整联蛋白的细胞的结合优选导致免疫脂质体内在化，用于脂质体包埋的细胞质递送。

8. 发明申请

US20110040249A1 Human Anti-IL-23 Antibodies, Compositions, Methods and Uses 有权
标题翻译：人类抗IL-23抗体，组合物，方法和用途
公开(公告)号：US20110040249A1
公开(公告)日：2011-02-17
申请号：US12855354
申请日：2010-08-12
申请人： JACQUELINE BENSON , JILL CARTON , MARK CUNNINGHAM , YEVGENIYA I. ORLOVSKY , ROBERT RAUCHENBERGER , RAYMOND SWEET
发明人： JACQUELINE BENSON , JILL CARTON , MARK CUNNINGHAM , YEVGENIYA I. ORLOVSKY , ROBERT RAUCHENBERGER , RAYMOND SWEET
IPC分类号： A61K39/395 , C07K16/24 , A61P37/00 , A61P9/00 , A61P31/00 , A61P25/00 , A61J1/14 , A61M5/00
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：人抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞及其制备和使用方法在诊断和/或治疗组合物，方法和装置中的应用。

9. 发明授权

US07790405B2 Solution phase biopanning method using engineered decoy proteins 有权
标题翻译：使用工程诱饵蛋白的溶液相生物淘选方法
公开(公告)号：US07790405B2
公开(公告)日：2010-09-07
申请号：US11112701
申请日：2005-04-22
申请人： Karyn O'Neil , Raymond Sweet , George Heavner
发明人： Karyn O'Neil , Raymond Sweet , George Heavner
IPC分类号： G01N33/53
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/005 , C07K16/244 , C07K16/36 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/76 , G01N33/6845 , G01N33/6854
摘要： The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains the targeted domain or epitope. The invention is based on the use of physical data, which may be combined with derived data, to ascertain that the decoy and the target differ only in the specific functional domain or epitope where the binding will be directed.
摘要翻译：本发明涉及将生物治疗分子选择指向靶生物分子的特定功能结构域的方法。选择是通过使用紧密相关的分子来引导的，其中一个是诱饵，另一个包含靶向结构域或表位。本发明基于物理数据的使用，其可以与衍生数据组合，以确定诱饵和靶标仅在绑定将被引导的特定功能域或表位上不同。

10. 发明申请

US20090235609A1 Rod with octagonal core purpose-built for civil construction 审中-公开
标题翻译：杆用八角核心专用于民用建筑
公开(公告)号：US20090235609A1
公开(公告)日：2009-09-24
申请号：US11628571
申请日：2005-03-17
申请人： Toshio Amanuma , Ricardo Hidetoshi Amanuma , John Raymond Sweet
发明人： Toshio Amanuma , Ricardo Hidetoshi Amanuma , John Raymond Sweet
IPC分类号： E04C5/00
CPC分类号： E04C5/0604
摘要： The object of this patent is an advance in the state of the art in the technique of manufacturing rods (2) aimed to be folded for the production of hangers (4) for the civil construction, the reinforced structures in particular, because it prevents the polygons generated in the folding of the hangers (4) form having non-co-planned edges as they are produced, which brings large savings to the process. The formation of hangers (4) with non-co-planned edges brings costs and delays to the civil construction, which are avoided with the use of the rod with octagonal core purpose-built for civil construction, object of this patent. Although the core of the rod with octagonal core purpose-built for civil construction is octagonal, according to the FIG. 8, its specific section is an octagonal structure, formed due to the corrugated material with which the rod (2) is made, according to FIG. 9.
摘要翻译：该专利的目的是在制造用于生产用于民用结构的吊架（4）的棒（2）的技术中的先进技术，特别是加强结构，因为它阻止了在衣架（4）的折叠中产生的多边形在产生时具有非共同规划的边缘，这为工艺带来了大量的节省。以非共同计划的边缘形成衣架（4）为民用建筑带来成本和延误，这是通过使用专用于民用建筑的八角核心杆避免的。虽然用于民用建筑的八角形核的杆的核心是八边形，如图8所示，其特定部分是由于根据图2制成的杆（2）的波纹材料而形成的八边形结构。 9。

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