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    • 9. 发明申请
    • MONOCLONAL ANTIBODY hPAM4
    • 单克隆抗体hPAM4
    • WO2003106495A2
    • 2003-12-24
    • PCT/GB2003/002593
    • 2003-06-16
    • IMMUNOMEDICS, INC.MCCALL, John, DouglasGOLDENBERG, David, M.HANSEN, HansQU, Zhengxing
    • GOLDENBERG, David, M.HANSEN, HansQU, Zhengxing
    • C07K16/00
    • A61K49/0008A61K47/68A61K51/1057A61K2039/505C07K14/4748C07K16/2896C07K2317/24
    • This invention relates to monovalent and multivalent, monospecific antibodies and to multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these antibodies has two or more binding sites where these binding sites have affinity towards different epitopes on a target antigen or different target antigens, or have affinity towards a target antigen and a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional antibodies in a host. More specifically, the present invention relates to the tumor-associated antibody designated PAM4. The invention further relates to humanized and human PAM4 antibodies, and the use of such antibodies in diagnosis and therapy.
    • 本发明涉及单价和多价单特异性抗体和多价多特异性抗体。 这些抗体的一个实施方案具有一个或多个相同的结合位点,其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些抗体的另一个实施方案具有两个或多个结合位点,其中这些结合位点对靶抗原或不同靶抗原上的不同表位具有亲和力,或对靶抗原和半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性抗体的重组载体。 更具体地,本发明涉及称为PAM4的肿瘤相关抗体。 本发明还涉及人源化和人类PAM4抗体,以及这些抗体在诊断和治疗中的用途。