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1. 发明授权

US07756306B2 Method and apparatus for extracting cerebral ventricular system from images 失效
标题翻译：从图像中提取脑室系统的方法和装置
公开(公告)号：US07756306B2
公开(公告)日：2010-07-13
申请号：US10547441
申请日：2003-02-27
申请人： Wieslaw Lucjan Nowinski , Yan Xia , Aamer Aziz , Qingmao Hu
发明人： Wieslaw Lucjan Nowinski , Yan Xia , Aamer Aziz , Qingmao Hu
IPC分类号： G06K9/00
CPC分类号： G06K9/342 , G06K9/3233 , G06K2209/05 , G06T7/11 , G06T7/187 , G06T2207/10088 , G06T2207/20156 , G06T2207/30016
摘要： A method and apparatus for extracting a cerebral ventricular system from images of one or more cerebral ventricular regions comprises defining multiple regions of interest (ROI) in the images, defining seed points within each ROI, growing images of ventricular regions while correcting for leakages into extraventricular space and connecting the ventricular regions grown.
摘要翻译：一种用于从一个或多个脑室区域的图像提取脑室系统的方法和装置包括在图像中定义多个感兴趣区域（ROI），在每个ROI内定义种子点，增加心室区域的图像，同时校正泄漏到室内空间和连接心室生长。

2. 发明申请

US20090129671A1 METHOD AND APPARATUS FOR IMAGE SEGMENTATION 审中-公开
标题翻译：图像分割的方法和装置
公开(公告)号：US20090129671A1
公开(公告)日：2009-05-21
申请号：US11910304
申请日：2006-03-28
申请人： Qingmao Hu , Wieslaw L. Nowinski
发明人： Qingmao Hu , Wieslaw L. Nowinski
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： G06K9/38 , G06T7/11 , G06T7/136 , G06T2207/10072 , G06T2207/30016
摘要： A 3D image may be segmented based on one or more intensity thresholds determined from a subset of the voxels in the 3D image. The subset may contain voxels in a 2D reference slice. A low threshold and a high threshold may be used for segmenting an image, and they may be determined using different thresholding methods, depending on the image type. In one method, two sets of bordering pixels are selected from an image. A statistical measure of intensity of each set of pixels is determined. An intensity threshold value is calculated from the statistical measures for segmenting the image. In another method, the pixels of an image are clustered into clusters of different intensity ranges. An intensity threshold for segmenting the image is calculated as a function of a mean intensity and a standard deviation for pixels in one of the clusters. A further method is a supervised range-constrained thresholding method.
摘要翻译：可以基于从3D图像中的体素的子集确定的一个或多个强度阈值来分割3D图像。子集可以包含二维参考片中的体元。可以使用低阈值和高阈值来分割图像，并且它们可以使用不同的阈值方法来确定，这取决于图像类型。在一种方法中，从图像中选择两组边界像素。确定每组像素的强度的统计量度。根据用于分割图像的统计度量计算强度阈值。在另一种方法中，图像的像素被聚集成不同强度范围的簇。根据平均强度和其中一个簇中的像素的标准偏差来计算用于分割图像的强度阈值。另一种方法是监督范围约束阈值法。

3. 发明授权

US08849000B2 Method and device for detecting bright brain regions from computed tomography images 有权
标题翻译：用于从计算机断层摄影图像检测亮脑区域的方法和装置
公开(公告)号：US08849000B2
公开(公告)日：2014-09-30
申请号：US13513453
申请日：2009-12-04
申请人： Qingmao Hu
发明人： Qingmao Hu
IPC分类号： G06K9/00 , G06T7/00 , G06T7/60 , A61B6/00 , A61B6/03
CPC分类号： G06T7/0012 , A61B6/03 , A61B6/501 , G06T7/11 , G06T7/136 , G06T7/155 , G06T7/62 , G06T7/68 , G06T2207/10081 , G06T2207/30016
摘要： A method and devices are disclosed to detect bright brain regions (BBRs) from clinical non-enhanced computed tomography images through large grayscale, large grayscale asymmetry with respect to the midsagittal plane (MSP), and large grayscale local contrast. An adaptive approach is disclosed to determine thresholds of the 3 features and adjust the window width for data conversion. The substantial grayscale variability of BBRs for a subject is addressed by finding the bright portion followed by recovering. Those BBR voxels symmetrical to the MSP are recovered, partial volume effects are compensated and the high grayscale regions which may not correspond to intracerebral hemorrhage are excluded. The disclosed method and system could be a useful tool to aid classifying stroke types, quantifying intracerebral hemorrhage and enhancing stroke therapy.
摘要翻译：公开了一种方法和装置，用于从临床非增强计算机断层摄影图像通过大灰度，相对于中位面（MSP）的大灰度不对称性和大灰度局部对比度来检测亮脑区域（BBR）。公开了一种自适应方法来确定3个特征的阈值并调整数据转换的窗口宽度。通过找到明亮部分，然后进行恢复来解决受试者的BBR的实质灰度变化。恢复与MSP对称的那些BBR体素，补偿部分体积效应，排除可能不对应于脑内出血的高灰度区域。所公开的方法和系统可以是帮助分类卒中类型，量化脑内出血和增强中风治疗的有用工具。

4. 发明授权

US08121375B2 Methods and devices for producing the parameters of the brain tissues and assessing data of the suitability for thrombolysis of a patient 有权
标题翻译：用于产生脑组织参数的方法和装置以及评估病人溶栓适应性的数据
公开(公告)号：US08121375B2
公开(公告)日：2012-02-21
申请号：US12341287
申请日：2008-12-22
申请人： Qingmao Hu
发明人： Qingmao Hu
IPC分类号： G06K9/00
CPC分类号： G01R33/56341 , A61B5/055 , A61B5/4076 , G01R33/5608 , G06T7/0012 , G06T7/136 , G06T2207/10088 , G06T2207/30016
摘要： This invention provides a method and a device for producing the parameters of the brain tissue of a patient quickly by using suitable magnetic resonance imaging, utilizing image processing and computer technology, achieving parameters pertaining to the infarction and the ischemic penumbra. This invention also provides a method and a device for producing and assessing data of the suitability for thrombolysis of a patient quickly and properly by using suitable magnetic resonance imaging, utilizing image processing and computer technology, achieving parameters pertaining to the infarction and the ischemic penumbra and predicting the suitability for thrombolysis.
摘要翻译：本发明提供一种通过使用适合的磁共振成像，利用图像处理和计算机技术，实现与梗塞和缺血半暗带相关的参数，快速产生患者脑组织参数的方法和装置。本发明还提供了一种利用图像处理和计算机技术，通过使用合适的磁共振成像，实现与梗塞和缺血半暗带相关的参数来快速，适当地产生和评估患者血栓溶解适应性的数据的方法和装置，以及预测溶栓的适用性。

5. 发明授权

US07889895B2 Method and apparatus for identifying pathology in brain images 失效
标题翻译：用于识别脑图像病理学的方法和装置
公开(公告)号：US07889895B2
公开(公告)日：2011-02-15
申请号：US10582725
申请日：2003-12-12
申请人： Wieslaw Lucjan Nowinski , Qingmao Hu
发明人： Wieslaw Lucjan Nowinski , Qingmao Hu
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： G06T7/0012 , G06T7/11 , G06T2207/10072 , G06T2207/30016
摘要： A method and apparatus for identifying pathology in a brain image comprises the steps of firstly determining the location of the midsagittal plane (MSP) of the brain illustrated in the image under examination by identifying the symmetry of the two hemispheres based on the determination of up to 16 approximated fissure line segments (AFLSs). Those AFLSs with a larger angular deviation from the MSP than a predefined threshold are considered as outlier AFLSs while the rest are taken as inlier AFLSs. The ratio of the number of the outlier AFLSs to the number of inlier AFLSs is then calculated. A comparison of the ratio with a further predetermined threshold value is made and if the ratio exceeds the further predetermined threshold value, pathology is present in the brain image.
摘要翻译：一种用于识别脑图像中的病理学的方法和装置包括以下步骤：首先通过基于最多至多的确定来确定两个半球的对称性来确定所检查的图像中所示的脑的中间正面（MSP）的位置 16个近似裂缝线段（AFLS）。与MSP相比具有较大角度偏离的那些AFLS比预定义的阈值被认为是异常AFLS，而其余的被认为是非线性AFLS。然后计算异常值AFLS的数量与异常AFLS的数量的比率。进行比率与另外的预定阈值的比较，如果比率超过另外的预定阈值，则脑图像中存在病理学。

6. 发明申请

US20100014727A1 METHODS AND DEVICES FOR PRODUCING THE PARAMETERS OF THE BRAIN TISSUES AND ASSESSING DATA OF THE SUITABILITY FOR THROMBOLYSIS OF A PATIENT 有权
标题翻译：用于生产脑组织参数的方法和装置，并评估用于患者血液透析的适用性的数据
公开(公告)号：US20100014727A1
公开(公告)日：2010-01-21
申请号：US12341287
申请日：2008-12-22
申请人： QINGMAO HU
发明人： QINGMAO HU
IPC分类号： G06K9/00
CPC分类号： G01R33/56341 , A61B5/055 , A61B5/4076 , G01R33/5608 , G06T7/0012 , G06T7/136 , G06T2207/10088 , G06T2207/30016
摘要： This invention provides a method and a device for producing the parameters of the brain tissue of a patient quickly by using suitable magnetic resonance imaging, utilizing image processing and computer technology, achieving parameters pertaining to the infarction and the ischemic penumbra. This invention also provides a method and a device for producing and assessing data of the suitability for thrombolysis of a patient quickly and properly by using suitable magnetic resonance imaging, utilizing image processing and computer technology, achieving parameters pertaining to the infarction and the ischemic penumbra and predicting the suitability for thrombolysis.
摘要翻译：本发明提供一种通过使用适合的磁共振成像，利用图像处理和计算机技术，实现与梗塞和缺血半暗带相关的参数，快速产生患者脑组织参数的方法和装置。本发明还提供了一种利用图像处理和计算机技术，通过使用合适的磁共振成像，实现与梗塞和缺血半暗带相关的参数来快速，适当地产生和评估患者血栓溶解适应性的数据的方法和装置，以及预测溶栓的适用性。

7. 发明授权

US08718345B2 Method and system for obtaining brain characteristic parameters, thrombolysis decision guideline system and method thereof 有权
标题翻译：获取脑特征参数的方法和系统，溶栓决策指导系统及其方法
公开(公告)号：US08718345B2
公开(公告)日：2014-05-06
申请号：US13376943
申请日：2009-06-16
申请人： Qingmao Hu
发明人： Qingmao Hu
IPC分类号： G06K9/00
CPC分类号： G01R33/5608 , A61B5/02007 , A61B5/055 , A61B5/4076 , G01R33/5602 , G01R33/56341 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T2207/10092 , G06T2207/30016
摘要： Method and system for obtaining brain characteristic parameters, thrombolysis decision guideline system and method thereof, provide middle of reference data for early diagnosis and treatment of acute ischemic brain death, and provide effective reference data for thrombolytic therapy. The present invention uses diffusion-weighted imaging, comparing to the clinical programs of diffusion-weighted imaging and perfusion weighted imaging, perfusion weighted imaging can omitted and the degree of functional characterization of perfusion abnormalities is reflected without the perfusion weighted imaging, to provide middle data of brain tissue can be saved and the risk of thrombolytic therapy. The present invention based on ADC low signal constraint and DWI high signal constraint DWI binarization processing to obtain the core area and transition area, that is more accurate.
摘要翻译：提供脑特征参数的方法和系统，溶栓决策指导系统及其方法，为早期诊断和治疗急性脑缺血脑死亡提供参考资料，为血栓溶解治疗提供有效的参考资料。本发明使用扩散加权成像，与扩散加权成像和灌注加权成像的临床程序相比，灌注加权成像可以省略，灌注异常的功能表征程度反映没有灌注加权成像，提供中间数据的脑组织可以节省血栓溶解治疗的风险。本发明基于ADC低信号约束和DWI高信号约束DWI二值化处理获得核心区域和过渡区域，即更准确。

8. 发明申请

US20120076387A1 METHOD AND SYSTEM FOR OBTAINING BRAIN CHARACTERISTIC PARAMETERS, THROMBOLYSIS DECISION GUIDELINE SYSTEM AND METHOD THEREOF 有权
标题翻译：获取脑特征参数的方法和系统，血栓形成决策指导系统及其方法
公开(公告)号：US20120076387A1
公开(公告)日：2012-03-29
申请号：US13376943
申请日：2009-06-16
申请人： Qingmao Hu
发明人： Qingmao Hu
IPC分类号： G06K9/00
CPC分类号： G01R33/5608 , A61B5/02007 , A61B5/055 , A61B5/4076 , G01R33/5602 , G01R33/56341 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T2207/10092 , G06T2207/30016
摘要： Method and system for obtaining brain characteristic parameters, thrombolysis decision guideline system and method thereof, provide middle of reference data for early diagnosis and treatment of acute ischemic brain death, and provide effective reference data for thrombolytic therapy. The present invention uses diffusion-weighted imaging, comparing to the clinical programs of diffusion-weighted imaging and perfusion weighted imaging, perfusion weighted imaging can omitted and the degree of functional characterization of perfusion abnormalities is reflected without the perfusion weighted imaging, to provide middle data of brain tissue can be saved and the risk of thrombolytic therapy. The present invention based on ADC low signal constraint and DWI high signal constraint DWI binarization processing to obtain the core area and transition area, that is more accurate.
摘要翻译：提供脑特征参数的方法和系统，溶栓决策指导系统及其方法，为早期诊断和治疗急性脑缺血脑死亡提供参考资料，为血栓溶解治疗提供有效的参考资料。本发明使用扩散加权成像，与扩散加权成像和灌注加权成像的临床程序相比，灌注加权成像可以省略，灌注异常的功能表征程度反映没有灌注加权成像，提供中间数据的脑组织可以节省血栓溶解治疗的风险。本发明基于ADC低信号约束和DWI高信号约束DWI二值化处理获得核心区域和过渡区域，即更准确。

9. 发明授权

US07409085B2 Method and apparatus for determining symmetry in 2d and 3d images 失效
标题翻译：用于确定2d和3d图像中的对称性的方法和装置
公开(公告)号：US07409085B2
公开(公告)日：2008-08-05
申请号：US10477295
申请日：2002-01-18
申请人： Qingmao Hu , Wieslaw Lucjan Nowinski
发明人： Qingmao Hu , Wieslaw Lucjan Nowinski
IPC分类号： G06K9/00 , G06K9/32 , G06K9/36
CPC分类号： G06T7/68 , G06T2207/30016
摘要： A method of determining symmetry in an image, a method of determining a symmetry plane line segment of a 3D image, a method of determining a symmetry line of a 2D image, and a computer program product. The method includes a) determining at least one searching line segment within a predefined search area of an image portion, the at least one searching line segment including a reference point (x, y) at its center and an angle θ with respect to a predetermined axis of the image portion; b) for each searching line segment, determining a first local characteristic in accordance with a measurement at points adjacent the searching line segment; c) determining the symmetry in the image in accordance with a calculation based on the first local characteristic.
摘要翻译：一种确定图像中的对称性的方法，确定3D图像的对称平面线段的方法，确定2D图像的对称线的方法以及计算机程序产品。该方法包括：a）确定图像部分的预定义搜索区域内的至少一个搜索线段，所述至少一个搜索线段包括其中心处的参考点（x，y）和相对于预定的图像部分的轴线; b）对于每个搜索线段，根据与搜索线段相邻的点处的测量来确定第一局部特征; c）根据基于第一局部特性的计算确定图像中的对称性。

10. 发明申请

US20070122033A1 Methods and apparatus for binarising images 审中-公开
标题翻译：二值化图像的方法和装置
公开(公告)号：US20070122033A1
公开(公告)日：2007-05-31
申请号：US10582439
申请日：2004-12-09
申请人： Qingmao Hu , Zujun Hou , Wieslaw Nowinski
发明人： Qingmao Hu , Zujun Hou , Wieslaw Nowinski
IPC分类号： G06K9/34 , G06K9/38 , G06K9/00
CPC分类号： G06K9/38 , G06T7/11 , G06T7/136 , G06T7/194 , G06T2207/10088 , G06T2207/20012 , G06T2207/30016
摘要： A method is proposed for binarising an image by deriving an intensity threshold and classifying pixels according to whether their intensity is below or above the threshold. In the derivation of the threshold, prior konwledge is used to define a region of interest (ROI) in the image. Furthermore, prior knowledge is used to select a range in the frequency distribution of the intensities of the pixels in the ROI, and that only data within this frequency range is used to derive the threshold. These techniques provide a highly effective mechanism for incorporating prior knowledge into the threshold selection which is critical whether the image is a medical image or not. In particular, a threshold can be found to binarise images which exhibits high robustness to imaging artefacts such a gray level inhomogeneity and noise.
摘要翻译：提出了一种通过导出强度阈值来对图像进行二进制化的方法，并根据它们的强度是否低于阈值来分类像素。在阈值的推导中，先前的konwledge用于定义图像中的感兴趣区域（ROI）。此外，使用现有知识来选择ROI中的像素的强度的频率分布中的范围，并且仅使用该频率范围内的数据来导出阈值。这些技术提供了将先验知识结合到阈值选择中的非常有效的机制，这对于图像是否是医学图像是至关重要的。特别地，可以发现阈值对于对成像伪像（如灰度不均匀性和噪声）表现出高鲁棒性的图像进行二值化。

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