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1. 发明申请

WO2004026316A1 NOVEL USE OF CARBOHYDRATES AND COMPOSITIONS 审中-公开
标题翻译：碳水化合物和组合物的新用途
公开(公告)号：WO2004026316A1
公开(公告)日：2004-04-01
申请号：PCT/FI2003/000674
申请日：2003-09-16
申请人： DANISCO A/S , RAUTONEN, Nina , APAJALAHTI, Juha , KETTUNEN, Anu , SIIKANEN, Osmo
发明人： RAUTONEN, Nina , APAJALAHTI, Juha , KETTUNEN, Anu , SIIKANEN, Osmo
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A23C9/133 , A23C9/137 , A23G1/56 , A23G2200/06 , A23L13/426 , A23L33/10 , A23L33/135 , A23V2002/00 , A23V2250/206 , A23V2250/5026 , A23V2250/5072 , A23V2250/6414
摘要： The present invention relates to the use of carbohydrates in the preparation of a composition for treating and/or preventing diseases and/or disorders caused by imbalanced fermentation in the colon comprising providing composition capable of maintaining a sustained and controlled fermentation throughout the colon of a subject by formulating slowly fermented complex oligomeric or polymeric carbohydrate(s) into a nutritionally, nutraceutically and/or pharmacologically acceptable composition. The present invention also relates to a composition comprising a slowly fermented complex oligomer or polymer carbohydrate as an active component for sustaining and controlling the fermentation throughout the colon of a subject.
摘要翻译：本发明涉及碳水化合物在制备用于治疗和/或预防由结肠不平衡发酵引起的疾病和/或障碍的组合物中的用途，其包括提供能够维持受试者整个结肠持续和控制发酵的组合物通过将缓慢发酵的复合寡聚或聚合碳水化合物配制成营养，营养和/或药学上可接受的组合物。本发明还涉及一种组合物，其包含缓慢发酵的复合低聚物或聚合物碳水化合物作为用于维持和控制受试者整个结肠发酵的活性成分。

2. 发明申请

US20100092429A1 Composition 审中-公开
标题翻译：组成
公开(公告)号：US20100092429A1
公开(公告)日：2010-04-15
申请号：US12518692
申请日：2007-12-10
申请人： Rautonen Nina , Arthur Ouwehand , Julian Stowell , Henna Makelainen
发明人： Rautonen Nina , Arthur Ouwehand , Julian Stowell , Henna Makelainen
IPC分类号： A61K35/74 , A23C9/123 , A23C9/13 , A23C9/152 , A23L1/29 , A23L1/30 , A23L2/39 , A61P1/00 , A61P37/00 , A61P17/00
CPC分类号： A23C9/1234 , A23C9/1307 , A23C9/152 , A23L2/39 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/00 , A23V2250/28 , A23V2200/08
摘要： The present invention provides a composition comprising: (a) one or more live Bifidobacterium lactis strains; and (b) a saccharide component; wherein the saccharide component comprises xylo-oligosaccharides with a degree of polymerisation of from 2 to 100.
摘要翻译：本发明提供一种组合物，其包含：（a）一种或多种活双歧杆菌活菌; 和（b）糖组分; 其中所述糖组分包含聚合度为2至100的低聚木糖。

3. 发明申请

WO2008122892A3 PROBIOTICS FOR USE IN REDUCING EOSINOPHILIA AND RESPIRATORY ALLERGIES 审中-公开
标题翻译：用于减少嗜酸性粒细胞减少和呼吸道过敏症的益生菌
公开(公告)号：WO2008122892A3
公开(公告)日：2008-12-18
申请号：PCT/IB2008001503
申请日：2008-03-26
申请人： DANISCO , ISOLAURI ERIKA , OUWEHAND ARTHUR , RAUTONEN NINA , SALMINEN SEPPO JAAKKO
发明人： ISOLAURI ERIKA , OUWEHAND ARTHUR , RAUTONEN NINA , SALMINEN SEPPO JAAKKO
IPC分类号： A61K35/74 , A23L1/30 , A61P37/02
CPC分类号： A61K35/747 , A23L33/135 , A23V2002/00 , A23Y2220/03 , A23Y2300/49 , A61K35/745 , A61K2035/115 , A23V2200/304 , A23V2200/3204
摘要： The present invention provides probiotic compositions suitable for reducing the incidence and duration of nasal eosinophilia and other parameters associated with birch pollen allergy. In some embodiments, the present invention provides methods and/or compositions suitable for reducing nasal and/or respiratory allergy symptoms.
摘要翻译：本发明提供了适用于降低鼻嗜酸性粒细胞增多症的发生率和持续时间以及与桦树花粉过敏相关的其它参数的益生菌组合物。在一些实施方案中，本发明提供适于减少鼻和/或呼吸性过敏症状的方法和/或组合物。

4. 发明申请

WO2007085970A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2007085970A2
公开(公告)日：2007-08-02
申请号：PCT/IB2007/001186
申请日：2007-01-26
申请人： DANISCO A/S , RAUTONEN, Nina , PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti
发明人： RAUTONEN, Nina , PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti
IPC分类号： A61K35/745 , A61K35/747
CPC分类号： A61K35/747 , A23K10/18 , A23K50/40 , A23K50/75 , A23L33/135 , A23L33/30 , A61K35/745
摘要： Use of at least one strain of a microorganism and/or a metabolite thereof in the manufacture of a support for administration to a subject for modulating satiety signalling, wherein the support is a pharmaceutically acceptable support or a food product. Suitably, the at least one strain of a microorganism and/or a metabolite thereof may be administered to the subject for the treatment and/or prevention of excess weight and/or a disease caused by excess weight. Likewise, the at least one strain of a microorganism and/or a metabolite thereof is administered to the subject for the treatment and/or prevention of obesity and/or a disease caused by obesity. Preferably, the microorganism is a probiotic microorganism. Suitably the microorganism may be a lactic acid bacterium. Li one embodiment the microorganism is a strain of Lactobacillus spp. and/or Bifidobacterium spp., for example a strain of Lactobacillus acidophilus, L. curvatus, L. salivarius and/or B. lactis.
摘要翻译：至少一种微生物菌株和/或其代谢物在制备用于施用受试者以调节饱腹感信号的载体中的用途，其中所述载体是药学上可接受的载体或食品。适当地，将微生物和/或其代谢物的至少一种菌株施用于受试者以治疗和/或预防超重和/或由超重引起的疾病。同样地，向受试者施用至少一种微生物和/或其代谢物，用于治疗和/或预防肥胖症和/或由肥胖引起的疾病。优选地，微生物是益生菌微生物。适当地，微生物可以是乳酸菌。李一个实例是微生物是一种乳杆菌属菌株。和/或双歧杆菌属，例如嗜酸乳杆菌，弯曲曲霉，唾液乳杆菌和/或乳酸乳杆菌的菌株。

5. 发明申请

WO2005032567A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2005032567A2
公开(公告)日：2005-04-14
申请号：PCT/IB2004/003273
申请日：2004-09-24
申请人： DANISCO A/S , RAUTONEN, Nina , NURMI, Jussi , NURMINEN, Päivi , PUOLAKKAINEN, Pauli
发明人： RAUTONEN, Nina , NURMI, Jussi , NURMINEN, Päivi , PUOLAKKAINEN, Pauli
IPC分类号： A61K35/74
CPC分类号： A61K35/745 , A23K10/16 , A23K10/18 , A23K50/75 , A61K31/19 , A61K31/205 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a microorganism and/or a metabolite thereof to at least increase the amount of a COX-1 mRNA in a cell. The present invention further relates to the use of a microorganism and/or a metabolite thereof in the manufacture of a medicament to treat the side effects associated with nonsteroidal antiinflammatory drugs (NSAIDs). The present invention further relates to a pharmaceutical preparation comprising in combination a nonsteroidal antiinflammatory drug (NSAIDs) and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The present invention yet further relates to a pharmaceutical preparation comprising in combination betaine or a pharmaceutically acceptable salt thereof and a microorganism and/or a metabolite thereof which is capable of at least increasing the amount of a COX-1 mRNA in a cell. The microorganism may suitably be a bacterium, preferably from the genus Bifidobacterium.
摘要翻译：本发明涉及使微生物和/或其代谢物至少增加细胞中COX-1mRNA的量的用途。本发明还涉及微生物和/或其代谢物在制备用于治疗与非甾体抗炎药（NSAID）相关的副作用的药物中的用途。本发明还涉及一种药物制剂，其包含非甾体抗炎药（NSAID）和能够至少增加细胞中COX-1mRNA量的微生物和/或其代谢物的组合。本发明还涉及包含组合甜菜碱或其药学上可接受的盐和能够至少增加细胞中COX-1 mRNA的量的微生物和/或其代谢物的药物制剂。微生物可以适当地是细菌，优选来自双歧杆菌属。

6. 发明申请

WO02091850A8 METHOD FOR PRODUCING A NUTRITION ADDITIVE, AN ADDITIVE AND ITS USE 审中-公开
标题翻译：生产营养添加剂，添加剂及其用途的方法
公开(公告)号：WO02091850A8
公开(公告)日：2003-07-31
申请号：PCT/FI0200393
申请日：2002-05-08
申请人： SUOMEN REHU OY , VUORENMAA JUHANI , RAUTONEN NINA
发明人： VUORENMAA JUHANI
IPC分类号： A23K10/16 , A23K10/38 , A23L33/145 , A61K36/06 , A61P1/00 , A61P1/14 , A23K1/00 , A23L1/09
CPC分类号： A23K10/38 , A23K10/16 , A23L33/145 , Y02P60/873
摘要： The invention relates to a method for producing a nutrition additive for use for the prevention of intestinal diseases, in which method brewery yeast is filtered and the filtered brewery yeast is treated hydrolytically so that the cellular structure breaks open and the effective concentration of oligo- and/or polysaccharides, betaglucane and/or proteins on the surface of the cellular structures is increased. Moreover, the invention relates to a nutrition additive produced by treating filtered brewery yeast by a hydrolytic process so that the cellular structure breaks open. In addition, the invention relates to the use of a nutrition additive in connection with the feeding of animals, the additive being used in an amount of 0.1 - 1.0 w-% of the total amount of raw material. The invention also relates to the use of the nutrition additive in question for humans for balancing intestinal microbes and preventing intestinal diseases.
摘要翻译：本发明涉及一种生产用于预防肠道疾病的营养添加剂的方法，其中方法啤酒酵母被过滤并且过滤的啤酒酵母被水解以使细胞结构断开，有效浓度低 /或细胞结构表面上的多糖，β-葡聚糖和/或蛋白质增加。此外，本发明涉及通过水解过程处理过滤的酿酒酵母以使细胞结构断开而产生的营养添加剂。此外，本发明涉及营养添加剂与动物喂养有关的用途，该添加剂的使用量为原料总量的0.1-1.0w％。本发明还涉及用于人类的营养添加剂在平衡肠微生物和预防肠道疾病中的用途。

7. 发明申请

WO2012150269A1 PROBIOTIC BACTERIA FOR THE TOPICAL TREATMENT OF SKIN DISORDERS 审中-公开
标题翻译：用于皮肤病症局部治疗的生物细菌
公开(公告)号：WO2012150269A1
公开(公告)日：2012-11-08
申请号：PCT/EP2012/058047
申请日：2012-05-02
申请人： DUPONT NUTRITION BIOSCIENCES APS , PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , RAUTONEN, Nina
发明人： PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , RAUTONEN, Nina
IPC分类号： A61K31/205 , A61K35/74 , A61P17/06 , A61P17/16
CPC分类号： A61K35/741 , A61K31/205 , A61K35/744 , A61K35/745 , A61K35/747
摘要： The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration.
摘要翻译：本发明涉及用于治疗与紧结功能相关的病症的益生菌和/或益生菌的细胞裂解液的益生菌和/或可溶性代谢物，其特征在于益生菌，可溶性将益生菌和/或益生菌的细胞裂解液的代谢物配制成局部给药。

8. 发明申请

WO2008155536A1 ANIMAL FEED PRODUCT 审中-公开
标题翻译：动物饲料产品
公开(公告)号：WO2008155536A1
公开(公告)日：2008-12-24
申请号：PCT/GB2008/002070
申请日：2008-06-17
申请人： DANISCO A/S , SCHULZE, Hagen, Klaus , TAYLOR, Robert, Barry , KETTUNEN, Hannele , OUWEHAND, Arthur, C. , SAARINEN, Markku , RAUTONEN, Nina , PEURANEN, Seppo , LINO BENTO, Maria, Helena , TIIHONEN, Kirsti, Kaarina
发明人： SCHULZE, Hagen, Klaus , TAYLOR, Robert, Barry , KETTUNEN, Hannele , OUWEHAND, Arthur, C. , SAARINEN, Markku , RAUTONEN, Nina , PEURANEN, Seppo , LINO BENTO, Maria, Helena , TIIHONEN, Kirsti, Kaarina
IPC分类号： A23K1/18 , A23K1/16 , A23K1/165
CPC分类号： A23K50/75 , A23K20/10 , A23K20/111 , A23K20/189 , A23K40/10
摘要： The present invention provides an animal feed additive obtainable by: (a) mixing water, an emulsion stabilizer and a physiologically acceptable carrier to form a gum solution; (b) adding to the gum solution, separately or combined, an oil blend comprising: (i) cinnamaldehyde and (ii) a compound selected from the group consisting of citral, eugenol, limonene, thymol, vanillin and combinations thereof; (c) mixing the gum solution and the oil blend and homogenizing this mixture under pressure to form an emulsion; and (d) spray drying and/or agglomerating the mixture to form a powder.
摘要翻译：本发明提供一种动物饲料添加剂，其可通过以下方法获得：（a）将水，乳剂稳定剂和生理学上可接受的载体混合以形成胶溶液; （b）单独或组合的添加到胶溶液中的油混合物，其包含：（i）肉桂醛和（ii）选自柠檬醛，丁子香酚，柠檬烯，百里酚，香草醛及其组合的化合物; （c）将胶溶液和油混合物混合并在压力下均化该混合物以形成乳液; 和（d）将混合物喷雾干燥和/或附聚以形成粉末。

9. 发明申请

WO2008122892A2 PROBIOTICS FOR USE IN REDUCING EOSINOPHILIA AND RESPIRATORY ALLERGIES 审中-公开
标题翻译：用于减少EOSINOPHILIA和呼吸过敏的益生菌
公开(公告)号：WO2008122892A2
公开(公告)日：2008-10-16
申请号：PCT/IB2008/001503
申请日：2008-03-26
申请人： DANISCO A/S , ISOLAURI, Erika , OUWEHAND, Arthur , RAUTONEN, Nina , SALMINEN, Seppo, Jaakko
发明人： ISOLAURI, Erika , OUWEHAND, Arthur , RAUTONEN, Nina , SALMINEN, Seppo, Jaakko
IPC分类号： A61K35/74 , A23L1/30 , A61P37/02
CPC分类号： A61K35/747 , A23L33/135 , A23V2002/00 , A23Y2220/03 , A23Y2300/49 , A61K35/745 , A61K2035/115 , A23V2200/304 , A23V2200/3204
摘要： The present invention provides probiotic compositions suitable for reducing the incidence and duration of nasal eosinophilia and other parameters associated with birch pollen allergy. In some embodiments, the present invention provides methods and/or compositions suitable for reducing nasal and/or respiratory allergy symptoms.
摘要翻译：本发明提供了适合于降低鼻嗜酸粒细胞增多症的发病率和持续时间以及与桦树花粉过敏有关的其他参数的益生菌组合物。在一些实施方案中，本发明提供了适合于减轻鼻和/或呼吸道过敏症状的方法和/或组合物。

10. 发明申请

WO2008071930A1 COMPOSITION 审中-公开
标题翻译：组成
公开(公告)号：WO2008071930A1
公开(公告)日：2008-06-19
申请号：PCT/GB2007/004714
申请日：2007-12-10
申请人： DANISCO A/S , RAUTONEN, Nina , OUWEHAND, Arthur , STOWELL, Julian , MAKELAINEN, Henna
发明人： RAUTONEN, Nina , OUWEHAND, Arthur , STOWELL, Julian , MAKELAINEN, Henna
IPC分类号： A23C9/123 , A23C9/13 , A23C9/152 , A23L1/00 , A23L1/29 , A23L1/30 , A23L2/39
CPC分类号： A23C9/1234 , A23C9/1307 , A23C9/152 , A23L2/39 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/00 , A23V2250/28 , A23V2200/08
摘要： The present invention provides a composition comprising: (a) one or more live Bifidobacterium lactis strains; and (b) a saccharide component; wherein the saccharide component comprises xylo-oligosaccharides with a degree of polymerisation of from 2 to 100.
摘要翻译：本发明提供一种组合物，其包含：（a）一种或多种活双歧杆菌活菌; 和（b）糖组分; 其中所述糖组分包含聚合度为2至100的低聚木糖。

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