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1. 发明公开

EP1583541A2 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 有权
标题翻译：化合物和方法增神经GENESIS
公开(公告)号：EP1583541A2
公开(公告)日：2005-10-12
申请号：EP03772495.2
申请日：2003-11-20
申请人： Neuronova AB , Bertilsson, Garan , Erlandsson, Rikard , Frisen, Jonas , Haegestrand, Anders , Heidrich, Jessica , Hellström, Kristina , Häggblad, Johan , Jansson, Katarina , Kortesmaa, Jarkko , Lindquist, Per , Lundh, Hanna , McGuire, Jacqueline , Mercer, Alex , Njberg, Karl , Ossoinak, Amina , Patrone, Cesare , Rönnholm, Harriet , Zachrisson, Olof , Wikström, Lilian
发明人： BERTILSSON, Göran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTRÖM, Kristina , HÄGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NJBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RÖNNHOLM, Harriet , ZACHRISSON, Olof , WIKSTRÖM, Lilian
IPC分类号： A61K31/675 , A61P25/00
CPC分类号： A61K38/164 , A61K31/675 , A61K38/22 , Y02A50/471
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.

2. 发明申请

WO2005066131A1 NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译：非核苷酸逆转录酶抑制剂
公开(公告)号：WO2005066131A1
公开(公告)日：2005-07-21
申请号：PCT/SE2004/002034
申请日：2004-12-30
申请人： MEDIVIR AB , SUND, Christian , ROUE, Nathalie , LINDSTRÖM, Stefan , ANTONOV, Dmitry , SAHLBERG, Christer , JANSSON, Katarina
发明人： SUND, Christian , ROUE, Nathalie , LINDSTRÖM, Stefan , ANTONOV, Dmitry , SAHLBERG, Christer , JANSSON, Katarina
IPC分类号： C07D213/75
CPC分类号： C07D409/12 , C07D405/12 , C07D405/14 , C07D409/14
摘要： Compounds of the formula Z: where; A is CH or N; R 1 is a substituent to a carbon atom in the ring containing A selected from -S(=O) p Ra, where Ra is -C 1 -C 4 alkyl, -ORx, -NRxRx, -NHNRxRx, - NHNHC(=O)ORx, -NRxOH; -C(=O)-Rb, where Rb is -CT-C4-alkyl, ORx, -NRxRx, -NHNRxRx, -NHC 1 -C 3 -alkyl-C(=O)Orx -NRxRc, where Rc is H, C 1 -C 4 alkyl, -NRxRx; -C(=0)Rd, -CN, S(=O)pRx where Rd is Rd is C1-C4-alkyl, -ORx, -NRxRx C 1 -C 3 -alkyl-O-Cl-C3alkylC(=O)ORx, -C 1 -C 3 -alkyl-COORx; -C 1 -C 3 alkyl-OH or C 1 -C 4 alkyl ethers or esters thereof (O-C l -C 3 alkyl)q-O-Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C 1 -C 4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, -S(=O),- or -CH 2 -, where r is 0, 1 or 2; R 3 -R 7 are substituents as defined in the specification; X is -(CR 8 R 8 ')n-D-(CR 8 R 8 ')m-; D is a bond, -NR 9 -, -0-, -S-, -S(=0)- or -S(=0) 2 -; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.
摘要翻译：式Z的化合物：其中; A是CH或N; R 1是含有选自-S（= O）p R a的A的环中的碳原子的取代基，其中R a是-C 1 -C 4烷基，-OR x，-NR x R x，-NHNR x R x，-NH NH（= O）OR x， NRxOH; -C（= O）-R b，其中R b是-C 1 -C 4 - 烷基，OR x，-NR x R x，-NHNR x R x，-NHC 1 -C 3 - 烷基-C（= O）OR x -NR x R c，其中R c是H， C4烷基，-NRxRx; -C（= O）R d，-CN，S（= O）p R x其中Rd是Rd是C 1 -C 4 - 烷基，-OR x，-NR x R x C 1 -C 3烷基-O-C 1 -C 3烷基C（= O）OR x， -C 1 -C 3 - 烷基 - COORx; -C 1 -C 3烷基-OH或C 1 -C 4烷基醚或其酯（O-Cl-C 3烷基）q-O-Rx具有1-3个杂原子的5或6元芳环p为1或2; R x独立地选自H，C 1 -C 4烷基或乙酰基; 或一对Rx可与相邻的N原子一起形成环; L是-O - ， - S（= O）， - 或-CH 2 - ，其中r是0,1或2; R3-R7是说明书中定义的取代基; X是 - （CR8R8'）n-D-（CR8R8'）m-; D是键，-NR 9 - ， - O - ， - S - ， - S（= O） - 或-S（= O）其药学上可接受的盐和前药具有作为HIV抗病毒剂的效用。

3. 发明申请

WO2004018655A3 METHOD FOR CULTURING STEM CELLS 审中-公开
标题翻译：培养干细胞的方法
公开(公告)号：WO2004018655A3
公开(公告)日：2004-09-02
申请号：PCT/IB0304388
申请日：2003-08-26
申请人： NEURONOVA AB , HAGGBLAD JOHAN , HORROCKS CAROLYN , JANSSON KATARINA , RONNHOLM HARRIET
发明人： HAGGBLAD JOHAN , HORROCKS CAROLYN , JANSSON KATARINA , RONNHOLM HARRIET
IPC分类号： C12N5/0797 , C12N5/06
CPC分类号： C12N5/0623 , C12N2500/20 , C12N2501/11 , C12N2501/115 , C12N2501/35 , C12N2501/70
摘要： The present invention provides methods of culturing, propagating, treating, and maintaining stem cells in the presence of a phosphate mimic. In particular, the invention relates to the propagation of stem cells in vitro, the formation of neurospheres in vitro, and to tissue culture of stem cells in the presence of a phosphate mimic. The invention further relates to the treatment of neurodegenerative disorders.
摘要翻译：本发明提供了在磷酸盐模拟物存在下培养，繁殖，治疗和维持干细胞的方法。特别地，本发明涉及体外干细胞的繁殖，体外神经球的形成以及在磷酸盐模拟物存在下干细胞的组织培养。本发明还涉及神经变性疾病的治疗。

4. 发明申请

WO2005081619A3 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 审中-公开
公开(公告)号：WO2005081619A3
公开(公告)日：2005-09-09
申请号：PCT/IB2004/004451
申请日：2004-11-19
申请人： NEURONOVA AB , BERTILSSON, Goran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTROM, Nina , HAGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NYBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RONNHOLM, Harriet , WIRKSTROM, Lilian , ZACHRISSON, Olof
发明人： BERTILSSON, Goran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTROM, Nina , HAGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NYBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RONNHOLM, Harriet , WIRKSTROM, Lilian , ZACHRISSON, Olof
IPC分类号： A61K38/22 , A61K38/23 , A61P25/00 , A61P25/16 , A61P25/28
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.

5. 发明申请

WO2004045592A3 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 审中-公开
标题翻译：化合物和增加神经发生的方法
公开(公告)号：WO2004045592A3
公开(公告)日：2004-11-04
申请号：PCT/IB0305311
申请日：2003-11-20
申请人： NEURONOVA AB , BERTILSSON GOERAN , ERLANDSSON RIKARD , FRISEN JONAS , HAEGESTRAND ANDERS , HEIDRICH JESSICA , HELLSTROEM KRISTINA , HAEGGBLAD JOHAN , JANSSON KATARINA , KORTESMAA JARKKO , LINDQUIST PER , LUNDH HANNA , MCGUIRE JACQUELINE , MERCER ALEX , NJBERG KARL , OSSOINAK AMINA , PATRONE CESARE , ROENNHOLM HARRIET , ZACHRISSON OLOF , WIKSTROEM LILIAN
发明人： BERTILSSON GOERAN , ERLANDSSON RIKARD , FRISEN JONAS , HAEGESTRAND ANDERS , HEIDRICH JESSICA , HELLSTROEM KRISTINA , HAEGGBLAD JOHAN , JANSSON KATARINA , KORTESMAA JARKKO , LINDQUIST PER , LUNDH HANNA , MCGUIRE JACQUELINE , MERCER ALEX , NJBERG KARL , OSSOINAK AMINA , PATRONE CESARE , ROENNHOLM HARRIET , ZACHRISSON OLOF , WIKSTROEM LILIAN
IPC分类号： A61K31/675 , A61K38/22 , A61P25/00
CPC分类号： A61K38/164 , A61K31/675 , A61K38/22
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.

6. 发明申请

WO2004045592A2 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 审中-公开
标题翻译：化合物和增加神经发生的方法
公开(公告)号：WO2004045592A2
公开(公告)日：2004-06-03
申请号：PCT/IB2003/005311
申请日：2003-11-20
申请人： NEURONOVA AB , BERTILSSON, Göran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTRÖM, Kristina , HÄGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NJBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RÖNNHOLM, Harriet , ZACHRISSON, Olof , WIKSTRÖM, Lilian
发明人： BERTILSSON, Göran , ERLANDSSON, Rikard , FRISEN, Jonas , HAEGESTRAND, Anders , HEIDRICH, Jessica , HELLSTRÖM, Kristina , HÄGGBLAD, Johan , JANSSON, Katarina , KORTESMAA, Jarkko , LINDQUIST, Per , LUNDH, Hanna , MCGUIRE, Jacqueline , MERCER, Alex , NJBERG, Karl , OSSOINAK, Amina , PATRONE, Cesare , RÖNNHOLM, Harriet , ZACHRISSON, Olof , WIKSTRÖM, Lilian
IPC分类号： A61K31/00
CPC分类号： A61K38/164 , A61K31/675 , A61K38/22 , Y02A50/471
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca¿2+? elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.
摘要翻译：本发明涉及通过使神经元组织与细胞内cAMP升高剂和细胞内Ca 2+升高剂接触而促进神经发生的方法。公开了用于促进神经发生的新型药剂。这些药剂包括增加细胞内cAMP的新型药剂。

7. 发明申请

WO2005081619A2 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 审中-公开
标题翻译：化合物和增加神经发生的方法
公开(公告)号：WO2005081619A2
公开(公告)日：2005-09-09
申请号：PCT/IB2004004451
申请日：2004-11-19
申请人： NEURONOVA AB , BERTILSSON GORAN , ERLANDSSON RIKARD , FRISEN JONAS , HAEGESTRAND ANDERS , HEIDRICH JESSICA , HELLSTROM NINA , HAGGBLAD JOHAN , JANSSON KATARINA , KORTESMAA JARKKO , LINDQUIST PER , LUNDH HANNA , MCGUIRE JACQUELINE , MERCER ALEX , NYBERG KARL , OSSOINAK AMINA , PATRONE CESARE , RONNHOLM HARRIET , WIRKSTROM LILIAN , ZACHRISSON OLOF
发明人： BERTILSSON GORAN , ERLANDSSON RIKARD , FRISEN JONAS , HAEGESTRAND ANDERS , HEIDRICH JESSICA , HELLSTROM NINA , HAGGBLAD JOHAN , JANSSON KATARINA , KORTESMAA JARKKO , LINDQUIST PER , LUNDH HANNA , MCGUIRE JACQUELINE , MERCER ALEX , NYBERG KARL , OSSOINAK AMINA , PATRONE CESARE , RONNHOLM HARRIET , WIRKSTROM LILIAN , ZACHRISSON OLOF
IPC分类号： A61K38/22 , A61K38/23 , A61K38/26
CPC分类号： A61K35/30 , A61K38/2278 , A61K38/23 , A61K38/26
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis modulating agents. Novel methods for treating neurological disorders using neurogenesis modulating agents are disclosed.
摘要翻译：本发明涉及通过将神经元组织与神经发生调节剂接触来促进神经发生的方法。公开了使用神经发生调节剂治疗神经障碍的新方法。

8. 发明申请

WO2004018655A2 COMPOSITIONS AND METHODS FOR CULTURING STEM CELLS 审中-公开
标题翻译：用于培养干细胞的组合物和方法
公开(公告)号：WO2004018655A2
公开(公告)日：2004-03-04
申请号：PCT/IB2003/004388
申请日：2003-08-26
申请人： NEURONOVA AB , HAGGBLAD, Johan , HORROCKS, Carolyn , JANSSON, Katarina , RONNHOLM, Harriet
发明人： HAGGBLAD, Johan , HORROCKS, Carolyn , JANSSON, Katarina , RONNHOLM, Harriet
IPC分类号： C12N5/00
CPC分类号： C12N5/0623 , C12N2500/20 , C12N2501/11 , C12N2501/115 , C12N2501/35 , C12N2501/70
摘要： The present invention provides methods of culturing, propagating, treating, and maintaining stem cells in the presence of a phosphate mimic. In particular, the invention relates to the propagation of stem cells in vitro , the formation of neurospheres in vitro , and to tissue culture of stem cells in the presence of a phosphate mimic. The invention further relates to the treatment of neurodegenerative disorders.
摘要翻译：本发明提供了在磷酸盐模拟物存在下培养，繁殖，治疗和维持干细胞的方法。特别地，本发明涉及体外干细胞的繁殖，体外神经球的形成以及在磷酸盐模拟物存在下干细胞的组织培养。本发明还涉及神经变性疾病的治疗。

9. 发明专利

AU2003280117A1 COMPOUNDS AND METHODS FOR INCREASING NEUROGENESIS 未知
公开(公告)号：AU2003280117A1
公开(公告)日：2004-06-15
申请号：AU2003280117
申请日：2003-11-20
申请人： BERTILSSON GORAN , ERLANDSSON RIKARD , FRISEN JONAS , HAEGESTRAND ANDERS , HEIDRICH JESSICA , HELLSTROM KRISTINA , HAGGBLAD JOHAN , JANSSON KATARINA , KORTESMAA JARKKO , LINDQUIST PER , LUNDH HANNA , MCGUIRE JACQUELINE , MERCER ALEX , NJBERG KARL , OSSOINAK AMINA , PATRONE CESARE , RONNHOLM HARRIET , ZACHRISSON OLOF , WIKSTROM LILIAN , NEURONOVA AB
发明人： BERTILSSON GORAN , ERLANDSSON RIKARD , FRISEN JONAS , HAEGESTRAND ANDERS , HEIDRICH JESSICA , HELLSTROM KRISTINA , HAGGBLAD JOHAN , JANSSON KATARINA , KORTESMAA JARKKO , LINDQUIST PER , LUNDH HANNA , MCGUIRE JACQUELINE , MERCER ALEX , NJBERG KARL , OSSOINAK AMINA , PATRONE CESARE , RONNHOLM HARRIET , ZACHRISSON OLOF , WIKSTROM LILIAN
IPC分类号： A61K31/675 , A61K38/16 , A61K38/22 , A61P25/00 , A61K31/00
摘要： The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with intracellular cAMP elevating agents and intracellular Ca elevating agents. Novel agents for promoting neurogenesis are disclosed. These agents include novel agents for increasing intracellular cAMP.

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