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1. 发明公开

EP1583541A2 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 有权
标题翻译：化合物和方法增神经GENESIS
公开(公告)号：EP1583541A2
公开(公告)日：2005-10-12
申请号：EP03772495.2
申请日：2003-11-20
申请人： Neuronova AB , Bertilsson, Garan , Erlandsson, Rikard , Frisen, Jonas , Haegestrand, Anders , Heidrich, Jessica , Hellström, Kristina , Häggblad, Johan , Jansson, Katarina , Kortesmaa, Jarkko , Lindquist, Per , Lundh, Hanna , McGuire, Jacqueline , Mercer, Alex , Njberg, Karl , Ossoinak, Amina , Patrone, Cesare , Rönnholm, Harriet , Zachrisson, Olof , Wikström, Lilian
发明人： BERTILSSON, Göran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTRÖM, Kristina , HÄGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NJBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RÖNNHOLM, Harriet , ZACHRISSON, Olof , WIKSTRÖM, Lilian
IPC分类号： A61K31/675 , A61P25/00
CPC分类号： A61K38/164 , A61K31/675 , A61K38/22 , Y02A50/471
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.

2. 发明申请

WO2004045592A2 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 审中-公开
标题翻译：化合物和增加神经发生的方法
公开(公告)号：WO2004045592A2
公开(公告)日：2004-06-03
申请号：PCT/IB2003/005311
申请日：2003-11-20
申请人： NEURONOVA AB , BERTILSSON, Göran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTRÖM, Kristina , HÄGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NJBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RÖNNHOLM, Harriet , ZACHRISSON, Olof , WIKSTRÖM, Lilian
发明人： BERTILSSON, Göran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTRÖM, Kristina , HÄGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NJBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RÖNNHOLM, Harriet , ZACHRISSON, Olof , WIKSTRÖM, Lilian
IPC分类号： A61K31/00
CPC分类号： A61K38/164 , A61K31/675 , A61K38/22 , Y02A50/471
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca¿2+? elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.
摘要翻译：本发明涉及通过使神经元组织与细胞内cAMP升高剂和细胞内Ca 2+升高剂接触而促进神经发生的方法。公开了用于促进神经发生的新型药剂。这些药剂包括增加细胞内cAMP的新型药剂。

3. 发明申请

WO1996033216A1 TRUNCATED IGF-I 审中-公开
标题翻译：关闭IGF-I
公开(公告)号：WO1996033216A1
公开(公告)日：1996-10-24
申请号：PCT/SE1996000520
申请日：1996-04-19
申请人： PHARMACIA AB , ERIKSSON, Rolf , JOHANSSON, Stig , RÖNNHOLM, Harriet , SKOTTNER, Anna , SONESSON, Karin
发明人： PHARMACIA AB
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： The invention relates to a truncated variant of IGF-I having 1-69 of the amino acids of authentic IGF-I (IGF-I(1-69)) and a method of obtaining the truncated IGF-I either by expressing of IGF-I in yeast cells, enzymatic cleavage and thereafter isolating the truncated IGF-I from the medium or by introducing a plasmid encoding for the truncated variant of IGF-I and expressing the truncated variant of IGF-I. The invention also relates to a pharmaceutical composition containing this new truncated variant of IGF-I and to the use of IGF-I(1-69) for the preparation of a medicament.
摘要翻译：本发明涉及具有1-69个正义IGF-1（IGF-I（1-69））氨基酸的IGF-I的截短变体，以及通过表达IGF- I在酵母细胞中，酶裂解，然后从培养基中分离截短的IGF-I，或通过引入编码IGF-1的截短变体的质粒并表达IGF-I的截短变体。本发明还涉及含有这种新的截短IGF-I变体的药物组合物和IGF-I（1-69）用于制备药物的药物组合物。

4. 发明申请

WO1996001275A1 O-GLYCOSYLATED AUTHENTIC IGF-I AND TRUNCATED VARIANTS THEREOF, A METHOD OF PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： O-糖苷化的认知IGF-I和其截短的变体，其制备方法和药物组合物
公开(公告)号：WO1996001275A1
公开(公告)日：1996-01-18
申请号：PCT/SE1995000774
申请日：1995-06-22
申请人： PHARMACIA AB , ERIKSSON, Rolf , JOHANSSON, Stig , RÖNNHOLM, Harriet , SKOTTNER, Anna , SONESSON, Karin
发明人： PHARMACIA AB
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： The invention relates to O-glycosylated authentic IGF-I, having three or more mannose residues to the Ser69 amino acid of the IGF-polypeptide chain or being truncated and having two mannose residues to the Thr29 amino acid of the truncated IGF-polypeptide chain. The O-glycosylated IGF-I according to the invention have substantially no insulin receptor affinity, which makes them valuable for use in therapeutic treatment. The invention also relates to a method of obtaining IGF-I as defined above by expressing IGF-I in yeast cells and isolating the claimed O-glycosylated IGF-I from the medium and to pharmaceutical composition containing these IGF-I together with a pharmaceutically acceptable carrier, diluent or excipient. It also relates to the use of the O-glycosylated IGF-I in the preparation of a medicament for the treatment of e.g. growth deficiency and insulin resistant states.
摘要翻译：本发明涉及对于IGF-多肽链的Ser69氨基酸具有三个或更多个甘露糖残基的O-糖基化的正义IGF-I，或被截短且具有两个截短的IGF-多肽链的Thr29氨基酸的甘露糖残基。根据本发明的O-糖基化IGF-I基本上没有胰岛素受体亲和力，这使得它们对于用于治疗性治疗是有价值的。本发明还涉及通过在酵母细胞中表达IGF-I并从培养基中分离要求保护的O-糖基化IGF-1以及含有这些IGF-I的药物组合物与药学上可接受的方法，获得如上定义的IGF-1的方法载体，稀释剂或赋形剂。它还涉及O-糖基化IGF-I在制备用于治疗例如儿童的药物中的用途。生长缺乏和胰岛素抵抗状态。

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