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1. 发明授权

US08138315B2 Anti-alpha V immunoliposome compositions, methods and uses 有权
标题翻译：抗-αV免疫脂质体组合物，方法和用途
公开(公告)号：US08138315B2
公开(公告)日：2012-03-20
申请号：US13105643
申请日：2011-05-11
申请人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
发明人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
IPC分类号： C12P21/08
CPC分类号： C07K16/2839 , A61K47/6849 , A61K47/6913 , A61K51/1027 , A61K51/1234 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
摘要： An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor comprising an alpha V subunit including αvβ1, αvβ3 αvβ5, αvβ6, or αvβ8 integrin cell receptors is described. The antibody-derived targeting ligand may be a Fab′ fragment, a scFv, or the like. Binding of the immunoliposome to αv-integrin expressing cells, preferably results in internalization of the immunoliposome for cytoplasmic delivery of a liposome-entrapped agent.
摘要翻译：靶向整合素受体的αV整联蛋白亚单位的免疫脂质体组合物，其由具有至少一种衍生自抗体的靶向配体的配体靶向脂质体组成，并且对至少一种整合素受体具有结合特异性，所述整联蛋白受体包含αv和bgr; αv＆bgr;3αv＆bgr; 5，αv＆bgr; 6或αv＆bgr; 8整合素细胞受体。抗体衍生的靶向配体可以是Fab'片段，scFv等。免疫脂质体与表达αv整联蛋白的细胞的结合优选导致免疫脂质体内在化，用于脂质体包埋的细胞质递送。

2. 发明申请

US20110268655A1 ANTI-ALPHA V IMMUNOLIPOSOME COMPOSITIONS, METHODS AND USES 有权
标题翻译：抗ALPHA V免疫球蛋白组合物，方法和用途
公开(公告)号：US20110268655A1
公开(公告)日：2011-11-03
申请号：US13105643
申请日：2011-05-11
申请人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
发明人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
IPC分类号： A61K39/395 , A61P35/00 , A61K51/12 , C07K16/28 , A61K9/127
CPC分类号： C07K16/2839 , A61K47/6849 , A61K47/6913 , A61K51/1027 , A61K51/1234 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
摘要： An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor comprising an alpha V subunit including αvβ1, αvβ3 αvβ5, αvβ6, or αvβ8 integrin cell receptors is described. The antibody-derived targeting ligand may be a Fab′ fragment, a scFv, or the like. Binding of the immunoliposome to αv-integrin expressing cells, preferably results in internalization of the immunoliposome for cytoplasmic delivery of a liposome-entrapped agent.
摘要翻译：靶向整合素受体的αV整联蛋白亚单位的免疫脂质体组合物，其由具有至少一种衍生自抗体的靶向配体的配体靶向脂质体组成，并且对至少一种整合素受体具有结合特异性，所述整联蛋白受体包含αv和bgr; αv＆bgr;3αv＆bgr; 5，αv＆bgr; 6或αv＆bgr; 8整合素细胞受体。抗体衍生的靶向配体可以是Fab'片段，scFv等。免疫脂质体与表达αv整联蛋白的细胞的结合优选导致免疫脂质体内在化，用于脂质体包埋的细胞质递送。

3. 发明申请

US20090175784A1 Anti-Alpha V Immunoliposome Composition, Methods, and Uses 审中-公开
标题翻译：抗αV免疫脂质体组成，方法和用途
公开(公告)号：US20090175784A1
公开(公告)日：2009-07-09
申请号：US12118994
申请日：2008-05-12
申请人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
发明人： Joshua Goldstein , Allen Magill , Deepak Saini , Linda A. Snyder , Raymond Sweet , Steve P. Weng
IPC分类号： A61K51/00 , C07K16/18 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/06 , C12N5/08 , A61K9/127 , A61K39/395 , C12P21/00
CPC分类号： C07K16/2839 , A61K47/6849 , A61K47/6913 , A61K51/1027 , A61K51/1234 , A61K2039/505 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622
摘要： An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor comprising an alpha V subunit including αvβ1, αvβ3 αvβ5, αvβ6, or αvβ8 integrin cell receptors is described. The antibody-derived targeting ligand may be a Fab′ fragment, a scFv, or the like. Binding of the immunoliposome to αv-integrin expressing cells, preferably results in internalization of the immunoliposome for cytoplasmic delivery of a liposome-entrapped agent.
摘要翻译：靶向由整合素受体组成的αV整联蛋白亚单位的免疫脂质体组合物，其由具有至少一种衍生自抗体的靶向配体的配体靶向脂质体组成，并且对至少一种整合素受体具有结合特异性，所述整联蛋白受体包含αV亚基，包括alphavbeta1，alphavbeta3 alphavbeta5 ，alphavbeta6或alphavbeta8整联蛋白细胞受体。抗体衍生的靶向配体可以是Fab'片段，scFv等。免疫脂质体与表达表达α-融合蛋白的细胞的结合优选地导致免疫脂质体内在化，用于脂质体包裹的药物的细胞质递送。

4. 发明授权

US08853371B2 Process for preparing unaggregated antibody Fc domains 有权
标题翻译：制备未聚集抗体Fc结构域的方法
公开(公告)号：US08853371B2
公开(公告)日：2014-10-07
申请号：US11875243
申请日：2007-10-19
申请人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
发明人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
IPC分类号： C07K17/00 , B01D15/38 , C07K1/22 , A61K39/395
CPC分类号： A61K39/39591 , B01D15/3809 , C07K1/22 , C07K2317/52 , C07K2319/30
摘要： Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
摘要翻译：公开了可用于产生纯化的Fc肽链溶液的方法。该方法采用蛋白A色谱分离从包含抗体Fc结构域的低分子量未聚集肽链分离包含抗体Fc结构域的高分子量聚集肽链。通过本发明方法获得的纯化的Fc肽链的溶液含有少于5％的聚集体和大于70％的经过纯化的Fc肽链。

5. 发明申请

US20090171072A1 Process for Preparing Unaggregated Antibody FC Domains 有权
标题翻译：制备未分类抗体FC域的方法
公开(公告)号：US20090171072A1
公开(公告)日：2009-07-02
申请号：US11875243
申请日：2007-10-19
申请人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
发明人： Pedro Alfonso , Michael Capaldi , Dennis Dong , Thomas R. Gervais , Joshua Goldstein , Allen B. Magill , Nicole Quinlan , Deepak Saini
IPC分类号： C07K16/00
CPC分类号： A61K39/39591 , B01D15/3809 , C07K1/22 , C07K2317/52 , C07K2319/30
摘要： Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification.
摘要翻译：公开了可用于产生纯化的Fc肽链溶液的方法。该方法采用蛋白A色谱分离从包含抗体Fc结构域的低分子量未聚集肽链分离包含抗体Fc结构域的高分子量聚集肽链。通过本发明方法获得的纯化的Fc肽链的溶液含有少于5％的聚集体和大于70％的经过纯化的Fc肽链。

6. 发明授权

US07912523B2 Crescent hinge 有权
标题翻译：月牙铰链
公开(公告)号：US07912523B2
公开(公告)日：2011-03-22
申请号：US12141762
申请日：2008-06-18
申请人： Vaibhava Anand , Deepak Saini
发明人： Vaibhava Anand , Deepak Saini
IPC分类号： H04M1/00
CPC分类号： H04M1/0216 , Y10T16/52 , Y10T16/5404 , Y10T16/54048
摘要： A portable electronic device includes a base or first member, a flip or second member, and a hinge mechanism pivotally connecting the second member to the first member for pivotal movement between a closed position and an open position. The hinge mechanism includes a first semi-annular elongated recess and a semi-annular elongated concave member with a semi-annular elongated concave surface, the semi-annular elongated rotation member being pivotally and slidably disposed within the first semi-annular elongated recess, and the semi-annular elongated concave surface of the semi-annular elongated rotation member being exposed when the first member and the second member are in the closed position and being not exposed when the first member and the second member are in the open position.
摘要翻译：便携式电子设备包括底座或第一构件，翻盖或第二构件以及将第二构件枢转地连接到第一构件的铰链机构，用于在关闭位置和打开位置之间枢转运动。铰链机构包括第一半环形细长凹槽和具有半环形细长凹面的半环形细长凹形构件，半环形细长旋转构件可枢转地并可滑动地设置在第一半环形细长凹槽内，以及当第一构件和第二构件处于关闭位置时，半环形细长旋转构件的半环形细长凹面露出，并且当第一构件和第二构件处于打开位置时不露出。

7. 外观设计

USD616405S1 Portable electronic device 有权
公开(公告)号：USD616405S1
公开(公告)日：2010-05-25
申请号：US29320017
申请日：2008-06-18
申请人： Vaibhava Anand , Deepak Saini
设计人： Vaibhava Anand , Deepak Saini

8. 发明申请

US20090318203A1 CRESCENT HINGE 有权
公开(公告)号：US20090318203A1
公开(公告)日：2009-12-24
申请号：US12141762
申请日：2008-06-18
申请人： Vaibhava ANAND , Deepak Saini
发明人： Vaibhava ANAND , Deepak Saini
IPC分类号： H04M1/00 , H05K7/16
CPC分类号： H04M1/0216 , Y10T16/52 , Y10T16/5404 , Y10T16/54048
摘要： A portable electronic device includes a base or first member, a flip or second member, and a hinge mechanism pivotally connecting the second member to the first member for pivotal movement between a closed position and an open position. The hinge mechanism includes a first semi-annular elongated recess and a semi-annular elongated concave member with a semi-annular elongated concave surface, the semi-annular elongated rotation member being pivotally and slidably disposed within the first semi-annular elongated recess, and the semi-annular elongated concave surface of the semi-annular elongated rotation member being exposed when the first member and the second member are in the closed position and being not exposed when the first member and the second member are in the open position.
摘要翻译：便携式电子设备包括底座或第一构件，翻盖或第二构件以及将第二构件枢转地连接到第一构件的铰链机构，用于在关闭位置和打开位置之间枢转运动。铰链机构包括第一半环形细长凹槽和具有半环形细长凹面的半环形细长凹形构件，半环形细长旋转构件可枢转地并可滑动地设置在第一半环形细长凹槽内，以及当第一构件和第二构件处于关闭位置时，半环形细长旋转构件的半环形细长凹面露出，并且当第一构件和第二构件处于打开位置时不露出。

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