专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003101495A1 METHODS AND COMPOSITIONS FOR RADIOIMMUNOTHERAPY OF BRAIN AND CNS TUMORS 审中-公开
标题翻译：脑和CNS肿瘤放射免疫学的方法和组合
公开(公告)号：WO2003101495A1
公开(公告)日：2003-12-11
申请号：PCT/GB2003/002334
申请日：2003-05-28
申请人： IMMUNOMEDICS, INC. , MCCALL, John, Douglas , GRIFFITHS, Gary, L. , GOLDENBERG, David, M.
发明人： GRIFFITHS, Gary, L. , GOLDENBERG, David, M.
IPC分类号： A61K51/10
CPC分类号： A61K51/109
摘要： A method for treating a brain tumor by administering to a patient (i) a multispecific antibody comprising at least one targeting arm that binds to a brain cancer antigen and at least one capture arm that binds to a radionuclide carrier; (ii) a therapeutic radionuclide carrier to which is bound a therapeutic radionuclide, wherein the multispecific antibody, radionuclide carrier and therapeutic radionuclide are administered in a substantially equimolar ratio.
摘要翻译：一种通过给予患者（i）包含至少一种与脑癌抗原结合的靶向臂的多特异性抗体和与放射性核素载体结合的至少一种捕获臂来治疗脑肿瘤的方法。（ii）与治疗性放射性核素结合的治疗性放射性核素载体，其中所述多特异性抗体，放射性核素载体和治疗性放射性核素以基本上等摩尔比施用。

2. 发明申请

WO0033874B1 BORON NEUTRON CAPTURE THERAPY USING PRE-TARGETING METHODS 审中-公开
标题翻译：用预靶向方法进行硼中子俘获治疗
公开(公告)号：WO0033874B1
公开(公告)日：2000-11-16
申请号：PCT/US9927915
申请日：1999-12-06
申请人： IMMUNOMEDICS INC , GRIFFITHS GARY L , GOVINDAN SERENGULAM V
发明人： GRIFFITHS GARY L , GOVINDAN SERENGULAM V
IPC分类号： A61K39/395 , A61K31/69 , A61K31/721 , A61K31/785 , A61K41/00 , A61K47/48 , A61K51/10 , A61P35/00 , C07K16/18 , C07K16/30 , C07K16/44 , C07K16/46 , G01N33/531 , G01N33/534 , G01N33/574 , G01N33/68
CPC分类号： G01N33/686 , A61K41/0095 , A61K47/665 , A61K47/6893 , A61K47/6897 , A61K47/6898 , A61K51/1078 , A61K51/1093 , A61K2039/505 , A61K2121/00 , A61K2123/00 , B82Y5/00 , C07K16/18 , C07K16/3007 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00 , G01N33/531 , G01N33/534 , G01N33/574
摘要： The present invention provides a method for targeting boron atoms to tumor cells in a patient. The method includes the steps of: (A) administering a targeting composition comprising a conjugate of: (i) at least one first antibody or antigen-binding antibody fragment which selectively binds to an antigen produced by or associated with the tumor cells and present at the tumor cells, and (ii) at least one second antibody or antibody fragment which specifically binds to a hapten on a boron compound; (B) optionally, a clearing composition; (C) said boron compound; and (D) optionally, a second clearing composition. The method may further comprise the step of irradiating the boron atoms of the boron compound, thereby effecting BNCT of the tumor cells. Compositions and kits for carrying out the method also are provided.
摘要翻译：本发明提供了一种将硼原子靶向患者肿瘤细胞的方法。该方法包括以下步骤：（A）施用包含以下物质的缀合物的靶向组合物：（i）至少一种第一抗体或抗原结合抗体片段，其选择性结合由肿瘤细胞产生或与之相关的抗原，和（ii）与硼化合物上的半抗原特异性结合的至少一种第二抗体或抗体片段; （B）任选的透明组合物; （C）所述硼化合物; 和（D）任选地，第二清澈组合物。该方法可以进一步包括照射硼化合物的硼原子从而实现肿瘤细胞的BNCT的步骤。还提供了用于实施该方法的组合物和试剂盒。

3. 发明申请

WO9966951A3 USE OF BI-SPECIFIC ANTIBODIES FOR PRE-TARGETING DIAGNOSIS AND THERAPY 审中-公开
标题翻译：用于预先诊断和治疗的BI特异性抗体的使用
公开(公告)号：WO9966951A3
公开(公告)日：2000-06-15
申请号：PCT/US9913879
申请日：1999-06-22
申请人： IMMUNOMEDICS INC , HANSEN HANS J , GRIFFITHS GARY L , LEUNG SHUI ON , MCBRIDE WILLIAM J , QU ZHENGXING
发明人： HANSEN HANS J , GRIFFITHS GARY L , LEUNG SHUI-ON , MCBRIDE WILLIAM J , QU ZHENGXING
IPC分类号： A61K33/22 , A61K39/395 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/08 , A61K51/10 , A61P35/00 , A61P43/00 , C07K16/18 , C07K16/30 , C07K16/42 , C07K16/44 , C07K16/46 , A01K67/027 , C12N15/13 , C12N15/62
CPC分类号： C07K16/468 , A61K47/67 , A61K47/6853 , A61K47/6863 , A61K47/6879 , A61K47/6893 , A61K47/6897 , A61K51/088 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K16/18 , C07K16/3007 , C07K16/4266 , C07K16/44 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译：本发明涉及具有特异性结合目标组织的至少一个臂和特异性结合可靶向缀合物的至少一个其他臂的双特异性抗体或抗体片段。可靶向缀合物包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。可靶向缀合物还包含一种或多种治疗剂或诊断剂或酶。本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

4. 发明申请

WO1998008548A3 STABLE RADIOIODINE CONJUGATES AND METHODS FOR THEIR SYNTHESIS 审中-公开
公开(公告)号：WO1998008548A3
公开(公告)日：1998-03-05
申请号：PCT/US1997014998
申请日：1997-08-27
申请人： IMMUNOMEDICS, INC. , GOVINDAN, Serengulam, V. , GRIFFITHS, Gary, L.
发明人： IMMUNOMEDICS, INC.
IPC分类号： A61K51/08

5. 发明申请

WO1998004293A1 IMPROVED DETECTION AND THERAPY OF LESIONS WITH BIOTIN-CHELATE CONJUGATES 审中-公开
标题翻译：改进的生物柴油凝胶的检测和治疗
公开(公告)号：WO1998004293A1
公开(公告)日：1998-02-05
申请号：PCT/US1997013285
申请日：1997-07-31
申请人： IMMUNOMEDICS, INC. , GRIFFITHS, Gary, L. , HANSEN, Hans, J. , KARACAY, Habibe
发明人： IMMUNOMEDICS, INC.
IPC分类号： A61K51/00
CPC分类号： A61K49/10 , A61K49/085 , A61K49/14 , A61K51/0497 , B82Y5/00
摘要： An improved method of detecting and/or treating lesions in a patient in which a pre-targeting approach is used wherein the total amount of radionuclide delivered to a target cell, tissue, or pathogen is dramatically increased. In this method, the chelate conjugate may be purified by chromatography after chelate formation, may contain multiple chelates or a blood transit-modifying linker or added within the chelate conjugate, or both; or a combination of these. The improved chelate conjugates can be used as detection of therapeutic agents to detect or treat the targeted cell, tissue, or pathogen.
摘要翻译：一种用于检测和/或治疗患者中的损伤的改进方法，其中使用预靶向方法，其中递送至靶细胞，组织或病原体的放射性核素的总量显着增加。在该方法中，螯合物形成后可以通过色谱法纯化螯合物缀合物，可以含有多个螯合物或血液转运修饰接头或加入到螯合缀合物内，或两者都可以。或这些的组合。改进的螯合物可用作检测或治疗靶细胞，组织或病原体的治疗剂的检测。

6. 发明申请

WO1996040289A1 THIOLATION OF PEPTIDES FOR RADIONUCLIDE-BASED RADIODETECTION AND RADIOTHERAPY 审中-公开
标题翻译：基于放射性核素的放射治疗和放射治疗的肽的断裂
公开(公告)号：WO1996040289A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008693
申请日：1996-06-07
申请人： IMMUNOMEDICS, INC. , GOVINDAN, Serengulam, V. , GRIFFITHS, Gary, L. , HANSEN, Hans, L.
发明人： IMMUNOMEDICS, INC.
IPC分类号： A61K51/00
CPC分类号： A61K51/088 , A61K51/083
摘要： A method of radiolabeling a peptide, e.g., somatostatin or an analogue thereof or vasoactive intestinal peptide, with a radioisotope of technetium or rhenium, comprises the steps of: (a) reacting the peptide with an acetyl-protected t -thiol-containing, amine-reactive bifunctional chelating agent; (b) deprotecting the acetyl- t -thiol group to generate a free t -thiol group; and either (c) admixing the peptide- t -thiol-containing conjugate with a stannous salt; and (d) reacting the mixture of step (c) with pertechnetate or perrhenate, or (c') adding reduced pertechnetate or perrhenate to said peptide- t -thiol-containing conjugate, thereby forming a radiolabeled peptide. Kits for effecting the radiolabeling method, and methods of tumor detection/imaging or therapy are provided.
摘要翻译：将肽，例如生长抑素或其类似物或血管活性肠肽与锝或铼的放射性同位素放射标记的方法包括以下步骤：（a）使肽与乙酰基保护的u 含硫醇的胺反应性双功能螯合剂; （b）使乙酰基-t硫醇基脱保护以产生游离叔硫醇基团; 并且（c）将含有肽-TH-硫醇的缀合物与亚锡盐混合; 和（d）使步骤（c）的混合物与高锝酸盐或高铼酸盐反应，或（c'）向所述含有肽-TH-硫醇的缀合物加入减少的高锝酸盐或高铼酸盐，由此形成放射性标记的肽。提供了用于实现放射性标记方法的试剂盒，以及肿瘤检测/成像或治疗方法。

7. 发明申请

WO2012058269A2 METHODS OF TREATING CANCER AND OTHER DISEASES 审中-公开
标题翻译：治疗癌症及其他疾病的方法
公开(公告)号：WO2012058269A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/057820
申请日：2011-10-26
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GOLDSBOROUGH, Andrew S. , DULCEY, Andres , HANDLEY, Misty , HALL, Matthew D. , BRIMACOMBE, Kyle , GRIFFITHS, Gary L. , GOTTESMAN, Michael M.
发明人： GOLDSBOROUGH, Andrew S. , DULCEY, Andres , HANDLEY, Misty , HALL, Matthew D. , BRIMACOMBE, Kyle , GRIFFITHS, Gary L. , GOTTESMAN, Michael M.
IPC分类号： C07C321/14
CPC分类号： C07C323/60
摘要： Disclosed are a method of treating cancer in a cell, a method of enhancing the chemotherapeutic treatment of a cancer treatment agent, a method of reducing resistance of a cancer cell to a chemotherapeutic agent, a method of reducing the amount or activity of an ABC-family mRNA and/or protein, a method of reducing the amount or activity of the ABCB1 mRNA and/or protein or the ABCC1 mRNA and/or protein in an animal cell undergoing cancer treatment, a method of reducing the amount or activity of glutathione and/or Bcl2 in the cancer cell, a method of treating other multidrug resistant diseases, and a method of treating a multidrug resistant cell such as a bacterial multidrug resistant Staphylococcus aureus (MRSA), tuberculosis, fungal infection, or MDR malaria, by administering a compound of the Formula (I): a diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein R 1 -R 4 are as described herein. Also disclosed are pharmaceutical compositions comprising a compound of formula (I), a diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
摘要翻译：公开了一种治疗细胞癌的方法，增强癌症治疗剂的化学治疗的方法，降低癌细胞对化学治疗剂的抗性的方法，降低ABC- 家族mRNA和/或蛋白质，在经历癌症治疗的动物细胞中减少ABCB1 mRNA和/或蛋白质或ABCC1 mRNA和/或蛋白质的量或活性的方法，减少谷胱甘肽的量或活性的方法和 /或Bcl2，治疗其他多药耐药性疾病的方法，以及治疗多药耐药性金黄色葡萄球菌（MRSA），结核病，真菌感染或MDR疟疾的多药耐药性细胞的方法，通过施用式（I）化合物：其非对映异构体或其药学上可接受的盐，其中R 1 -R 4如本文所述。还公开了包含式（I）化合物，其非对映异构体或其药学上可接受的盐和药学上可接受的载体的药物组合物。

8. 发明申请

WO2005084179A3 IMPROVED METHOD FOR PREPARING CONJUGATES OF PROTEINS AND CHELATING AGENTS 审中-公开
标题翻译：制备蛋白质和螯合剂结合物的改进方法
公开(公告)号：WO2005084179A3
公开(公告)日：2006-03-16
申请号：PCT/US2004040046
申请日：2004-12-01
申请人： IMMUNOMEDICS INC , GRIFFITHS GARY L , GOVINDAN SERENGULAM V
发明人： GRIFFITHS GARY L , GOVINDAN SERENGULAM V
IPC分类号： A61K51/00 , A61K51/10 , C07K14/52 , C07K14/525 , C07K14/54 , C07K16/46 , A61K51/08
CPC分类号： A61K51/1027 , A61K51/0482 , A61K51/1045
摘要： Improved synthesis methods are provided for preparing conjugates of proteins and chelating agents. In the synthesis methods, non-stable bonds are hydrolyzed after the conjugate is synthesized, for example by treating the conjugate with a quenching agent. The synthesis method provides conjugates that are substantially free of non-stable bonds between the protein and the chelating agent, such that the chelating agent is less likely to dissociate with the conjugate after the conjugate has been stored for extended periods. The conjugate may be useful for therapeutic or diagnostic methods.
摘要翻译：提供改进的合成方法用于制备蛋白质和螯合剂的缀合物。在合成方法中，在合成共轭物后，例如通过用猝灭剂处理缀合物，非稳定键被水解。合成方法提供基本上不含蛋白质和螯合剂之间非稳定键的缀合物，使得螯合剂在缀合物长时间储存后不太可能与缀合物解离。缀合物可用于治疗或诊断方法。

9. 发明申请

WO1999011294A1 STABLE RADIOIODINE CONJUGATES AND METHODS FOR THEIR SYNTHESIS 审中-公开
标题翻译：稳定的放射性素结合物及其合成方法
公开(公告)号：WO1999011294A1
公开(公告)日：1999-03-11
申请号：PCT/US1997023711
申请日：1997-12-19
申请人： IMMUNOMEDICS, INC. , GOVINDAN, Serengulam, V. , GRIFFITHS, Gary, L.
发明人： IMMUNOMEDICS, INC.
IPC分类号： A61K51/04
CPC分类号： A61K51/0491 , A61K51/088 , A61K51/10 , A61K51/1093 , C07H3/04 , C07K1/1077 , G01N33/543
摘要： Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable bonds such as amide bonds are coupled to cell targeting protein. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to protein. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to protein. In a fourth method, a hydrazide-appended protein is coupled to a radioiodinated carbohydrate or a thiolated protein is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated protein. Radioiodinated residualizing protein conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.
摘要翻译：描述了将放射性碘化肽或碳水化合物结构与缀合物的产率和质量提高的蛋白质缀合的方法。在一种方法中，特异设计的含有非代谢性键如酰胺键的放射性碘化双功能肽与细胞靶向蛋白偶联。在第二种方法中，也含有氨基多羧酸盐的放射性碘化的不可代谢的双功能肽与蛋白质偶联。在第三种方法中，放射性碘化双官能氨基多羧酸盐与蛋白质偶联。在第四种方法中，酰肼附着的蛋白质与放射性碘化碳水化合物偶联，或硫醇化蛋白质与酰肼附着和放射性碘化碳水化合物偶联。在第五种方法中，使用monoderivatized氰尿酰氯来缀合硫醇化蛋白质。通过这些方法制备的放射性碘化残留蛋白质缀合物在体内特别稳定，适用于放射免疫检测和放射免疫治疗。

10. 发明申请

WO2011090710A3 COMPOSITE PROBES AND USE THEREOF IN SUPER RESOLUTION METHODS 审中-公开
公开(公告)号：WO2011090710A3
公开(公告)日：2011-07-28
申请号：PCT/US2010/062214
申请日：2010-12-28
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KNUTSON, Jay, R. , GRIFFITHS, Gary, L.
发明人： KNUTSON, Jay, R. , GRIFFITHS, Gary, L.
IPC分类号： G01N33/52 , G01N33/58 , G01N21/64
摘要： Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式